Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Ding, Dalian ^a,b,c,d   Qi, Weidong ^e   Yu, Dongzhen ^b   Jiang, Haiyan ^a   Han, Chul ^f   Kim, Mi Jung ^f   Katsuno, Kana ^d   Hsieh, Yun Hua ^d   Miyakawa, Takuya ^d   Salvi, Richard ^a   Tanokura, Masaru ^d   Someya, Shinichi ^f  

^a UNIVERSITY AT BUFFALO   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

^d UNIVERSITY OF TOKYO   (Japan)

^e FUDAN UNIVERSITY   (China)

^f UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL DERIVATIVE; M 2319; MEFLOQUINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL LEVEL; COCHLEA; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; HAIR CELL; MONOTHERAPY; NERVE CELL DEGENERATION; NERVE FIBER; NEUROPROTECTION; NONHUMAN; NUCLEOLUS; OTOTOXICITY; OXIDATION REDUCTION REACTION; RAT;

ANIMALS; APOPTOSIS; CASPASE 3; COCHLEA; HAIR CELLS, AUDITORY; MEFLOQUINE; NAD; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84890815650     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0079817     Document Type: Article

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