Use of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry comparisons of ester vapors

Toxicology and Applied Pharmacology

Volumn 183, Issue 1, 2002, Pages 23-40

  Frederick, Clay B ^a   Lomax, Larry G ^a   Black, Kurt A ^a   Finch, Lavorgie ^a   Scribner, Harvey E ^a   Kimbell, Julia S ^b   Morgan, Kevin T ^b   Subramaniam, Ravi P ^b   Morris, John B ^c  

^a ROHM AND HAAS COMPANY   (United States)

^b CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^c UNIVERSITY OF CONNECTICUT   (United States)

Author keywords

Acrylic acid; Computational fluid dynamics (CFD); Esterase; Ethyl acrylate; Interspecies extrapolation; Nasal cavity; Olfactory; Physiologically based pharmacokinetic (PBPK); Risk assessment

Indexed keywords

ACETIC ACID ETHYL ESTER; ACETONE; ACRYLIC ACID; ACRYLIC ACID ETHYL ESTER; ESTER; ESTERASE; ESTERASE INHIBITOR; GLUTATHIONE; THIOL DERIVATIVE; VOLATILE ORGANIC COMPOUND;

AIRFLOW; ANATOMY; ANIMAL TISSUE; ARTICLE; CAUSE OF DEATH; COMPUTER MODEL; COMPUTER SIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DOSIMETRY; ENZYME ACTIVITY; EXPLANT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INHALATION; LD 50; LETHALITY; LIVER; LUNG; METABOLISM; MORTALITY; NONHUMAN; NOSE CAVITY; OLFACTORY EPITHELIUM; PHYSIOLOGY; PROTEIN DEPLETION; RAT; RISK ASSESSMENT; STEADY STATE; THEORETICAL MODEL; TOXICITY TESTING; VAPOR;

ANIMALIA; RODENTIA;

EID: 0036382866     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.2002.9451     Document Type: Article

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