-
1
-
-
0037591344
-
Human prorenin has "gate and handle" regions for its non-proteolytic activation
-
Suzuki F, Hayakawa M, Nakagawa T, Nasir UM, Ebihara A, Iwasawa A, Ishida Y, Nakamura Y, Murakami K (2003) Human prorenin has "gate and handle" regions for its non-proteolytic activation. J Biol Chem 278:22217-22222
-
(2003)
J Biol Chem
, vol.278
, pp. 22217-22222
-
-
Suzuki, F.1
Hayakawa, M.2
Nakagawa, T.3
Nasir, U.M.4
Ebihara, A.5
Iwasawa, A.6
Ishida, Y.7
Nakamura, Y.8
Murakami, K.9
-
2
-
-
33750600468
-
Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system
-
Nabi AHMN, Kageshima A, Uddin M, Nakagawa T, Park E, Suzuki F (2006) Binding properties of rat prorenin and renin to the recombinant rat renin/prorenin receptor prepared by a baculovirus expression system. Int J Mol Med 18:483-488
-
(2006)
Int J Mol Med
, vol.18
, pp. 483-488
-
-
Ahmn, N.1
Kageshima, A.2
Uddin, M.3
Nakagawa, T.4
Park, E.5
Suzuki, F.6
-
3
-
-
0036266596
-
Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
-
Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer J-D (2002) Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 109:1417-1427
-
(2002)
J Clin Invest
, vol.109
, pp. 1417-1427
-
-
Nguyen, G.1
Delarue, F.2
Burckle, C.3
Bouzhir, L.4
Giller, T.5
Sraer, J.-D.6
-
4
-
-
30944469631
-
Renin increases mesangial cell transforming growth factor-b1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms
-
Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, Noble NA, Border W (2006) Renin increases mesangial cell transforming growth factor-b1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms. Kidney Int 69:105-113
-
(2006)
Kidney Int
, vol.69
, pp. 105-113
-
-
Huang, Y.1
Wongamorntham, S.2
Kasting, J.3
McQuillan, D.4
Owens, R.T.5
Yu, L.6
Noble, N.A.7
Border, W.8
-
5
-
-
34548483245
-
The (pro)renin receptor and the kidney
-
Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Itoh H (2007) The (pro)renin receptor and the kidney. Semin Nephrol 27:524-528
-
(2007)
Semin Nephrol
, vol.27
, pp. 524-528
-
-
Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
Sakoda, M.4
Itoh, H.5
-
7
-
-
33748044643
-
Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage
-
Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Nakagawa T, Nishiyama A, Kawachi H, Shimizu F, Inagami T (2006) Contribution of non-proteolytically activated prorenin in glomeruli to hypertensive renal damage. J Am Soc Nephrol 17:2495-2503
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2495-2503
-
-
Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
Sakoda, M.4
Nakagawa, T.5
Nishiyama, A.6
Kawachi, H.7
Shimizu, F.8
Inagami, T.9
-
8
-
-
33845608395
-
A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein
-
Schefe J, Menk M, Reinemund J, Effertz K, Hobbs R, Pandolfi P, Ruiz P, Unger T, Funke-Kaiser H (2006) A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res 99:1355-1366
-
(2006)
Circ Res
, vol.99
, pp. 1355-1366
-
-
Schefe, J.1
Menk, M.2
Reinemund, J.3
Effertz, K.4
Hobbs, R.5
Pandolfi, P.6
Ruiz, P.7
Unger, T.8
Funke-Kaiser, H.9
-
9
-
-
34548490929
-
Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats
-
Krebs C, Hamming I, Sadaghiani S, Steinmetz OM, Meyer-Schwesinger C, Fehr S, Stahl RAK, Garrelds IM, Danser AHJ, Goor, Contrepas A, Nguyen G, Wenzel U (2007) Antihypertensive therapy upregulates renin and (pro)renin receptor in the clipped kidney of Goldblatt hypertensive rats. Kidney Int 72:725-730
-
(2007)
Kidney Int
, vol.72
, pp. 725-730
-
-
Krebs, C.1
Hamming, I.2
Sadaghiani, S.3
Steinmetz, O.M.4
Meyer-Schwesinger, C.5
Fehr, S.6
Stahl, R.A.K.7
Garrelds, I.M.8
Danser, A.H.J.9
Goor10
Contrepas, A.11
Nguyen, G.12
Wenzel, U.13
-
10
-
-
34249881320
-
Slowly progressive, angiotensin II-independent glomerulosclerosis in human-renin/prorenin-receptor-transgenic rats
-
Kaneshiro Y, Ichihara A, Sakoda M, Takemitsu T, Nabi AN, Uddin MN, Nakagawa T, Nishiyama A, Suzuki F, Inagami T, Itoh H (2007) Slowly progressive, angiotensin II-independent glomerulosclerosis in human-renin/prorenin-receptor- transgenic rats. J Am Soc Nephrol 18:1789-1795
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1789-1795
-
-
Kaneshiro, Y.1
Ichihara, A.2
Sakoda, M.3
Takemitsu, T.4
Nabi, A.N.5
Uddin, M.N.6
Nakagawa, T.7
Nishiyama, A.8
Suzuki, F.9
Inagami, T.10
Itoh, H.11
-
11
-
-
33644983896
-
Elevated blood pressure and heart rate in human renin receptor transgenic rats
-
Burckle CA, Jan Danser AH, Muller DN, Garrelds IM, Gasc JM, Popova E, Plehm R, Peters J, Bader M, Nguyen G (2006) Elevated blood pressure and heart rate in human renin receptor transgenic rats. Hypertension 47:1-5
-
(2006)
Hypertension
, vol.47
, pp. 1-5
-
-
Burckle, C.A.1
Jan Danser, A.H.2
Muller, D.N.3
Garrelds, I.M.4
Gasc, J.M.5
Popova, E.6
Plehm, R.7
Peters, J.8
Bader, M.9
Nguyen, G.10
-
12
-
-
33747060126
-
Increased expression of cyclooxygenase-2 in renal cortex of human-prorenin-receptor-gene transgenic rats
-
Kaneshiro Y, Ichihara A, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, Hayashi M, Inagami T (2006) Increased expression of cyclooxygenase-2 in renal cortex of human-prorenin-receptor-gene transgenic rats. Kidney Int 70:641-646
-
(2006)
Kidney Int
, vol.70
, pp. 641-646
-
-
Kaneshiro, Y.1
Ichihara, A.2
Takemitsu, T.3
Sakoda, M.4
Suzuki, F.5
Nakagawa, T.6
Hayashi, M.7
Inagami, T.8
-
13
-
-
34547693066
-
Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor
-
Nabi AHMN, Uddin M, Nakagawa T, Iwata H, Ichihara A, Inagami T, Suzuki F (2007) Role of "handle" region of prorenin prosegment in the non-proteolytic activation of prorenin by binding to membrane anchored (pro)renin receptor. Front Biosci 12:4810-4817
-
(2007)
Front Biosci
, vol.12
, pp. 4810-4817
-
-
Ahmn, N.1
Uddin, M.2
Nakagawa, T.3
Iwata, H.4
Ichihara, A.5
Inagami, T.6
Suzuki, F.7
-
14
-
-
0020598553
-
Changes in blood pressure, urinary kallikrein, and urinary prostaglandin E2 in rats with streptozotocin-induced diabetes
-
Hayashi M, Senba S, Saito I, Kitajima W, Saruta T (1983) Changes in blood pressure, urinary kallikrein, and urinary prostaglandin E2 in rats with streptozotocin-induced diabetes. Naunyn Schmiedebergs Arch Pharmacol 322:290-294
