Prediction of type 1 diabetes: The natural history of the prediabetic period

Advances in Experimental Medicine and Biology

Volumn 552, Issue , 2004, Pages 268-290

  Eisenbarth, George S ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUTAMATE DECARBOXYLASE 65; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR3 ANTIGEN; HLA DR4 ANTIGEN; IMMUNOGLOBULIN G; INSULIN; ORAL ANTIDIABETIC AGENT; PANCREAS ISLET CELL ANTIBODY;

CELL DESTRUCTION; CELLULAR IMMUNITY; CLINICAL TRIAL; ENVIRONMENTAL FACTOR; GENETIC SUSCEPTIBILITY; HEREDITY; HLA TYPING; HUMAN; HYPERGLYCEMIA; IMMUNOASSAY; IMPAIRED GLUCOSE TOLERANCE; INSULIN DEPENDENT DIABETES MELLITUS; MOLECULAR TYPING; NON INSULIN DEPENDENT DIABETES MELLITUS; ONSET AGE; ORAL GLUCOSE TOLERANCE TEST; PANCREAS SECRETION; POPULATION; PREGNANCY DIABETES MELLITUS; PREVALENCE; PRIORITY JOURNAL; RELATIVE; REVIEW; RISK FACTOR;

ADOLESCENT; ADULT; AGE FACTORS; ANIMALS; AUTOANTIBODIES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DISEASE PROGRESSION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFANT; INFANT, NEWBORN; ISLETS OF LANGERHANS; PREDIABETIC STATE; REMISSION INDUCTION; TIME FACTORS;

EID: 11844297833     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Review

References (206)

1. Verge CF, Eisenbarth GS. Prediction of type I diabetes: The natural history of the prediabetic period. 1996; 1st:230-258.
2. Kawasaki E, Eisenbarth G. High-Throughput radioassays for autoantibodies to recombinant autoantigens. Frontiers in Bioscience 2000; 5:181-190.
3. Leslie RD, Atkinson MA, Notkins AL. Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetes. Diabetologia 1999; 42:3-14.
4. Flanders G, Graves P, Rewers M. Prevention of type 1 diabetes from laboratory to public health. [Review] [91 refs]. Autoimmunity 1999; 29:235-246.
5. Riley WJ, Maclaren NK, Krischer J et al. A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes. N Engl J Med 1990; 323:1167-1172.
6. Bonifacio E, Bingley PJ, Shattock M et al. Quantification of islet-cell antibodies and prediction of insulin-dependent diabetes. Lancet 1990; 335:147-149.
7. Verge CF, Gianani R, Kawasaki E et al. Prediction of type I diabetes in first-degree relatives using a combination of insulin, GAD and ICA512bdc/IA-2 autoantibodies. Diabetes 1996; 45:926-933.
8. Verge CF, Stenger D, Bonifacio E et al. Combined use of autoantibodies (IA-2ab, Gadab, IAA, ICA) in type 1 diabetes: Combinatorial islet autoantibody workshop. Diabetes 1998; 47:1857-1866.
9. Strebelow M, Schlosser M, Ziegler B et al. Karlsburg Type I diabetes risk study of a general population: Frequencies and interactions of the four major Type I diabetes- associated autoantibodies studied in 9419 schoolchildren. Diabetologia 1999; 42:661-670.
10. Christie MR, Roll U, Payton MA et al. Validity of screening for individuals at risk for type I diabetes by combined analysis of antibodies to recombinant proteins. Diabetes Care 1997; 20:965-970.
11. Vardi P, Crisa L, Jackson RA et al. Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type I (insulin-dependent) diabetic patients. Diabetologia 1991; 34:93-102.
12. Deschamps I, Khalil I. The role of DQ alpha - beta heterodimers in genetic susceptibility to insulin-dependent diabetes. Diabetes Metab Rev 1993; 9:71-92.
13. Bingley PJ, Christie MR, Bonifacio E et al. Combined analysis of autoantibodies improves prediction of IDDM in islet cell antibody-positive relatives. Diabetes 1994; 43:1304-1310.
14. Naserke HE, Ziegler AG, Lampasona V et al. Early development and spreading of autoantibodies to epitopes of IA-2 and their association with progression to type 1 diabetes. J Immunol 1998; 161:6963-6969.
15. Kimpimaki T, Kulmala P, Savola K et al. Disease-Associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. Childhood Diabetes in Finland Study Group [In Process Citation]. J Clin Endocrinol Metab 2000 Mar; 85(3):1126-32 2000; 85:1126-1132.
16. Kimpimaki T, Kulmala P, Savola K et al. Disease-Associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. Childhood Diabetes in Finland Study Group [In Process Citation]. J Clin Endocrinol Metab 2000 Mar; 85(3):1126-32 2000; 85:1126-1132.
17. Pietropaolo M, Peakman M, Pietropaolo SL et al. Combined analysis of GAD65 and ICA512(IA-2) autoantibodies in organ and nonorgan-specific autoimmune diseases confers high specificity for insulin-dependent diabetes mellitus. J Autoimmun 1998; 11:1-10.
18. Yu L, Cuthbertson DD, Maclaren N et al. Expression of GAD65 and Islet Cell Antibody (ICA512) autoantibodies amongst cytoplasmic ICA+ relatives is associated with eligibility for Diabetes Prevention Trial Type-1. Diabetes 2001; 50:1735-1740.
