메뉴 건너뛰기




Volumn , Issue , 2005, Pages 119-140

Reactive Vapors in the Nasal Cavity

Author keywords

Computational fluid dynamics; DNA adduct formation; Esters; Formaldehyde; Nasal airways; Organic acids; PBPK CFD models; Pharmacodynamic models; Protein adduct formation; Reference concentration estimations; Respiratory tract; RfC estimations; Risk assessment

Indexed keywords


EID: 84890616409     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/0471478768.ch5     Document Type: Chapter
Times cited : (1)

References (39)
  • 1
    • 0016245299 scopus 로고
    • Effect of respiratory airflow rate on removal of soluble vapors by the nose
    • Aharonson, E. F., Menkes, H., Gurtner, G., Swift, D. L., and Proctor, D. F. (1974). Effect of respiratory airflow rate on removal of soluble vapors by the nose. J. Appl. Physiol. 37, 654-657.
    • (1974) J. Appl. Physiol. , vol.37 , pp. 654-657
    • Aharonson, E.F.1    Menkes, H.2    Gurtner, G.3    Swift, D.L.4    Proctor, D.F.5
  • 2
    • 0032694562 scopus 로고    scopus 로고
    • Clearance concepts applied to the metabolism of inhaled vapors in tissues lining the nasal cavity
    • Andersen, M. E., and Sarangapani, R. (1999). Clearance concepts applied to the metabolism of inhaled vapors in tissues lining the nasal cavity. Inhal. Toxicol. 11, 873-897.
    • (1999) Inhal. Toxicol. , vol.11 , pp. 873-897
    • Andersen, M.E.1    Sarangapani, R.2
  • 3
    • 0035021263 scopus 로고    scopus 로고
    • Physiologically based clearance/extraction models for compounds metabolized in the nose: An example with methyl methacrylate
    • Andersen, M. E., and Sarangapani, R. (2001). Physiologically based clearance/extraction models for compounds metabolized in the nose: An example with methyl methacrylate. Inhal. Toxicol. 13, 397-414.
    • (2001) Inhal. Toxicol. , vol.13 , pp. 397-414
    • Andersen, M.E.1    Sarangapani, R.2
  • 4
    • 0032720992 scopus 로고    scopus 로고
    • Dosimetric adjustment factors for methyl methacrylate derived from a steady-state analysis of a physiologically based clearance-extraction model
    • Andersen, M. E., Sarangapani, R., Frederick, C. B., and Kimbell, J. S. (1999). Dosimetric adjustment factors for methyl methacrylate derived from a steady-state analysis of a physiologically based clearance-extraction model. Inhal. Toxicol. 11, 899-926.
    • (1999) Inhal. Toxicol. , vol.11 , pp. 899-926
    • Andersen, M.E.1    Sarangapani, R.2    Frederick, C.B.3    Kimbell, J.S.4
  • 5
    • 0033795067 scopus 로고    scopus 로고
    • Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: An example with acrylic acid
    • Andersen, M., Sarangapani, R., Gentry, R., Clewell, H., Covington, T., and Frederick, C. B. (2000). Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: An example with acrylic acid. Toxicol. Sci. 57, 312-325.
    • (2000) Toxicol. Sci. , vol.57 , pp. 312-325
    • Andersen, M.1    Sarangapani, R.2    Gentry, R.3    Clewell, H.4    Covington, T.5    Frederick, C.B.6
  • 6
    • 0037452444 scopus 로고    scopus 로고
    • Physiologically-based kinetic modeling of vapours toxic to the respiratory tract
    • Bogdanffy, M. S., and Sarangapani, R. (2003). Physiologically-based kinetic modeling of vapours toxic to the respiratory tract. Toxicol. Lett. 138, 103-117.
    • (2003) Toxicol. Lett. , vol.138 , pp. 103-117
    • Bogdanffy, M.S.1    Sarangapani, R.2
  • 7
    • 0032429050 scopus 로고    scopus 로고
    • Analysis of vinyl acetate metabolism in rat and human nasal tissues by an in vitro gas uptake technique
    • Bogdanffy, M. S., Sarangapani, R., Kimbell, J. S., Frame, S. R., and Plowchalk, D. R. (1998). Analysis of vinyl acetate metabolism in rat and human nasal tissues by an in vitro gas uptake technique. Toxicol. Sci. 46, 235-246.
