메뉴 건너뛰기




Volumn 45, Issue 6, 2013, Pages 1273-1292

Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: A systematic review of randomized trials

Author keywords

Beta hydroxy beta methylbutyrate; Cachexia; Muscle atrophy; Proteolytic pathways; Training

Indexed keywords

2 OXOISOCAPROIC ACID; AMINO ACID DERIVATIVE; ARGININE; ASCORBIC ACID; BETA HYDROXY BETA METHYLBUTYRATE; C REACTIVE PROTEIN; CARBOHYDRATE; COLLAGEN; CREATINE; GLUCOSE; GLYCINE; HYDROXYPROLINE; LEUCINE; LYSINE; PLACEBO; SUGAR; TAURINE; UNCLASSIFIED DRUG; BETA-HYDROXYISOVALERIC ACID; VALERIC ACID DERIVATIVE;

EID: 84890446916     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-013-1592-z     Document Type: Review
Times cited : (80)

References (71)
  • 1
    • 79960090926 scopus 로고    scopus 로고
    • Exercise-induced muscle damage is not attenuated by maximuscle β-hydroxy-β-methylbutyrate-1000™ supplementation
    • 10.1519/JSC.0b013e3181f7c3a8
    • Abumrad NN, Rathmacher JA (2011) Exercise-induced muscle damage is not attenuated by maximuscle β-hydroxy-β-methylbutyrate-1000™ supplementation. J Stren Cond Res 25:1-2
    • (2011) J Stren Cond Res , vol.25 , pp. 1-2
    • Abumrad, N.N.1    Rathmacher, J.A.2
  • 2
    • 79952026816 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia
    • 1:CAS:528:DC%2BC3MXjsFWntrs%3D
    • Aversa Z, Bonetto A, Costelli P et al (2011) Beta-hydroxy-beta- methylbutyrate (HMB) attenuates muscle and body weight loss in experimental cancer cachexia. Int J Onc 38:713-720
    • (2011) Int J Onc , vol.38 , pp. 713-720
    • Aversa, Z.1    Bonetto, A.2    Costelli, P.3
  • 3
    • 84863844871 scopus 로고    scopus 로고
    • β-hydroxy-β-methylbutyrate (hmb) prevents dexamethasone-induced myotube atrophy
    • 22705301 10.1016/j.bbrc.2012.06.029 1:CAS:528:DC%2BC38XpvVOlt7o%3D
    • Aversa Z, Alamdari N, Castillero E et al (2012) β-hydroxy-β- methylbutyrate (hmb) prevents dexamethasone-induced myotube atrophy. Biochem Biophys Res Commun 423:739-743
    • (2012) Biochem Biophys Res Commun , vol.423 , pp. 739-743
    • Aversa, Z.1    Alamdari, N.2    Castillero, E.3
  • 4
    • 60349095217 scopus 로고    scopus 로고
    • Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), l-arginine, and l-lysine
    • 10.1177/0148607108322403 1:CAS:528:DC%2BD1MXitl2qsbk%3D
    • Baier S, Johannsen D, Abumrad N et al (2009) Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of beta-hydroxy-beta-methylbutyrate (HMB), l-arginine, and l-lysine. JPEN J Parenter Enter Nutr 33:71-82
    • (2009) JPEN J Parenter Enter Nutr , vol.33 , pp. 71-82
    • Baier, S.1    Johannsen, D.2    Abumrad, N.3
  • 5
    • 51649122773 scopus 로고    scopus 로고
    • RTOG. A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122)
    • 10.1007/s00520-008-0403-7
    • Berk L, James J, Schwartz A et al (2008) RTOG. A randomized, double-blind, placebo-controlled trial of a beta-hydroxyl beta-methyl butyrate, glutamine, and arginine mixture for the treatment of cancer cachexia (RTOG 0122). Supp Care Can 16:1179-1188
    • (2008) Supp Care Can , vol.16 , pp. 1179-1188
    • Berk, L.1    James, J.2    Schwartz, A.3
  • 6
    • 79953772897 scopus 로고    scopus 로고
    • The effects of an amino acid supplement on glucose homeostasis, inflammatory markers, and incretins after laparoscopic gastric bypass
    • 21463799 10.1016/j.jamcollsurg.2010.12.040
    • Breitman I, Saraf N, Kakade M et al (2011) The effects of an amino acid supplement on glucose homeostasis, inflammatory markers, and incretins after laparoscopic gastric bypass. J Am Coll Surg 212:617-625
    • (2011) J Am Coll Surg , vol.212 , pp. 617-625
    • Breitman, I.1    Saraf, N.2    Kakade, M.3
  • 7
    • 0033817572 scopus 로고    scopus 로고
    • Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: A randomized, double-blind, placebo-controlled study
    • 10.1177/0148607100024003133 1:CAS:528:DC%2BD3cXlvFGmtrs%3D
    • Clark RH, Feleke G, Din M et al (2000) Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. JPEN J Parenter Enter Nutr 24:133-139
    • (2000) JPEN J Parenter Enter Nutr , vol.24 , pp. 133-139
    • Clark, R.H.1    Feleke, G.2    Din, M.3
  • 8
    • 79954441250 scopus 로고    scopus 로고
    • Nutritional effect of oral supplement enriched in beta-hydroxy-beta- methylbutyrate, glutamine and arginine on resting metabolic rate after laparoscopic gastric bypass
    • 20953883 10.1007/s00464-010-1371-9
    • Clements RH, Saraf N, Kakade M et al (2011) Nutritional effect of oral supplement enriched in beta-hydroxy-beta-methylbutyrate, glutamine and arginine on resting metabolic rate after laparoscopic gastric bypass. Surg Endosc 25:1376-1382
    • (2011) Surg Endosc , vol.25 , pp. 1376-1382
    • Clements, R.H.1    Saraf, N.2    Kakade, M.3
  • 9
    • 0038198795 scopus 로고    scopus 로고
    • The effects of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on indices of health in highly trained athletes
    • 1:CAS:528:DC%2BD3sXlsVemtrY%3D
    • Crowe MJ, O'Connor DM, Lukins JE (2003) The effects of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on indices of health in highly trained athletes. Int J Sport Nutr Exer Metab 13:184-197
    • (2003) Int J Sport Nutr Exer Metab , vol.13 , pp. 184-197
    • Crowe, M.J.1    O'Connor, D.M.2    Lukins, J.E.3
  • 10
    • 35148898785 scopus 로고    scopus 로고
    • Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli
    • 17609254 10.1152/ajpendo.00314.2007 1:CAS:528:DC%2BD2sXht1WltbjK
    • Eley HL, Russell ST, Baxter JH et al (2007) Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am J Physiol Endocrinol Metab 293:E923-E931
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Eley, H.L.1    Russell, S.T.2    Baxter, J.H.3
  • 11
    • 57349163257 scopus 로고    scopus 로고
    • Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by beta-hydroxy-beta-methylbutyrate
    • 18854427 10.1152/ajpendo.90530.2008 1:CAS:528:DC%2BD1cXhsFWgtb%2FM
    • Eley HL, Russell ST, Tisdale MJ (2008a) Attenuation of depression of muscle protein synthesis induced by lipopolysaccharide, tumor necrosis factor, and angiotensin II by beta-hydroxy-beta-methylbutyrate. Am J Physiol Endocrinol Metab 295:E1409-E1416
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Eley, H.L.1    Russell, S.T.2    Tisdale, M.J.3
  • 12
    • 57349098717 scopus 로고    scopus 로고
    • Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-alpha and angiotensin II by beta-hydroxy-beta-methylbutyrate
    • 18840762 10.1152/ajpendo.90567.2008 1:CAS:528:DC%2BD1cXhsFWgtb%2FN
    • Eley HL, Russell ST, Tisdale MJ (2008b) Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-alpha and angiotensin II by beta-hydroxy-beta-methylbutyrate. Am J Physiol Endocrinol Metab 295:E1417-E1426
    • (2008) Am J Physiol Endocrinol Metab , vol.295
    • Eley, H.L.1    Russell, S.T.2    Tisdale, M.J.3
  • 13
    • 16544394413 scopus 로고    scopus 로고
    • Effect of beta-hydroxy-beta-methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women
    • 15105032 10.1016/j.nut.2004.01.009 1:CAS:528:DC%2BD2cXjsVeltL8%3D
    • Flakoll P, Sharp R, Baier S et al (2004) Effect of beta-hydroxy-beta- methylbutyrate, arginine, and lysine supplementation on strength, functionality, body composition, and protein metabolism in elderly women. Nutrition 20:445-451
    • (2004) Nutrition , vol.20 , pp. 445-451
    • Flakoll, P.1    Sharp, R.2    Baier, S.3
  • 14
    • 0026729002 scopus 로고
    • Role of leucine and other amino acids in regulating protein metabolism in vivo
    • 1616025 1:CAS:528:DyaK38XltVyksLs%3D
