Thromboxane receptors in smooth muscle promote hypertension, vascular remodeling, and sudden death

Hypertension

Volumn 61, Issue 1, 2013, Pages 166-173

  Sparks, Matthew A ^a,b   Makhanova, Natalia A ^a,b   Griffiths, Robert C ^a,b   Snouwaert, John N ^c   Koller, Beverly H ^c   Coffman, Thomas M ^a,b,d  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Ang II; death; hypertension; muscle, smooth; thromboxanes

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ANGIOTENSIN II; THROMBOXANE A2 RECEPTOR; THROMBOXANE B2;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; HEART VENTRICLE HYPERTROPHY; HEMODYNAMICS; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SHOCK; SMOOTH MUSCLE FIBER; SUDDEN DEATH; SYSTOLIC BLOOD PRESSURE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; AORTA; BLOOD PRESSURE; DEATH, SUDDEN; HYPERTENSION; MICE; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RECEPTORS, THROMBOXANE; THROMBOXANE A2; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS;

EID: 84871620138     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.193250     Document Type: Article

References (34)

1. Neri Serneri GG, Gensini GF, Abbate R, Mugnaini C, Favilla S, Brunelli C, Chierchia S, Parodi O. Increased fbrinopeptide A formation and thromboxane A2 production in patients with ischemic heart disease: relationships to coronary pathoanatomy, risk factors, and clinical manifestations. Am Heart J. 1981;101:185-194. (Pubitemid 11184165)
2. Mehta JL, Lawson D, Mehta P, Saldeen T. Increased prostacyclin and thromboxane A2 biosynthesis in atherosclerosis. Proc Natl Acad Sci USA. 1988;85:4511-4515.
3. Francois H, Athirakul K, Mao L, Rockman H, Coffman TM. Role for thromboxane receptors in angiotensin-II-induced hypertension. Hypertension. 2004;43:364-369. (Pubitemid 38174140)
4. Mousa AA, Strauss JF 3rd, Walsh SW. Reduced methylation of the throm-boxane synthase gene is correlated with its increased vascular expression in preeclampsia. Hypertension. 2012;59:1249-1255.
5. Chamorro A. TP receptor antagonism: a new concept in atherothrombosis and stroke prevention. Cerebrovasc Dis. 2009;27 Suppl 3:20-27.
6. Kinsella BT, O'Mahony DJ, Fitzgerald GA. The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. J Pharmacol Exp Ther. 1997;281:957-964. (Pubitemid 27203832)
7. Namba T, Sugimoto Y, Hirata M, Hayashi Y, Honda A, Watabe A, Negishi M, Ichikawa A, Narumiya S. Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis. Biochem Biophys Res Commun. 1992;184:1197-1203.
8. Takahashi N, Takeuchi K, Abe T, Sugawara A, Abe K. Immunolocalization of rat thromboxane receptor in the kidney. Endocrinology. 1996;137:5170-5173. (Pubitemid 26403365)
9. Mannon RB, Coffman TM, Mannon PJ. Distribution of binding sites for thromboxane A2 in the mouse kidney. Am J Physiol. 1996;271(6 pt 2):F1131-F1138.
10. Myers A, Penhos J, Ramey E, Ramwell P. Thromboxane agonism and antagonism in a mouse sudden death model. J Pharmacol Exp Ther. 1983;224:369-372. (Pubitemid 13139092)
11. Patrono C, Ciabattoni G, Pinca E, Pugliese F, Castrucci G, De Salvo A, Satta MA, Peskar BA. Low dose aspirin and inhibition of thromboxane B2 production in healthy subjects. Thromb Res. 1980;17:317-327. (Pubitemid 10129020)
12. De Clerck F, Beetens J, Van de Water A, Vercammen E, Janssen PA. R 68 070: thromboxane A2 synthetase inhibition and thromboxane A2/prosta-glandin endoperoxide receptor blockade combined in one molecule-II. Pharmacological effects in vivo and ex vivo. Thromb Haemost. 1989;61:43-49. (Pubitemid 19092666)
13. Thomas DW, Mannon RB, Mannon PJ, Latour A, Oliver JA, Hoffman M, Smithies O, Koller BH, Coffman TM. Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. J Clin Invest. 1998;102:1994-2001. (Pubitemid 29001846)
14. Kawada N, Dennehy K, Solis G, Modlinger P, Hamel R, Kawada JT, Aslam S, Moriyama T, Imai E, Welch WJ, Wilcox CS. TP receptors regulate renal hemodynamics during angiotensin II slow pressor response. Am J Physiol Renal Physiol. 2004;287:F753-F759. (Pubitemid 39280511)
