Involvement of glomerular renin2angiotensin system (RAS) activation in the development and progression of glomerular injury

Clinical and Experimental Nephrology

Volumn 16, Issue 2, 2012, Pages 214-220

  Kagami, Shoji ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Angiotensin II; Glomerulosclerosis; Renin Angiotensin system; TGF b; Tissue fibrosis

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN II [3-8]; ANGIOTENSIN III; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUTAMYL AMINOPEPTIDASE; MEMBRANE METALLOENDOPEPTIDASE; MESSENGER RNA; MICROSOMAL AMINOPEPTIDASE; PLATELET DERIVED GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; RENIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ALBUMINURIA; CHRONIC KIDNEY DISEASE; DISEASE COURSE; GLOMERULOPATHY; GLOMERULOSCLEROSIS; HORMONE SYNTHESIS; HUMAN; IMMUNOGLOBULIN A NEPHROPATHY; KIDNEY FAILURE; NONHUMAN; PATHOGENESIS; PROTEIN EXPRESSION; RENAL PROTECTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; GLOMERULUS; KIDNEY DISEASE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANGIOTENSIN II; ANIMALS; DISEASE PROGRESSION; HUMANS; KIDNEY DISEASES; KIDNEY GLOMERULUS; RENIN-ANGIOTENSIN SYSTEM;

EID: 84863722393     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-011-0568-0     Document Type: Review

References (49)