19. Krischer JP, Schatz D, Riley WJ et al. Insulin and islet cell autoantibodies as time-dependent covariates in the development of insulin-dependent diabetes: A prospective study in relatives. J Clin Endocrinol Metab 1993; 77:743-749.
20. Maclaren N, Lan M, Coutant R et al. Only multiple autoantibodies to islet cells (ICA), insulin, GAD65, IA-2 and IA-2beta predict immune-mediated (Type 1) diabetes in relatives. J Autoimmun 1999; 12:279-287.
21. Eisenbarth GS, Verge CF, Allen H et al. The design of trials for the prevention of IDDM. Diabetes 1993; 42:941-947.
22. Chase HP, Dolan LM, Krischer JP et al. First phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes. J Pediatr 2001; 138:244-249.
23. Bingley PJftIG. Interactions of age, islet cell antibodies, insulin autoantibodies, and first-phase insulin response in predicting risk of progression to IDDM in ICA+ relatives: The ICARUS data set. Diabetes 1996; 45:1720-1728.
24. Ziegler AG, Ziegler R, Vardi P et al. Life table analysis of progression to diabetes of anti-insulin autoantibody-positive relatives of individuals with type I diabetes. Diabetes 1989; 38:1320-1325.
25. Gianani R, Pugliese A, Bonner-Weir S et al. Prognostically significant heterogeneity of cytoplasmic islet cell antibodies in relatives of patients with type I diabetes. Diabetes 1992; 41:347-353.
26. Marshall MO, Hoyer PE, Petersen JS et al. Contribution of glutamate decarboxylase antibodies to the reactivity of islet cell cytoplasmic antibodies. J Autoimmun 1994; 7:497-508.
27. Gianani R, Jackson R, Eisenbarth GS. Evidence that the autoantigen of restricted ICA is GAD. Diabetes Res Clin Prac 1991; 14(suppl. 1):S13.
28. Gianani R, Rabin DU, Verge CF et al. ICA512 autoantibody radioassay. Diabetes 1995; 44:1340-1344.
29. Pugliese A, Gianani R, Moromisato R et al. HLA-DQB1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes 1995; 44:608-613.
30. Schatz D, Krischer J, Horne G et al. Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives. J Clin Invest 1994; 93:2403-2407.
31. Bingley PJ, Bonifacio E, Shattock M et al. Can islet cell antibodies predict IDDM in the general population? Diabetes Care 1993; 16:45-50.
32. Kupila A, Muona P, Simell T et al. Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia 2001; 44:290-297.
33. Rewers M, Norris JM, Eisenbarth GS et al. Beta-cell autoantibodies in infants and toddlers without IDDM relatives: Diabetes autoimmunity study in the young (Daisy). J Autoimmun 1996; 9:405-410.
34. Schenker M, Hummel M, Ferber K et al. Early expression and high prevalence of islet autoantibodies for DR3/4 heterozygous and DR4/4 homozygous offspring of parents with Type I diabetes: The German BABYDIAB study. Diabetologia 1999; 42:671-677.
35. Virtanen SM, Laara E, Hypponen E et al. Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: A nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group. Diabetes 2000; 49:912-917.
36. Naserke HE, Schenker M, Ziegler AG. Frequency of islet autoantibodies in relatives of patients with Type II diabetes or gestational diabetes. Diabetologia 1999; 42:1377-
37. Turner R, Stratton I, Horton V et al. UKPDS 25: Autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet 1997; 350:1288-1293.
38. Horton V, Stratton I, Bottazzo GF et al. Genetic heterogeneity of autoimmune diabetes: Age of presentation in adults is influenced by HLA DRB1 and DQB1 genotypes (UKPDS 43). UK Prospective Diabetes Study (UKPDS) Group. Diabetologia 1999; 42:608-616.
39. Zimmet PZ, Tuomi T, Mackay IR et al. Latent autoimmune diabetes mellitus in adults (LADA): The role of antibodies to glutamic acid decarboxylase in diagnosis and prediction of insulin dependency. Diabet Med 1994; 11:299-303.
40. Carlsson A, Sundkvist G, Groop L et al. Insulin and glucagon secretion in patients with slowly progressing autoimmune diabetes (LADA). J Clin Endocrinol Metab 2000; 85(1):76-80.
41. Srikanta S, Ganda OP, Rabizadeh A et al. First-degree relatives of patients with type I diabetes mellitus. Islet cell antibodies and abnormal insulin secretion. N Engl J Med 1985; 313:461-464.
42. Rewers M, LaPorte RE, King H et al. Trends in the prevalence and incidence of diabetes: Insulin-dependent diabetes mellitus in childhood. World Health Stat Q 1988; 41:179-189.
43. Laakso M, Pyorala K. Age at onset and type of diabetes. Diabetes Care 1985; 8:114-117.
44. Japan IDDM Epidemiological Study Group. Lack of regional variation in IDDM risk in Japan. Diabetes Care 1993; 16:796-800.
45. Notsu K, Oka N, Note S et al. Islet cell antibodies in the Japanese population and subjects with type I (insulin-dependent) diabetes. Diabetologia 1985; 28:660-662.