15. Keen HL, Brands MW, Smith MJ Jr, Shek EW, Hall JE. Thromboxane is required for full expression of angiotensin hypertension in rats. Hypertension. 1997;29(1 pt 2):310-314. (Pubitemid 27074061)
16. Facemire CS, Griffths R, Audoly LP, Koller BH, Coffman TM. The impact of microsomal prostaglandin e synthase 1 on blood pressure is determined by genetic background. Hypertension. 2010;55:531-538.
17. Keen HL, Brands MW, Smith MJ Jr, Shek EW, Hall JE. Inhibition of thromboxane synthesis attenuates insulin hypertension in rats. Am J Hypertens. 1997;10(10 pt 1):1125-1131. (Pubitemid 27486345)
18. Francois H, Makhanova N, Ruiz P, Ellison J, Mao L, Rockman HA, Coffman TM. A role for the thromboxane receptor in L-NAME hypertension. Am J Physiol Renal Physiol. 2008;295:F1096-F1102.
19. Pfster SL, Kotulock DA, Campbell WB. Vascular smooth muscle throm-boxane A2 receptors mediate arachidonic acid-induced sudden death in rabbits. Hypertension. 1997;29(1 pt 2):303-309. (Pubitemid 27074060)
20. Gao H, Peng B, Welch WJ, Wilcox CS. Central thromboxane receptors: mRNA expression and mediation of pressor responses. Am J Physiol. 1997;272(5 pt 2):R1493-R1500.
21. Muzumdar MD, Tasic B, Miyamichi K, Li L, Luo L. A global double-fuorescent Cre reporter mouse. Genesis. 2007;45:593-605. (Pubitemid 350013057)
22. Félétou M, Huang Y, Vanhoutte PM. Vasoconstrictor prostanoids. Pfugers Arch. 2010;459:941-950.
23. Torres Duarte AP, Ramwell P, Myers A. Sex differences in mouse platelet aggregation. Thromb Res. 1986;43:33-39. (Pubitemid 16016277)
24. Sparks MA, Parsons KK, Stegbauer J, Gurley SB, Vivekanandan-Giri A, Fortner CN, Snouwaert J, Raasch EW, Griffths RC, Haystead TA, Le TH, Pennathur S, Koller B, Coffman TM. Angiotensin II type 1A receptors in vascular smooth muscle cells do not infuence aortic remodeling in hypertension. Hypertension. 2011;57:577-585.
25. Yuhki K, Kojima F, Kashiwagi H, Kawabe J, Fujino T, Narumiya S, Ushikubi F. Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies. Pharmacol Ther. 2011;129:195-205.
26. Kabashima K, Tokura Y. The potential of selected prostanoid receptors as targets in a new therapeutic strategy for allergy and immune diseases. Curr Drug Saf. 2007;2:186-192. (Pubitemid 47578124)
27. Ishizuka T, Higashino H. TP receptor as a therapeutic target in atherosclerosis and related cardiovascular diseases. Recent Pat Cardiovasc Drug Discov. 2006;1:241-247.
28. Félétou M, Cohen RA, Vanhoutte PM, Verbeuren TJ. TP receptors and oxidative stress hand in hand from endothelial dysfunction to atherosclerosis. Adv Pharmacol. 2010;60:85-106.
29. Nasjletti A. Arthur C. Corcoran Memorial Lecture. The role of eico-sanoids in angiotensin-dependent hypertension. Hypertension. 1998;31 (1 pt 2):194-200.
30. Lin L, Nasjletti A. Role of endothelium-derived prostanoid in angiotensin-induced vasoconstriction. Hypertension. 1991;18:158-164.
31. Rocca B, Loeb AL, Strauss JF 3rd, Vezza R, Habib A, Li H, FitzGerald GA. Directed vascular expression of the thromboxane A2 receptor results in intrauterine growth retardation. Nat Med. 2000;6:219-221. (Pubitemid 30082370)
32. Gelosa P, Sevin G, Pignieri A, Budelli S, Castiglioni L, Blanc-Guillemaud V, Lerond L, Tremoli E, Sironi L. Terutroban, a thromboxane/pros-taglandin endoperoxide receptor antagonist, prevents hypertensive vascular hypertrophy and fbrosis. Am J Physiol Heart Circ Physiol. 2011;300:H762-H768.
33. Darius H, Lefer AM. Blockade of thromboxane and the prevention of eicosanoid-induced sudden death in mice. Proc Soc Exp Biol Med. 1985;180:364-368. (Pubitemid 16201286)
34. Cyphert JM, Allen IC, Church RJ, Latour AM, Snouwaert JN, Coffman TM, Koller BH. Allergic infammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse. Am J Physiol Lung Cell Mol Physiol. 2012;302:L140-L151.