    • (1998) Toxicol. Sci. , vol.46 , pp. 235-246
    • Bogdanffy, M.S.1    Sarangapani, R.2    Kimbell, J.S.3    Frame, S.R.4    Plowchalk, D.R.5
  • 8
    • 0032822298 scopus 로고    scopus 로고
    • A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity
    • Bogdanffy, M. S., Sarangapani, R., Plowchalk, D. R., Jarabek, A., and Andersen, M. E. (1999a). A biologically based risk assessment for vinyl acetate-induced cancer and noncancer inhalation toxicity. Toxicol. Sci. 51, 19-35.
    • (1999) Toxicol. Sci. , vol.51 , pp. 19-35
    • Bogdanffy, M.S.1    Sarangapani, R.2    Plowchalk, D.R.3    Jarabek, A.4    Andersen, M.E.5
  • 9
    • 0032717493 scopus 로고    scopus 로고
    • High-affinity nasal extraction of vinyl acetate vapor is carboxylesterase dependent
    • Bogdanffy, M. S., Manning, L. A., and Sarangapani, R. (1999b). High-affinity nasal extraction of vinyl acetate vapor is carboxylesterase dependent. Inhal. Toxicol. 11, 927-941.
    • (1999) Inhal. Toxicol. , vol.11 , pp. 927-941
    • Bogdanffy, M.S.1    Manning, L.A.2    Sarangapani, R.3
  • 10
    • 0031837429 scopus 로고    scopus 로고
    • CFD-PBPK hybrid model for simulating gas and vapor uptake in the rat nose
    • Bush, M. L., Frederick, C. B., Kimbell, J. S., and Ultman, J. S. (1998). CFD-PBPK hybrid model for simulating gas and vapor uptake in the rat nose. Toxicol. Appl. Pharmacol. 150, 133-145.
    • (1998) Toxicol. Appl. Pharmacol. , vol.150 , pp. 133-145
    • Bush, M.L.1    Frederick, C.B.2    Kimbell, J.S.3    Ultman, J.S.4
  • 11
    • 0025823449 scopus 로고
    • Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: Pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man
    • Casanova, M., Morgan, K. T., Steinhagen, W. H., Everitt, J. I., Popp, J. A., and Heck, H. D. (1991). Covalent binding of inhaled formaldehyde to DNA in the respiratory tract of rhesus monkeys: Pharmacokinetics, rat-to-monkey interspecies scaling, and extrapolation to man. Fundam. Appl. Toxicol. 17, 409-428.
    • (1991) Fundam. Appl. Toxicol. , vol.17 , pp. 409-428
    • Casanova, M.1    Morgan, K.T.2    Steinhagen, W.H.3    Everitt, J.I.4    Popp, J.A.5    Heck, H.D.6
  • 12
    • 0033670964 scopus 로고    scopus 로고
    • Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in Fischer 344 rats, rhesus monkeys, and humans
    • Conolly, R. B., Lilly, P. D., and Kimbell, J. S. (2000). Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in Fischer 344 rats, rhesus monkeys, and humans. Environ. Health Perspect. 108(Suppl 5), 919-924.
    • (2000) Environ. Health Perspect. , vol.108 , Issue.SUPPL 5 , pp. 919-924
    • Conolly, R.B.1    Lilly, P.D.2    Kimbell, J.S.3
  • 13
    • 0036176499 scopus 로고    scopus 로고
    • Dose response for formaldehydeinduced cytotoxicity in the human respiratory tract
    • Conolly, R. B., Kimbell, J. S., Janszen, D. B., and Miller, F. J. (2002). Dose response for formaldehydeinduced cytotoxicity in the human respiratory tract. Regul. Toxicol. Pharmacol. 35, 32-43.
    • (2002) Regul. Toxicol. Pharmacol. , vol.35 , pp. 32-43
    • Conolly, R.B.1    Kimbell, J.S.2    Janszen, D.B.3    Miller, F.J.4
  • 15
    • 0031737679 scopus 로고    scopus 로고
    • Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways
    • Frederick, C. B., Bush, M. L., Lomax, L. G., Black, K. A., Finch, L., Kimbell, J. S., Morgan, K. T., Subramaniam, R. P., Morris, J. B., and Ultman, J. S. (1998). Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicol. Appl. Pharmacol. 152, 211-231.
