Dietary protein and muscle in older persons

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 17, Issue 1, 2014, Pages 5-11

  Paddon Jones, Douglas ^a   Leidy, Heather ^b  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b University of Missouri   (United States)

Author keywords

Ageing; Nutrition; Sarcopenia; Satiety; Strength

Indexed keywords

GHRELIN; GLUCAGON LIKE PEPTIDE 1; MUSCLE PROTEIN; PEPTIDE YY;

AGING; BED REST; BODY FAT; BODY MASS; BODY WEIGHT; CALORIC INTAKE; DIETARY REFERENCE INTAKE; FOOD INTAKE; FUNCTIONAL STATUS; HUMAN; HUNGER; META ANALYSIS (TOPIC); METABOLIC SYNDROME X; MUSCLE; MUSCLE MASS; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRITIONAL REQUIREMENT; OBESITY; PHYSICAL INACTIVITY; POSTPRANDIAL STATE; PROTEIN DIET; PROTEIN INTAKE; PROTEIN METABOLISM; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SARCOPENIA; SATIETY; SKELETAL MUSCLE; WAIST CIRCUMFERENCE; WEIGHT REDUCTION;

AGING; BODY COMPOSITION; BODY WEIGHT; DIETARY PROTEINS; ENERGY INTAKE; HUMANS; MUSCLE PROTEINS; MUSCLE, SKELETAL; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SARCOPENIA;

EID: 84890932409     PISSN: 13631950     EISSN: 14736519     Source Type: Journal    
DOI: 10.1097/MCO.0000000000000011     Document Type: Review

References (47)