46. Boehm BO, Manfras B, Seibler J et al. Epidemiology and immunogenetic background of islet cell antibody positive nondiabetic schoolchildren. Diabetes 1991; 40:1435-1439.
47. Diabetes Epidemiology Research International (DERI) Group. Geographic patterns of childhood insulin-dependent diabetes mellitus. Diabetes 1988; 37:1113-1119.
48. Levy-Marchal C, Tichet J, Fajardy I et al. Islet cell antibodies in normal French schoolchildren. Diabetologia 1992; 35:577-582.
49. Levy-Marchal C, Papoz L, de Beaufort C et al. Incidence of juvenile type I (insulin-dependent) diabetes mellitus in France. Diabetologia 1990; 33:465-469.
50. Bruining GJ, Molenaar JL, Grobbee DE et al. Ten-year follow-up study of islet-cell antibodies and childhood diabetes mellitus. Lancet 1989; 1:1100-1103.
51. Green A, Gale EAM, Patterson CC. Incidence of childhood-onset insulin-dependent diabetes mellitus: The EURODIAB ACE Study. Lancet 1992; 339:905-909.
52. Bergua M, Sole J, Marion G et al. Prevalence of islet cell antibodies, insulin antibodies and hyperglycemia in 2291 schoolchildren. Diabetologia 1987; 30:724-726.
53. Serrano Rios M, Moy CS, Martin-Serrano R et al. Incidence of type I (insulin-dependent) diabetes mellitus in subjects 0-14 years of age in the Comunidad of Madrid, Spain. Diabetologia 1990; 33:422-424.
54. Elliott RB, Pilcher CC, McGregor MA. Protection from diabetes in normal school children using nicotinamide. Autoimmunity 1993; 15 (Suppl):57
55. Scott RS, Brown LJ, Darlow BA et al. Temporal variation in incidence of IDDM in Canterbury, New Zealand. Diabetes Care 1992; 15:895-899.
56. Rowe RE, Leech NJ, Nepom GT et al. High genetic risk for IDDM in the Pacific Northwest. First report from the Washington State Diabetes Prediction Study. Diabetes 1994; 43:87-94.
57. Dokheel TM, The Pittsburgh Epidemiology Research Group. An epidemic of childhood diabetes in the United States? Diabetes Care 1993; 16:1606-1611.
58. Verge CF, Silink M, Howard NJ. The incidence of childhood IDDM in New South Wales, Australia. Diabetes Care 1994; 17:693-696.
59. Colman PG, McNair PD, Caudwell JP et al. Screening of an apparent 'hot spot' of IDDM for markers of preclinical IDDM. Autoimmunity 1993; 15(Suppl):31
60. Bingley PJ, Bonifacio E, Shattock M et al. Can islet cell antibodies predict IDDM in the general population? Diabetes Care 1993; 16(1):45-50.
61. Bingley PJ, Gale EA. Incidence of insulin dependent diabetes in England: A study in the Oxford region, 1985-6. BMJ 1989; 298:558-560.
62. Dahlquist G, Blom L, Holmgren G et al. The epidemiology of diabetes in Swedish children 0-14 years - a six year prospective study. Diabetologia 1985; 28:802-808.
63. Landin-Olsson M, Palmer JP, Lernmark A et al. Predictive value of islet cell and insulin autoantibodies for Type 1 (insulin-dependent) diabetes mellitus in a population- based study of newly-diagnosed diabetic and matched control children. Diabetologia 1992; 35:1068-1073.
64. Karjalainen JK. Islet cell antibodies as predictive markers for IDDM in children with high background incidence of disease. Diabetes 1990; 39:1144-1150.
65. Tuomilehto J, Lounamaa R, Tuomilehto-Wolf E et al. Epidemiology of childhood diabetes mellitus in Finland - background of a nationwide study of type I (insulin-dependent) diabetes mellitus. Diabetologia 1992; 35:70-76.
66. Karjalainen J, Salmela P, Ilonen J et al. A comparison of childhood and adult type 1 diabetes mellitus. N Engl J Med 1989; 320:881-886.
67. Tuomi T, Groop LC, Zimmet PZ et al. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a noninsulin- dependent onset of disease. Diabetes 1993; 42:359-362.
68. Pilcher CC, Elliott RB. Ontogeny of islet cell and insulin autoantibodies in first degree relatives of IDDM. Autoimmunity 1993; 15:78
69. Ziegler AG, Hillebrand B, Rabl W et al. On the appearance of islet associated autoimmunity in offspring of diabetic mothers: A prospective study from birth. Diabetologia 1993; 36:402-408.
70. Vardi P, Soloveicik L, Barzilai D et al. Insulin binding activity in cord blood of normal pregnancies. Autoimmunity 1993; 50.
71. Ziegler A-G, Hummel M, Schenker M et al. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes. The 2-year analysis of the German BABYDIAB study. Diabetes 1999; 48:460-468.
72. Baekkeskov S, Kanaani J, Jaume JC et al. Does GAD have a unique role in triggering IDDM? J Autoimmun 2000; 15:279-286.
73. Wegmann DR, Eisenbarth GS. It's Insulin. J Autoimmun 2000; 15:286-291.
74. Vardi P, Dib SA, Tuttleman M et al. Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of type I diabetes mellitus. Diabetes 1987; 36:1286-1291.