-
(1983)
Naunyn Schmiedebergs Arch Pharmacol
, vol.322
, pp. 290-294
-
-
Hayashi, M.1
Senba, S.2
Saito, I.3
Kitajima, W.4
Saruta, T.5
-
15
-
-
0024268789
-
Human prorenin: Pathophysiology and clinical implications
-
Derkx F, Schalekamp M (1988) Human prorenin: pathophysiology and clinical implications. Clin Exp Hypertens A10:1213-1225
-
(1988)
Clin Exp Hypertens
, vol.10
, pp. 1213-1225
-
-
Derkx, F.1
Schalekamp, M.2
-
16
-
-
9644283069
-
Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for non-proteolytic activation of prorenin
-
Ichihara A, Hayashi M, Kaneshiro Y, Suzuki F, Nakagawa T, Tada Y, Koura Y, Nishiyama A, Okada H, Uddin MN, Nabi AHMN, Ishida Y, Inagami T, Saruta T (2004) Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for non-proteolytic activation of prorenin. J Clin Invest 114:1128-1135
-
(2004)
J Clin Invest
, vol.114
, pp. 1128-1135
-
-
Ichihara, A.1
Hayashi, M.2
Kaneshiro, Y.3
Suzuki, F.4
Nakagawa, T.5
Tada, Y.6
Koura, Y.7
Nishiyama, A.8
Okada, H.9
Uddin, M.N.10
Ahmn, N.11
Ishida, Y.12
Inagami, T.13
Saruta, T.14
-
17
-
-
34447272037
-
Regression of nephropathy developed in diabetes by (pro)renin receptor blockade
-
Takahashi H, Ichihara A, Kaneshiro Y, Inomata K, Sakoda M, Takemitsu T, Nishiyama A, Itoh H (2007) Regression of nephropathy developed in diabetes by (pro)renin receptor blockade. J Am Soc Nephrol 18:2054-2061
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 2054-2061
-
-
Takahashi, H.1
Ichihara, A.2
Kaneshiro, Y.3
Inomata, K.4
Sakoda, M.5
Takemitsu, T.6
Nishiyama, A.7
Itoh, H.8
-
18
-
-
33745824649
-
Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor deficient mice
-
Ichihara A, Suzuki F, Nakagawa T, Kaneshiro Y, Takemitsu T, Sakoda M, Nabi AHMN, Nishiyama A, Sugaya T, Hayashi M, Inagami T (2006) Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor deficient mice. J Am Soc Nephrol 17:1950-1961
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 1950-1961
-
-
Ichihara, A.1
Suzuki, F.2
Nakagawa, T.3
Kaneshiro, Y.4
Takemitsu, T.5
Sakoda, M.6
Ahmn, N.7
Nishiyama, A.8
Sugaya, T.9
Hayashi, M.10
Inagami, T.11
-
19
-
-
0033811667
-
Increased gene expression of components of the renin-angiotensin system in glomeruli of genetically hypertensive rats
-
Obata J, Nakamura T, Takano H, Naito A, Kimura H, Yoshida Y, Shimizu F, Guo DF, Inagami T (2000) Increased gene expression of components of the renin-angiotensin system in glomeruli of genetically hypertensive rats. J Hypertens 18:1247-1255
-
(2000)
J Hypertens
, vol.18
, pp. 1247-1255
-
-
Obata, J.1
Nakamura, T.2
Takano, H.3
Naito, A.4
Kimura, H.5
Yoshida, Y.6
Shimizu, F.7
Guo, D.F.8
Inagami, T.9
-
20
-
-
34347350179
-
Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells
-
Huang Y, Noble N, Zhang J, Xu C, Border W (2007) Renin-stimulated TGF-beta1 expression is regulated by a mitogen-activated protein kinase in mesangial cells. Kidney Int 72:42-52
-
(2007)
Kidney Int
, vol.72
, pp. 42-52
-
-
Huang, Y.1
Noble, N.2
Zhang, J.3
Xu, C.4
Border, W.5
-
21
-
-
37849044605
-
(Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells
-
Sakoda M, Ichihara A, Kaneshiro Y, Takemitsu T, Nakazato Y, Migita T, Nabi AHMN, Nakagawa T, Suzuki F, Inagami T, Itoh H (2007) (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells. Hypertens Res 30:1139-1146
-
(2007)
Hypertens Res
, vol.30
, pp. 1139-1146
-
-
Sakoda, M.1
Ichihara, A.2
Kaneshiro, Y.3
Takemitsu, T.4
Nakazato, Y.5
Migita, T.6
Ahmn, N.7
Nakagawa, T.8
Suzuki, F.9
Inagami, T.10
Itoh, H.11
-
22
-
-
33751084042
-
Cardiovascular effects of nonproteolytic activation of prorenin
-
Susic D, Lippton H, Knight M, Frohlich ED (2006) Cardiovascular effects of nonproteolytic activation of prorenin. Hypertension 48:e113
-
(2006)
Hypertension
, vol.48
, pp. 113
-
-
Susic, D.1
Lippton, H.2
Knight, M.3
Frohlich, E.D.4
-
23
-
-
34447287846
-
Renin and its putative receptor remain enigmas
-
Luft FC (2007) Renin and its putative receptor remain enigmas. J Am Soc Nephrol 18:1989-1992
-
(2007)
J Am Soc Nephrol
, vol.18
, pp. 1989-1992
-
-
Luft, F.C.1
-
24
-
-
33646160993
-
Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension
-
Ichihara A, Kaneshiro Y, Takemitsu T, Sakoda M, Suzuki F, Nakagawa T, Nishiyama A, Inagami T, Hayashi M (2006) Non-proteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension. Hypertension 47:894-900
-
(2006)
Hypertension
, vol.47
, pp. 894-900
-
-
Ichihara, A.1
Kaneshiro, Y.2
Takemitsu, T.3
Sakoda, M.4
Suzuki, F.5
Nakagawa, T.6
Nishiyama, A.7
Inagami, T.8
Hayashi, M.9
-
25
-
-
35848948398
-
Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor
-
Batenburg WW, Krop MK, Garrelds IM, deVries R, deBruin RJA, Burckle CA, Muller DN, Bader M, Nguyen G, Danser AHJ (2007) Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor. J Hypertens 25:2441-2453
-
(2007)
J Hypertens
, vol.25
, pp. 2441-2453
-
-
Batenburg, W.W.1
Krop, M.K.2
Garrelds, I.M.3
Devries, R.4
Debruin, R.J.A.5
Burckle, C.A.6
Muller, D.N.7
Bader, M.8
Nguyen, G.9
Danser, A.H.J.10
-
26
-
-
39749098706
-
Prorenin and renin-induced extracellular signal regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide
-
Feldt S, Batenburg WW, Mazak I, Maschke U, Wellner M, Kvakan H, Dechend R, Fiebeler A, Burckle C, Contrepas A, Danser AHJ, Bader M, Nguyen G, Luft FC, Muller DN (2008) Prorenin and renin-induced extracellular signal regulated kinase 1/2 activation in monocytes is not blocked by aliskiren or the handle-region peptide. Hypertension 51:682-688
-
(2008)
Hypertension
, vol.51
, pp. 682-688
-
-
Feldt, S.1
Batenburg, W.W.2
Mazak, I.3
Maschke, U.4
Wellner, M.5
Kvakan, H.6
Dechend, R.7
Fiebeler, A.8
Burckle, C.9
Contrepas, A.10
Danser, A.H.J.11
Bader, M.12
Nguyen, G.13
Luft, F.C.14
Muller, D.N.15
-
27
-
-
33750266798
-
Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II
-
Saris J, 'tHoen P, Garrelds I, Dekkers D, denDunnen J, Lamers J, JanDanser A (2006) Prorenin induces intracellular signaling in cardiomyocytes independently of angiotensin II. Hypertension 48:564-571
-
(2006)
Hypertension
, vol.48
, pp. 564-571
-
-
Saris, J.1
'Thoen, P.2
Garrelds, I.3
Dekkers, D.4
Dendunnen, J.5
Lamers, J.6
Jandanser, A.7
|