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1
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84882879271
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The renal microcirculation
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Tuma RF, Duran WN, Ley K, editors 2nd ed. Academic Press
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Navar LG, Arendshorst WJ, Pallone TL, et al. The renal microcirculation. In: Tuma RF, Duran WN, Ley K, editors. Handbook of physiology: Microcirculation, 2nd ed. Academic Press; 2008. pp. 550-683.
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Handbook of Physiology: Microcirculation
, pp. 550-683
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Navar, L.G.1
Arendshorst, W.J.2
Pallone, T.L.3
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2
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84874606155
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Activation of the renin-angiotensin system by a low-salt diet does not augment intratubular angiotensinogen and angiotensin II in rats
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This study demonstrates that when the intrarenal RAS is physiologically activated by a low-sodium diet, the increases in kidney renin and Ang II contents are not associated with stimulation of the intratubular Ang II or AGT levels as reflected by their excretion rates. Thus, the Ang II-mediated augmentation of urinary Ang II and AGT that occurs in hypertensive models reflects a pathological stimulation of the intratubular RAS
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Shao W, Seth DM, Prieto MC, et al. Activation of the renin-angiotensin system by a low-salt diet does not augment intratubular angiotensinogen and angiotensin II in rats. Am J Physiol Renal Physiol 2013; 304:F505-F514. This study demonstrates that when the intrarenal RAS is physiologically activated by a low-sodium diet, the increases in kidney renin and Ang II contents are not associated with stimulation of the intratubular Ang II or AGT levels as reflected by their excretion rates. Thus, the Ang II-mediated augmentation of urinary Ang II and AGT that occurs in hypertensive models reflects a pathological stimulation of the intratubular RAS.
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(2013)
Am J Physiol Renal Physiol
, vol.304
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Shao, W.1
Seth, D.M.2
Prieto, M.C.3
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3
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0036839479
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Effects of dietary salt changes on renal renin-angiotensin system in rats
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Ingert C, Grima M, Coquard C, et al. Effects of dietary salt changes on renal renin-angiotensin system in rats. Am J Physiol Renal Physiol 2002; 283:F995-F1002.
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Am J Physiol Renal Physiol
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Ingert, C.1
Grima, M.2
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4
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0023369627
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The glomerular and tubular actions of angiotensin II
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Blantz RC. The glomerular and tubular actions of angiotensin II. Am J Kidney Dis 1987; 10 (1 Suppl 1):2-6.
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Am J Kidney Dis
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Blantz, R.C.1
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5
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0002838119
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Renal actions of angiotensin ii and at1 receptor blockers
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Epstein M, Brunner HR, editors Philadelphia, PA: Hanley & Belfus, Inc
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Navar LG, Harrison-Bernard LM, Imig JD, Mitchell KD. Renal actions of angiotensin II and AT1 receptor blockers. In: Epstein M, Brunner HR, editors. Angiotensin II receptor antagonists. Philadelphia, PA: Hanley & Belfus, Inc; 2000. pp. 189-214.
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Angiotensin II Receptor Antagonists
, pp. 189-214
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Navar, L.G.1
Harrison-Bernard, L.M.2
Imig, J.D.3
Mitchell, K.D.4
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7
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84863503716
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Liver angiotensinogen is the primary source of renal angiotensin II
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This study demonstrates that in normal nonhypertensive mice, the primary source of AGT responsible for intrarenal Ang II formation is derived from the liver
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Matsusaka T, Niimura F, Shimizu A, et al. Liver angiotensinogen is the primary source of renal angiotensin II. J Am Soc Nephrol 2012; 23:1181-1189. This study demonstrates that in normal nonhypertensive mice, the primary source of AGT responsible for intrarenal Ang II formation is derived from the liver.
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J Am Soc Nephrol
, vol.23
, pp. 1181-1189
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Matsusaka, T.1
Niimura, F.2
Shimizu, A.3
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8
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84863514954
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The increasing complexity of the intratubular renin-angiotensin system
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Navar LG, Satou R, Gonzalez-Villalobos RA. The increasing complexity of the intratubular renin-angiotensin system. J Am Soc Nephrol 2012; 23:1130-1132.
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J Am Soc Nephrol
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Navar, L.G.1
Satou, R.2
Gonzalez-Villalobos, R.A.3
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9
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33646590610
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Efferent arterioles exclusively express the subtype 1A angiotensin receptor: Functional insights from genetic mouse models
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Harrison-Bernard LM, Monjure CJ, Bivona BJ. Efferent arterioles exclusively express the subtype 1A angiotensin receptor: Functional insights from genetic mouse models. Am J Physiol Renal Physiol 2006; 290:F1177-F1186.
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Am J Physiol Renal Physiol
, vol.290
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Harrison-Bernard, L.M.1
Monjure, C.J.2
Bivona, B.J.3
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10
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84873035303
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AT(2) receptors: Beneficial counter-regulatory role in cardiovascular and renal function
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Padia SH, Carey RM. AT(2) receptors: Beneficial counter-regulatory role in cardiovascular and renal function. Pflugers Arch 2013; 465:99-110.
