The increasing complexity of the intratubular renin-angiotensin system

Journal of the American Society of Nephrology

Volumn 23, Issue 7, 2012, Pages 1130-1132

  Navar, L Gabriel ^a   Satou, Ryousuke ^a   Gonzalez Villalobos, Romer A ^b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN RECEPTOR; ANGIOTENSINOGEN; MESSENGER RNA; RENIN;

EDITORIAL; HORMONE ACTION; HORMONE RECEPTOR INTERACTION; HUMAN; KIDNEY PROXIMAL TUBULE; LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TISSUE DISTRIBUTION;

EID: 84863514954     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2012050493     Document Type: Editorial

References (35)

1. Douglas JG, Hopfer U: Novel aspect of angiotensin receptors and signal transduction in the kidney. Annu Rev Physiol 56: 649-669, 1994 (Pubitemid 24111876)
2. Navar LG, Harrison-Bernard LM, Imig JD, Mitchell KD: Renal actions of angiotensin II and AT1 receptor blockers. In: Angiotensin II Receptor Antagonists, edited by Epstein M, Brunner HR, Philadelphia, Hanley & Belfus, Inc., 2000, p 189
3. Seikaly MG, Arant BS Jr, Seney FD Jr: Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest 86: 1352-1357, 1990 (Pubitemid 20370446)
4. Braam B, Mitchell KD, Fox J, Navar LG: Proximal tubular secretion of angiotensin II in rats. Am J Physiol 264: F891-F898, 1993 (Pubitemid 23149720)
5. Navar LG, Harrison-Bernard LM, Wang C-T, Cervenka L, Mitchell KD: Concentrations and actions of intraluminal angiotensin II. J Am Soc Nephrol 10[Suppl 11]: S189-S195, 1999 (Pubitemid 29038186)
6. Baum M, Quigley R, Quan A: Effect of luminal angiotensin II on rabbit proximal convoluted tubule bicarbonate absorption. Am J Physiol 273: F595-F600, 1997
7. Zhuo JL, Li XC, Garvin JL, Navar LG, Carretero OA: Intracellular ANG: Intracellular ANG II induces cytosolic Ca2+ mobilization by stimulating intracellular AT1 receptors in proximal tubule cells. Am J Physiol Renal Physiol 290: F1382-F1390, 2006 (Pubitemid 43830763)
8. Peti-Peterdi J, Warnock DG, Bell PD: Angiotensin II directly stimulates ENaC activity in the cortical collecting duct via AT(1) receptors. J Am Soc Nephrol 13: 1131-1135, 2002 (Pubitemid 34441392)
9. Kovács G, Peti-Peterdi J, Rosivall L, Bell PD: Angiotensin II directly stimulates macula densa Na-2Cl-K cotransport via apical AT(1) receptors. Am J Physiol Renal Physiol 282: F301-F306, 2002 (Pubitemid 34654561)
10. Komlosi P, Fuson AL, Fintha A, Peti-Peterdi J, Rosivall L, Warnock DG, Bell PD: Angiotensin I conversion to angiotensin II stimulates cortical collecting duct sodium transport. Hypertension 42: 195-199, 2003 (Pubitemid 36944596)
11. Navar LG, Imig JD, Zou L, Wang C-T: Intrarenal production of angiotensin II. Semin Nephrol 17: 412-422, 1997 (Pubitemid 27398453)
12. Zhou Y, Boron WF: Role of endogenously secreted angiotensin II in the CO2-induced stimulation of HCO3 reabsorption by renal proximal tubules. Am J Physiol Renal Physiol 294: F245-F252, 2008
13. Darby IA, Congiu M, Fernley RT, Sernia C, Coghlan JP: Cellular and ultrastructural location of angiotensinogen in rat and sheep kidney. Kidney Int 46: 1557-1560, 1994 (Pubitemid 24370461)
14. Terada Y, Tomita K, Nonoguchi H, Marumo F: PCR localization of angiotensin II receptor and angiotensinogenmRNAs in rat kidney. Kidney Int 43: 1251-1259, 1993 (Pubitemid 23161411)
15. Ingelfinger JR, Zuo WM, Fon EA, Ellison KE, Dzau VJ: In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal renin angiotensin system. J Clin Invest 85: 417-423, 1990 (Pubitemid 20070047)
16. Satou R, Gonzalez-Villalobos RA, Miyata K, Ohashi N, Urushihara M, Acres OW, Navar LG, Kobori H: IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells. Mol Cell Endocrinol 311: 24-31, 2009
17. Pohl M, Kaminski H, Castrop H, Bader M, Himmerkus N, Bleich M, Bachmann S, Theilig F: Intrarenal renin angiotensin system revisited: Role of megalin-dependent endocytosis along the proximal nephron. J Biol Chem285: 41935-41946, 2010
