A hybrid computational fluid dynamics and physiologically based pharmacokinetic model for comparison of predicted tissue concentrations of acrylic acid and other vapors in the rat and human nasal cavities following inhalation exposure

Inhalation Toxicology

Volumn 13, Issue 5, 2001, Pages 359-376

  Frederick, C B ^a   Gentry, P R ^a   Bush, M L ^a   Lomax, L G ^a   Black, K A ^a   Finch, L ^a   Kimbell, J S ^a   Morgan, K T ^a   Subramaniam, R P ^a   Morris, J B ^a   Ultman, J S ^a  

^a ROHM AND HAAS COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACRYLIC ACID; CARBOXYLIC ACID;

ARTICLE; COMPARATIVE STUDY; DOSIMETRY; GAS DIFFUSION; HUMAN; METABOLISM; NONHUMAN; NOSE CAVITY; OLFACTORY EPITHELIUM; PARTITION COEFFICIENT; PRIORITY JOURNAL; RAT; RESPIRATORY AIRFLOW; RISK ASSESSMENT; SIMULATION; TISSUE LEVEL; VAPOR;

EID: 0035003225     PISSN: 08958378     EISSN: None     Source Type: Journal    
DOI: 10.1080/08958370151126248     Document Type: Article

References (24)

1. Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment: An example with acrylic acid
2. A CFD-PBPK hybrid model for simulating gas and vapor uptake in the rat nose
3. A physiologically based pharmacokinetic and pharmacodynamic model to describe oral dosing of rats with ethyl acrylate and its implications for risk assessment
4. Comparison of four biologically based dosimetry models for the deposition of rapidly metabolized vapors in the rodent nasal cavity
5. Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways
6. Comparative morphometry of the nasal cavity in rats and mice
7. Inhalation RfC methodology - Dosimetric adjustments and dose-response estimation of noncancer toxicity in the upper respiratory tract
8. Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat
9. Correlation of regional formaldehyde flux predictions with the distribution of formaldehyde-induced squamous metaplasia in F344 rat nasal passages
10. Nasal diagrams: A tool for recording the distribution of nasal lesions in rats and mice
11. Inhalation toxicity of acrylic acid
12. Metabolism of acrylate esters in rat tissue homogenates
13. Airflow, gas deposition, and lesion distribution in the nasal passages
14. A method for measuring upper respiratory tract vapor uptake and its applicability to quantitative inhalation risk assessment
15. Upper respiratory tract uptake of acrylate ester and acid vapors
16. A physiologically based pharmacokinetic model for nasal uptake and metabolism of nonreactive vapors
17. Data-derived safety factors for the evaluation of food additives and environ mental contaminants
18. Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx