Whey protein and essential amino acids promote the reduction of adipose tissue and increased muscle protein synthesis during caloric restriction-induced weight loss in elderly, obese individuals

Nutrition Journal

Volumn 11, Issue 1, 2012, Pages

  Coker, Robert H ^a   Miller, Sharon ^b   Schutzler, Scott ^a   Deutz, Nicolaas ^a   Wolfe, Robert R ^a  

^a Center for Translational Research in Aging and Longevity   (United States)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Fat; Obesity; Protein

Indexed keywords

CHOLESTEROL; ESSENTIAL AMINO ACID; GLUCOSE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; MILK PROTEIN; MUSCLE PROTEIN; PHENYLALANINE; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADIPOSE TISSUE; AGED; ARTICLE; BODY COMPOSITION; BODY MASS; BODY WEIGHT; CALORIC RESTRICTION; CONTROLLED STUDY; ENERGY EXPENDITURE; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GROUPS BY AGE; HUMAN; LEAN BODY WEIGHT; LIPID BLOOD LEVEL; MALE; MEAL; METABOLIC PARAMETERS; NORMAL HUMAN; OBESITY; PROTEIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; SKELETAL MUSCLE; WEIGHT REDUCTION;

ADIPOSE TISSUE; AGED; AGED, 80 AND OVER; AMINO ACIDS, ESSENTIAL; BODY COMPOSITION; BODY WEIGHT; CALORIC RESTRICTION; ENERGY INTAKE; FEMALE; HUMANS; MALE; MILK PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; OBESITY; WEIGHT LOSS;

EID: 84870712685     PISSN: None     EISSN: 14752891     Source Type: Journal    
DOI: 10.1186/1475-2891-11-105     Document Type: Article

References (33)