75. Vardi P, Ziegler AG, Matthews JH et al. Concentration of insulin autoantibodies at onset of type I diabetes. Inverse log-linear correlation with age. Diabetes Care 1988; 11:736-739.
76. Martino GV, Tappaz ML, Braghi S et al. Autoantibodies to glutamic acid decarboxylase (GAD) detected by an immuno-trapping enzyme activity assay: Relation to insulin- dependent diabetes mellitus and islet cell antibodies. J Autoimmun 1991; 4:915-923.
77. DeAizpurua HJ, Harrison LC, Cram DS. An ELISA for antibodies to recombinant glutamic acid decarboxylase in IDDM. Diabetes 1992; 41:1182-1187.
78. DeAizpurua HJ, Harrison LC. Glutamic acid decarboxylase in insulin-dependent diabetes mellitus [published erratum appears in Diabetes Metab Rev 1992 Oct; 8(3):following table of contents]. Diabetes Metab Rev 1992; 8:133-147.
79. Thivolet CH, Tappaz M, Durand A et al. Glutamic acid decarboxylase (GAD) autoantibodies are additional predictive markers of Type 1 (insulin-dependent) diabetes mellitus in high risk individuals. Diabetologia 1992; 35:570-576.
80. Sohnlein P, Muller M, Syren K et al. Epitope spreading and a varying but not disease-specific GAD65 antibody response in Type I diabetes. The Childhood Diabetes in Finland Study Group. Diabetologia 2000; 43:210-217.
81. Hawa M, Fava D, Medici F et al. Antibodies to IA-2 and GAD65 in type 1 and type 2 diabetes. Diabetes Care 2000; 23:228.
82. Dotta F, Previti M, Tiberti C et al. Identification of the GM2-1 islet ganglioside: Similarities with a major neuronal autoantigen. Diabetes 1992; 41:365A.
83. Larsson L-I, Nielsen JH, Hutton JC et al. Pancreatic hormones are expressed on the surface of human and rat islet cells through exocytotic sites. Eur J Cell Biol 1989; 48:45-51.
84. Aguilar-Diosdado M, Parkinson D, Corbett JA et al. Potential autoantigens in IDDM. Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the beta-cell surface. Diabetes 1994; 43(3):418-425.
85. Petersen JS, Russel S, Marshall MO et al. Differential expression of glutamic acid decarboxylase in rat and human islets. Diabetes 1993; 42:484-495.
86. Foulis AK, Liddle CN, Farquharson MA et al. The histopathology of the pancreas in type 1 (insulin-dependent) diabetes mellitus: A 25-year review of deaths in patients under 20 years of age in the United Kingdom. Diabetologia 1986; 29:267-274.
87. Sutherland DE, Sibley R, Xu XA et al. Twin-to-twin pancreas transplantation: Reversal and reenactment of the pathogenesis of type I diabetes. Trans Assoc Am Physicians 1984; 97:80-87.
88. Arslanian SL, Becker DJ, Rabin B et al. Correlates of insulin antibodies in newly diagnosed children with insulin-dependent diabetes before insulin therapy. Diabetes 1985; 34:926-930.
89. Karjalainen J, Knip M, Mustonen A et al. Relation between insulin antibody and complement-fixing islet cell antibody at clinical diagnosis of IDDM. Diabetes 1986; 35:620-622.
90. Mcevoy RC, Witt ME, Ginsberg-Fellner F et al. Anti-insulin antibodies in children with type I diabetes mellitus. Genetic regulation of production and presence at diagnosis before insulin replacement. Diabetes 1986; 35:634-641.
91. Jackson RA, Vardi P, Herskowitz RD et al. Dual parameter linear model for prediction of onset of type I diabetes in islet cell antibody positive relatives. Clin Res 1988; 36:585A
92. Castano L, Ziegler AG, Ziegler R et al. Characterization of insulin autoantibodies in relatives of patients with type 1 diabetes. Diabetes 1993; 42:1202-1209.
93. Williams AJK, Bingley PJ, Bonifacio E et al. A novel micro-assay for insulin autoantibodies. J Autoimmun 1997; 10:473-478.
94. Naserke HE, Dozio N, Ziegler A-G et al. Comparison of a novel micro-assay for insulin autoantibodies with the conventional radiobinding assay. Diabetologia 1998; 41:681-683.
95. Yu L, Robles DT, Abiru N et al. Early expression of antiinsulin autoantibodies of humans and the NOD mouse: Evidence for early determination of subsequent diabetes. Proc Natl Acad Sci USA 2000; 97:1701-1706.
96. Abiru N, Maniatis AK, Yu L et al. Peptide and MHC specific breaking of humoral tolerance to native insulin with the B:9-23 peptide in diabetes prone and normal mice. Diabetes 2001; 50:1274-1281.
97. Olmos P, A'Hern R, Heaton DA et al. The significance of the concordance rate for type 1 (insulin- dependent) diabetes in identical twins. Diabetologia 1988; 31:747-750.
98. Soltesz G, Madacsy L, Bekefi D et al. The Hungarian childhood diabetes epidemiology group: Rising incidence of type 1 diabetes in Hungarian children. Diabetic Med 1994; 7:111-114.