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Pflugers Arch
, vol.465
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Padia, S.H.1
Carey, R.M.2
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11
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84856097765
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Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: A novel therapeutic target for hypertension
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Hilliard LM, Jones ES, Steckelings UM, et al. Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: A novel therapeutic target for hypertension. Hypertension 2012; 59:409-414.
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(2012)
Hypertension
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, pp. 409-414
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Hilliard, L.M.1
Jones, E.S.2
Steckelings, U.M.3
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12
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84879729229
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Improvement in renal hemodynamics following combined angiotensin II infusion and AT1R blockade in aged female sheep following fetal unilateral nephrectomy
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Singh RR, Lankadeva YR, Denton KM, Moritz KM. Improvement in renal hemodynamics following combined angiotensin II infusion and AT1R blockade in aged female sheep following fetal unilateral nephrectomy. PLoS One 2013; 8:e68036.
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(2013)
PLoS One
, vol.8
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Singh, R.R.1
Lankadeva, Y.R.2
Denton, K.M.3
Moritz, K.M.4
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13
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79952769061
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Salt-induced renal injury in SHRs is mediated by AT1 receptor activation
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Susic D, Frohlich ED, Kobori H, et al. Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. J Hypertens 2011; 29:716-723.
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J Hypertens
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, pp. 716-723
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Susic, D.1
Frohlich, E.D.2
Kobori, H.3
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14
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83455242856
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AT1 receptor-mediated augmentation of angiotensinogen, oxidative stress, and inflammation in ANG II-salt hypertension
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Experiments performed on chronic Ang II infused rats fed a high-salt diet demonstrated that a high-salt diet independently stimulates oxidative stress, which synergizes with elevated Ang II levels to limit peroxynitrite formation and markedly exacerbate collagen deposition, mesangial expansion, glomerular and interstitial fibrosis and macrophage infiltration, leading to greater tissue injury
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Lara LS, McCormack M, Semprum-Prieto LC, et al. AT1 receptor-mediated augmentation of angiotensinogen, oxidative stress, and inflammation in ANG II-salt hypertension. Am J Physiol Renal Physiol 2012; 302:F85-F94. Experiments performed on chronic Ang II infused rats fed a high-salt diet demonstrated that a high-salt diet independently stimulates oxidative stress, which synergizes with elevated Ang II levels to limit peroxynitrite formation and markedly exacerbate collagen deposition, mesangial expansion, glomerular and interstitial fibrosis and macrophage infiltration, leading to greater tissue injury.
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(2012)
Am J Physiol Renal Physiol
, vol.302
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Lara, L.S.1
McCormack, M.2
Semprum-Prieto, L.C.3
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15
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84864592547
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Sexual dimorphism in urinary angiotensinogen excretion during chronic angiotensin II-salt hypertension
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Rands VF, Seth DM, Kobori H, Prieto MC. Sexual dimorphism in urinary angiotensinogen excretion during chronic angiotensin II-salt hypertension. Gend Med 2012; 9:207-218.
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(2012)
Gend Med
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, pp. 207-218
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Rands, V.F.1
Seth, D.M.2
Kobori, H.3
Prieto, M.C.4
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16
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84866562664
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Urinary angiotensinogen excretion and ambulatory blood pressure
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Zou J, Li Y, Li FH, et al. Urinary angiotensinogen excretion and ambulatory blood pressure. J Hypertens 2012; 30:2000-2006.
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(2012)
J Hypertens
, vol.30
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Zou, J.1
Li, Y.2
Li, F.H.3
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17
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84875189283
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The renal angiotensin system does not reveal its secrets with a cross-sectional analysis of urinary angiotensinogen levels
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Braam B. The renal angiotensin system does not reveal its secrets with a cross-sectional analysis of urinary angiotensinogen levels. J Hypertens 2013; 31:840.
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(2013)
J Hypertens
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, pp. 840
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Braam, B.1
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18
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33645527609
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An unexpected role for angiotensin II in the link between dietary salt and proximal reabsorption
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Thomson SC, Deng A, Wead L, et al. An unexpected role for angiotensin II in the link between dietary salt and proximal reabsorption. J Clin Invest 2006; 116:1110-1116.
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J Clin Invest
, vol.116
, pp. 1110-1116
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Thomson, S.C.1
Deng, A.2
Wead, L.3
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19
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84873057309
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Endothelium-derived nitric oxide supports renin cell recruitment through the nitric oxide-sensitive guanylate cyclase pathway
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Neubauer B, Machura K, Kettl R, et al. Endothelium-derived nitric oxide supports renin cell recruitment through the nitric oxide-sensitive guanylate cyclase pathway. Hypertension 2013; 61:400-407.
