The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro

Malaria Journal

Volumn 2, Issue , 2003, Pages 1-14

  Dow, Geoffrey S ^a   Hudson, Thomas H ^a   Vahey, Maryanne ^a   Koenig, Michael L ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); CALCIUM; CALRETICULIN; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MEFLOQUINE; THAPSIGARGIN; DIMETHYL SULFOXIDE; I KAPPA B; PROTEIN C JUN;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALCIUM TRANSPORT; CELL FUNCTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; EMBRYO; ENDOPLASMIC RETICULUM; EXTRACELLULAR CALCIUM; IN VITRO STUDY; NERVE CELL; NEUROTOXICITY; NONHUMAN; RAT; STRESS; TRANSCRIPTION REGULATION; UPREGULATION; ANIMAL MODEL; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; INTERMETHOD COMPARISON; MOUSE; NEUROBLASTOMA CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SAMPLE SIZE; STATISTICAL ANALYSIS;

EID: 3042545579     PISSN: 14752875     EISSN: None     Source Type: Journal    
DOI: 10.1186/1475-2875-2-1     Document Type: Article

References (25)

1. Phillips-Howard PA and ter Kuile FO: CNS adverse events associated with antimalarial agents: Fact or fiction? Drug Safety 1995, 12:370-383.
2. Schlagenhauf P: Mefloquine for malaria chemoprophylaxis 1992-1998 J Travel Med 1999, 6:122-123.
3. Kollaritsch H, Karbwang J, Wiedermann G, Mikolasek A, Na-Bangchang K and Wernsdorfer WH: Mefloquine concentration profiles during prophylactic dose regimens Wien Klin Wochenschr 2000, 112:441-7.
4. Simpson JA, Price R, ter Kuile F, Teja-Isavatharm P, Nosten F, Chongsuphajaisiddhi T, Looareesuwan S, Aarons L and White NJ: Population pharmacokinetics of mefloquine in patients with acute falciparum malaria Clin Pharmacol Ther 1999, 66:472-84.
5. Lee HS and Go ML: Effects of mefloquine on Ca2+ uptake and release by dog brain microsomes Arch Int Pharmacodyn Ther 1995, 331:221-231.
6. Go ML, Lee HS and Palade P: Effects of mefloquine on Ca2+ Uptake by crude microsomes of rabbit skeletal muscle Arch Int Pharmacodyn 1995, 329:255-271.
7. Dow GS: Effect of sample size and P-value filtering techniques on the detection of transcriptional changes induced in rat neuroblastoma cells by mefloquine Malaria J 2003, 2:4.
8. Mengesdorf T, Althausen S, Oberndorfer I and Paschen W: Response of neurons to an irreversible inhibition of endoplasmic reticulum CA2+-ATPase: relationship between global protein synthesis and expression and translation of individual genes Biochem J 2001, 356:805-812.
9. Racay P, Kaplan P and Lehotsky J: Control of CA2+ homeostasis in neuronal cells Gen Physiol Biophys 1996, 15:193-210.
10. Morgan AJ and Jacob R: Ionomycin enhances Ca2+ influx by stimulating store-regulated cation entry and not by a direct action at the plasma membrane Biochem J 1994, 300:665-672.
11. Berridge MJ: The endoplasmic reticulum: a multifunctional signaling organelle Cell Calcium 2002 2002, 32:235-249.
12. Kaufman RJ: Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls Genes Dev 1999, 12:1211-1233.
13. Pahle HK and Baeuerle PA: The ER-overload response: activation of NF-kB TIBS 1997, 22:63-67.
14. Koenig ML, Sgarlat CM, Yourick DL, Long JB and Meyerhoff JL: In vitro neuroprotection against glutamate-induced toxicity by pGlu-Glu-Pro-NH(2) (EEP) Peptides 2001, 22:2091-2097.
15. Vahey M, Nau M, Jogodzinski J, Yalley-Ogunro M, Taubman N, Micjeal N and Lewis M: Impact of viral infection on the gene expression profiles of proliferating normal human peripheral blood mononuclear cells infected with HIV-RF AIDS Research and Human Retroviruses 2002, 18:179-192.
16. Koumenis C, Naczki C, Koritzinsky M, Rastani S, Diehl A, Sonenberg N, Koromila A and Wouters BG: Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2α Mol Cell Biol 2002, 22:7405-7416.
17. Putney JW, Broad LM, Braun FJ, Lievremont JP and Bird GSJ: Mechanisms of capacitative calcium entry J Cell Sci 1999, 12:2223-2229.
18. Choi DW: Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage TINS 1988, 11:465-469.
19. Hartley DM, Kurth MC, Bjerkness L, Weiss JH and Choi DW: Glutamate receptor-induced 45Ca2+ accumulation in cortical cell cultures correlates with subsequent neuronal degeneration J Neurosci 1993, 13:1993-2000.
20. Brust JCM: Circulation of the brain In Principles of Neuroscience Edited by: Kandel ER, Schwartz JH, Jessell TM. New York: McGraw-Hill; 2000:1302-1316.
21. Kandel ER: Disorders of mood: Depression, mania and anxiety disorders In Principles of Neuroscience Edited by: Kandel ER, Schwartz JH, Jessell TM. New York: McGraw-Hill; 2000:1209-1226.
22. Iverson S, Kupferman I and Kandel ER: Emotional states and feelings In Principles of Neuroscience Edited by: Kandel ER, Schwartz JH, Jessell TM. New York: McGraw-Hill; 2000:1209-1226.
23. Baudry S, Pham YT, Baune B, Vidrequin S, Crevoisier C, Gimenez F and Farinotti R: Stereoselective passage of mefloquine through the blood-brain barrier in the rat J Pharm Pharmacol 1997, 49:1086-90.
24. Pham YT, Nosten F, Farinotti R, White NJ and Gimenez F: Cerebral uptake of mefloquine enantiomers in fatal cerebral malaria Int J Pharmacol Ther 1999, 37:58-6.
25. Jones R, Kunsman G, Levine B, Smith M and Stahl C: Mefloquine distribution in postmortem cases Forensic Sci Int 1994, 68:29-32.