Cord blood islet autoantibodies and seasonal association with the type 1 diabetes high-risk genotype

Journal of Perinatology

Volumn 28, Issue 3, 2008, Pages 211-217

  Lynch, K F ^a   Lernmark, B ^a   Merlo, J ^a   Cilio, C M ^a   Ivarsson, S A ^a   Lernmark, A ^a,b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; HLA DQ ANTIGEN; INSULIN ANTIBODY; PANCREAS ISLET CELL ANTIBODY;

ANTIBODY DETECTION; ARTICLE; AUTOIMMUNITY; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; FEMALE; FOLLOW UP; GASTROENTERITIS; GENETIC ASSOCIATION; GENOTYPE; HEREDITY; HIGH RISK PATIENT; HLA TYPING; HUMAN; HUMAN TISSUE; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; NEWBORN; PREDICTION; PREGNANCY; PREVALENCE; QUESTIONNAIRE; RISK ASSESSMENT; SEASONAL VARIATION; UMBILICAL CORD BLOOD;

AUTOANTIBODIES; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS, TYPE 1; ENVIRONMENTAL EXPOSURE; FEMALE; FETAL BLOOD; GASTROENTERITIS; GENETIC PREDISPOSITION TO DISEASE; GLUTAMATE DECARBOXYLASE; HISTOCOMPATIBILITY TESTING; HLA-DQ ANTIGENS; HUMANS; INFANT, NEWBORN; ISLETS OF LANGERHANS; ODDS RATIO; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PREGNANCY IN DIABETICS; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 8; SEASONS;

EID: 40349100434     PISSN: 07438346     EISSN: 14765543     Source Type: Journal    
DOI: 10.1038/sj.jp.7211912     Document Type: Article

References (44)