99. Verge CF, Gianani R, Yu L et al. Late progression to diabetes and evidence for chronic beta cell autoimmunity in identical twins of patients with type I diabetes. J Investig Med 1995; 43:227A-
100. Savilahti E, Simell O, Koskimies S et al. Celiac disease in insulin-dependent diabetes mellitus. J Pediatr 1986; 108:690-693.
101. Maclaren NK, Riley WJ. Thyroid, gastric, and adrenal autoimmunities associated with insulin-dependent diabetes mellitus. Diabetes Care 1985; 8(Suppl 1):34-38.
102. Kronenberg M, Siu G, Hood LE et al. The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Ann Rev Immunol 1986; 4:529-591.
103. Joner G and Sovik O. Increasing incidence of diabetes mellitus in norwegian children 0-14 years of age, 1973-1982. Diabetologia 1989; 32:79-83.
104. Green A, Andersen PK, Svendsen AJ et al. Increasing incidence of early onset type I (insulin-dependent) diabetes mellitus: A study of Danish male birth cohorts. Diabetologia 1992; 35:178-182.
105. Soltesz G, Madacsy L, Bekefi D et al. Rising incidence of type 1 diabetes in Hungarian children (1978-1987). Hungarian Childhood Diabetes Epidemiology Group. Diabetic Med 1990; 7:111-114.
106. Tuomilehto J, Rewers M, Reunanen A et al. Increasing trend in type I (insulin-dependent) diabetes mellitus in childhood in Finland. Analysis of age, calendar time, and birth cohort effects during 1965 to 1984. Diabetologia 1991; 34:282-287.
107. Drykoningen CEM, Mulder ALM, Vaandrager GJ et al. The incidence of male childhood type 1 (insulin-dependent) diabetes mellitus is rising rapidly in the Netherlands. Diabetologia 1992; 35:139-142.
108. Nystrom L, Dahlquist G, Rewers M et al. The Swedish childhood diabetes study: An analysis of the temporal variation in diabetes incidence, 1978-1987. Int J Epidemiol 1990; 19:141-146.
109. Rewers M, LaPorte RE, Walczak M et al. Apparent epidemic of insulin dependent diabetes mellitus in Midwestern Poland. Diabetes 1987; 36:106-113.
110. Hayashi T, Faustman D. Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis. J Biol Chem 2000; 275:5238-5247.
111. Onkamo P, Vaananen S, Karvonen M et al. Worldwide increase in incidence of Type I diabetes - the analysis of the data on published incidence trends. Diabetologia 1999; 42:1395-1403.
112. Variation and trends in incidence of childhood diabetes in Europe. EURODIAB ACE Study Group. Lancet 2000; 355:873-876.
113. Elliott RB, Pilcher C, Edgar BW. Geographic IDDM in Polynesia and Macronesia: The epidemiology of insulin dependent diabetes in Polynesian children born and reared in Polynesia, compared with Polynesian children resident in Auckland, New Zealand. Diabetes in the Young Bulletin (Proc of the ISGD) 1989; 20:16.
114. Bodansky HJ, Staines A, Stephenson C et al. Evidence for an environmental effect in the aetiology of insulin dependent diabetes in a transmigratory population. BMJ 1992; 304:1020-1022.
115. Dahlquist G, Blom L, Holmgren G et al. The epidemiology of diabetes in Swedish children 0-14 years - a six year prospective study. Diabetologia 1985; 28:802-808.
116. Kostraba JN, Gay EC, Cai Y et al. Incidence of insulin-dependent diabetes mellitus in Colorado. Epidemiology 1992; 3:232-238.
117. Menser MA, Forrest JM, Bransby RD. Rubella infection and diabetes mellitus. Lancet 1978; 1:57-60.
118. Rubinstein P, Walker ME, Fedun B et al. The HLA system in congenital rubella patients with and without diabetes. Diabetes 1982; 31:1088-1091.
119. Clarke WL, Shaver KA, Bright GM et al. Autoimmunity in congenital rubella syndrome. J Pediatr 1984; 104:370-373.
120. Yoon J-W, Morishima T, McClintock PR et al. Virus-induced diabetes mellitus: Mengovirus infects pancreatic beta cells in strains of mice resistant to the diabetogenic effect of encephalomyocarditis virus. J Virol 1984; 50:684-690.
121. Tuvemo T, Dahlquist G, Frisk G et al. The Swedish childhood diabetes study III: IgM against coxsackie B viruses in newly diagnosed type 1 (insulin-dependent) diabetic children - no evidence of increased antibody frequency. Diabetologia 1989; 32:745-747.
122. Kaufman DL, Erlander MG, ClareSalzler M et al. Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest 1992; 89:283-292.
123. Karounos DG, Simmerman L, Hickman SL et al. Identification of the p52-Rubella related autoantigen as an insulin secretory granule protein. Diabetes 1993; 42 (Suppl 1):221A
124. Anonymous. Lack of regional variation in IDDM risk in Japan. Japan IDDM Epidemiology Study Group. Diabetes Care 1993; 16:796-800.
125. Dahlquist GG. Primary and secondary prevention strategies of pretype 1 diabetes. Potentials and pitfalls. [Review]. Diabetes Care 1999; 22 Suppl 2:B4-B6.