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(2013)
Hypertension
, vol.61
, pp. 400-407
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Neubauer, B.1
Machura, K.2
Kettl, R.3
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20
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84862621036
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Enzymatic processing of angiotensin peptides by human glomerular endothelial cells
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Velez JC, Ierardi JL, Bland AM, et al. Enzymatic processing of angiotensin peptides by human glomerular endothelial cells. Am J Physiol Renal Physiol 2012; 302:F1583-F1594.
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(2012)
Am J Physiol Renal Physiol
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Velez, J.C.1
Ierardi, J.L.2
Bland, A.M.3
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21
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84874360564
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Network modeling reveals steps in angiotensin peptide processing
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Schwacke JH, Spainhour JC, Ierardi JL, et al. Network modeling reveals steps in angiotensin peptide processing. Hypertension 2013; 61:690-700.
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(2013)
Hypertension
, vol.61
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Schwacke, J.H.1
Spainhour, J.C.2
Ierardi, J.L.3
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22
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84861142409
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Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II
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Doblinger E, Hocherl K, Mederle K, et al. Angiotensin AT1 receptor-associated protein Arap1 in the kidney vasculature is suppressed by angiotensin II. Am J Physiol Renal Physiol 2012; 302:F1313-F1324.
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Am J Physiol Renal Physiol
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Doblinger, E.1
Hocherl, K.2
Mederle, K.3
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23
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84860262206
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Angiotensin-converting enzyme 2 regulates renal atrial natriuretic peptide through angiotensin-(1-7)
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Bernardi S, Burns WC, Toffoli B, et al. Angiotensin-converting enzyme 2 regulates renal atrial natriuretic peptide through angiotensin-(1-7). Clin Sci (Lond) 2012; 123:29-37.
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(2012)
Clin Sci (Lond)
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, pp. 29-37
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Bernardi, S.1
Burns, W.C.2
Toffoli, B.3
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24
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84863230494
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Angiotensin-(1-7)-induced activation of ERK1/2 is cAMP/protein kinase A-dependent in glomerular mesangial cells
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Liu GC, Oudit GY, Fang F, et al. Angiotensin-(1-7)-induced activation of ERK1/2 is cAMP/protein kinase A-dependent in glomerular mesangial cells. Am J Physiol Renal Physiol 2012; 302:F784-F790.
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Am J Physiol Renal Physiol
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Liu, G.C.1
Oudit, G.Y.2
Fang, F.3
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25
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84873057372
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Evolving concepts on regulation and function of renin in distal nephron
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Prieto MC, Gonzalez AA, Navar LG. Evolving concepts on regulation and function of renin in distal nephron. Pflugers Arch 2013; 465:121-132.
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(2013)
Pflugers Arch
, vol.465
, pp. 121-132
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Prieto, M.C.1
Gonzalez, A.A.2
Navar, L.G.3
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26
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84861194973
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Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes
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Yamaleyeva LM, Gilliam-Davis S, Almeida I, et al. Differential regulation of circulating and renal ACE2 and ACE in hypertensive mRen2.Lewis rats with early-onset diabetes. Am J Physiol Renal Physiol 2012; 302:F1374-F1384.
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(2012)
Am J Physiol Renal Physiol
, vol.302
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Yamaleyeva, L.M.1
Gilliam-Davis, S.2
Almeida, I.3
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27
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84873058423
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Direct evidence for intrarenal chymasedependent angiotensin II formation on the diabetic renal microvasculature
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Park S, Bivona BJ, Ford SM Jr, et al. Direct evidence for intrarenal chymasedependent angiotensin II formation on the diabetic renal microvasculature. Hypertension 2013; 61:465-471.
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(2013)
Hypertension
, vol.61
, pp. 465-471
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Park, S.1
Bivona, B.J.2
Ford Jr., S.M.3
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28
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84873056684
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Regulation of renin secretion by renal juxtaglomerular cells
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Friis UG, Madsen K, Stubbe J, et al. Regulation of renin secretion by renal juxtaglomerular cells. Pflugers Arch 2013; 465:25-37.
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Pflugers Arch
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, pp. 25-37
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Friis, U.G.1
Madsen, K.2
Stubbe, J.3
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30
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79551560598
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Renin and prorenin receptor in hypertension: What's new
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Nguyen G. Renin and prorenin receptor in hypertension: what's new Curr Hypertens Rep 2011; 13:79-85.
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Curr Hypertens Rep
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Nguyen, G.1
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31
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43449113857
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Involvement of (pro)renin receptor in the glomerular filtration barrier
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Ichihara A, Sakoda M, Kurauchi-Mito A, et al. Involvement of (pro)renin receptor in the glomerular filtration barrier. J Mol Med 2008; 86:629-635.
