2-Thioxanthines are mechanism-based inactivators of myeloperoxidase that block oxidative stress during inflammation

Journal of Biological Chemistry

Volumn 286, Issue 43, 2011, Pages 37578-37589

  Tide, Anna Karin ^c   Sjögren, Tove ^b   Svensson, Mats ^a   Bernlind, Alexandra ^a   Senthilmohan, Revathy ^e   Auchère, Francoise ^e   Norman, Henrietta ^a   Markgren, Per Olof ^a   Gustavsson, Susanne ^a   Schmidt, Staffan ^a   Lundquist, Stefan ^a   Forbes, Louisa V ^e   Magon, Nicholas J ^e   Paton, Louise N ^e   Jameson, Guy N L ^d   Eriksson, Håkan ^d   Kettle, Anthony J ^e  

^a ASTRAZENECA R AND D   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c ASTRAZENECA   (United Kingdom)

^d UNIVERSITY OF OTAGO   (New Zealand)

^e UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ACHILLES' HEEL; ACTIVE SITE; HEME GROUP; MOUSE MODELS; MYELOPEROXIDASE; POOR INHIBITORS; PROSTHETIC GROUPS; THYROID PEROXIDASE; X RAY CRYSTAL STRUCTURES;

CHLORINE; CHLORINE COMPOUNDS; ENZYMES; FREE RADICALS; HYDROGEN PEROXIDE; MAMMALS; MASS SPECTROMETRY; OXIDATIVE STRESS; PORPHYRINS;

PATHOLOGY;

2 THIOXANTHINE DERIVATIVE; 3 (TETRAHYDROFURAN 2 YLMETHYL) 2 THIOXO 7H PURIN 6 ONE; 3 [(4 FLUOROPHENYL)METHYL] 2 THIOXO 7H PURIN 6 ONE; 3 [[TETRAHYDROFURAN 2 YL]METHYL] 2 THIOXO 7H PURIN 6 ONE; 3 ISOBUTYL 2 THIOXO 7H PURIN 6 ONE; HEME; MYELOPEROXIDASE; THYROID PEROXIDASE; THYROXINE; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHLORINATION; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME BLOOD LEVEL; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INFLAMMATION; MASS SPECTROMETRY; MOUSE; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PERITONITIS; PRIORITY JOURNAL; THYROXINE BLOOD LEVEL; X RAY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; HUMANS; INFLAMMATION; MICE; NEUTROPHILS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PERITONITIS; PEROXIDASE; XANTHINES;

EID: 80054798514     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.266981     Document Type: Article

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