Age- and islet autoimmunity-associated differences in amino acid and lipid metabolites in children at risk for type 1 diabetes

Diabetes

Volumn 60, Issue 11, 2011, Pages 2740-2747

  Pflueger, Maren ^a   Seppänen Laakso, Tuulikki ^b   Suortti, Tapani ^b   Hyötyläinen, Tuulia ^b   Achenbach, Peter ^a   Bonifacio, Ezio ^c   Orešič, Matej ^b   Ziegler, Anette G ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c Deutsche Forschungsgemeinschaft   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AUTOANTIBODY; GLUTAMATE DECARBOXYLASE ANTIBODY; IA 2A ANTIBODY; INSULIN ANTIBODY; LIPID; METHIONINE; UNCLASSIFIED DRUG; ZNT8A ANTIBODY;

AMINO ACID METABOLISM; ARTICLE; AUTOIMMUNITY; CHILD; CONTROLLED STUDY; FEMALE; FOLLOW UP; GENOTYPE; GROUPS BY AGE; HUMAN; INFANT; INSULIN DEPENDENT DIABETES MELLITUS; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; METABOLITE; PARENT; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK FACTOR; SCHOOL CHILD; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

ADOLESCENT; AGE OF ONSET; AGING; AMINO ACIDS; AUTOANTIBODIES; AUTOIMMUNITY; CHILD; CHILD, PRESCHOOL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COHORT STUDIES; DIABETES MELLITUS, TYPE 1; ENDOPHENOTYPES; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GERMANY; HUMANS; INFANT; ISLETS OF LANGERHANS; LIPID METABOLISM; LIPIDS; MALE; PREDIABETIC STATE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 80755152896     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db10-1652     Document Type: Article

References (22)

1. Atkinson MA, Eisenbarth GS. Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet 2001;358:221-229 (Pubitemid 32718550)
2. Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG. Brief communication: early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents. Ann Intern Med 2004;140:882-886
3. Bonifacio E, Mayr A, Knopff A, Ziegler AG. Endocrine autoimmunity in families with type 1 diabetes: frequent appearance of thyroid autoimmunity during late childhood and adolescence. Diabetologia 2009;52:185-192
4. Ziegler AG, Nepom GT. Prediction and pathogenesis in type 1 diabetes. Immunity 2010;32:468-478
5. Achenbach P, Koczwara K, Knopff A, Naserke H, Ziegler AG, Bonifacio E. Mature high-affinity immune responses to (pro)insulin anticipate the autoimmune cascade that leads to type 1 diabetes. J Clin Invest 2004;114:589-597 (Pubitemid 39572109)
6. Nicholson JK, Holmes E, Wilson ID. Gut microorganisms, mammalian metabolism and personalized health care. Nat Rev Microbiol 2005;3:431-438 (Pubitemid 40590386)
7. Holmes E, Loo RL, Stamler J, et al. Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 2008;453:396-400 (Pubitemid 351693125)
8. Oresic M, Vidal-Puig A, Hänninen V. Metabolomic approaches to phenotype characterization and applications to complex diseases. Expert Rev Mol Diagn 2006;6:575-585 (Pubitemid 44179943)
9. Rezzi S, Ramadan Z, Martin FP, et al. Human metabolic phenotypes link directly to specific dietary preferences in healthy individuals. J Proteome Res 2007;6:4469-4477 (Pubitemid 350158522)
10. Oresic M, Simell S, Sysi-Aho M, et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J Exp Med 2008;205:2975-2984
11. Ziegler AG, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 1999;48:460-468 (Pubitemid 29106857)
12. Achenbach P, Lampasona V, Landherr U, et al. Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk. Diabetologia 2009;52:1881-1888
13. Schlosser M, Mueller PW, Törn C, Bonifacio E, Bingley PJ; Participating Laboratories. Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies. Diabetologia 2010;53:2611-2620
14. Törn C, Mueller PW, Schlosser M, Bonifacio E, Bingley PJ; Participating Laboratories. Diabetes Antibody Standardization Program: evaluation of assays for autoantibodies to glutamic acid decarboxylase and islet antigen-2. Diabetologia 2008;51:846-852
15. Fraley C, Raftery AE. Model-based methods of classification: using the mclust software in chemometrics. J Stat Softw 2007;18:1-13
16. TEDDY Study Group. The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design. Pediatr Diabetes 2007;8:286-298
17. Warensjö E, Smedman A, Stegmayr B, et al. Stroke and plasma markers of milk fat intake - a prospective nested case-control study. Nutr J 2009;8:21
18. 13C]methionine. Am J Physiol 1988;255:E322-E331
19. Chuang JC, Yu CL, Wang SR. Modulation of lymphocyte proliferation by enzymes that degrade amino acids. Clin Exp Immunol 1990;82:469-472
20. Sundrud MS, Koralov SB, Feuerer M, et al. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science 2009;324:1334-1338
21. Niculescu MD, Zeisel SH. Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. J Nutr 2002;132(Suppl.):2333S-2335S (Pubitemid 34848102)
22. Scriver CR, Rosenberg LE. Amino Acids Metabolism and Its Disorders. Philadelphia, Saunders, 1973