Dose-dependent responses of myofibrillar protein synthesis with beef ingestion are enhanced with resistance exercise in middle-aged men

Applied Physiology, Nutrition and Metabolism

Volumn 38, Issue 2, 2013, Pages 120-125

  Robinson, Meghann J ^a   Burd, Nicholas A ^a   Breen, Leigh ^a   Rerecich, Tracy ^a   Yang, Yifan ^a   Hector, Amy J ^a   Baker, Steven K ^a   Phillips, Stuart M ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Aging; Muscle; Muscle metabolism; Nutrition; Protein metabolism; Sarcopenia

Indexed keywords

AMINO ACID; MUSCLE PROTEIN;

ANIMAL; ARTICLE; BLOOD; CATTLE; EXERCISE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; MEAT; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

AMINO ACIDS; ANIMALS; CATTLE; EXERCISE; GENE EXPRESSION REGULATION; HUMANS; MALE; MEAT; MIDDLE AGED; MUSCLE PROTEINS;

EID: 84874431641     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/apnm-2012-0092     Document Type: Article

References (38)

1. Biolo, G., Tipton, K.D., Klein, S., and Wolfe, R.R. 1997. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. Am. J. Physiol. 273: E122-E129. PMID:9252488.
2. Borsheim, E., Tipton, K.D., Wolf, S.E., and Wolfe, R.R. 2002. Essential amino acids and muscle protein recovery from resistance exercise. Am. J. Physiol. Endocrinol. Metab. 283: E648-E657. doi:10.1152/ajpendo.00466.2001. PMID: 12217881.
3. Burd, N.A., Holwerda, A.M., Selby, K.C., West, D.W., Staples, A.W., Cain, N.E., et al. 2010. Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men. J. Physiol. 588: 3119-3130. doi:10.1113/jphysiol.2010.192856. PMID:20581041.
4. Burd, N.A., West, D.W., Rerecich, T., Prior, T., Baker, S.K., and Phillips, S.M. 2011. Validation of a single biopsy approach and bolus protein feeding to determine myofibrillar protein synthesis in stable isotope tracer studies in humans. Nutr. Metab. (Lond.), 8: 15. doi:10.1186/1743-7075-8-15. PMID: 21388545.
5. Chernoff, R. 2004. Protein and older adults. J. Am. Coll. Nutr. 23: 627S-630S. PMID:15640517.
6. Churchward-Venne, T.A., Burd, N.A., Mitchell, C.J., West, D.W., Philp, A., Marcotte, G.R., et al. 2012. Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J. Physiol. doi:10.1113/ jphysiol.2012.228833. PMID:22451437.
7. Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., et al. 2005. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 19: 422-424. doi:10.1096/fj.04-2640fje. PMID:15596483.
8. Dideriksen, K.J., Reitelseder, S., Petersen, S.G., Hjort, M., Helmark, I.C., Kjaer, M., and Holm, L. 2011. Stimulation of muscle protein synthesis by whey and caseinate ingestion after resistance exercise in elderly individuals. Scand. J. Med. Sci. Sports. doi:10.1111/j.1600-0838.2011.01318.x. PMID:21535185.
9. Dreyer, H.C., Drummond, M.J., Pennings, B., Fujita, S., Glynn, E.L., Chinkes, D.L., et al. 2008. Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. Am. J. Physiol. Endocrinol. Metab. 294: E392-E400. doi:10.1152/ajpendo.00582.2007. PMID:18056791.
10. Drummond, M.J., Dreyer, H.C., Pennings, B., Fry, C.S., Dhanani, S., Dillon, E.L., et al. 2008. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J. Appl. Physiol. 104: 1452-1461. doi:10.1152/japplphysiol.00021.2008. PMID:18323467.
11. Glover, E.I., Phillips, S.M., Oates, B.R., Tang, J.E., Tarnopolsky, M.A., Selby, A., et al. 2008. Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion. J. Physiol. 586. doi:10.1113/jphysiol.2008.160333. PMID:18955382.
