The paradox of overnutrition in aging and cognition

Annals of the New York Academy of Sciences

Volumn 1287, Issue 1, 2013, Pages 31-43

  Fielding, Roger A ^a   Gunstad, John ^b   Gustafson, Deborah R ^c,d   Heymsfield, Steven B ^e   Kral, John G ^f   Launer, Lenore J ^g   Penninger, Josef ^h   Phillips, David I W ⁱ   Scarmeas, Nikolaos ^j,k  

^a TUFTS UNIVERSITY   (United States)

^b KENT STATE UNIVERSITY   (United States)

^c SUNY Downstate Medical Center   (United States)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

^f SUNY DOWNSTATE MEDICAL CENTER   (United States)

^g NATIONAL INSTITUTE ON AGING   (United States)

^h ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

ⁱ UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^j University of Athens ^*  (United States)

^k UNIVERSITY OF ATHENS   (Greece)

more..

Author keywords

Alzheimer's disease; Cognitive decline; Obesity; Overnutrition; Sarcopenia

Indexed keywords

SONIC HEDGEHOG PROTEIN;

ADIPOCYTE; AFRICAN AMERICAN; AGING; ALZHEIMER DISEASE; ARTICLE; BARIATRIC SURGERY; BODY COMPOSITION; BRAIN INFARCTION; CAENORHABDITIS ELEGANS; CELL DIFFERENTIATION; COGNITION; DEGENERATIVE DISEASE; DEMENTIA; DEVELOPMENTAL PLASTICITY; DIABETES MELLITUS; DISEASE ASSOCIATION; DROSOPHILA MELANOGASTER; FUNCTIONAL GENOMICS; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HERITABILITY; METABOLIC DISORDER; MUSCLE MASS; MUSCLE STRENGTH; NONHUMAN; OBESITY; OVERNUTRITION; PLASTICITY; PROTEIN INDUCTION; RACE DIFFERENCE; RISK ASSESSMENT; RNA INTERFERENCE; SARCOPENIA; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SYSTEMS BIOLOGY; VASCULAR AMYLOIDOSIS; VASCULAR DISEASE;

EID: 84878425102     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12138     Document Type: Article

References (66)

