Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: An example with acrylic acid

Toxicological Sciences

Volumn 57, Issue 2, 2000, Pages 312-325

  Andersen, Melvin ^a   Sarangapani, Ramesh ^b,c   Gentry, Robinan ^b,c   Clewell, Harvey ^b,c   Covington, Tammie ^b,c   Frederick, Clay B ^d  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b ICF Consulting   (United States)

^c ICF Consulting   (United States)

^d ROHM AND HAAS COMPANY   (United States)

Author keywords

Acrylic acid toxicity; Interspecies dosimetry; Nasal inhalation; Olfactory epithelium degeneration; Rat; Reference concentration; RfC

Indexed keywords

ACRYLIC ACID;

ACCURACY; ANALYTIC METHOD; ARTICLE; BREATHING PATTERN; DOSIMETRY; HUMAN; INHALATION; INTERMETHOD COMPARISON; MODEL; MOUSE; NONHUMAN; OLFACTORY EPITHELIUM; RAT; REFERENCE VALUE; RISK ASSESSMENT; TOXICITY TESTING;

EID: 0033795067     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/57.2.312     Document Type: Article

References (34)

1. Cell proliferation responses in rat nasal epithelium following repeated exposures to vinyl acetate vapor
2. Overview of coenzyme A metabolism and its role in cellular toxicity
3. Acrylic acid health effects overview
4. Subchronic inhalation studies of styrene in CD rats and CD-1 mice
5. Acrylic acid induces the glutathione-independent mitochondrial permeability transition in vitro
6. The regional hydrolysis of ethyl acrylate to acrylic acid in the rat nasal cavity
7. Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways
8. A hybrid computational fluid dynamics and physiologically-based pharmacokinetic model for comparison of predicted tissue concentrations of acrylic acid and other vapors in the rat and human nasal cavities following inhalation exposure
9. The subacute inhalation toxicity of 109 industrial chemicals
10. Inhalation RfC methodology: Dosimetric adjustment and dose-response estimates of non-cancer toxicity in the upper respiratory tract
11. Degeneration and recovery of rat olfactory epithelium following inhalation of dibasic esters
12. Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages
13. Regional histopathology of the mouse nasal cavity following two weeks of exposure to acrylic acid for either 6 or 22 hours per day
14. Chronic inhalation toxicity and oncogenicity of methyl methacrylate in rats and hamsters
15. Structure-activity relationships in the hydrolysis of acrylate and methacrylate esters by carboxylesterase in vitro
16. Nasal toxicity of chloroform in male F-344 rats and female B6C3F1 mice following a 1-week inhalation exposure
17. Inhalation toxicity of acrylic acid
18. Metabolism of acrylate esters in rat tissue homogenates
19. Chronic toxicity and oncogenicity bioassay of inhaled ethyl acrylate in Fischer 344 rats and B6C3F1 mice
20. Upper respiratory tract uptake of acrylate ester and acid vapors
21. A physiologically based pharmacokinetic model for nasal uptake and metabolism of nonreactive vapors
22. Physiologically based modeling of vinyl acetate uptake, metabolism, and intracellular pH changes in the rat nasal cavity
23. Chronic toxicity and oncogenicity of inhaled methyl acrylate and n-butyl acrylate in Sprague-Dawley rats
24. Data-derived safety factors for evaluation of food additives and environmental contaminants
25. Metabolism and disposition of n-butyl acrylate in male Fischer rats
26. Potentiation of acrylate ester toxicity by prior treatment with the carboxylesterase inhibitor triorthotolyl phosphate (TOTP)
27. Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro
28. Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx
29. Cytotoxicity of dibasic esters (DBE) metabolites in rat nasal explants