12. Guralnik, J.M., Simonsick, E.M., Ferrucci, L., Glynn, R.J., Berkman, L.F., Blazer, D.G., et al. 1994. A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J. Gerontol. 49: M85-M94. doi:10. 1093/geronj/49.2.M85. PMID:8126356.
13. Haley, S.M., Jette, A.M., Coster, W.J., Kooyoomjian, J.T., Levenson, S., Heeren, T., and Ashba, J. 2002. Late Life Function and Disability Instrument: II. Development and evaluation of the function component. J. Gerontol. A Biol. Sci. Med, Sci. 57: M217-M222. doi:10.1093/gerona/57.4.M217. PMID:11909886.
14. Janssen, I., and Ross, R. 2005. Linking age-related changes in skeletal muscle mass and composition with metabolism and disease. J. Nutr. Health Aging, 9: 408-419. PMID:16395513.
15. Katsanos, C.S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., and Wolfe, R.R. 2005. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am. J. Clin. Nutr. 82: 1065-1073. PMID:16280440.
16. Katsanos, C.S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., and Wolfe, R.R. 2006. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am. J. Physiol. Endocrinol. Metab. 291: E381-E387. doi:10.1152/ajpendo.00488. 2005. PMID:16507602.
17. Kumar, V., Selby, A., Rankin, D., Patel, R., Atherton, P., Hildebrandt, W., et al. 2009. Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men. J. Physiol. 587: 211-217. doi:10.1113/jphysiol.2008.164483. PMID:19001042.
18. Moore, D.R., Phillips, S.M., Babraj, J.A., Smith, K., and Rennie, M.J. 2005. Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. Am. J. Physiol. Endocrinol. Metab. 288: E1153-E1159. doi:10.1152/ajpendo.00387.2004. PMID: 15572656.
19. Moore, D.R., Robinson, M.J., Fry, J.L., Tang, J.E., Glover, E.I., Wilkinson, S.B., et al. 2009a. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am. J. Clin. Nutr. 89: 161-168. doi:10.3945/ajcn.2008.26401. PMID:19056590.
20. Moore, D.R., Tang, J.E., Burd, N.A., Rerecich, T., Tarnopolsky, M.A., and Phillips, S.M. 2009b. Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise. J. Physiol. 587: 897-904. doi:10.1113/jphysiol.2008.164087. PMID: 19124543.
21. Pennings, B., Koopman, R., Beelen, M., Senden, J.M.G., Saris, W.H., and Van Loon, L.J.C. 2011. Exercising before protein intake allows for greater use of dietary protein-derived amino acids for de novo muscle protein synthesis in both young and elderly men. Am. J. Clin. Nutr. doi:10.3945/ajcn.2010. 29649. PMID:21084649.
22. Pennings, B., Groen, B., de Lange, A., Gijsen, A.P., Zorenc, A.H., Senden, J.M., and van Loon, L.J. 2012. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men. Am. J. Physiol. Endocrinol. Metab. 302: E992-E999. doi:10.1152/ajpendo.00517.2011. PMID:22338070.
23. Rasmussen, B.B., Tipton, K.D., Miller, S.L., Wolf, S.E., and Wolfe, R.R. 2000. An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise. J. Appl. Physiol. 88: 386-392. PMID: 10658002.
24. Rieu, I., Balage, M., Sornet, C., Giraudet, C., Pujos, E., Grizard, J., et al. 2006. Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J. Physiol. 575: 305-315. doi:10.1113/ jphysiol.2006.110742. PMID:16777941.
25. Sheffield-Moore, M., Yeckel, C.W., Volpi, E., Wolf, S.E., Morio, B., Chinkes, D.L., et al. 2004. Postexercise protein metabolism in older and younger men following moderate-intensity aerobic exercise. Am. J. Physiol. Endocrinol. Metab. 287: E513-E522. doi:10.1152/ajpendo.00334.2003. PMID:15149953.