18. Gonzalez-Villalobos R, Klassen RB, Allen PL, Navar LG, Hammond TG: Megalin binds and internalizes angiotensin II. Am J Physiol Renal Physiol 288: F420-F427, 2005 (Pubitemid 40105402)
19. Pan N, Luo J, Kaiser SJ, Frome WL, Dart RA, Tewksbury DA: Specific receptor for angiotensinogen on human renal cells. Clin Chim Acta 373: 32-36, 2006 (Pubitemid 44292170)
20. Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, Nishiyama A, Ichikawa I: Liver angiotensinogen is the primary source of renal angiotensin II. J Am Soc Nephrol 23: 1181-1189, 2012
21. Kobori H, Prieto-Carrasquero MC, Ozawa Y, Navar LG: AT1 receptor mediated augmentation of intrarenal angiotensinogen in angiotensin II-dependent hypertension. Hypertension 43: 1126-1132, 2004 (Pubitemid 38579925)
22. Kobori H, Harrison-Bernard LM, Navar LG: Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension. J Am Soc Nephrol 12: 431-439, 2001 (Pubitemid 32180011)
23. Gonzalez-Villalobos RA, Seth DM, Satou R, Horton H, Ohashi N, Miyata K, Katsurada A, Tran DV, Kobori H, Navar LG: Intrarenal angiotensin II and angiotensinogen augmentation in chronic angiotensin II-infused mice. Am J Physiol Renal Physiol 295: F772-F779, 2008
24. Navar LG, Kobori H, Prieto MC, Gonzalez-Villalobos RA: Intratubular renin-angiotensin system in hypertension. Hypertension 57: 355-362, 2011
25. Christensen EI, Verroust PJ, Nielsen R: Receptor-mediated endocytosis in renal proximal tubule. Pflugers Arch 458: 1039-1048, 2009
26. Biemesderfer D: Regulated intramembrane proteolysis of megalin: Linking urinary protein and gene regulation in proximal tubule? Kidney Int 69: 1717-1721, 2006
27. Christ A, Terryn S, Schmidt V, Christensen EI, Huska MR, Andrade- Navarro MA, Hübner N, Devuyst O, Hammes A, Willnow TE: The soluble intracellular domain of megalin does not affect renal proximal tubular function in vivo. Kidney Int 78: 473-477, 2010
28. Kobori H, Nangaku M, Navar LG, Nishiyama A: The intrarenal reninangiotensin system: From physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev 59: 251-287, 2007 (Pubitemid 47481436)
29. Gonzalez-Villalobos RA, Satou R, Ohashi N, Semprun-Prieto LC, Katsurada A, Kim C, Upchurch GM, Prieto MC, Kobori H, Navar LG: Intrarenal mouse renin-angiotensin system during ANG II-induced hypertension and ACE inhibition. Am J Physiol Renal Physiol 298: F150-F157, 2010
30. Lara LS, McCormack M, Semprum-Prieto LC, Shenouda S, Majid DS, Kobori H, Navar LG, Prieto MC: AT1 receptor-mediated augmentation of angiotensinogen, oxidative stress, and inflammation in ANG II-salt hypertension. Am J Physiol Renal Physiol 302: F85-F94, 2012
31. Ying J, Stuart D, Hillas E, Gociman BR, Ramkumar N, Lalouel JM, Kohan DE: Overexpression of mouse angiotensinogen in renal proximal tubule causes salt-sensitive hypertension in mice. Am J Hypertens 25: 684-689, 2012
32. Tojo A, Onozato ML, Kurihara H, Sakai T, Goto A, Fujita T: Angiotensin II blockade restores albumin reabsorption in the proximal tubules of diabetic rats. Hypertens Res 26: 413-419, 2003 (Pubitemid 36701683)
33. Kobori H, Nishiyama A, Harrison-Bernard LM, Navar LG: Urinary angiotensinogen as an indicator of intrarenal angiotensin status in hypertension. Hypertension 41: 42-49, 2003 (Pubitemid 36056790)
34. Satou R, Miyata K, Gonzalez-Villalobos RA, Ingelfinger JR, Navar LG, Kobori H: Interferon-g biphasically regulates angiotensinogen expression via a JAK-STAT pathway and suppressor of cytokine signaling 1 (SOCS1) in renal proximal tubular cells. FASEB J 26: 1821-1830, 2012
35. Navar LG, Prieto MC, Satou R, Kobori H: Intrarenal angiotensin II and its contribution to the genesis of chronic hypertension. Curr Opin Pharmacol 11: 180-186, 2011