1. Tigerstedt R, Bergman PG. Niere und Kreislauf. Skand Arch Physiol. 1898;8:223-71.
2. Bader M. Tissue renin-Angiotensin-Aldosterone systems: targets for pharmacological therapy. Annu Rev Pharmacol Toxicol. 2010;50:439-65.
3. Dzau VJ. Tissue angiotensin and pathobiology of vascular disease: A unifying hypothesis. Hypertension. 2001;37:1047-52.
4. Bader M, Ganten D. Update on tissue renin-Angiotensin systems. J Mol Med (Berl). 2008;86:615-21.
5. Suzuki Y, Ruiz-Ortega M, Lorenzo O, Ruperez M, Esteban V, Egido J. Inflammation and angiotensin II. Int J Biochem Cell Biol. 2003;35:881-900.
6. Yosypiv IV. Renin-Angiotensin system in ureteric bud branching morphogenesis: insights into the mechanisms. Pediatr Nephrol. 2011;26:1499-512.
7. Kobori H, Nangaku M, Navar LG, Nishiyama A. The intrarenal renin-Angiotensin system: from physiology to the pathobiology of hypertension and kidney disease. Pharmacol Rev. 2007;59: 251-87.
8. Lai KN, Leung JC, Tang SC. The renin-Angiotensin system (diabetes and the kidney). In: Lai KN, Tang SC, editors. Contributions to nephrology. Basel: Karger; 2011. vol. 170, p. 135-44.
9. Warner FJ, Lubel JS, McCaughan GW, Angus PW. Liver fibrosis: A balance of ACEs? Clin Sci (Lond). 2007;113:109-18.
10. Velez JC. The importance of the intrarenal renin-Angiotensin system. Nat Clin Pract Nephrol. 2009;5:89-100.
11. Rüster C, Wolf G. Angiotensin II as a morphogenic cytokine stimulating renal fibrogenesis. J Am Soc Nephrol. 2011;22: 1189-99.
12. Mustafa MR, Dharmani M, Kunheen NK, Sim MK. Effects of des-Aspartate-Angiotensin I on the actions of angiotensin III in the renal and mesenteric vasculature of normo- and hypertensive rats. Regul Pept. 2004;120:15-22.
13. Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci USA. 2003;100:8258-63.
14. Chai SY, Fernando R, Peck G, Ye SY, Mendelsohn FA, Jenkins TA, et al. The angiotensin IV/AT4 receptor. Cell Mol Life Sci. 2004;61:2728-37.
15. Nguyen G, Delarue F, Burcklé C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest. 2002; 109:1417-27.
16. Nguyen G, Muller DN. The biology of the (pro)renin receptor. J Am Soc Nephrol. 2010;21:18-23.
17. Ferrario CM, Varagic J. The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function. Am J Physiol Ren Physiol. 2010;298:F1297-305.
18. Kriz W, LeHir M. Pathways to nephron loss starting from glomerular diseases-insights from animal models. Kidney Int. 2005; 67:404-19.
19. Qian Y, Feldman E, Pennathur S, Kretzler M, Brosius FC 3rd. From fibrosis to sclerosis: mechanisms of glomerulosclerosis in diabetic nephropathy. Diabetes. 2008;57:1439-45.
20. Brenner BM. Remission of renal disease: recounting the challenge, acquiring the goal. J Clin Invest. 2002;110:1753-8.
21. Taal MW, Brenner BM. Renoprotective benefits of RAS inhibition: from ACEI to angiotensin II antagonists. Kidney Int. 2000;57:1803-17.
22. Wühl E, Schaefer F. Therapeutic strategies to slow chronic kidney disease progression. Pediatr Nephrol. 2008;23:705-16.
23. Seikaly MG, Arant BS Jr, Seney FD Jr. Endogenous angiotensin concentrations in specific intrarenal fluid compartments of the rat. J Clin Invest. 1990;86:1352-7.
24. Atiyeh BA, Arant BS Jr, Henrich WL, Seikaly MG. In vitro production of angiotensin II by isolated glomeruli. Am J Physiol. 1995;268(2 Pt 2):F266-72.
25. Lai KN, Leung JC, Lai KB, To WY, Yeung VT, Lai FM. Gene expression of the renin-Angiotensin system in human kidney. J Hypertens. 1998;16:91-102.
26. Del Prete D, Gambaro G, Lupo A, Anglani F, Brezzi B, Magistroni R, Graziotto R, Furci L, Modena F, Bernich P, Albertazzi A, D'Angelo A, Maschio G. Precocious activation of genes of the renin-Angiotensin system and the fibrogenic cascade in IgA glomerulonephritis. Kidney Int. 2003;64:149-59.
27. Ye M, Wysocki J, William J, Soler MJ, Cokic I, Batlle D. Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes. J Am Soc Nephrol. 2006;17:3067-75.
28. Wagner J, Gehlen F, Ciechanowicz A, Ritz E. Angiotensin II receptor type 1 gene expression in human glomerulonephritis and diabetes mellitus. J Am Soc Nephrol. 1999;10:545-51.
29. Suzuki K, Han GD, Miyauchi N, Hashimoto T, Nakatsue T, Fujioka Y, et al. Angiotensin II type 1 and type 2 receptors play opposite roles in regulating the barrier function of kidney glomerular capillary wall. Am J Pathol. 2007;170:1841-53.
