Telomerase unplugged

ACS Chemical Biology

Volumn 2, Issue 3, 2007, Pages 155-158

  Cristofari, Gaël ^a   Sikora, Katarzyna ^a   Lingner, Joachim ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; NUCLEIC ACID BINDING PROTEIN; PROTECTION OF TELOMERES 1 INTERACTING PROTEIN; SHELTERIN; SINGLE STRANDED DNA; TELOMERASE; TELOMERE BINDING PROTEIN; TELOMERE BINDING PROTEIN ALPHA; TELOMERIC REPEAT BINDING FACTOR 1; TELOMERIC REPEAT BINDING FACTOR 1 INTERACTING NUCLEAR PROTEIN 2; TELOMERIC REPEAT BINDING FACTOR 1 INTERACTING NUCLEAR PROTEIN 2 AND PROTECTION OF TELOMERES 1 INTERACTING PROTEIN; TELOMERIC REPEAT BINDING FACTOR 2; UNCLASSIFIED DRUG; MULTIPROTEIN COMPLEX; POT1 PROTEIN, HUMAN; PTOP PROTEIN, HUMAN; SHELTERIN, HUMAN; TINF2 PROTEIN, HUMAN;

ARTICLE; CELL CYCLE S PHASE; CELL DIVISION; CILIATE; CRYSTAL STRUCTURE; ENZYME INHIBITION; FUNGAL STRAIN; MOLECULAR MECHANICS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SENESCENCE; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW;

HUMANS; MULTIPROTEIN COMPLEXES; TELOMERASE; TELOMERE-BINDING PROTEINS;

EID: 34248549623     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb700037c     Document Type: Article

References (26)

1. Smogorzewska, A., and de Lange, T. (2004) Regulation of telomerase by telomeric proteins, Annu. Rev. Biochem. 73, 177-208.
2. Hug, N., and Lingner, J. (2006) Telomere length homeostasis, Chromosoma 115, 413-425.
3. Cristofari, G., and Lingner, J. (2006) Telomere length homeostasis requires that telomerase levels are limiting, EMBO J. 25, 565-574.
4. Wang, F., Podell, E. R., Zaug, A. J., Yang, Y., Baciu, P., Cech, T. R., and Lei, M. (2007) The POT1-TPP1 telomere complex is a telomerase processivity factor, Nature 445, 506-510.
5. Xin, H., Liu, D., Wan, M., Safari, A., Kim, H., Sun, W., O'Connor, M. S., and Songyang, Z. (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase, Nature 445, 559-562.
6. de Lange, T. (2005) Shelterin: the protein complex that shapes and safeguards human telomeres, Genes Dev. 19, 2100-2110.
7. Liu, D., Safari, A., O'Connor, M. S., Chan, D. W., Laegeler, A., Qin, J., and Songyang, Z. (2004) PTOP interacts with POT1 and regulates its localization to telomeres, Nat. Cell Biol. 6, 673-680.
8. Ye, J. Z., Hockemeyer, D., Krutchinsky, A. N., Loayza, D., Hooper, S. M., Chait, B. T., and de Lange, T. (2004) POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex, Genes Dev. 18, 1649-1654.
9. Houghtaling, B. R., Cuttonaro, L., Chang, W., and Smith, S. (2004) A dynamic molecular link between the telomere length regulator TRF1 and the chromosome end protector TRF2, Curr. Biol. 14, 1621-1631.
10. Baumann, P., and Cech, T. R. (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans, Science 292, 1171-115.
11. Lei, M., Podell, E. R., and Cech, T. R. (2004) Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection, Nat. Struct. Mol. Biol. 11, 1223-1229.
12. Lei, M., Zaug, A. J., Podell, E. R., and Cech, T. R. (2005) Switching human telomerase on and off with hPOT1 protein in vitro, J. Biol. Chem. 280, 20449-20456.
13. Kim, S. H., Kaminker, P., and Campisi, J. (1999) TIN2, a new regulator of telomere length in human cells, Nat. Genet. 23, 405-412.
14. Ye, J. Z., and de Lange, T. (2004) TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex, Nat. Genet. 36, 618-623.
15. Griffith, J. D., Comeau, L., Rosenfield, S., Stansel, R. M., Bianchi, A., Moss, H., and de Lange, T. (1999) Mammalian telomeres end in a large duplex loop, Cell 97, 503-514.
16. Loayza, D., and de Lange, T. (2003) POT1 as a terminal transducer of TRF1 telomere length control, Nature 423, 1013-1018.
17. Kelleher, C., Kurth, I., and Lingner, J. (2005) Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro, Mol. Cell. Biol. 25, 808-818.
18. Teixeira, M. T., Americ, M., Sperisen, P., and Lingner, J. (2004) Telomere length homeostasis is achieved via a switch between telomerase-extendible and -nonextendible states, Cell 117, 323-335.
19. Zaug, A. J., Podell, E. R., and Cech, T. R. (2005) Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro, Proc. Natl. Acad. Sci. U.S.A. 102, 10864-10869.
20. Pennock, E., Buckley, K., and Lundblad, V. (2001) Cdc13 delivers separate complexes to the telomere for end protection and replication, Cell 104, 387-396.
21. Chandra, A., Hughes, T. R., Nugent, C. I., and Lundblad, V. (2001) Cdc13 both positively and negatively regulates telomere replication, Genes Dev. 15, 404-414.
22. Verdun, R. E., and Karlseder, J. (2006) The DNA damage machinery and homologous recombination pathway act consecutively to protect human telomeres, Cell 127, 709-720.
23. Broccoli, D., Smogorzewska, A., Chong, L., and de Lange, T. (1997) Human telomeres contain two distinct Myb-related proteins, IRF1 and TRF2, Nat. Genet. 17, 231-225.
24. Bilaud, T., Brun, C., Ancelin, K., Koering, C. E., Laroche, T., and Gilson, E. (1997) Telomeric localization of TRF2, a novel human telobox protein, Nat. Genet. 17, 236-239.
25. O'Connor, M. S., Safari, A., Xin, H., Liu, D., and Songyang, Z. (2006) A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly, Proc. Natl. Acad. Sci. U.S.A. 103, 11874-11879.
26. Zhu, X. D., Kuster, B., Mann, M., Petrini, J. H., and de Lange, T. (2000) Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres, Nat Genet. 25, 347-352.