Anti-obesity phenotypic screening looking to increase OBR cell surface expression

Journal of Biomolecular Screening

Volumn 19, Issue 1, 2014, Pages 88-99

  Kim, Tae Hee ^a,b   Choi, Dong Hwa ^c   Vauthier, Virginie ^d,e,f   Dam, Julie ^d,e,f   Li, Xiaolan ^a,g   Nam, Yeon Ju ^c   Ko, Yoonae ^a   Kwon, Ho Jeong ^b   Shin, Sang Hoon ^c,h   Cechetto, Jonathan ^a   Soloveva, Veronica ^a   Jockers, Ralf ^d,e,f  

^a Institute Pasteur Korea   (South Korea)

^b Yonsei University   (South Korea)

^c Gyeonggi Institute of Science and Technology Promotion   (South Korea)

^d INSERM   (France)

^e CNRS   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

^g ZHEJIANG GONGSHANG UNIVERSITY   (China)

^h KKDF   (South Korea)

Author keywords

high content screening; leptin receptor; obesity; OBR; phenotypic screening

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; JANUS KINASE 2; LEPTIN RECEPTOR; OBR RECEPTOR; STAT3 PROTEIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ARTICLE; BIOASSAY; CELL CLONE; CELL MEMBRANE; CELL SURFACE; CELLULAR DISTRIBUTION; CYTOTOXICITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; LIGAND BINDING; MOLECULAR WEIGHT; OBESITY; PHENOTYPE; PHENOTYPIC ASSAY; PRIORITY JOURNAL; WESTERN BLOTTING;

HIGH-CONTENT SCREENING; LEPTIN RECEPTOR; OBESITY; OBR; PHENOTYPIC SCREENING;

CELL LINE; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION; GENES, REPORTER; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; OBESITY; PHENOTYPE; RECEPTORS, LEPTIN; RECOMBINANT FUSION PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84890827857     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057113499185     Document Type: Article

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