1. Landi F, Liperoti R, Russo A, et al. Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study. Clin Nutr 2012; 31: 652-658.
2. Fisher SR, Goodwin JS, Protas EJ, et al. Ambulatory activity of older adults hospitalized with acute medical illness. J Am Geriatr Soc 2011; 59: 91-95.
3. Wolfe RR, Miller SL. The recommended dietary allowance of protein: a misunderstood concept. JAMA 2008; 299: 2891-2893. (Pubitemid 351930889)
4. Wolfe RR, Miller SL, Miller KB. Optimal protein intake in the elderly. Clin Nutr 2008; 27: 675-684.
5. Houston DK, Nicklas BJ, Ding J, et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 2008; 87: 150-155.
6. Volpi E, Campbell WW, Dwyer JT, et al. Is the optimal level of protein intake for older adults greater than the recommended dietary allowance? J Gerontol A Biol Sci Med Sci 2013; 68: 677-681.
7. Fielding RA, Vellas B, Evans WJ, et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc 2011; 12: 249-256.
8. Phillips SM. Dietary protein requirements and adaptive advantages in athletes. Br J Nutr 2012; 108 (Suppl 2):S158-S167.
9. Fulgoni VL. Current protein intake in America: analysis of the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr 2008; 87:1554S-1557S.
10. Layman DK. Dietary guidelines should reflect new understandings about adult protein needs. Nutr Metab (Lond) 2009; 6:12.
11. English KL, Paddon-Jones D. Protecting muscle mass and function in older adults during bed rest. Curr Opin Clin Nutr Metab Care 2010; 13: 34-39.
12. Wall BT, Dirks ML, van Loon LJ. Skeletal muscle atrophy during short-term disuse: implications for age-related sarcopenia. Ageing Res Rev 2013; 12: 898-906.
13. Drewnowski A, Fulgoni VL, Young MK, Pitman S. Nutrient-rich foods: applying nutrient navigation systems to improve public health. J Food Sci 2008; 73:H222-H228.
14. Tang M, Armstrong CL, Leidy HJ, Campbell WW. Normal vs. high-protein weight loss diets in men: effects on body composition and indices of metabolic syndrome. Obesity (Silver Spring) 2013; 21:E204-E210.
15. Coker RH, Miller S, Schutzler S, et al. Whey protein and essential amino acids promote the reduction of adipose tissue and increased muscle protein synthesis during caloric restriction-induced weight loss in elderly, obese individuals. Nutr J 2012; 11:105.
16. Fielding RA, Gunstad J, Gustafson DR, et al. The paradox of overnutrition in aging and cognition. Ann N Y Acad Sci 2013; 1287: 31-43.
17. Leidy HJ, Tang M, Armstrong CL, et al. The effects of consuming frequent, higher protein meals on appetite and satiety during weight loss in overweight/ obese men. Obesity (Silver Spring) 2011; 19: 818-824.
18. Bollwein J, Diekmann R, Kaiser MJ, et al. Distribution but not amount of protein intake is associated with frailty: a cross-sectional investigation in the region of Nurnberg. Nutr J 2013; 12:109. This cross-sectional study highlights that even when older adults exceed the RDA for protein, an even protein distribution may be associated with muscle loss/fraility.
19. Bouillanne O, Curis E, Hamon-Vilcot B, et al. Impact of protein pulse feeding on lean mass in malnourished and at-risk hospitalized elderly patients: a randomized controlled trial. Clin Nutr 2013; 32: 186-192.
20. Paddon-Jones D, Rasmussen BB. Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care 2009; 12: 86-90.
21. Wycherley TP, Moran LJ, Clifton PM, et al. Effects of energy-restricted highprotein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2012; 96: 1281-1298.
22. Dong JY, Zhang ZL, Wang PY, Qin LQ. Effects of high-protein diets on body weight, glycaemic control, blood lipids and blood pressure in type 2 diabetes: meta-analysis of randomised controlled trials. Br J Nutr 2013; 110: 781-789.
23. Santesso N, Akl EA, Bianchi M, et al. Effects of higher- versus lower-protein diets on health outcomes: a systematic review and meta-analysis. Eur J Clin Nutr 2012; 66: 780-788.
24. Cederholm T, Cruz-Jentoft AJ, Maggi S. Sarcopenia and fragility fractures. Eur J Phys Rehabil Med 2013; 49: 111-117.
25. Paddon-Jones D, Sheffield-MooreM, Urban RJ, et al. Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. J Clin Endocrinol Metab 2004; 89: 4351-4358. (Pubitemid 39244437)
26. Ferrando AA, Paddon-Jones D, Hays NP, et al. EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly. Clin Nutr 2010; 29: 18-23.
27. English KL. Effects of leucine on skeletal muscle during 14 d bed rest in middle-aged adults. Galveston, TX: The University of Texas Medical Branch; 2013.
28. Kortebein P, Symons TB, Ferrando A, et al. Functional impact of 10 days of bed rest in healthy older adults. J Gerontol A Biol Sci Med Sci 2008; 63: 1076-1081.
29. Symons TB, Sheffield-Moore M, Mamerow MM, et al. The anabolic response to resistance exercise and a protein-rich meal is not diminished by age. J Nutr Health Aging 2011; 15: 376-381.
30. English KL, Paddon-Jones D. Protecting muscle mass and function in older adults during bed rest. Curr Opin Clin Nutr Metab Care 2010; 13: 34-39.
31. Deutz NE, Pereira SL, Hays NP, et al. Effect of b-hydroxy-b- methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults. Clin Nutr 2013; 32: 704-712. This study reports that a low volume supplement (HMB) partially preserved muscle mass during physical inactivity. This has potential application for clinical populations and individuals unable to consume sufficient protein during periods of metabolic stress.
32. Casperson SL, Sheffield-Moore M, Hewlings SJ, Paddon-Jones D. Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for protein. Clin Nutr 2012; 31: 512-519.
33. Leidy HJ. Evidence supporting a diet rich in protein to improve appetite control, satiety, and weight management across the lifespan. American Meat Science Association 65th Reciprocal Meat Conference; 17-20 June 2012; North Dakota State University, Fargo, North Dakota. 2012. pp. 1-5.
34. van der Klaauw A, Keogh J, Henning E, et al. High protein intake stimulates GLP1 and PYY release. Obesity 2013; 21: 1602-1607.
35. Leidy HJ, Lepping RJ, Savage CR, Harris CT. Neural responses to visual food stimuli after a normal vs. higher protein breakfast in breakfast-skipping teens: a pilot fMRI study. Obesity (Silver Spring) 2011; 19: 2019-2025.
36. Leidy HJ, Ortinau LC, Douglas SM, Hoertel HA. Beneficial effects of a higherprotein breakfast on the appetitive, hormonal, and neural signals controlling energy intake regulation in overweight/obese, 'breakfast-skipping,' lateadolescent girls. Am J Clin Nutr 2013; 97: 677-688.
37. Leidy HJ, Mattes RD, Campbell WW. Effects of acute and chronic protein intake on metabolism, appetite, and ghrelin during weight loss. Obesity (Silver Spring) 2007; 15: 1215-1225. (Pubitemid 46932477)
38. Leidy HJ, Carnell NS, Mattes RD, Campbell WW. Higher protein intake preserves lean mass and satiety with weight loss in preobese and obese women. Obesity (Silver Spring) 2007; 15: 421-429. (Pubitemid 46407324)
39. Symons TB, Sheffield-Moore M, Wolfe RR, Paddon-Jones D. A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J Am Diet Assoc 2009; 109: 1582-1586.
40. Phillips BE, Hill DS, Atherton PJ. Regulation of muscle protein synthesis in humans. Curr Opin Clin Nutr Metab Care 2012; 15: 58-63.
41. Yang Y, Breen L, Burd NA, et al. Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men. Br J Nutr 2012; 108: 1780-1788.
42. Robinson MJ, Burd NA, Breen L, et al. Dose-dependent responses of myofibrillar protein synthesis with beef ingestion are enhanced with resistance exercise in middle-aged men. Appl Physiol Nutr Metab 2013; 38: 120-125.
43. Leidy HJ, Armstrong CL, Tang M, et al. The influence of higher protein intake and greater eating frequency on appetite control in overweight and obese men. Obesity (Silver Spring) 2010; 18: 1725-1732.
44. Leidy HJ, Tang M, Armstrong CL, et al. The effects of consuming frequent, higher protein meals on appetite and satiety during weight loss in overweight/ obese men. Obesity (Silver Spring) 2011; 19: 818-824.
45. Arciero P J, Ormsbee M J, Gentile C L, et al. Increased protein intake and meal frequency reduces abdominal fat during energy balance and energy deficit. Obesity (Silver Spring) 2013; 21: 1357-1366.
46. Leidy HJ. The benefits of breakfast consumption to combat obesity and diabetes in young people. Am J Lifestyle Med 2013; 7: 98-104.
47. Leidy HJ, Bossingham MJ, Mattes RD, Campbell WW. Increased dietary protein consumed at breakfast leads to an initial and sustained feeling of fullness during energy restriction compared to other meal times. Br J Nutr 2009; 101: 798-803.