    • (1998) Toxicol. Appl. Pharmacol. , vol.152 , pp. 211-231
    • Frederick, C.B.1    Bush, M.L.2    Lomax, L.G.3    Black, K.A.4    Finch, L.5    Kimbell, J.S.6    Morgan, K.T.7    Subramaniam, R.P.8    Morris, J.B.9    Ultman, J.S.10
  • 16
    • 0026658925 scopus 로고
    • A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment
    • Frederick, C. B., Potter, D. W., Chang-Mateu, M. I., and Andersen, M. E. (1992). A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment. Toxicol. Appl. Pharmacol. 114, 246-260.
    • (1992) Toxicol. Appl. Pharmacol. , vol.114 , pp. 246-260
    • Frederick, C.B.1    Potter, D.W.2    Chang-Mateu, M.I.3    Andersen, M.E.4
  • 17
    • 0035003225 scopus 로고    scopus 로고
    • Ahybrid computational fluid dynamics and physiologically based pharmacokinetic model for comparison of predicted tissue concentrations of acrylic acid and other vapors in the rat and human nasal cavities following inhalation exposure
    • Frederick, C. B., Gentry, P. R., Bush, M. L., Lomax, L. G., Black, K. A., Finch, L., Kimbell, J. S., Morgan, K. T., Subramaniam, R. P., Morris, J. B., and Ultman, J. S. (2001). Ahybrid computational fluid dynamics and physiologically based pharmacokinetic model for comparison of predicted tissue concentrations of acrylic acid and other vapors in the rat and human nasal cavities following inhalation exposure. Inhal. Toxicol. 13, 359-376.
    • (2001) Inhal. Toxicol. , vol.13 , pp. 359-376
    • Frederick, C.B.1    Gentry, P.R.2    Bush, M.L.3    Lomax, L.G.4    Black, K.A.5    Finch, L.6    Kimbell, J.S.7    Morgan, K.T.8    Subramaniam, R.P.9    Morris, J.B.10    Ultman, J.S.11
  • 19
    • 0025737963 scopus 로고
    • A model for the uptake of inhaled vapors in the nose of the dog during cyclic breathing
    • Gerde, P., and Dahl, A. R. (1991). A model for the uptake of inhaled vapors in the nose of the dog during cyclic breathing. Toxicol. Appl. Pharmacol. 109, 276-288.
    • (1991) Toxicol. Appl. Pharmacol. , vol.109 , pp. 276-288
    • Gerde, P.1    Dahl, A.R.2
  • 20
    • 0030267103 scopus 로고    scopus 로고
    • Comparison of contact site cancer potency across dose routes: case study with epichlorohydrin
    • Ginsberg, G. L., Pepelko, W. E., Goble, R. L., and Hattis, D. B. (1996). Comparison of contact site cancer potency across dose routes: case study with epichlorohydrin. Risk Anal. 16, 667-681.
    • (1996) Risk Anal , vol.16 , pp. 667-681
    • Ginsberg, G.L.1    Pepelko, W.E.2    Goble, R.L.3    Hattis, D.B.4
  • 21
    • 0031106285 scopus 로고    scopus 로고
    • Comparison of inhaled formaldehyde dosimetry predictions with DNA-protein cross-link measurements in the rat nasal passages
    • Hubal, E. A., Schlosser, P. M., Conolly, R. B., and Kimbell, J. S. (1997). Comparison of inhaled formaldehyde dosimetry predictions with DNA-protein cross-link measurements in the rat nasal passages. Toxicol. Appl. Pharmacol. 143, 47-55.
    • (1997) Toxicol. Appl. Pharmacol. , vol.143 , pp. 47-55
    • Hubal, E.A.1    Schlosser, P.M.2    Conolly, R.B.3    Kimbell, J.S.4
  • 22
    • 0034946823 scopus 로고    scopus 로고
    • Deposition of fine and coarse aerosols in a rat nasal mold
    • Kelly, J. T., Kimbell, J. S., and Asgharian, B. (2001). Deposition of fine and coarse aerosols in a rat nasal mold. Inhal. Toxicol. 13, 577-588.
    • (2001) Inhal. Toxicol. , vol.13 , pp. 577-588
    • Kelly, J.T.1    Kimbell, J.S.2    Asgharian, B.3
  • 23
    • 0035011346 scopus 로고    scopus 로고
    • Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages
    • Kimbell, J. S., and Subramaniam, R. P. (2001). Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages. Inhal. Toxicol. 13, 325-334.