126. Lonnrot M, Korpela K, Knip M et al. Enterovirus infection as a risk factor for beta-cell autoimmunity in a prospectively observed birth cohort: The Finnish Diabetes Prediction and Prevention Study. Diabetes 2000; 49:1314-1318.
127. Norris JM, Beaty B, Klingensmith G et al. Lack of association between early exposure to cow's milk protein and β-cell autoimmunity: Diabetes Autoimmunity Study in the Young (DAISY). JAMA 1996; 276:609-614.
128. Graves PM, Rewers M. The role of enteroviral infections in the development of IDDM: Limitations of current approaches. Diabetes 1997; 46:161-168.
129. Graves PM, Barriga KJ, Norris JM et al. Lack of association between early childhood immunizations and beta-cell autoimmunity. Diabetes Care 1999; 22:1694-1697.
130. Honeyman MC, Coulson BS, Stone NL et al. Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Diabetes 2000; 49:1319-1324.
131. Medzhitov R, Preston-Hurlburt P, Janeway CA. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388:394-397.
132. Like AA, Guberski DL, Butler L. Influence of environmental viral agents on frequency and tempo of diabetes mellitus in BB/Wor rats. Diabetes 1991; 40:259-262.
133. Wilberz S, Partke HJ, Dagnaes-Hansen F et al. Persistent MHV (mouse hepatitis virus) infection reduces the incidence of diabetes mellitus in nonobese diabetic mice. Diabetologia 1991; 34:2-5.
134. Oldstone MB. Prevention of type 1 diabetes in nonobese diabetic mice by virus infection. Science 1988; 239:500-502.
135. Dyrberg T, Schwimmbeck PL, Oldstone MB. Inhibition of diabetes in BB rats by virus infection. J Clin Invest 1988; 81:928-931.
136. Guberski DL, Thomas VA, Shek WR et al. Induction of Type 1 diabetes by Kilham's rat virus in diabetes-resistant BB/Wor rats. Science 1991; 254:1010-1013.
137. Yoon JW. Role of viruses in the pathogenesis of IDDM. Ann Med 1991; 23:437-445.
138. Yoon J-W, McClintock PR, Bachurski CJ et al. Virus-induced diabetes mellitus. No evidence for immune mechanisms in the destruction of beta-cells by the D variant of encephalyomyocarditis virus. Diabetes 1985; 34:922-925.
139. Virtanen S, Rasanen L, Aro A et al. Infant feeding in finnish children less than 7 yr of age with newly diagnosed IDDM. Childhood Diabetes in Finland Study Group. Diabetes Care 1991; 14:415-417.
140. Virtanen SM, Rasanen L, Aro A et al. Feeding in infancy and the risk of type 1 diabetes mellitus in Finnish children. The 'Childhood Diabetes in Finland' Study Group. Diabetic Med 1992; 9:815-819.
141. Mayer EJ, Hamman RF, Gay EC et al. Reduced risk of IDDM among breast-fed children. The Colorado IDDM Registry. Diabetes 1988; 37:1625-1632.
142. Verge CF, Howard NJ, Irwig L et al. Environmental factors in childhood IDDM: A population-based, case-control study. Diabetes Care 1994; 17:1381-1389.
143. Kyvik KO, Green A, Svendsen A et al. Breast feeding and the development of type I diabetes mellitus. Diabetic Med 1992; 9:233-235.
144. Gerstein HC. Cow's milk exposure and type I diabetes mellitus - a critical overview of the clinical literature. Diabetes Care 1994; 17:13-19.
145. Johansson C, Samuelsson U, Ludvigsson J. A high weight gain early in life is associated with an increased risk of type I (insulin-dependent) diabetes mellitus. Diabetologia 1994; 37:91-94.
146. Karjalainen J, Martin JM, Knip M et al. A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus [see comments]. N Engl J Med 1992; 327:302-307.
147. Savilahti E, Akerblom HK, Tainio V-M et al. Children with newly diagnosed insulin dependent diabetes mellitus have increased levels of cow's milk antibodies. Diabetes Res 1988; 7:137-140.
148. Yokota A, Yamaguchi Y, Ueda Y et al. Comparison of islet cell antibodies, islet cell surface antibodies and anti-bovine serum albumin antibodies in type 1 diabetes. Diabetes Res Clin Prac 1990; 9:211-217.
149. Pocecco M, Nicoloso F, Tonini G et al. Increased levels of cow's milk antibodies in children with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Horm Metab Res 1991; 35:67-67.
150. Dahlquist G, Savilahti E, Landin-Olsson M. An increased level of antibodies to beta-lactoglobulin is a risk determinant of early-onset Type I (insulin-dependent) diabetes mellitus independent of islet cell antibodies and early introduction of cow's milk. Diabetologia 1992; 35:980-984.
151. Karjalainen J, Saukkonen T, Savilahti E et al. Disease-associated anti-bovine serum albumin antibodies in type I (insulin-dependent) diabetes mellitus are detected by particle concentration fluoroimmunoassay, and not by enzyme linked immunoassay. Diabetologia 1992; 35:985-990.
