Is the optimal level of protein intake for older adults greater than the recommended dietary allowance?

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 68, Issue 6, 2013, Pages 677-681

  Volpi, Elena ^a   Campbell, Wayne W ^b   Dwyer, Johanna T ^c   Johnson, Mary Ann ^d   Jensen, Gordon L ^e   Morley, John E ^f   Wolfe, Robert R ^g  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b PURDUE UNIVERSITY   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

^e PENNSYLVANIA STATE UNIVERSITY   (United States)

^f SAINT LOUIS UNIVERSITY   (United States)

^g UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGED; AGING; BODY COMPOSITION; EVIDENCE BASED MEDICINE; HEALTH CARE POLICY; HUMAN; NUTRITIONAL REQUIREMENT; NUTRITIONAL STATUS; PRACTICE GUIDELINE; PROTEIN INTAKE; REVIEW; SARCOPENIA; VERY ELDERLY;

AGED; AGED, 80 AND OVER; AGING; BODY COMPOSITION; DIETARY PROTEINS; EVIDENCE-BASED MEDICINE; GUIDELINES AS TOPIC; HUMANS; NUTRITION POLICY; NUTRITIONAL REQUIREMENTS; NUTRITIONAL STATUS; SARCOPENIA;

EID: 84878291232     PISSN: 10795006     EISSN: 1758535X     Source Type: Journal    
DOI: 10.1093/gerona/gls229     Document Type: Article

References (49)