1. Ashrafi, K., F.Y. Chang, J.L. Watts, et al. 2003. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421: 268-272.
2. Dietzl, G., D. Chen, F. Schnorrer, et al. 2007. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 448: 151-156.
3. Pospisilik, J. A., D. Schramek, H. Schnider, et al. 2010. Drosophila genome-wide obesity screen reveals Hedgehog as a determinant of brown versus white adipose cell fate. Cell 140: 148-160.
4. Teperino, R., S. Amann, M. Bayer, et al. 2012. Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell 151: 414-426.
5. Elling, U., J. Taubenschmid, G. Wirnsberger, et al. 2011. Forward and Reverse Genetics through Derivation of Haploid Mouse Embryonic Stem Cells. Cell Stem. Cells 9: 563-574.
6. Carette, J.E., C.P. Guimaraes, M. Varadarajan, et al. 2009. Haploid genetic screens in human cells identify host factors used by pathogens. Science 326: 1231-1235.
7. Streisinger, G., C. Walker, N. Dower, et al. 1981. Production of clones of homozygous diploid zebra fish (Brachydanio rerio). Nature 291: 293-296.
8. Fall, C.H. 2004. Fetal Programming and the Risk of Noncommunicable Disease. Indian J. Pediatr. S1: 13-20.
9. Bateson, P., D. Barker, T. Clutton-Brock, et al. 2004. Developmental plasticity and human health. Nature 430: 419-421.
10. Phillips, D.I. 2007. Programming of the stress response: a fundamental mechanism underlying the long-term effects of the fetal environment? J. Intern. Med. 261: 453-460.
11. Cruz-Jentoft, A.J., J.P. Baeyens, J.M. Bauer, et al. 2010. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 39: 412-423.
12. Arden, N.K. & T.D. Spector 1997. Genetic influences on muscle strength, lean body mass, and bone mineral density: a twin study. J. Bone Miner. Res. 12: 2076-2081.
13. Heymsfield, S.B., M. Heo, D. Thomas & A. Pietrobelli 2011. Scaling of body composition to height: relevance to height-normalized indexes. Am. J. Clin. Nutr. 93: 736-740.
14. Heymsfield, S.B., R. Scherzer, A. Pietrobelli, et al. 2009. Body mass index as a phenotypic expression of adiposity: quantitative contribution of muscularity in a population-based sample. Int. J. Obes. 33: 1363-1373.
15. Morley, J.E., R.N. Baumgartner, R. Roubenoff, et al. 2001. Sarcopenia. J. Lab. Clin. Med. 137: 231-243.
16. Jette, A.M., S.F. Assmann, D. Rooks, et al. 1998. Interrelationships among disablement concepts. J. Gerontol. 53A: M395-M404.
17. Jette, A.M. & L.G. Branch 1981. The Framingham Disability Study: II. Physical disability among the aging. Am. J. Public Health. 71: 1211-1216.
18. Fielding, R.A., B. Vellas, W.J. Evans, et al. 2011. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. JAMDA 12: 249-256.
19. Baumgartner, R.N., K.M. Koehler, D. Gallagher, et al. 1998. Epidemiology of Sarcopenia among the elderly in New Mexico. Am. J. Epidemiol. 147: 755-763.
20. Clark, D.J. & R.A. Fielding 2012. Neuromuscular contributions to age-related weakness. J. Gerontol. A. Biol. Sci. Med. Sci. 67: 41-47.
21. Reid, K.F. & R.A. Fielding 2012. Skeletal muscle power: a critical determinant of physical functioning in older adults. Exercise Sport Sci. R. 40: 4-12.
22. Stern, Y., B. Gurland, T.K. Tatemichi, et al. 1994. Influence of Education and Occupation on the Incidence of Alzheimer's Disease. JAMA. 271: 1004-1010.
23. Manly, J.J., P. Touradji, M.X. Tang & Y. Stern 2003. Literacy and memory decline among ethnically diverse elders. J. Clin. Exp. Neuropsychol. 25: 680-690.
24. Stern, Y., G.E. Alexander, I. Prohovnik & R. Mayeux 1992. Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease. Ann. Neurol. 32: 371-3765.
25. Steffener, J. & Y. Stern 2012. Exploring the neural basis of cognitive reserve in aging. Biochim. Biophys. Acta. 1822: 467-473.
26. Flegal, K.M., M.D. Carroll, B.K. Kit & C.L. Ogden 2012. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 307: 491-497.
27. Launer, L.J. 2009. Diabetes: vascular or neurodegenerative: an epidemiologic perspective. Stroke 40: S53-55.
28. Gorelick, P.B., A. Scuteri, S.E. Black, et al. 2011. American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 42: 2672-2713.
29. Saczynski, J.S., S. Siggurdsson, P.V. Jonsson, et al. 2009. Glycemic status and brain injury in older individuals: the age gene/environment susceptibility-Reykjavik study. Diabetes Care 32: 1608-1613.
30. Gustafson, D.R. 2006. Adiposity indices and dementia. Lancet Neurol. 5: 713-720.
31. Gustafson, D.R., E. Rothenberg, K. Blennow, et al. 2003. An 18-year follow up of overweight and risk for Alzheimer's disease. Arch. Intern. Med. 163: 1524-1528.
32. Gustafson, D. 2008. A life course of adiposity and dementia. Eur. J. Pharmacol. 585: 163-175.
33. Anstey, K.J., N. Cherbuin, M. Budge & J. Young 2011. Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies. Obes. Rev. 12: e426-437.