152. Karjalainen J, Cheung R, Vandermeulen JM et al. T cell proliferation response against bovine albumin (BSA) follows the natural course and is restricted to the linear ABBOS sequence in insulin-dependent diabetes mellitus. Autoimmunity 1993; 15(Suppl):62A
153. Atkinson MA, Bowman MA, Kuo-Jang K et al. Lack of immune responsiveness to bovine serum albumin in insulin- dependent diabetes. N Engl J Med 1993; 329:1853-1858.
154. Elliott RB, Martin JM. Dietary protein: A trigger of insulin-dependent diabetes in the BB rat? Diabetologia 1984; 26:297-299.
155. Daneman D, Fishman L, Clarson C et al. Dietary triggers of insulin-dependent diabetes in the BB rat. Diabetes Res 1987; 5:93-97.
156. Coleman DL, Kuzava JE, Leiter EH. Effect of diet on incidence of diabetes in nonobese diabetic mice. Diabetes 1990; 39:432-436.
157. Elliott RB, Reddy SN, Bibby NJ et al. Dietary prevention of diabetes in the nonobese diabetic mouse. Diabetologia 1988; 31:62-64.
158. Paronen J, Knip M, Savilahti E et al. Effect of cow's milk exposure and maternal type 1 diabetes on cellular and humoral immunization to dietary insulin in infants at genetic risk for type 1 diabetes. Finnish Trial to Reduce IDDM in the Genetically at Risk Study Group. Diabetes 2000; 49:1657-1665.
159. Srikanta S, Ganda OP, Gleason RE et al. Pretype I diabetes. Linear loss of beta cell response to intravenous glucose. Diabetes 1984; 33:717-720.
160. Eisenbarth GS. Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 1986; 314:1360-1368.
161. Bleich D, Jackson RA, Soeldner JS et al. Analysis of metabolic progression to type I diabetes in ICA+ relatives of patients with type I diabetes. Diabetes Care 1990; 13:111-118.
162. McCulloch DK, Klaff LJ, Kahn SE et al. Nonprogression of subclinical B-cell dysfunction among first degree relatives of IDDM patients. 5 year follow-up of the Seattle Family Study. Diabetes 1990; 39:549-556.
163. Beer SF, Heaton DA, Alberti KG et al. Impaired glucose tolerance precedes but does not predict insulin-depedendent diabetes mellitus: A study of identical twins. Diabetologia 1990; 33:497-502.
164. Kobayashi T, Itoh T, Kosaka K et al. Time course of islet cell antibodies and beta-cell function in noninsulin-dependent stage of type I diabetes. Diabetes 1987; 36:510-517.
165. Tunbridge WMG, Brewis M, French JM et al. Natural history of autoimmune thyroiditis. BMJ 1981; 282:258-262.
166. Spencer KM, Tarn A, Dean BM et al. Fluctuating islet-cell autoimmunity in unaffected relatives of patients with insulin-dependent diabetes. Lancet 1984; 1:764-766.
167. Chase HP, Voss MA, Butler-Simon N et al. Diagnosis of pretype I diabetes. J Pediatr 1987; 111:807-812.
168. Thivolet C, Beaufrere B, Geburher L et al. Autoantibodies and genetic factors associated with the development of type I (insulin-dependent) diabetes in first degree relatives of diabetic patients. Diabetologia 1991; 34:186-191.
169. Millward BA, Alviggi L, Hoskins PJ et al. Immune changes associated with insulin dependent diabetes may remit without causing the disease: A study in identical twins. Br Med J (Clin Res Ed) 1986; 292:793-796.
170. Helmke K, Otten A, Willems WR et al. Islet cell antibodies and the development of diabetes mellitus in relation to mumps infection and mumps vaccination. Diabetologia 1986; 29:30-33.
171. Landin-Olsson M, Karlsson A, Dahlquist G et al. Islet cell and other organ-specific autoantibodies in all children developing Type 1 (insulin-dependent) diabetes mellitus in Sweden during one year and in matched control children. Diabetologia 1989; 32:387-395.
172. Landin-Olsson M. Precision of the islet-cell antibody assay depends on the pancreas. J Clin Lab Anal 1990; 4:289-294.
173. Kulmala P, Rahko J, Savola K et al. Stability of autoantibodies and their relation to genetic and metabolic markers of Type I diabetes in initially unaffected schoolchildren. Diabetologia 2000; 43:457-464.
174. Yu J, Yu L, Bugawan TL et al. Transient anti-islet autoantibodies: Infrequent occurrence and lack of association with genetic risk factors. J Clin Endocrinol Metab 2000; 85:2421-2428.
175. Colman PG, Steele C, Couper JJ et al. Islet autoimmunity in infants with a Type I diabetic relative is common but is frequently restricted to one autoantibody. Diabetologia 2000; 43:203-209.
176. Carel JC, Boitard C, Bougneres PF. Decreased insulin response to glucose in islet cell antibody-negative siblings of type 1 diabetic children. J Clin Invest 1993; 92:509-513.
177. Pilcher CC, Elliott RB. A sensitive and reproducible method for the assay of human islet cell antibodies. J Immunol Methods 1990; 129:111-117.
178. Santiago JV. Insulin therapy in the last decade. A pediatric perspective. Diabetes Care 1993; 16 (Suppl 3):143-154.
179. McCulloch DK, Koerker DJ, Kahn SE et al. Correlations of in vivo beta-cell function tests with beta-cell mass and pancreatic insulin content in streptozocin-treated baboons. Diabetes 1991; 40:673-679.