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J Mol Med
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Ichihara, A.1
Sakoda, M.2
Kurauchi-Mito, A.3
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33
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84863336147
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Receptor-mediated nonproteolytic activation of prorenin and induction of TGF-beta1 and PAI-1 expression in renal mesangial cells
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Studies on mesangial cells demonstrated the presence of PRR and its ability to mediate nonproteolytic activation of prorenin. Activation of PRR led to AT1 receptor independent stimulation of transforming growth factor b1, plasminogen activator inhibitor-1 and fibronectin expression. With addition of AGT, there were further increases in expression of these factors. This study demonstrates that PRR activation of prorenin in mesangial cells leads to Ang II-independent as well as Ang II-dependent activation of these factors
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Zhang J, Wu J, Gu C, et al. Receptor-mediated nonproteolytic activation of prorenin and induction of TGF-beta1 and PAI-1 expression in renal mesangial cells. Am J Physiol Renal Physiol 2012; 303:F11-F20. Studies on mesangial cells demonstrated the presence of PRR and its ability to mediate nonproteolytic activation of prorenin. Activation of PRR led to AT1 receptor independent stimulation of transforming growth factor b1, plasminogen activator inhibitor-1 and fibronectin expression. With addition of AGT, there were further increases in expression of these factors. This study demonstrates that PRR activation of prorenin in mesangial cells leads to Ang II-independent as well as Ang II-dependent activation of these factors
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(2012)
Am J Physiol Renal Physiol
, vol.303
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Zhang, J.1
Wu, J.2
Gu, C.3
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34
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84856271704
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Sodium depletion enhances renal expression of (pro)-renin receptor via cyclic GMP-protein kinase G signaling pathway
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Renal PRR expression was evaluated in rats maintained on either normal or lowsodium diets. The low-sodium diet augmented PRR expression in renal glomeruli as well as in tubular segments. Blockade of guanylyl cyclase decreased PKG activity and prevented the increased PRR expression. The results demonstrate that sodium depletion upregulates PRR expression via the cGMP-PKG signalling pathway
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Huang J, Siragy HM. Sodium depletion enhances renal expression of (pro)-renin receptor via cyclic GMP-protein kinase G signaling pathway. Hypertension 2012; 59:317-323. Renal PRR expression was evaluated in rats maintained on either normal or lowsodium diets. The low-sodium diet augmented PRR expression in renal glomeruli as well as in tubular segments. Blockade of guanylyl cyclase decreased PKG activity and prevented the increased PRR expression. The results demonstrate that sodium depletion upregulates PRR expression via the cGMP-PKG signalling pathway.
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(2012)
Hypertension
, vol.59
, pp. 317-323
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Huang, J.1
Siragy, H.M.2
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35
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84871334693
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In vivo regulation of renal expression of (pro)renin receptor by a low-sodium diet
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Matavelli LC, Huang J, Siragy HM. In vivo regulation of renal expression of (pro)renin receptor by a low-sodium diet. Am J Physiol Renal Physiol 2012; 303:F1652-F1657.
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Am J Physiol Renal Physiol
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Matavelli, L.C.1
Huang, J.2
Siragy, H.M.3
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36
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84880117320
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Losartan preserves glomerular basement membrane anionic charge sites in a rat model of nephropathy
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Liu Y, Zhou D, Xiao X, et al. Losartan preserves glomerular basement membrane anionic charge sites in a rat model of nephropathy. J Nephrol 2013; 26:660-666.
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(2013)
J Nephrol
, vol.26
, pp. 660-666
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Liu, Y.1
Zhou, D.2
Xiao, X.3
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37
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84868626379
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Multiphoton imaging of the glomerular permeability of angiotensinogen
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The investigators used multiphoton microscopy to visualize and quantify glomerular permeability of AGT in intact mouse and rat kidneys. The sieving coefficient of human AGT was only 25% of the sieving coefficient of albumin. AGT glomerular permeability was only slightly higher in a model of kidney disease. The authors conclude that most of the urinary AGT originates from the tubules rather than from glomerular filtration
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Nakano D, Kobori H, Burford JL, et al. Multiphoton imaging of the glomerular permeability of angiotensinogen. J Am Soc Nephrol 2012; 23:1847-1856. The investigators used multiphoton microscopy to visualize and quantify glomerular permeability of AGT in intact mouse and rat kidneys. The sieving coefficient of human AGT was only 25% of the sieving coefficient of albumin. AGT glomerular permeability was only slightly higher in a model of kidney disease. The authors conclude that most of the urinary AGT originates from the tubules rather than from glomerular filtration.
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(2012)
J Am Soc Nephrol
, vol.23
, pp. 1847-1856
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Nakano, D.1
Kobori, H.2
Burford, J.L.3
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38
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84881013153
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Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability
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This study investigated the mechanisms resonsible for the increases in glomerular ermeability elicited by acute Ang II infusions The results indicate that the increases in ermeability are due rimarily to Ang II deendent generation of reactive oxygen secies and increases in calcium influx with some contribution from Rac-1 and RhoA
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Axelsson J, Rippe A, Sverrisson K, Rippe B. Scavengers of reactive oxygen species, paracalcitol, RhoA, and Rac-1 inhibitors and tacrolimus inhibit angiotensin II-induced actions on glomerular permeability. Am J Physiol Renal Physiol 2013; 305:F237-F243. This study investigated the mechanisms responsible for the increases in glomerular permeability elicited by acute Ang II infusions. The results indicate that the increases in permeability are due primarily to Ang II dependent generation of reactive oxygen species and increases in calcium influx with some contribution from Rac-1 and RhoA.
