Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides

Biochemical Journal

Volumn 421, Issue 1, 2009, Pages 79-86

  Rees, Martin D ^a   Bottle, Steven E ^b   Fairfull Smith, Kathryn E ^b   Malle, Ernst ^c   Whitelock, John M ^d   Davies, Michael J ^e  

^a HEART RESEARCH INSTITUTE   (Australia)

^b QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e University of Sydney   (Australia)

Author keywords

Hypochlorous acid; Myeloperoxidase; Neutrophil; Nitroxide; Protein oxidation; Superoxide

Indexed keywords

HYPOCHLOROUS ACID; MYELOPEROXIDASE; NEUTROPHIL; NITROXIDE; PROTEIN OXIDATION; SUPEROXIDE;

ACIDS; CHLORINE COMPOUNDS; HYDROGEN; HYDROGEN PEROXIDE; OXIDATION; OXYGEN;

NITROGEN OXIDES;

ALBUMIN; HEME; HYDROGEN PEROXIDE; HYPOCHLOROUS ACID; MYELOPEROXIDASE; NITROXIDE DERIVATIVE; PERLECAN; SUPEROXIDE DISMUTASE; HYDROXYLAMINE; NITROGEN OXIDE; PEROXIDASE;

ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INFLAMMATORY DISEASE; NEUTROPHIL COUNT; OXIDATION; OXIDATIVE STRESS; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; MOLECULAR GENETICS; NEUTROPHIL; OXIDATION REDUCTION REACTION;

ANIMALIA;

HEME; HUMANS; HYDROXYLAMINES; HYPOCHLOROUS ACID; MOLECULAR SEQUENCE DATA; NEUTROPHILS; NITROGEN OXIDES; OXIDATION-REDUCTION; PEROXIDASE;

EID: 67650281758     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20090309     Document Type: Article

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