180. Allen HF, Jeffers BW, Klingensmith GJ et al. First-phase insulin release in normal children. J Pediatr 1993; 123:733-738.
181. Arslanian S, Austin A. Determinants of first and second phase insulin secretion in healthy adolescents. Pediatr Res 1993; 3:S74.
182. Cutfield WS, Bergman RN, Menon RK et al. The modified minimal model: Application to measurement of insulin sensitivity in children. J Clin Endocrinol Metab 1990; 70:1644-1650.
183. Smith CP, Williams AJK, Thomas JM et al. The pattern of basal and stimulated insulin responses to intravenous glucose in first degree relatives of type I (insulin-dependent) diabetic children and unrelated adults aged 5 to 50 years. Diabetologia 1988; 31:430-434.
184. Colman PG, Stewart V, Kean J et al. Comparison of two commonly used standard IVGTTs. Diabetes Care 1992; 15:1053-1055.
185. Bingley PJ, Colman P, Eisenbarth GS et al. Standardization of IVGTT to predict IDDM. Diabetes Care 1992; 15:1313-1316.
186. Rayman G, Clark P, Schneider AE et al. The first phase insulin response to intravenous glucose is highly reproducible. Diabetologia 1990; 33:631-634.
187. Smith CP, Tarn AC, Thomas JM et al. Between and within subject variation of the first phase insulin response to intravenous glucose. Diabetologia 1988; 31:123-125.
188. McNair PD, Colman PG, Alford FP et al. Reproducibility of the first phase insulin response (FPIR) in the intravenous glucose tolerance test (IVGTT) is not improved by retrograde cannulation and arterialisation or by the use of a lower glucose dose. Autoimmunity 1993.
189. Rowe RE, Leech NJ, McCullock DK. Does drawing blood from a retrogradely cannulated hand vein improve reproducibility in the intravenous glucose tolerance test (IVGTT)? Autoimmunity 1993; 15(Suppl):79.
190. Leech NJ, Rowe RE, Bucksa J et al. HbA1c may be an early indicator of islet cell dysfunction. Autoimmunity 1993; 15(Suppl):75.
191. Signore A, Chianelli M, Ferretti E et al. New tools for imaging insulins in pre diabetes. Autoimmunity 1993; 15(Suppl):64-64.
192. Yuh WTC, Wiese JA, Abu-Yousef MM et al. Pancreatic transplant imaging. Radiology 1988; 167:679-683.
193. Kelcz F, Sollinger HW, Pirsch JD. MRI of the pancreas transplant: Lack of correlation between imaging and clinical status. Mag Res Med 1991; 21:30-38.
194. Fernandez MP, Bernardino ME, Neylan JF et al. Diagnosis of pancreatic transplant dysfunction: Value of gadopentetate dimeglumine-enhanced MR imaging. AJR 1991; 156:1171-1176.
195. Hanafusa T, Miyazaki A, Miyagawa J et al. Examination of islets in the pancreas biopsy specimens from newly diagnosed type I (insulin-dependent) diabetic patients. Diabetologia 1990; 33:105-111.
196. Martin S, Pawlowski B, Greulich B et al. Natural course of remission in IDDM during 1st year after diagnosis. Diabetes Care 1992; 15:66-74.
197. Schiffrin A, Suissa S, Weitzner G et al. Factors predicting course of B-cell function in IDDM. Diabetes Care 1992; 15:997-1001.
198. Knip M, Llonen J, Mustonen A et al. Evidence of an accelerated B-cell destruction in HLA-Dw3/ Dw4 heterozygous children with type I (insulin-dependent) diabetes. Diabetologia 1986; 29:347-351.
199. Baisch JM, Weeks T, Giles R et al. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N Engl J Med 1990; 322:1836-1841.
200. Erlich HA, Griffith RL, Bugawan TL et al. Implication of specific DQB1 alleles in genetic susceptibility and resistance by identification of IDDM siblings with novel HLA-DQB1 allele and unusual DR2 and DR1 haplotypes. Diabetes 1991; 40:478-481.
201. Karasik A, O'Hara C, Srikanta S et al. Genetically programmed selective islet beta-cell loss in diabetic subjects with Wolfram's syndrome. Diabetes Care 1989; 12:135-138.
202. Kadowaki T, Kadowaki H, Mori Y et al. A subtype of diabetes mellitus associated with a mutation of mitochondrial DNA. N Engl J Med 1994; 330:962-968.
203. Bowden DW, Gravius TC, Akots G et al. Identification of genetic markers flanking the locus for maturity-onset diabetes of the young on human chromosome 20. Diabetes 1992; 41:88-92.
204. Froguel P, Zouali H, Vionnet N et al. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus [see comments]. N Engl J Med 1993; 328:697-702.
205. Carlsson A, Sundkvist G, Groop L et al. Insulin and glucagon secretion in patients with slowly progressing autoimmune diabetes (LADA). J Clin Endocrinol Metab 2000; 85:76-80.
206. Herskowitz-Dumont R, Wolfsdorf JI, Jackson RA et al. Distinction between transient hyperglycemia and early insulin-dependent diabetes mellitus in childhood: A prospective study of incidence and prognostic factors. J Pediatr 1993; 123:347-354.