Deficiency of phospholipase A2 group 7 decreases intestinal polyposis and colon tumorigenesis in ApcMinl+ mice

Cancer Research

Volumn 73, Issue 9, 2013, Pages 2806-2816

  Xu, Changxin ^a   Reichert, Ethan C ^a   Nakano, Tomoyuki ^a   Lohse, Mariah ^a   Gardner, Alison A ^a   Revelo, Mónica P ^b   Topham, Matthew K ^a,b   Stafforini, Diana M ^a,b  

^a UNIVERSITY OF UTAH   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA ARRESTIN 1; GUANINE NUCLEOTIDE BINDING PROTEIN; PH DOMAIN AND LEUCINE RICH REPEAT PROTEIN PHOSPHATASE 2; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 GROUP VII; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASE B; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR RECEPTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; PLA2G7 PROTEIN, HUMAN; PLA2G7 PROTEIN, MOUSE;

ADENOMATOUS POLYPOSIS COLI GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; COLON CARCINOGENESIS; COLON TUMOR; COMPLEX FORMATION; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GASTROINTESTINAL POLYPOSIS; GENE DELETION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SIGNAL TRANSDUCTION; ALLELE; ANIMAL; C57BL MOUSE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY; MUTATION; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC MOUSE; TUMOR CELL LINE;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ALLELES; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL POLYPOSIS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUTATION; PHOSPHOLIPASES A2; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

MLCS; MLOWN;

EID: 84877742337     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-2374     Document Type: Article

References (50)