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(2013)
Am J Physiol Renal Physiol
, vol.305
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Axelsson, J.1
Rippe, A.2
Sverrisson, K.3
Rippe, B.4
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39
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84863722393
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Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury
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Kagami S. Involvement of glomerular renin-angiotensin system (RAS) activation in the development and progression of glomerular injury. Clin Exp Nephrol 2012; 16:214-220.
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Clin Exp Nephrol
, vol.16
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Kagami, S.1
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40
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84863229640
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Intrarenal dopamine modulates progressive angiotensin II-mediated renal injury
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Yang S, Yao B, Zhou Y, et al. Intrarenal dopamine modulates progressive angiotensin II-mediated renal injury. Am J Physiol Renal Physiol 2012; 302:F742-F749.
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Am J Physiol Renal Physiol
, vol.302
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Yang, S.1
Yao, B.2
Zhou, Y.3
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41
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84856121099
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P47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice
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This study tested the role of activation of p47(phox)/neutrophil oxidase 2 in enhancing the afferent arteriolar contractions to Ang II. Afferent arterioles from p47(phox)-/-mice had a lesser myogenic response and reduced contraction to Ang II. Although chronic Ang II infusions increased the contractile sensitivity of afferent arterioles to acute Ang II in wild-type mice, it was decreased in p47(phox)-/-mice. The results indicate that p47(phox) is required for the increased myogenic and contractile responses to Ang II
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Lai EY, Solis G, Luo Z, et al. p47(phox) is required for afferent arteriolar contractile responses to angiotensin II and perfusion pressure in mice. Hypertension 2012; 59:415-420. This study tested the role of activation of p47(phox)/neutrophil oxidase 2 in enhancing the afferent arteriolar contractions to Ang II. Afferent arterioles from p47(phox)-/-mice had a lesser myogenic response and reduced contraction to Ang II. Although chronic Ang II infusions increased the contractile sensitivity of afferent arterioles to acute Ang II in wild-type mice, it was decreased in p47(phox)-/-mice. The results indicate that p47(phox) is required for the increased myogenic and contractile responses to Ang II.
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(2012)
Hypertension
, vol.59
, pp. 415-420
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Lai, E.Y.1
Solis, G.2
Luo, Z.3
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42
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34748859681
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The intrarenal renin-angiotensin system: From physiology to the pathobiology of hypertension and kidney disease
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Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-angiotensin system: From physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 2007; 59:251-287.
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Pharmacol Rev
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Kobori, H.1
Nangaku, M.2
Navar, L.G.3
Nishiyama, A.4
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43
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84867715574
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Vascular smooth muscle function of renal glomerular and interlobar arteries predicts renal damage in rats
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Vavrinec P, Henning RH, Goris M, et al. Vascular smooth muscle function of renal glomerular and interlobar arteries predicts renal damage in rats. Am J Physiol Renal Physiol 2012; 303:F1187-F1195.
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Am J Physiol Renal Physiol
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Vavrinec, P.1
Henning, R.H.2
Goris, M.3
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44
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84884557758
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Interactions between adenosine, angiotensin II and nitric oxide on the afferent arteriole influence sensitivity of the tubuloglomerular feedback
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Persson AE, Lai EY, Gao X, et al. Interactions between adenosine, angiotensin II and nitric oxide on the afferent arteriole influence sensitivity of the tubuloglomerular feedback. Front Physiol 2013; 4:187.
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(2013)
Front Physiol
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, pp. 187
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Persson, A.E.1
Lai, E.Y.2
Gao, X.3
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45
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84873282383
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Interaction between nitric oxide and superoxide in the macula densa in aldosterone-induced alterations of tubuloglomerular feedback
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Zhang Q, Lin L, Lu Y, et al. Interaction between nitric oxide and superoxide in the macula densa in aldosterone-induced alterations of tubuloglomerular feedback. Am J Physiol Renal Physiol 2013; 304:F326-F332.
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(2013)
Am J Physiol Renal Physiol
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Zhang, Q.1
Lin, L.2
Lu, Y.3
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47
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84861108864
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Connecting tubule glomerular feedback mediates acute tubuloglomerular feedback resetting
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Wang H, D'Ambrosio MA, Garvin JL, et al. Connecting tubule glomerular feedback mediates acute tubuloglomerular feedback resetting. Am J Physiol Renal Physiol 2012; 302:F1300-F1304.