1. Notkins AL, Lemmark A. Autoimmune type 1 diabetes: Resolved and unresolved issues. J Clin Invest 2001; 108: 1247-1252.
2. Eisenbarth GS. Prediction of type 1 diabetes: The natural history of the prediabetic period. Adv Exp Med Biol 2004; 552: 268-290.
3. Pihoker C, Gilliam LK, Hampe CS, Lemmark A. Autoanbbodies in diabetes. Diabetes 2005; 54(Suppl 2): S52-S61.
4. Skyler JS, Diabetes Prevention Trial - Type I Diabetes Study Group. Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 2002; 346: 1685-1691.
5. Gale EA, Bingley PJ, Emmett CL, Collier T. European Nicotinamide Diabetes Intervention Trial (ENDIT): A randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 2004; 363: 925-931.
6. Graham J, Hagopian WA, Kockum I, Li LS, Sanjeevi CB, Lowe RM et al Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes 2002; 51: 1346-1355.
7. Rewers M, Bugawan TL, Norris JM, Blair A, Beaty B, Hoffman M et al Newborn screening for HLA markers associated with IDDM: Diabetes autoinummity study in the young (DAISY), Diabetologia 1996; 39 807-812.
8. Greener M. PANDA identifies babies at risk of developing type 1 diabetes. Mol Med Today 2000; 6: 3.
9. Ilonen J, Reijonen H, Knip M, Simell O. Population-based genetic screening for IDDM susceptibility as a source of HLA-genotyped control subjects. Diabetologia 1996; 39: 123.
10. Roll U, Christie MR, Fuchtenbusch M, Payton MA, Hawkes CJ, Ziegler AG. Perinatal autoinummity in offspring of diabetic parents. The German Multicenter BABY-DIAB Study: Detection of humoral immune responses to islet antigens in early childhood. Diabetes 1996; 45: 967-973.
11. Concannon P, Erlich HA, Julier C, Morahan G, Nerup J, Pociot F et al Type 1-diabetes: Evidence for susceptibility loci from four genome-wide linkage scans in 1435 multiplex families. Diabetes 2005; 54: 2995-3001.
12. Komulainen J, Kulmala P, Savola K, Lounamaa R, Ilonen J, Reijonen H et al. Clinical, autoimmune, and genetic characteristics of very young children with type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes Care 1999; 22: 1950-1955.
13. Atkinson MA, Eisenbarth GS. Type 1 diabetes: New perspectives on disease pathogenesis and treatment. Lancet 2001; 358: 221-229.
14. Dahlquist G, Blom L, Tuvemo T, Nystrom L, Sandstrom A, Wall S. The Swedish Childhood Diabetes Study - results from a nine year case register and a one year case-referent study indicating that type 1 (insulin-dependent) diabetes mellitus is associated with both type 2 (non-insulin-dependent) diabetes mellitus and autoimmune disorders. Diabetologia 1989; 32: 2-6.
15. Olmos P, A'Hem R, Heaton DA, Millward BA, Risley D, Pyke DA et al. The significance of the concordance rate for type 1 (insulin-dependent) diabetes in identical twins. - Diabetologia 1988; 31: 747-750.
16. Hyoty H, Taylor KW. The role of viruses in human diabetes. Diabetologia 2002; 45: 1353-1361.
17. Green A, Patterson CC. Trends in the incidence of childhood-onset diabetes in Europe 1989-1998 Diabetologia 2001; 44(Suppl 3 : B3-B8.
18. Pundziute- ycka A, Dahlquist G, Nystrom L, Arnqvist H, Bjork E, Blohme G et al. The incidence of type I diabetes has not increased but shifted to a younger age at diagnosis in the 0- 34 years group in Sweden 1983-1998. Diabetologia 2002; 45: 783-791.
19. Dahlquist GG, Ivarsson S, Lindberg B, Forsgren M. Maternal enteroviral infection during pregnancy as a risk factor for childhood IDDM. A population-based case-control study, Diabetes 1995; 44: 408-413.
20. Hyoty H, Hiltunen M, Knip M, Laakkonen M, Vahasalo P, Karjalanen J et al. A prospective study of the role of coxsackie B and other enterovirus infections in the pathogenesis of IDDM. Childhood Diabetes in Finland (DiMe) Study Group. Diabetes 1995; 44: 652-657.
21. Stene LC, Barriga K, Norris JM, Hoffman M, Klingensmith G, Erlich HA et al. Symptoms of common maternal infections in pregnancy and risk of islet autoimmunity in early childhood. Diabetes Care [2003; 26: 3136-3141.
22. Dahlquist G, Kallen B. Maternal-child blood group incompatibility and other perinatal events increase the risk for early-onset type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1992; 35 671-675.
23. Bingley PJ, Douek IF, Rogers CA, Gale EA Influence of maternal age at delivery and birth order on risk of type 1 diabetes in childhood: prospective population based family study. Bart's-Oxford Family Study Group. BMJ 2000; 321: 420-424.
24. Blom I, Dahlquist G, Nystrom L, Sandstrom A, Wall S. The Swedish Childhood Diabetes Study - social and perinatal determinants for diabetes in childhood. Diabetologia 1989; 32: 7-13.
25. Stene LC, Barriga K, Norris JM, Hoffman M, Erlich HA, Eisenbarth GS et al. Perinatal factors and development of islet autaimmunity in early childhood: The diabetes autommaunity study in the young. Am J Epidemiol 2004; 160: 3-10.
26. Stene LC, Magnus P, Lie RT, Sovik O, Joner G. Maternal and paternal age at delivery, birth order, and risk of childhood onset type 1 diabetes: population based cohort study. BMJ 2001; 323: 369.
27. Stene LC, Magnus P, lie RT, Sovik O, Joner G. Birth weight and childhood onset type 1 diabetes: Population based cohort study. BMJ 2001; 322: 889-892.
28. Lindberg B, Ivarsson SA, Landin-Olsson M, Sundkvist G, Svanberg L, Lemmark A. Islet autoantibodies in cord blood from children who developed type I (insulin-dependent) diabetes mellitus before 15 years of age. Diabetologia 1999; 42: 181-187.
29. Elfving AM, Lindberg BA, Nystrom L, Sundkvist G, Lemmark A, Ivarsson SA. Islet autoantibodies in cord blood from patients who developed type 1 diabetes mellitus at 15-30 years of age. Autoimmunity 2003; 36 227-231.
30. Koczwara K, Bonifacio E, Ziegler AG. Transmission of maternal islet antibodies and risk of autoimmune diabetes in offspring of mothers with type 1 diabetes. Diabetes 2004; 53: 1-4.
31. Ivarsson SA, Ackefors M, Carlsson A, Ekberg G, Falorni A, Kockum I et al. Glutamate decarboxylase antibodies in non-diabetic pregnancy precedes insulin-dependent diabetes in the mother but not necessarily in the offspring. Autoimmunity 1997; 26: 261-269.
32. Larsson K, Elding-Larsson H, Cederwall E, Kockum K, Neiderud J, Sjoblad S et al. Genetic and perinatal factors as risk for childhood type 1 diabetes. Diabetes Metab Res Rev 2004; 20: 429-437.
33. Lernmark B, Elding-Larsson H, Hansson G, Lindberg B, Lynch K, Sjoblad S. Parent responses to participation in genetic screening for diabetes risk. Pediatr Diabetes 2004; 5: 174-181.
34. Larsson HE, Lynch K, Lernmark B, Nilsson A, Hansson G, Almgren P et al. Diabetes-associated HLA genotypes affect birthweight in the general population. Diabetologia 2005; 48: 1484-1491.
35. Grubin CE, Daniels T, Toivola B, Landin-Olsson M, Hagopian WA, Li L et al. A novel radioligand binding assay to determine diagnostic accuracy of isoform-specific glutamic acid decarboxylase antibodies in childhood IDDM. Diabetologia 1994; 37: 344-350.
36. Lan MS, Lu J, Goto Y, Notkins AL. molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol 1994; 13: 505-514.
37. Adams SF. The seasonal variation in the onset of acute diabetes. Arch Intern Ned 1926; 37: 861-864.
38. Joner G, Sovik O. Incidence, age at onset and seasonal variation of diabetes mellitus in Norwegian children, 1973-1977. Acta Paediatr Scand 1981; 70: 329-335.
39. Samuelsson U, Carstensen J, Lofman O, Nordfeldt S. Seasonal variation in the diagnosis of type 1 diabetes in south-east Sweden. Diabetes Res Clin Pract 2007; 76: 75-81.
40. Kimpimaki T, Kupila A, Hamalainen AM, Kukko M, Kulmala P, Savola K et al. The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: The Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab 2001; 86: 4782-4788.
41. Rolandsson O, Hagg E, Janer M, Rutledge E, Gaur LK, Nilsson M et al High GAD65 autoantibody levels in nondiabefic adults are associated with HIA but not with CTLA-4 or INS VNTR. J Intern Med 2003; 253 447-453.
42. Larsson HE, Lynch K, Lernmark B, Hansson G, Lernmark A, Ivarsson SA. Relationship between increased relative birthweight and infections during pregnancy in children with a high-risk diabetes HLA genotype. Diabelologia 2007; 50: 1161-1169.
43. Elfving M, Number of islet autoantibodies present in newly-diagnosed: type 1 diabetic children born to non-diabetic mothers is affected by islet autoandbodies present at birth. Pediatr Diabetes 2008 (in press).
44. Rewers M. Islet autoantibodies in cord blood: Maternal, fetal, or neither? Diabetes Metab Res Rev 2002; 18: 2-4.