Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates

Journal of Biological Chemistry

Volumn 288, Issue 51, 2013, Pages 36636-36647

  Forbes, Louisa V ^a   Sjögren, Tove ^b   Auchère, Françoise ^a   Jenkins, David W ^c   Thong, Bob ^c   Laughton, David ^c   Hemsley, Paul ^c   Pairaudeau, Garry ^c   Turner, Rufus ^a   Eriksson, Hâkan ^d   Unitt, John F ^c   Kettle, Anthony J ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b ASTRAZENECA R AND D   (Sweden)

^c ASTRAZENECA   (United Kingdom)

^d ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BINDING AFFINITIES; HEME POCKETS; INFLAMMATORY DISEASE; MYELOPEROXIDASE; OXIDATIVE DAMAGE; REVERSIBLE INHIBITIONS; SUBSTITUTED AROMATIC;

BINDING ENERGY;

AROMATIC COMPOUNDS;

2 (3,5 BISTRIFLUOROMETHYLBENZYLAMINO) 6 OXO 1H PYRIMIDINE 5 CARBOHYDROXAMIC ACID; 2 (BENZYLAMINO) 6 OXO 3H PYRIMIDINE 5 CARBOHYDROXAMIC ACID; 4 BENZYL 2 HYDROXYBENZENECARBOHYDROXAMIC ACID; CARBOXYLIC ACID; HALIDE; HEME; HX 1; HX 2; HX 3; HYDROGEN PEROXIDE; HYDROXAMIC ACID DERIVATIVE; HYPOHALOUS ACID; MYELOPEROXIDASE; SALICYLHYDROXAMIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; CHLORINATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; INFLAMMATION; NEUTROPHIL; OXIDATIVE STRESS; PRIORITY JOURNAL;

CRYSTAL STRUCTURE; ENZYME INHIBITORS; HYDROXAMATE; MYELOPEROXIDASE; NEUTROPHIL; OXIDATIVE STRESS; REVERSIBLE INHIBITION; SURFACE PLASMON RESONANCE (SPR);

AMINO ACID SEQUENCE; BINDING SITES; CELL LINE, TUMOR; ENZYME INHIBITORS; HUMANS; HYDROCARBONS, AROMATIC; HYDROXAMIC ACIDS; KINETICS; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PEROXIDASE; PROTEIN BINDING;

EID: 84890909211     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.507756     Document Type: Article

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