30. Takamatsu M, Urushihara M, Kondo S, Shimizu M, Morioka T, Oite T, et al. Glomerular angiotensinogen protein is enhanced in pediatric IgA nephropathy. Pediatr Nephrol. 2008;23:1257-67.
31. Arai M, Wada A, Isaka Y, Akagi Y, Sugiura T, Miyazaki M, et al. In vivo transfection of genes for renin and angiotensinogen into the glomerular cells induced phenotypic change of the mesangial cells and glomerular sclerosis. Biochem Biophys Res Commun. 1995;206:525-32.
32. Shi L, Nikolic D, Liu S, Lu H, Wang S. Activation of renal reninangiotensin system in upstream stimulatory factor 2 transgenic mice. Am J Physiol Ren Physiol. 2009;296:F257-65.
33. Singh R, Singh AK, Leehey DJ. A novel mechanism for angiotensin II formation in streptozotocin-diabetic rat glomeruli. Am J Physiol Ren Physiol. 2005;288:F1183-90.
34. Lee LK, Meyer TW, Pollock AS, Lovett DH. Endothelial cell injury initiates glomerular sclerosis in the rat remnant kidney. J Clin Invest. 1995;96:953-64.
35. Kagami S, Border WA, Miller DE, Noble NA. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest. 1994;93:2431-7.
36. Kagami S, Kuhara T, Okada K, Kuroda Y, Border WA, Noble NA. Dual effects of angiotensin II on the plasminogen/plasmin system in rat mesangial cells. Kidney Int. 1997;51:664-71.
37. Kondo S, Shimizu M, Urushihara M, Tsuchiya K, Yoshizumi M, Tamaki T, et al. Addition of the antioxidant probucol to angiotensin II type I receptor antagonist arrests progressive mesangioproliferative glomerulonephritis in the rat. J Am Soc Nephrol. 2006;17:783-94.
38. Urushihara M, Takamatsu M, Shimizu M, Kondo S, Kinoshita Y, Suga K, et al. ERK5 activation enhances mesangial cell viability and collagen matrix accumulation in rat progressive glomerulonephritis. Am J Physiol Ren Physiol. 2010;298:F167-76.
39. Kinoshita Y, Kondo S, Urushihara M, Suga K, Matsuura S, Takamatsu M, et al. Angiotensin II type I receptor blockade suppresses glomerular renin-Angiotensin system activation, oxidative stress, and progressive glomerular injury in rat antiglomerular basement membrane glomerulonephritis. Transl Res. 2011; 158: 235-248.
40. Nakamura T, Kataoka K, Tokutomi Y, Nako H, Toyama K, Dong YF, et al. Novel mechanism of salt-induced glomerular injury: critical role of eNOS and angiotensin II. J Hypertens. 2011;29: 1528-35.
41. Oudit GY, Herzenberg AM, Kassiri Z, Wong D, Reich H, Khokha R, et al. Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis. Am J Pathol. 2006;168:1808-20.
42. Reich HN, Oudit GY, Penninger JM, Scholey JW, Herzenberg AM. Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int. 2008; 74: 1610-6.
43. Mizuiri S, Hemmi H, Arita M, Aoki T, Ohashi Y, Miyagi M, et al. Increased ACE and decreased ACE2 expression in kidneys from patients with IgA nephropathy. Nephron Clin Pract. 2011;117: c57-66.
44. Velez JC, Ryan KJ, Harbeson CE, Bland AM, Budisavljevic MN, Arthur JM, et al. Angiotensin I is largely converted to angiotensin (1-7) and angiotensin (2-10) by isolated rat glomeruli. Hypertension. 2009;53:790-7.
45. Velez JC, Bland AM, Arthur JM, Raymond JR, Janech MG. Characterization of renin-Angiotensin system enzyme activities in cultured mouse podocytes. Am J Physiol Ren Physiol. 2007;293: F398-407.
46. Velez JC, Janech MG, Arthur JM, Raymond JR. Cultured human glomerular endothelial cells display ACE-mediated angiotensin- II-generating capacity and limited angiotensin-II-degrading activity. Am Soc Nephrol Annual Meeting; 2010 (in abstract).
47. Singh R, Singh AK, Alavi N, Leehey DJ. Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucose. J Am Soc Nephrol. 2003;14:873-80.
48. Cristovam PC, Arnoni CP, de Andrade MC, Casarini DE, Pereira LG, Schor N, et al. ACE-dependent and chymase-dependent angiotensin II generation in normal and glucose-stimulated human mesangial cells. Exp Biol Med. 2008;233:1035-43.
49. Aragão DS, Cunha TS, Arita DY, Andrade MC, Fernandes AB, Watanabe IK, et al. Purification and characterization of angiotensin converting enzyme 2 (ACE2) from murine model of mesangial cell in culture. Int J Biol Macromol. 2011;49:79-84.