1. Cheung AF, Carter AM, Kostova KK, Woodruff JF, Crowley D, Bronson RT, et al. Complete deletion of Apc results in severe polyposis in mice. Oncogene 2011;29:1857-64.
2. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420: 860-7.
3. Rutter M, Saunders B, Wilkinson K, Rumbles S, Schofield G, Kamm M, et al. Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology 2004;126:451-9.
4. Wang H, Chakrabarty S. Platelet-activating factor activates mitogenactivated protein kinases, inhibits proliferation, induces differentiation and suppresses the malignant phenotype of human colon carcinoma cells. Oncogene 2003;22:2186-91.
5. Kume K, Shimizu T. Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. J Biol Chem 1997; 272:22898-904.
6. Honda Z, Ishii S, Shimizu T. Platelet-activating factor receptor. J Biochem 2002;131:773-9.
7. Ishii S, Shimizu T. Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog Lipid Res 2000; 39:41-82.
8. Aponte M, Jiang W, Lakkis M, Li MJ, Edwards D, Albitar L, et al. Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer. Cancer Res 2008;68:5839-48.
9. Longo WE, Polities G, Vernava AM III, Deshpande Y, Niehoff M, Chandel B, et al. Platelet-activating factor mediates trinitrobenzene induced colitis. Prostaglandins Leukot Essent Fatty Acids 1994;51: 419-24.
10. Caplan MS, Kelly A, Hsueh W. Endotoxin and hypoxia-induced intestinal necrosis in rats: the role of platelet activating factor. Pediatr Res 1992;31:428-34.
11. Wallace JL, Steel G, Whittle BJ, Lagente V, Vargaftig B. Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists. Gastroenterology 1987;93:765-73.
12. Lu J, Pierce M, Franklin A, Jilling T, Stafforini DM, Caplan M. Dual roles of endogenous platelet-activating factor acetylhydrolase in a murine model of necrotizing enterocolitis. Pediatr Res 2010;68:225-30.
13. Braeuer RR, Zigler M, Villares GJ, Dobroff AS, Bar-Eli M. Transcriptional control of melanoma metastasis: the importance of the tumor microenvironment. Semin Cancer Biol 2011;21:83-8.
14. Yao Y, Wolverton JE, Zhang Q, Marathe GK, Al-Hassani M, Konger RL, et al. Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species. J Immunol 2009;182:2842-8.
15. Kim HA, Seo KH, Kang YR, Ko HM, Kim KJ, Back HK, et al. Mechanisms of platelet-activating factor-induced enhancement of VEGF expression. Cell Physiol Biochem 2011;27:55-62.
16. Qu X, Huang L, Burthart T, Crawford SE, Caplan MS, Hsueh W. Endotoxin induces PAF production in the rat ileum: quantitation of tissue PAF by an improved method. Prostaglandins 1996;51:249-62.
17. Claud EC, Lu J, Wang XQ, Abe M, Petrof EO, Sun J, et al. Plateletactivating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2008;294:G1191-200.
18. Tan XD, Chang H, Qu XW, Caplan M, Gonzalez-Crussi F, Hsueh W. Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin. Br J Pharmacol 2000;129:1522-9.
19. Parker MA, Bazan HE, Marcheselli V, Rodriguez de Turco EB, Bazan NG. Platelet-activating factor induces permeability transition and cytochrome c release in isolated brain mitochondria. J Neurosci Res 2002;69:39-50.
20. Wu B, Iwakiri R, Ootani A, Fujise T, Tsunada S, Fujimoto K. Plateletactivating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. Faseb J 2003;17:1156-8.
21. Denizot Y, Gainant A, Guglielmi L, Bouvier S, Cubertafond P, Mathonnet M. Tissue concentrations of platelet-activating factor in colorectal carcinoma: inverse relationships with Dukes' stage of patients. Oncogene 2003;22:7222-4.
22. Denizot Y, Truffinet V, Bouvier S, Gainant A, Cubertafond P, Mathonnet M. Elevated plasma phospholipase A2 and platelet-activating factor acetylhydrolase activity in colorectal cancer. Mediators Inflamm 2004;13:53-4.
23. Denizot Y, Descottes B, Truffinet V, Valleix D, Labrousse F, Mathonnet M. Platelet-activating factor and liver metastasis of colorectal cancer. Int J Cancer 2005;113:503-5.
24. McMurray HR, Sampson ER, Compitello G, Kinsey C, Newman L, Smith B, et al. Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype. Nature 2008;453:1112-6.
25. Taketo MM. Mouse models of gastrointestinal tumors. Cancer Sci 2006;97:355-61.
26. Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science 1992;256:668-70.
27. Al-Salihi MA, Terrece Pearman A, Doan T, Reichert EC, Rosenberg DW, Prescott SM, et al. Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression. Cancer Lett 2009;273:225-32.
28. Blank ML, Lee T, Fitzgerald V, Snyder F. A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid). J Biol Chem 1981;256:175-8.
29. Lu J, Caplan MS, Li D, Jilling T. Polyunsaturated fatty acids block platelet-activating factor-induced phosphatidylinositol 3 kinase/Aktmediated apoptosis in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2008;294:G1181-90.
30. Zhang XP, Hintze TH. cAMP signal transduction induces eNOS activation by promoting PKB phosphorylation. Am J Physiol Heart Circ Physiol 2006;290:H2376-84.
31. Chen Z, Rola-Pleszczynski M, Stankova J. Activation of ERK1/2 by platelet-activating factor receptor is independent of receptor internalisation and G-protein activation. Cell Signal 2003;15:843-50.
32. Rocher G, Letourneux C, Lenormand P, Porteu F. Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity. J Biol Chem 2007; 282:5468-77.
33. Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell 2005;18:13-24.
34. McCluskey A, Sakoff JA. Small molecule inhibitors of serine/threonine protein phosphatases. Mini Rev Med Chem 2001;1:43-55.
35. Grady EF. Cell signaling. Beta-arrestin, a two-fisted terminator. Science 2007;315:605-6.
36. DeFea KA. Beta-arrestins as regulators of signal termination and transduction: how do they determine what to scaffold? Cell Signal 23:621-9.
37. Lefkowitz RJ, Shenoy SK. Transduction of receptor signals by betaarrestins. Science 2005;308:512-7.
38. Chen Z, Dupre DJ, Le Gouill C, Rola-Pleszczynski M, Stankova J. Agonist-induced internalization of the platelet-activating factor receptor is dependent on arrestins but independent of G-protein activation. Role of the C terminus and the (D/N)PXXY motif. J Biol Chem 2002;277:7356-62.
39. Uhlen M, Oksvold P, Fagerberg L, Lundberg E, Jonasson K, Forsberg M, et al. Towards a knowledge-based Human Protein Atlas. Nat Biotechnol 2010;28:1248-50.
40. Cormier RT, Hong KH, Halberg RB, Hawkins TL, Richardson P, Mulherkar R, et al. Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet 1997;17:88-91.
41. Belinsky GS, Rajan TV, Saria EA, Giardina C, Rosenberg DW. Expression of secretory phospholipase A2 in colon tumor cells potentiates tumor growth. Mol Carcinog 2007;46:106-16.
42. Kennedy BP, Payette P, Mudgett J, Vadas P, Pruzanski W, Kwan M, et al. A natural disruption of the secretory group II phospholipase A2 gene in inbred mouse strains. J Biol Chem 1995;270:22378-85.
43. Burke JE, Dennis EA. Phospholipase A2 structure/function, mechanism, and signaling. J Lipid Res 2009;50 Suppl:S237-42.
44. Vainio P, Lehtinen L, Mirtti T, Hilvo M, Seppanen-Laakso T, Virtanen J, et al. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Oncotarget 2011;2:1176-90.
45. Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 2004;118:229-41.
46. Keely S, Glover LE, Weissmueller T, MacManus CF, Fillon S, Fennimore B, et al. Hypoxia-inducible factor-dependent regulation of platelet- activating factor receptor as a route for gram-positive bacterial translocation across epithelia. Mol Biol Cell 2010;21:538-46.
47. Jilling T, Lu J, Jackson M, Caplan MS. Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis. Pediatr Res 2004;55:622-9.
48. Ahamed J, Ali H. Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. J Biol Chem 2002;277:22685-91.
49. Beaulieu JM, Sotnikova TD, Marion S, Lefkowitz RJ, Gainetdinov RR, Caron MG. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell 2005;122: 261-73.
50. Liu J, Weiss HL, Rychahou P, Jackson LN, Evers BM, Gao T. Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. Oncogene 2009;28:994-1004.