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(2012)
Am J Physiol Renal Physiol
, vol.302
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Wang, H.1
D'Ambrosio, M.A.2
Garvin, J.L.3
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48
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84863897722
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Mechanisms of angiotensin IIenhanced connecting tubule glomerular feedback
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This study examined the mechanism by which luminal Ang II potentiates the connecting tubule TGF mechanism. The data indicate the Ang II mediated stimulation of AT1 receptors stimulates the PKC/NOX2/O2-athway leading to enhancement of CTGF by luminal Ang II
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Ren Y, D'Ambrosio MA, Wang H, et al. Mechanisms of angiotensin IIenhanced connecting tubule glomerular feedback. Am J Physiol Renal Physiol 2012; 303:F259-F265. This study examined the mechanism by which luminal Ang II potentiates the connecting tubule TGF mechanism. The data indicate the Ang II mediated stimulation of AT1 receptors stimulates the PKC/NOX2/O2-pathway leading to enhancement of CTGF by luminal Ang II.
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Am J Physiol Renal Physiol
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Ren, Y.1
D'Ambrosio, M.A.2
Wang, H.3
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49
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84874609706
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Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type i receptors
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Patinha D, Fasching A, Pinho D, et al. Angiotensin II contributes to glomerular hyperfiltration in diabetic rats independently of adenosine type I receptors. Am J Physiol Renal Physiol 2013; 304:F614-F622.
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Patinha, D.1
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Pinho, D.3
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50
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Involvement of the intrarenal renin-angiotensin system in experimental models of glomerulonephritis
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Urushihara M, Kinoshita Y, Kondo S, Kagami S. Involvement of the intrarenal renin-angiotensin system in experimental models of glomerulonephritis. J Biomed Biotechnol 2012; 2012:601786.
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Urushihara, M.1
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51
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Cardinal role of the intrarenal renin-angiotensin system in the pathogenesis of diabetic nephropathy
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Kobori H, Kamiyama M, Harrison-Bernard LM, Navar LG. Cardinal role of the intrarenal renin-angiotensin system in the pathogenesis of diabetic nephropathy. J Investig Med 2013; 61:256-264.
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Kobori, H.1
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52
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The complex interplay between cyclooxygenase-2 and angiotensin ii in regulating kidney function
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Green T, Gonzalez AA, Mitchell KD, Navar LG. The complex interplay between cyclooxygenase-2 and angiotensin II in regulating kidney function. Curr Opin Nephrol Hypertens 2012; 21:7-14.
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Green, T.1
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Mitchell, K.D.3
Navar, L.G.4
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53
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84871620138
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Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death
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This study used mice with cell-specific deletion of thromboxane-rotein receptors in vascular smooth muscle in order to determine its role in mediating Ang II induced hypertension. Although acute vascular responses to Ang II were not affected, the absence of thromboxane-rotein receptors markedly attenuated the chronic Ang II induced hypertension and structural remodelling
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Sparks MA, Makhanova NA, Griffiths RC, et al. Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death. Hypertension 2013; 61:166-173. This study used mice with cell-specific deletion of thromboxane-protein receptors in vascular smooth muscle in order to determine its role in mediating Ang II induced hypertension. Although acute vascular responses to Ang II were not affected, the absence of thromboxane-protein receptors markedly attenuated the chronic Ang II induced hypertension and structural remodelling.
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(2013)
Hypertension
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Sparks, M.A.1
Makhanova, N.A.2
Griffiths, R.C.3
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54
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84868295313
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Renal heme oxygenase-1 induction with hemin augments renal hemodynamics, renal autoregulation, and excretory function
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Botros FT, Dobrowolski L, Navar LG. Renal heme oxygenase-1 induction with hemin augments renal hemodynamics, renal autoregulation, and excretory function. Int J Hypertens 2012; 2012:8.
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Int J Hypertens
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Botros, F.T.1
Dobrowolski, L.2
Navar, L.G.3
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55
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84859423821
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Effects of tempol and candesartan on neural control of the kidney
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Eppel GA, Head GA, Denton KM, Evans RG. Effects of tempol and candesartan on neural control of the kidney. Auton Neurosci 2012; 168: 48-57.
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Eppel, G.A.1
Head, G.A.2
Denton, K.M.3
Evans, R.G.4
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56
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Nitric oxide synthase inhibition activates L-and T-type Ca2 channels in afferent and efferent arterioles
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Feng MG, Navar LG. Nitric oxide synthase inhibition activates L-and T-type Ca2 channels in afferent and efferent arterioles. Am J Physiol Renal Physiol 2006; 290:F873-F879.
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Am J Physiol Renal Physiol
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Feng, M.G.1
Navar, L.G.2
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Angiotensin II-mediated constriction of afferent and efferent arterioles involves T-type Ca2 channel activation
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Feng MG, Navar LG. Angiotensin II-mediated constriction of afferent and efferent arterioles involves T-type Ca2 channel activation. Am J Nephrol 2004; 24:641-648.
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58
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Fuller AJ, Hauschild BC, Gonzalez-Villalobos R, et al. Calcium and chloride channel activation by angiotensin II-AT1 receptors in preglomerular vascular smooth muscle cells. Am J Physiol Renal Physiol 2005; 289:F760-F767.