26. Smith, G.I., Villareal, D.T., Lambert, C.P., Reeds, D.N., Mohammed, B.S., and Mittendorfer, B. 2010. Timing of the initial muscle biopsy does not affect the measured muscle protein fractional synthesis rate during basal, postabsorptive conditions. J. Appl. Physiol. 108: 363-368. doi:10.1152/japplphysiol.00957. 2009. PMID:19940095.
27. Symons, T.B., Schutzler, S.E., Cocke, T.L., Chinkes, D.L., Wolfe, R.R., and Paddon-Jones, D. 2007. Aging does not impair the anabolic response to a protein-rich meal. Am. J. Clin. Nutr. 86: 451-456. PMID:17684218.
28. Symons, T.B., Sheffield-Moore, M., Wolfe, R.R., and Paddon-Jones, D. 2009. A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J. Am. Diet. Assoc. 109: 1582-1586. doi:10.1016/j.jada.2009.06.369. PMID:19699838.
29. Symons, T.B., Sheffield-Moore, M., Mamerow, M.M., Wolfe, R.R., and Paddon-Jones, D. 2011. The anabolic response to resistance exercise and a protein rich meal is not diminished by age. J. Nutr. Health Aging, 15(5): 376-381. doi:10.1007/s12603-010-0319-z. PMID:21528164.
30. Tang, J.E., Manolakos, J.J., Kujbida, G.W., Lysecki, P.J., Moore, D.R., and Phillips, S.M. 2007. Minimal whey protein with carbohydrate stimulates muscle protein synthesis following resistance exercise in trained young men. Appl. Physiol. Nutr. Metab. 32: 1132-1138. doi:10.1139/H07-076. PMID: 18059587.
31. Tipton, K.D., Rasmussen, B.B., Miller, S.L., Wolf, S.E., Owens-Stovall, S.K., Petrini, B.E., and Wolfe, R.R. 2001. Timing of amino acid-carbohydrate ingestion alters anabolic response of muscle to resistance exercise. Am. J. Physiol. Endocrinol. Metab. 281: E197-E206. PMID:11440894.
32. Volpi, E., Mittendorfer, B., Rasmussen, B.B., and Wolfe, R.R. 2000. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J. Clin. Endocrinol. Metab. 85: 4481-4490. doi:10.1210/jc.85.12.4481. PMID:11134097.
33. Welle, S., and Thornton, C. 1998. High-protein meals do not enhance myofibrillar synthesis after resistance exercise in 62-to 75-yr-old men and women. Am. J. Physiol. Endocrinol. Metab. 274: E677-E683. PMID:9575829.
34. Wilkinson, S.B., Tarnopolsky, M.A., Macdonald, M.J., Macdonald, J.R., Armstrong, D., and Phillips, S.M. 2007. Consumption of fluid skim milk promotes greater muscle protein accretion after resistance exercise than does consumption of an isonitrogenous and isoenergetic soy-protein beverage. Am. J. Clin. Nutr. 85: 1031-1040. PMID:17413102.
35. Witard, O.C., Tieland, M., Beelen, M., Tipton, K.D., van Loon, L.J., and Koopman, R. 2009. Resistance exercise increases postprandial muscle protein synthesis in humans. Med. Sci. Sports Exerc. 41: 144-154. doi:10.1249/ MSS.0b013e3181844e79. PMID:19092695.
36. Yang, Y., Breen, L., Burd, N.A., Hector, A.J., Churchward-Venne, T.A., Josse, A.J., et al. 2012. Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men. Br. J. Nutr. In press. doi:10.1017/ S0007114511007422. PMID:22313809.
37. Yarasheski, K.E., Zachwieja, J.J., and Bier, D.M. 1993. Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am. J. Physiol. 265: E210-E214. PMID:8368290.
38. Zello, G.A., Wykes, L.J., Ball, R.O., and Pencharz, P.B. 1995. Recent advances in methods of assessing dietary amino acid requirements for adult humans. J. Nutr. 125: 2907-2915. PMID:7500168.