1. Role of dietary protein in the sarcopenia of aging. Paddon-Jones D, Short KR, Campbell WW, Volpi E, Wolfe RR, Am J Clin Nutr 2008 87 5 1562S 1566S 18469288 (Pubitemid 351679811)
2. Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health. Hughes VA, Frontera WR, Wood M, Evans WJ, Dallal GE, Roubenoff R, Fiatarone-Singh MA, J Geronotol A Biol Sci Med Sci 2001 56 5 209 B217 10.1093/gerona/56.5.B209
3. Epidemiology of sarcopenia among the elderly in New Mexico [published erratum appears in. Baumgartner RN, Koehler KM, Gallagher D, et al. Am J Epidemiol 1999 149 12 755 763
4. Obese sarcopenia in patients with end-stage renal disease is associated with inflammation and increased mortality. Honda H, Qureshi AR, Axelsson J, Heimburger O, Suliman ME, Barany P, Stenvinkel P, Lindholm B, Am J Clin Nutr 2007 86 3 633 638 17823427 (Pubitemid 47435829)
5. Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. Janssen I, Heymsfield SB, Ross R, J Am Geriatr Soc 2002 50 5 889 896 10.1046/j.1532-5415. 2002.50216.x 12028177 (Pubitemid 34496687)
6. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. Cuthbertson D, Smith K, Babraj J, Leese G, Waddell T, Atherton P, Wackerhage H, Taylor PM, Rennie MJ, FASEB J 2005 19 3 422 424 15596483 (Pubitemid 40316537)
7. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR, J Clin Endocrinol Metab 2000 85 12 4481 4490 10.1210/jc.85.12.4481 11134097 (Pubitemid 32157622)
8. The financial burden of overweight and obesity among elderly Americans: the dynamics of weight, longevity, and health care cost. Yang Z, Hall AG, Health Serv Res 2008 43 3 849 868 18454771 (Pubitemid 351623951)
9. Health consequences of obesity in the elderly: a review of four unresolved questions. Zamboni M, Mazzali G, Zoico E, Harris TB, Meigs JB, Di Francesco V, Fantin F, Bissoli L, Bosello O, Int J Obes (London) 2005 29 9 1011 1029 10.1038/sj.ijo.0803005 (Pubitemid 41192208)
10. The cardiometabolic syndrome and sarcopenic obesity in older persons. Dominguez LJ, Barbagallo M, J Cardiometab Syndr 2007 2 3 183 189 10.1111/j.1559-4564.2007.06673.x 17786082
11. The danger of weight loss in the elderly. Miller SL, Wolfe RR, J Nutr Health Aging 2008 12 7 487 491 10.1007/BF02982710 18615231
12. The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. Campbell WW, Trappe TA, Wolfe RR, Evans WJ, J Geronotol A Biol Sci Med Sci. 2001 56 273 373 M380
13. Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein. Paddon-Jones D, Sheffield-Moore M, Katsanos CS, Zhang XJ, Wolfe RR, Exp Gerontol 2006 41 215 219 10.1016/j.exger.2005.10.006 16310330 (Pubitemid 43165694)
14. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction. Volpi E, Mittendorfer B, Wolf SE, Wolfe RR, Am J Physiol 1999 277 3 Pt 1 513 E520 10484364
15. Effects of lifestyle changes to reduce risks of diabetes and associated cardiovascular risks: results from large scale efficacy trial. Horton ES, Obesity (Silver Spring) 2009 17 Suppl 3 43 S48
16. Effect of amino acid supplementation on muscle mass, strength and physical function in elderly. Boersheim E, Bui QU, Tissier S, Kobayashi H, Ferrando AA, Wolfe RR, Clin Nutr 2008 27 2 189 195 10.1016/j.clnu.2008.01.001 18294740
17. Wolfe RR, Radioactive and stable isotope tracers in biomedicine: principles and practice of kinetic analysis New York: Wiley-Liss, Inc. 1992
18. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR, Am J Clin Nutr 2003 78 2 250 258 12885705 (Pubitemid 39655228)
19. Computational model of in vivo human energy metabolism during semistarvation and refeeding. Hall KD, Am J Physiol Endocrinol Metab 2006 291 23 E37 10.1152/ajpendo.00523.2005 16449298 (Pubitemid 44035307)
20. Sample size and power estimation for studies with health related quality of life outcomes: a comparison of four methods using the SF-36. Walters SJ, Health Qual Life Outcomes 2004 25 2 26
21. EAA supplementation to increase nitrogen intake improves muscle function during bedrest in the elderly. Ferrando AA, Paddon-Jones D, Hays NP, Kortebein P, Ronsen O, Williams RH, McComb A, Symons TB, Wolfe RR, Evans WJ, Clin Nutr 2010 29 1 18 23 10.1016/j.clnu.2009.03.009 19419806
22. Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content. Katsanos CS, Chinkes DL, Paddon-Jones D, Zhang XJ, Aarsland A, Wolfe R, Nutr Res 2008 28 10 651 658 10.1016/j.nutres.2008.06.007 19083472
23. Energy expenditure by doubly-labeled water: water validation in humans and proposed calculations. Schoeller DA, Ravussin E, Schutz Y, Acheson KJ, Baertschi P, Jequier E, Am J Physiol Endocrinol Metab 1986 250 823 R830
24. Dietary guidelines for Americans Washington, DC: US Department of Health and Human Services 6 2005
25. The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. Campbell WW, Trappe TA, Wolfe RR, Evans WJ, J Gerontol A Biol Sci Med Sci 2001 56 373 M380 10.1093/gerona/56.6. M373 11382798
26. The underappreciated role of muscle in health and disease. Wolfe RR, Am J Clin Nutr 2006 84 3 475 482 16960159 (Pubitemid 44713395)
27. Dietary reference intakes for energy, carbohydrate, fiber, fat, fatty acids, cholesterol, protein, and amino acids (macronutrients). Protein and amino acids Institute of Medicine, Food and Nutrition Board Internet: http://www.nap.edu/books/0309085373/html/2002 (accessed 19 June 2006)
28. Obesity and weight management in the elderly. Han TS, Tajar A, Lean ME, Br Med Bull 2011 97 169 196 10.1093/bmb/ldr002 21325341
29. The impact of exercise training compared to caloric restriction on hepatic and peripheral insulin resistance in obesity. Coker RH, Williams RH, Yeo SE, Kortebein PM, Bodenner DL, Kern PA, Evans WJ, J Clin Endocrinol Metab 2009 94 11 4258 4266 10.1210/jc.2008-2033 19808853
30. Physical activity in US older adults with diabetes mellitus: prevalence and correlates of meeting physical activity recommendations. Zhao G, Ford ES, Li C, Balluz LS, J Am Geriatr Soc 2011 59 1 132 137 10.1111/j.1532-5415.2010. 03236.x 21226683
31. Weight control practices among U.S. adults, 2001-2002. Weiss EC, Galuska DA, Khan LK, Serdula MK, Am J Prev Med 2006 31 18 24 10.1016/j.amepre.2006.03. 016 16777538 (Pubitemid 43956601)
32. Physical activity in US Adults compliance with the physical activity guidelines for Americans. Tucker JM, Welk GJ, Beyler NK, Am J Prev Med 2011 40 4 454 461 10.1016/j.amepre.2010.12.016 21406280
33. Obesity, sarcopenia and their functional consequences in old age. Visser M, Proc Nutr Soc 2011 70 1 114 118 10.1017/S0029665110003939 21092365