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Fuller, A.J.1
Hauschild, B.C.2
Gonzalez-Villalobos, R.3
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59
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Fellner SK, Arendshorst WJ. Angiotensin II-stimulated Ca2 entry mechanisms in afferent arterioles: Role of transient receptor potential canonical channels and reverse Na/Ca2 exchange. Am J Physiol Renal Physiol 2008; 294:F212-F219.
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Fellner, S.K.1
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Hansen PB, Poulsen CB, Walter S, et al. Functional importance of L-and p/qtype voltage-gated calcium channels in human renal vasculature. Hypertension 2011; 58:464-470.
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61
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Zhao D, Zhang J, Blaustein MP, Navar LG. Attenuated renal vascular responses to acute angiotensin II infusion in smooth muscle-specific Na/Ca2 exchanger knockout mice. Am J Physiol Renal Physiol 2011; 301:F574-F579.
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Zhao, D.1
Zhang, J.2
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Mehta PK, Griendling KK. Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol 2007; 292:C82-C97.
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Higuchi S, Ohtsu H, Suzuki H, et al. Angiotensin II signal transduction through the AT1 receptor: Novel insights into mechanisms and pathophysiology. Clin Sci (Lond) 2007; 112:417-428.
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64
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Garrido AM, Griendling KK. NADPH oxidases and angiotensin II receptor signaling. Mol Cell Endocrinol 2009; 302:148-158.
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Garrido, A.M.1
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65
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Sex differences in the enhanced responsiveness to acute angiotensin II in growth-restricted rats: Role of fasudil, a Rho kinase inhibitor
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Ojeda NB, Royals TP, Alexander BT. Sex differences in the enhanced responsiveness to acute angiotensin II in growth-restricted rats: Role of fasudil, a Rho kinase inhibitor. Am J Physiol Renal Physiol 2013; 304:F900-F907.
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Royals, T.P.2
Alexander, B.T.3
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66
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84861861135
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The transcription factor ETS-1 regulates angiotensin II-stimulated fibronectin production in mesangial cells
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Mesangial cells were used to evaluate the mechanism by which Ang II stimulates fibronectin production in glomeruli. Ang II increases expression of the transcription factor, erythroblostosis virus E26 oncogen homolog-1 (ETS-1), leading to fibronectin production. This study shows that Ang II induces phosphorylation of ETS-1 via AT1 receptor activation, which leads to Erk1/2 and Akt/PKB phosphorylation. These results help delineate the mechanisms by which Ang II stimulates production of extracellular matrix protein in mesangial cells
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Hua P, Feng W, Rezonzew G, et al. The transcription factor ETS-1 regulates angiotensin II-stimulated fibronectin production in mesangial cells. Am J Physiol Renal Physiol 2012; 302:F1418-F1429. Mesangial cells were used to evaluate the mechanism by which Ang II stimulates fibronectin production in glomeruli. Ang II increases expression of the transcription factor, erythroblostosis virus E26 oncogen homolog-1 (ETS-1), leading to fibronectin production. This study shows that Ang II induces phosphorylation of ETS-1 via AT1 receptor activation, which leads to Erk1/2 and Akt/PKB phosphorylation. These results help delineate the mechanisms by which Ang II stimulates production of extracellular matrix protein in mesangial cells.
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(2012)
Am J Physiol Renal Physiol
, vol.302
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Hua, P.1
Feng, W.2
Rezonzew, G.3
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68
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84877930434
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Immunosuppression preserves renal autoregulatory function and microvascular P2X1 receptor reactivity in ANG IIhypertensive rats
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Chronic Ang II infusions lead to infiltration of activated lymhocytes and imairment of renal and glomerular haemodynamics including reduced autoregulatory caability The author demonstrated that treatment with an anti-inflammatory agent revents the lymhocyte infiltration and reserves the autoregulatory caability
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Guan Z, Giddens MI, Osmond DA, et al. Immunosuppression preserves renal autoregulatory function and microvascular P2X1 receptor reactivity in ANG IIhypertensive rats. Am J Physiol Renal Physiol 2013; 304:F801-F807. Chronic Ang II infusions lead to infiltration of activated lymphocytes and impairment of renal and glomerular haemodynamics including reduced autoregulatory capability. The author demonstrated that treatment with an anti-inflammatory agent prevents the lymphocyte infiltration and preserves the autoregulatory capability.
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(2013)
Am J Physiol Renal Physiol
, vol.304
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Guan, Z.1
Giddens, M.I.2
Osmond, D.A.3
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69
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84890058204
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Renal nitric oxide synthase and antioxidant preservation in Cyp1a1-Ren-2 transgenic rats with inducible malignant hypertension
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Cunningham MW Jr, Sasser JM, West CA, et al. Renal nitric oxide synthase and antioxidant preservation in Cyp1a1-Ren-2 transgenic rats with inducible malignant hypertension. Am J Hypertens 2013; 26:1242-1249.