1. Fulgoni VL, III. Current protein intake in America: analysis of the National Health and Nutrition Examination Survey, 2003-2004. Am J Clin Nutr. 2008;87:1554S-1557S.
2. Locher JL, Ritchie CS, Roth DL, Sen B, Vickers KS, Vailas LI. Food choice among homebound older adults: motivations and perceived barriers. J Nutr Health Aging. 2009;13:659-664.
3. Donini LM, Savina C, Piredda M, et al. Senile anorexia in acute-ward and rehabilitations settings. J Nutr Health Aging. 2008;12:511-517.
4. Morley JE. Anorexia, weight loss, and frailty. J Am Med Dir Assoc. 2010;11:225-228.
5. Morley JE. Nutrition and the aging male. Clin Geriatr Med. 2010;26: 287-299.
6. Toffanello ED, Inelmen EM, Minicuci N, et al. Ten-year trends in dietary intake, health status and mortality rates in free-living elderly people. J Nutr Health Aging. 2010;14:259-264.
7. Ziliak JP, Gundersen C. Food insecurity among older adults, a report submitted to AARP Foundation. 2011. http://www.aarp.org/content/dam/aarp/aarp- foundation/pdf-2011/AARPFoundation-HungerReport-2011.pdf
8. Lee JS, Johnson MA, Brown A. Older Americans Act Nutrition Program improves participants' food security in Georgia. J Nutr Gerontol Geriatr. 2011;30:122-139.
9. Brewer DP, Catlett CS, Porter KN, et al. Physical limitations contribute to food insecurity and the food insecurity-obesity paradox in older adults at senior centers in Georgia. J Nutr Elder. 2010;29:150-169.
10. Coleman-Jensen A, Nord M, Andrews M, Carlson S. Household Food Security in the United States in 2010. ERR-125, U.S. Dept. of Agriculture, Econ. Res. Serv. 2012. http://www.ers.usda.gov/Publications/ERR125/ERR125.pdf
11. Lee JS, Fischer JG, Johnson MA. Food insecurity, food and nutrition programs, and aging: experiences from Georgia. J Nutr Elder. 2010;29:116-149.
12. Motil KJ, Matthews DE, Bier DM, Burke JF, Munro HN, Young VR. Whole-body leucine and lysine metabolism: response to dietary protein intake in young men. Am J Physiol. 1981;240:E712-E721.
13. Morse MH, Haub MD, Evans WJ, Campbell WW. Protein requirement of elderly women: nitrogen balance responses to three levels of protein intake. J Gerontol A Biol Sci Med Sci. 2001;56:M724-M730.
14. Zanni E, Calloway DH, Zezulka AY. Protein requirements of elderly men. J Nutr. 1979;109:513-524.
15. Cheng AH, Gomez A, Bergan JG, Lee TC, Monckeberg F, Chichester CO. Comparative nitrogen balance study between young and aged adults using three levels of protein intake from a combination wheatsoy- milk mixture. Am J Clin Nutr. 1978;31:12-22.
16. Campbell WW, Johnson CA, McCabe GP, Carnell NS. Dietary protein requirements of younger and older adults. Am J Clin Nutr. 2008;88:1322-1329.
17. Campbell WW, Crim MC, Dallal GE, Young VR, Evans WJ. Increased protein requirements in elderly people: new data and retrospective reassessments. Am J Clin Nutr. 1994;60:501-509.
18. Kurpad AV, Vaz M. Protein and amino acid requirements in the elderly. Eur J Clin Nutr. 2000;54(suppl 3):S131-S142.
19. Campbell WW, Trappe TA, Wolfe RR, Evans WJ. The recommended dietary allowance for protein may not be adequate for older people to maintain skeletal muscle. J Gerontol A Biol Sci Med Sci. 2001;56:M373-M380.
20. Houston DK, Nicklas BJ, Ding J, et al. Dietary protein intake is associated with lean mass change in older, community-dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr. 2008;87:150-155.
21. Bartali B, Frongillo EA, Stipanuk MH, et al. Protein intake and muscle strength in older persons: does inflammation matter? J Am Geriatr Soc. 2012;60:480-484.
22. Beasley JM, LaCroix AZ, Neuhouser ML, et al. Protein intake and incident frailty in the Women's Health Initiative observational study. J Am Geriatr Soc. 2010;58:1063-1071.
23. Biolo G, Fleming RY, Maggi SP, Nguyen TT, Herndon DN, Wolfe RR. Inverse regulation of protein turnover and amino acid transport in skeletal muscle of hypercatabolic patients. J Clin Endocrinol Metab. 2002;87:3378-3384.
24. Prado CM, Antoun S, Sawyer MB, Baracos VE. Two faces of drug therapy in cancer: drug-related lean tissue loss and its adverse consequences to survival and toxicity. Curr Opin Clin Nutr Metab Care. 2011;14:250-254.
25. Benton MJ, Wagner CL, Alexander JL. Relationship between body mass index, nutrition, strength, and function in elderly individuals with chronic obstructive pulmonary disease. J Cardiopulm Rehabil Prev. 2010;30:260-263.
26. Studenski S, Perera S, Patel K, et al. Gait speed and survival in older adults. JAMA. 2011;305:50-58.
27. Peel NM, Kuys SS, Klein K. Gait speed as a measure in geriatric assessment in clinical settings: a systematic review. J Gerontol A Biol Sci Med Sci. 2012 Aug24. [Epub ahead of print] doi:10.1093/gerona/gls174
28. Hicks GE, Shardell M, Alley DE, et al. Absolute strength and loss of strength as predictors of mobility decline in older adults: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2012;67:66-73.
29. Fujita S, Dreyer HC, Drummond MJ, et al. Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol (Lond). 2007;582(Pt 2):813-823.
30. Glynn EL, Fry CS, Drummond MJ, et al. Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr. 2010;140:1970-1976.
31. Symons TB, Sheffield-Moore M, Wolfe RR, Paddon-Jones D. A moderate serving of high-quality protein maximally stimulates skeletal muscle protein synthesis in young and elderly subjects. J Am Diet Assoc. 2009;109:1582-1586.
32. Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr. 2005;82:1065-1073.
33. Katsanos CS, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab. 2006;291:E381-E387.
34. Volpi E, Kobayashi H, Sheffield-Moore M, Mittendorfer B, Wolfe RR. Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults. Am J Clin Nutr. 2003;78:250-258.
35. Cuthbertson D, Smith K, Babraj J, et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 2005;19:422-424.
36. Paddon-Jones D, Rasmussen BB. Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care. 2009;12:86-90.
37. Rhodes D, Clemens J, Goldman J, Moshfegh A. 2007-2008 What We Eat in America, NHANES Tables 1-36. U.S. Department of Agriculture, Agricultural Research Service. 2010. www.ars.usda.gov/Services/docs.htm?docid=18349
38. Stenholm S, Harris TB, Rantanen T, Visser M, Kritchevsky SB, Ferrucci L. Sarcopenic obesity: definition, cause and consequences. Curr Opin Clin Nutr Metab Care. 2008;11:693-700.
39. Morley JE. Weight loss in older persons: new therapeutic approaches. Curr Pharm Des. 2007;13:3637-3647.
40. Kim YS, Lee Y, Chung YS, et al. Prevalence of sarcopenia and sarcopenic obesity in the korean population based on the fourth korean national health and nutritional examination surveys. J Gerontol A Biol Sci Med Sci. 2012;67:1107-1113.
41. Jensen GL, Hsiao PY. Obesity in older adults: relationship to functional limitation. Curr Opin Clin Nutr Metab Care. 2010;13: 46-51.
42. Fielding RA, Vellas B, Evans WJ, et al. Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc. 2011;12:249-256.
43. Villareal DT, Chode S, Parimi N, et al. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med. 2011;364: 1218-1229.
44. Farnsworth E, Luscombe ND, Noakes M, Wittert G, Argyiou E, Clifton PM. Effect of a high-protein, energy-restricted diet on body composition, glycemic control, and lipid concentrations in overweight and obese hyperinsulinemic men and women. Am J Clin Nutr. 2003;78:31-39.
45. Weigle DS, Breen PA, Matthys CC, et al. A high-protein diet induces sustained reductions in appetite, ad libitum caloric intake, and body weight despite compensatory changes in diurnal plasma leptin and ghrelin concentrations. Am J Clin Nutr. 2005;82:41-48.
46. Walker DK, Dickinson JM, Timmerman KL, et al. Exercise, amino acids, and aging in the control of human muscle protein synthesis. Med Sci Sports Exerc. 2011;43:2249-2258.
47. Timmerman KL, Dhanani S, Glynn EL, et al. A moderate acute increase in physical activity enhances nutritive flow and the muscle protein anabolic response to mixed nutrient intake in older adults. Am J Clin Nutr. 2012;95:1403-1412.
48. Drummond MJ, Dickinson JM, Fry CS, et al. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab. 2012;302:E1113-E1122.
49. Ferrando AA, Paddon-Jones D, Hays NP, et al. EAA supplementation to increase nitrogen intake improves muscle function during bed rest in the elderly. Clin Nutr. 2010;29:18-23.