    • (2001) Inhal. Toxicol. , vol.13 , pp. 325-334
    • Kimbell, J.S.1    Subramaniam, R.P.2
  • 24
    • 0027313660 scopus 로고
    • Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat
    • Kimbell, J. S., Gross, E. A., Joyner, D. R., Godo, M. N., and Morgan, K. T. (1993). Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat. Toxicol. Appl. Pharmacol. 121, 253-263.
    • (1993) Toxicol. Appl. Pharmacol. , vol.121 , pp. 253-263
    • Kimbell, J.S.1    Gross, E.A.2    Joyner, D.R.3    Godo, M.N.4    Morgan, K.T.5
  • 26
    • 0035172387 scopus 로고    scopus 로고
    • Dosimetry modeling of inhaled formaldehyde: Comparisons of local flux predictions in the rat, monkey, and human nasal passages
    • Kimbell, J. S., Subramaniam, R. P., Gross, E. A., Schlosser, P. M., and Morgan, K. T. (2001b). Dosimetry modeling of inhaled formaldehyde: Comparisons of local flux predictions in the rat, monkey, and human nasal passages. Toxicol. Sci. 64, 100-110.
    • (2001) Toxicol. Sci. , vol.64 , pp. 100-110
    • Kimbell, J.S.1    Subramaniam, R.P.2    Gross, E.A.3    Schlosser, P.M.4    Morgan, K.T.5
  • 27
    • 0021809463 scopus 로고
    • A model of the regional uptake of gaseous pollutants in the lung I. The sensitivity of the uptake of ozone in the human lung to lower respiratory tract secretions and exercise
    • Miller, F. J., Overton, J. H., Jr., Jaskot, R. H., and Menzel, D. B. (1985). A model of the regional uptake of gaseous pollutants in the lung. I. The sensitivity of the uptake of ozone in the human lung to lower respiratory tract secretions and exercise. Toxicol. Appl. Pharmacol. 79, 11-27.
    • (1985) Toxicol. Appl. Pharmacol. , vol.79 , pp. 11-27
    • Miller, F.J.1    Overton Jr., J.H.2    Jaskot, R.H.3    Menzel, D.B.4
  • 28
    • 0027455128 scopus 로고
    • Aphysiologically based pharmacokinetic model for nasal uptake and metabolism of nonreactive vapors
    • Morris, J. B., Hassett, D. N., and Blanchard, K. T. (1993). Aphysiologically based pharmacokinetic model for nasal uptake and metabolism of nonreactive vapors. Toxicol. Appl. Pharmacol. 123, 120-129.
    • (1993) Toxicol. Appl. Pharmacol. , vol.123 , pp. 120-129
    • Morris, J.B.1    Hassett, D.N.2    Blanchard, K.T.3
  • 29
    • 0036189604 scopus 로고    scopus 로고
    • Predicted regional flux of hydrogen sulfide correlates with distribution of nasal olfactory lesions in rats
    • Moulin, F. J., Brenneman, K. A., Kimbell, J. S., and Dorman, D. C. (2002). Predicted regional flux of hydrogen sulfide correlates with distribution of nasal olfactory lesions in rats. Toxicol. Sci. 66, 7-15.
    • (2002) Toxicol. Sci. , vol.66 , pp. 7-15
    • Moulin, F.J.1    Brenneman, K.A.2    Kimbell, J.S.3    Dorman, D.C.4
  • 30
    • 0025001426 scopus 로고
    • A respiratory tract dosimetry model for air toxics
    • Overton, J. H. (1990). A respiratory tract dosimetry model for air toxics. Toxicol. Ind. Health 6, 171-180.
    • (1990) Toxicol. Ind. Health , vol.6 , pp. 171-180
    • Overton, J.H.1
  • 31
    • 0035015147 scopus 로고    scopus 로고
    • Dosimetry modeling of highly soluble reactive gases in the respiratory tract
    • Overton, J. H. (2001). Dosimetry modeling of highly soluble reactive gases in the respiratory tract. Inhal. Toxicol. 13, 347-357.
    • (2001) Inhal. Toxicol. , vol.13 , pp. 347-357
  • 32
    • 0023256786 scopus 로고
    • A model of the regional uptake of gaseous pollutants in the lung II. The sensitivity of ozone uptake in laboratory animal lungs to anatomical and ventilatory parameters
    • Overton, J. H., Graham, R. C., and Miller, F. J. (1987). A model of the regional uptake of gaseous pollutants in the lung. II. The sensitivity of ozone uptake in laboratory animal lungs to anatomical and ventilatory parameters. Toxicol. Appl. Pharmacol. 88, 418-432.