34. Whitmer, R.A., E.P. Gunderson, C.P. Quesenberry, Jr., et al. 2007 Body mass index in midlife and risk of Alzheimer disease and vascular dementia. Curr. Alzheimer Res. 4: 103-109.
35. Whitmer, R.A., D.R. Gustafson, E. Barrett-Connor, et al. 2008. Central obesity and increased risk of dementia more than three decades later. Neurology 71: 1057-1064.
36. Fitzpatrick, A.L., L.H. Kuller, O.L. Lopez, et al. 2009. Midlife and late-life obesity and the risk of dementia: cardiovascular health study. Arch. Neurol. 66: 336-342.
37. Kivipelto, M., T. Ngandu, L. Fratiglioni, et al. 2005. Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Arch. Neurol. 62: 1556-1560.
38. Gustafson, D.R., K. Bäckman, M. Waern, et al. 2009. Adiposity indicators and dementia over 32 years in Sweden. Neurology 73: 1559-1566.
39. Gustafson, D., K. Bäckman, E. Joas, et al. 2012. A 37-year longitudinal follow-up of body mass index and dementia in women. J. Alzheimers Dis. 28: 162-171.
40. Daviglus, M.L. et al. 2011. Risk factors and preventive interventions for Alzheimer disease: state of the science. Arch. Neurol. 68: 1185-1190.
41. Plassman, B.L. et al. 2010. Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life. Ann. Int. Med. 153: 182-193.
42. Morris, M.C. & C.C. Tangney 2011. A potential design flaw of randomized trials of vitamin supplements. JAMA 305: 1348-1349.
43. Gu, Y. & N. Scarmeas 2011. Dietary patterns in Alzheimer's disease and cognitive aging. Curr. Alzheimer Res. 8: 510-519.
44. Galasko, D.R. et al. 2012. Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures. Arch. Neurol. 69: 836-441.
45. Stanek, K. & J. Gunstad 2012. Can bariatric surgery reduce risk of Alzheimer's disease? Prog. Neuropsychopharmacol. Biol. Psychiatry; online July 2012.
46. Buchwald, H., Y. Avidor, E. Braunwald, et al. 2004. Bariatric surgery: a systematic review and meta-analysis. JAMA 292: 1724-1737.
47. Gunstad, J., G. Strain, M.J. Devlin, et al. 2011. Improved memory function 12 weeks after bariatric surgery. Surg. Obes.Relat. Dis. 7: 465-472.
48. Becker, D., L. Balcer & S. Galetta 2012. The neurological complications of nutritional deficiency following bariatric surgery. J. Obes 608534.
49. Hurd, M.D., P. Martorell, A. Delavande, et al. 2013. Monetary costs of dementia in the United States. N. Eng. J. Med. 368: 1326-1334.
50. Olshansky, S.J., B.A. Carnes, R. Hershow, et al. 2005. Misdirection on the road to Shangri-La. Sci. Aging Knowledge Environ. 28: pe15.
51. Lozano, R., M. Naghavi, K. Foreman, et al. 2010. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study. Lancet 380: 2095-2128.
52. Kral, J.G., P. Otterbeck & M. Garcia-Touza 2010. Preventing and treating the accelerated ageing of obesity. Maturitas 66: 223-230.
53. Heymsfield, S.B. & W.T. Cefalu 2013. Does body mass index adequately convey a patient's mortality risk? JAMA 309: 87-88.
54. Reiman, E.M., Y.T. Quiroz, A.S. Fleisher, et al. 2012. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study. Lancet Neurol. 11: 1048-1056.
55. Kral, J.G. 2004. Preventing and treating obesity in girls and young women to curb the epidemic. Obes. Res. 12: 1539-1546.
56. Danese, A. & B.S. McEwen 2012. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol. Behav. 106: 29-39.
57. Rideout, C.A., W. Linden & S.I. Barr 2006. High cognitive dietary restraint is associated with increased cortisol excretion in postmenopausal women. J. Gerontol. A. Biol. Sci. Med. Sci. 61: 628-633.
58. Kral, J.G. 2009. Psychosurgery for obesity. Obesity Facts 2: 339-341.
59. Borody, T.J. & J. Campbell 2012. Fecal microbiota transplantation: techniques, applications, and issues. Gastroenterol. Clin. North Am. 41: 781-803.
60. Fortes, C., S. Mastroeni, A. Sperati, et al. 2013. Walking four times weekly for at least 15min is associated with longevity in a cohort of very elderly people. Maturitas 24: 246-251.
61. Saczynski, J.S., S. Siggurdsson, P.V. Jonsson, et al. 2009. Glycemic status and brain injury in older individuals: the age gene/environment susceptibility-Reykjavik study. Diabetes Care 1608-1613.
62. Mayeda, E.R., M.N. Haan, A.M. Kanaya, et al. 2013. Type 2 Diabetes and 10-Year Risk of Dementia and Cognitive Impairment Among Older Mexican Americans. Diabetes Care. 2013 Mar 20. [Epub ahead of print]
63. Strittmatter, W.J. 2012. Alzheimer's disease: the new promise. J. Clin. Invest. 122: 1191. Re: Talbot, K., H.Y. Wang, H. Kazi, et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J. Clin. Invest. 122: 1316-3138.
64. Hubbard B.P., A.P. Gomes, H. Dai, et al. Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science 339: 1216-1219.
65. Johnson S.C., P.S. Rabinovitch & M. Kaeberlein 2013. mTOR is a key modulator of ageing and age-related disease. Nature 493: 338-345.
66. Carlsson L.M., M. Peltonen, S. Ahlin, et al. 2012. Bariatric surgery and prevention of type 2 diabetes in Swedish obese subjects. N. Engl. J. Med. 367: 695-704.