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Z Shan P Shi AE Cuadra Y Dong, et al. 2010 Involvement of the brain (pro)renin receptor in cardiovascular homeostasis Circ Res 107 934 938 1:CAS:528:DC%2BC3cXht1Gku7nN 10.1161/CIRCRESAHA.110.226977 20689062 These authors showed that downregulation of PRR expression in the supraoptic nuclei by injection of small-hairpin RNA induced a decrease of blood pressure in spontaneously hypertensive rats. These results suggest that PRR plays a role in the central control of blood pressure
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1:CAS:528:DC%2BD1MXlslCitbs%3D 10.1161/HYPERTENSIONAHA.108.127258 19380613 This paper is the first to show the existence of a soluble form of PRR, generated by intracellular cleavage of PRR by furin. Importantly, this soluble PRR was also found in human plasma
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C Cousin D Bracquart A Contrepas, et al. 2009 Soluble form of the (pro)renin receptor generated by intracellular cleavage by furin is secreted in plasma Hypertension 53 1077 108 1:CAS:528:DC%2BD1MXlslCitbs%3D 10.1161/HYPERTENSIONAHA.108.127258 19380613 This paper is the first to show the existence of a soluble form of PRR, generated by intracellular cleavage of PRR by furin. Importantly, this soluble PRR was also found in human plasma
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Oct 6 (Epub ahead of print). This very important paper reports the first crystal structure of angiotensinogen and the existence of two forms of angiotensinogen, reduced and oxidized. Oxidized angiotensinogen more effectively releases angiotensin in the presence of renin when bound to PRR, suggesting that the transition from the reduced to the oxidized form of angiotensinogen is one key element of the control of blood pressure at the cellular level
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•• Zhou A, Carrell RW, Murphy MP, et al. A redox switch in angiotensinogen modulates angiotensin release. Nature 2010 Oct 6 (Epub ahead of print). This very important paper reports the first crystal structure of angiotensinogen and the existence of two forms of angiotensinogen, reduced and oxidized. Oxidized angiotensinogen more effectively releases angiotensin in the presence of renin when bound to PRR, suggesting that the transition from the reduced to the oxidized form of angiotensinogen is one key element of the control of blood pressure at the cellular level.
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A Advani DJ Kelly AJ Cox, et al. 2009 The (Pro)renin receptor: site-specific and functional linkage to the vacuolar H+ -ATPase in the kidney Hypertension 54 261 269 1:CAS:528:DC%2BD1MXosFWiurs%3D 10.1161/HYPERTENSIONAHA. 109.128645 19546380 This is the first paper to suggest a functional link between PRR and the V-ATPase in intercalated cells of the distal renal tubule
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CM Cruciat B Ohkawara SP Acebron, et al. 2010 Requirement of prorenin receptor and vacuolar H+ -ATPase-mediated acidification for Wnt signaling Science 327 459 463 1:CAS:528:DC%2BC3cXnt1ahsQ%3D%3D 10.1126/science.1179802 20093472 By using a genome-wide siRNA approach, the authors showed that PRR is essential for canonical Wnt/β-catenin signaling. PRR binds and internalizes the complex Fz- LRP5/6, and LRP5/6 is phosphorylated in the acidic environment provided by V-ATPase. Knockdown of PRR expression leads to abnormal CNS patterning and death of the embryo
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Science
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1:CAS:528:DC%2BC3cXptlCmuro%3D 10.1016/j.cub.2010.05.057 20579879 The authors provide evidence that PRR is also essential to noncanonical Wnt/PCP signaling
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T Hermle D Saltukoglu J Grünewald, et al. 2010 Regulation of Frizzled-dependent planar polarity signaling by a V-ATPase subunit Curr Biol 20 1269 1276 1:CAS:528:DC%2BC3cXptlCmuro%3D 10.1016/j.cub.2010.05.057 20579879 The authors provide evidence that PRR is also essential to noncanonical Wnt/PCP signaling
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1:CAS:528:DC%2BC3cXptlCmurw%3D 10.1016/j.cub.2010.05.028 20579883 The authors provide evidence that PRR is also essential to noncanonical Wnt/PCP signaling in Drosophila
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T Buechling K Bartscherer B Ohkawara, et al. 2010 Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor Curr Biol 20 1263 1268 1:CAS:528:DC%2BC3cXptlCmurw%3D 10.1016/j.cub.2010.05.028 20579883 The authors provide evidence that PRR is also essential to noncanonical Wnt/PCP signaling in Drosophila
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1:CAS:528:DC%2BC3cXosV2hs7Y%3D 10.1161/CIRCRESAHA.110.224667 20570919 This is the first report of a conditional knockout of PRR in cardiomyocytes. The mice have lethal heart failure at 3 weeks, attributed to a defect in V-ATPase function
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K Kinouchi A Ichihara M Sano, et al. 2010 The (Pro)renin receptor/ATP6AP2 is essential for vacuolar H+ -ATPase assembly in murine cardiomyocytes Circ Res 107 30 34 1:CAS:528:DC%2BC3cXosV2hs7Y%3D 10.1161/CIRCRESAHA.110.224667 20570919 This is the first report of a conditional knockout of PRR in cardiomyocytes. The mice have lethal heart failure at 3 weeks, attributed to a defect in V-ATPase function
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