    • (1987) Toxicol. Appl. Pharmacol. , vol.88 , pp. 418-432
    • Overton, J.H.1    Graham, R.C.2    Miller, F.J.3
  • 33
    • 0035158879 scopus 로고    scopus 로고
    • Dosimetry modeling of inhaled formaldehyde: The human respiratory tract
    • Overton, J. H., Kimbell, J. S., and Miller, F. J. (2001). Dosimetry modeling of inhaled formaldehyde: The human respiratory tract. Toxicol. Sci. 64, 122-134.
    • (2001) Toxicol. Sci. , vol.64 , pp. 122-134
    • Overton, J.H.1    Kimbell, J.S.2    Miller, F.J.3
  • 34
    • 0017603437 scopus 로고
    • Hepatic clearance of drugs. I. Theoretical considerations of a "wellstirred" model and a "parallel-tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and hepatocellular enzymatic activity on hepatic drug clearance
    • Pang, K. S., and Rowland, M. (1977). Hepatic clearance of drugs. I. Theoretical considerations of a "wellstirred" model and a "parallel-tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and hepatocellular enzymatic activity on hepatic drug clearance. J. Pharmacokinet. Biopharm. 5, 625-653.
    • (1977) J. Pharmacokinet. Biopharm. , vol.5 , pp. 625-653
    • Pang, K.S.1    Rowland, M.2
  • 35
    • 0031062288 scopus 로고    scopus 로고
    • Physiologically based modeling of vinyl acetate uptake, metabolism, and intracellular pH changes in the rat nasal cavity
    • Plowchalk, D. R., Andersen, M. E., and Bogdanffy, M. S. (1997). Physiologically based modeling of vinyl acetate uptake, metabolism, and intracellular pH changes in the rat nasal cavity. Toxicol. Appl. Pharmacol. 142, 386-400.
    • (1997) Toxicol. Appl. Pharmacol. , vol.142 , pp. 386-400
    • Plowchalk, D.R.1    Andersen, M.E.2    Bogdanffy, M.S.3
  • 36
    • 0037638889 scopus 로고    scopus 로고
    • Benchmark dose risk assessment for formaldehyde using airflow modeling and a single-compartment DNA-protein cross-link dosimetry model to estimate human equivalent doses
    • Schlosser, P. M., Lilly, P. D., Conolly, R. B., Janszen, D. B., and Kimbell, J. S. (2003). Benchmark dose risk assessment for formaldehyde using airflow modeling and a single-compartment, DNA-protein cross-link dosimetry model to estimate human equivalent doses. Risk Anal. 23, 473-487.
    • (2003) Risk Anal , vol.23 , pp. 473-487
    • Schlosser, P.M.1    Lilly, P.D.2    Conolly, R.B.3    Janszen, D.B.4    Kimbell, J.S.5
  • 37
    • 0031889332 scopus 로고    scopus 로고
    • Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx
    • Subramaniam, R. P., Richardson, R. B., Morgan, K. T., and Kimbell, J. S. (1998). Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx. Inhal. Toxicol. 10, 91-120.
    • (1998) Inhal. Toxicol. , vol.10 , pp. 91-120
    • Subramaniam, R.P.1    Richardson, R.B.2    Morgan, K.T.3    Kimbell, J.S.4
  • 38
    • 2942750427 scopus 로고    scopus 로고
    • Ethyl acrylate risk assessment with a hybrid computational fluid dynamics and physiologically based nasal dosimetry model
    • Sweeney, L. M., Andersen, M. E., and Gargas, M. L. (2004). Ethyl acrylate risk assessment with a hybrid computational fluid dynamics and physiologically based nasal dosimetry model. Toxicol. Sci. 79, 394-403.
    • (2004) Toxicol. Sci. , vol.79 , pp. 394-403
    • Sweeney, L.M.1    Andersen, M.E.2    Gargas, M.L.3
  • 39
    • 0003536223 scopus 로고
    • US EPA U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Washington, D.C., EPA/600/8-90/066F
    • US EPA (1994). Methods of Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry, U.S. Environmental Protection Agency, Office of Research and Development, Office of Health and Environmental Assessment, Washington, D.C., EPA/600/8-90/066F.
    • (1994) Methods of Derivation of Inhalation Reference Concentrations and Application of Inhalation Dosimetry


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.