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Cunningham Jr., M.W.1
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West, C.A.3
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70
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Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin i infusion
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Gonzalez-Villalobos RA, Billet S, Kim C, et al. Intrarenal angiotensin-converting enzyme induces hypertension in response to angiotensin I infusion. J Am Soc Nephrol 2011; 22:449-459.
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J Am Soc Nephrol
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Billet, S.2
Kim, C.3
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71
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84877114487
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The absence of intrarenal ACE protects against hypertension
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This study demonstrates the important role of intrarenal ACE-mediated Ang II formation in mediating the hypertension elicited by chronic Ang II infusions. Transgenic mice lacking ACE in the kidneys had a reduced blood pressure response and decreased intrarenal Ang II accumulation. They also did not show activation of ion transporters in the loop of Henle and distal nephron that were induced by chronic Ang II infusion in wild-type mice. Thus, renal ACE activity is required to have the augmentation of intrarenal Ang II that occurs in response to chronic Ang II infusions
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Gonzalez-Villalobos RA, Janjoulia T, Fletcher NK, et al. The absence of intrarenal ACE protects against hypertension. J Clin Invest 2013; 123:2011-2023. This study demonstrates the important role of intrarenal ACE-mediated Ang II formation in mediating the hypertension elicited by chronic Ang II infusions. Transgenic mice lacking ACE in the kidneys had a reduced blood pressure response and decreased intrarenal Ang II accumulation. They also did not show activation of ion transporters in the loop of Henle and distal nephron that were induced by chronic Ang II infusion in wild-type mice. Thus, renal ACE activity is required to have the augmentation of intrarenal Ang II that occurs in response to chronic Ang II infusions
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(2013)
J Clin Invest
, vol.123
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Gonzalez-Villalobos, R.A.1
Janjoulia, T.2
Fletcher, N.K.3
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72
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Impaired pressure natriuresis resulting in salt-sensitive hypertension is caused by tubulointerstitial immune cell infiltration in the kidney
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The authors investigated the relationship between renal inflammation and impaired renal function that occurs in salt-sensitive hypertension induced by chronic administration of a nitric oxide synthase inhibitor. This model showed an increase in tubulointerstitial inflammatory cells. Treatment with an immune suppressive agent to reduce inflammation ameliorated much of the renal functional impairment and tissue injury
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Franco M, Tapia E, Bautista R, et al. Impaired pressure natriuresis resulting in salt-sensitive hypertension is caused by tubulointerstitial immune cell infiltration in the kidney. Am J Physiol Renal Physiol 2013; 304:F982-F990. The authors investigated the relationship between renal inflammation and impaired renal function that occurs in salt-sensitive hypertension induced by chronic administration of a nitric oxide synthase inhibitor. This model showed an increase in tubulointerstitial inflammatory cells. Treatment with an immune suppressive agent to reduce inflammation ameliorated much of the renal functional impairment and tissue injury.
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Am J Physiol Renal Physiol
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Franco, M.1
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Franco M, Bautista R, Tapia E, et al. Contribution of renal purinergic receptors to renal vasoconstriction in angiotensin II-induced hypertensive rats. Am J Physiol Renal Physiol 2011; 300:F1301-F1309.
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74
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Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats
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Mitchell KD, Bagatell SJ, Miller CS, et al. Genetic clamping of renin gene expression induces hypertension and elevation of intrarenal Ang II levels of graded severity in Cyp1a1-Ren2 transgenic rats. J Renin Angiotensin Aldosterone Syst 2006; 7:74-86.
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Miller, C.S.3
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Direct renin inhibition with aliskiren normalizes blood pressure in Cyp1a1-Ren2 transgenic rats with inducible angiotensin II-dependent malignant hypertension
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Howard CG, Mullins JJ, Mitchell KD. Direct renin inhibition with aliskiren normalizes blood pressure in Cyp1a1-Ren2 transgenic rats with inducible angiotensin II-dependent malignant hypertension. Am J Med Sci 2011; 341:383-387.
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Howard, C.G.1
Mullins, J.J.2
Mitchell, K.D.3
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76
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Chronic direct renin inhibition with aliskiren prevents the development of hypertension in Cyp1a1-Ren2 transgenic rats with inducible Ang II-dependent hypertension
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Huang L, Howard CG, Mitchell KD. Chronic direct renin inhibition with aliskiren prevents the development of hypertension in Cyp1a1-Ren2 transgenic rats with inducible Ang II-dependent hypertension. Am J Med Sci 2012; 344:301-306.
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Renal functional responses to selective intrarenal renin inhibition in Cyp1a1-Ren2 transgenic rats with ANG II-dependent malignant hypertension
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Howard CG, Mitchell KD. Renal functional responses to selective intrarenal renin inhibition in Cyp1a1-Ren2 transgenic rats with ANG II-dependent malignant hypertension. Am J Physiol Renal Physiol 2012; 302:F52-F59.
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Howard, C.G.1
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