    • Frexes-Steed M, Lacy DB, Collins J et al (1992) Role of leucine and other amino acids in regulating protein metabolism in vivo. Am J Physiol 262:E925-E935
    • (1992) Am J Physiol , vol.262
    • Frexes-Steed, M.1    Lacy, D.B.2    Collins, J.3
  • 15
    • 79951680457 scopus 로고    scopus 로고
    • Free acid gel form of β-hydroxy-β-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt
    • 21134325 10.1017/S0007114510003582 1:CAS:528:DC%2BC3MXpvV2ksw%3D%3D
    • Fuller JC Jr, Sharp RL, Angus HF et al (2011a) Free acid gel form of β-hydroxy-β-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt. Br J Nutr 105:367-372
    • (2011) Br J Nutr , vol.105 , pp. 367-372
    • Fuller Jr., J.C.1    Sharp, R.L.2    Angus, H.F.3
  • 16
    • 80455129283 scopus 로고    scopus 로고
    • Vitamin D status affects strength gains in older adults supplemented with a combination of β-hydroxy-β-methylbutyrate, arginine, and lysine: A cohort study
    • 10.1177/0148607111413903 1:CAS:528:DC%2BC3MXhs1Sns7vL
    • Fuller JC, Baier S, Flakoll P et al (2011b) Vitamin D status affects strength gains in older adults supplemented with a combination of β-hydroxy-β-methylbutyrate, arginine, and lysine: a cohort study. JPEN J Parenter Enter Nutr 35:757-762
    • (2011) JPEN J Parenter Enter Nutr , vol.35 , pp. 757-762
    • Fuller, J.C.1    Baier, S.2    Flakoll, P.3
  • 17
    • 0033674307 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methylbutyrate ingestion, part I: Effects on strength and fat free mass
    • 11128859 10.1097/00005768-200012000-00022 1:CAS:528: DC%2BD3MXhtlGhsA%3D%3D
    • Gallagher PM, Carrithers JA, Godard MP et al (2000a) Beta-hydroxy-beta- methylbutyrate ingestion, part I: effects on strength and fat free mass. Med Sci Sports Exerc 32:2109-2115
    • (2000) Med Sci Sports Exerc , vol.32 , pp. 2109-2115
    • Gallagher, P.M.1    Carrithers, J.A.2    Godard, M.P.3
  • 18
    • 0033664168 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methylbutyrate ingestion, part II: Effects on hematology, hepatic and renal function
    • 11128860 10.1097/00005768-200012000-00023 1:CAS:528: DC%2BD3MXhtlGhsQ%3D%3D
    • Gallagher PM, Carrithers JA, Godard MP et al (2000b) Beta-hydroxy-beta- methylbutyrate ingestion, part II: effects on hematology, hepatic and renal function. Med Sci Sports Exerc 32:2116-2119
    • (2000) Med Sci Sports Exerc , vol.32 , pp. 2116-2119
    • Gallagher, P.M.1    Carrithers, J.A.2    Godard, M.P.3
  • 19
    • 79955469592 scopus 로고    scopus 로고
    • Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats
    • 10.1016/j.ghir.2010.12.006 1:CAS:528:DC%2BC3MXlsFamtbk%3D
    • Gerlinger-Romero F, Guimarães-Ferreira L, Giannocco G et al (2011) Chronic supplementation of beta-hydroxy-beta methylbutyrate (HMβ) increases the activity of the GH/IGF-I axis and induces hyperinsulinemia in rats. Grow Horm IGF Res 21:57-62
    • (2011) Grow Horm IGF Res , vol.21 , pp. 57-62
    • Gerlinger-Romero, F.1    Guimarães-Ferreira, L.2    Giannocco, G.3
  • 20
    • 80052417248 scopus 로고    scopus 로고
    • β-hydroxy-β-methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats
    • 10.1152/ajpregu.00840.2010 1:CAS:528:DC%2BC3MXht1SkurbM
    • Hao Y, Jackson JR, Wang Y et al (2011) β-hydroxy-β- methylbutyrate reduces myonuclear apoptosis during recovery from hind limb suspension-induced muscle fiber atrophy in aged rats. Am J Physiol Reg Integ Comp Physiol 301:R701-R715
    • (2011) Am J Physiol Reg Integ Comp Physiol , vol.301
    • Hao, Y.1    Jackson, J.R.2    Wang, Y.3
  • 21
    • 10344240458 scopus 로고    scopus 로고
    • Effects of beta-hydroxy beta-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity training
    • Hoffman JR, Cooper J, Wendell M et al (2004) Effects of beta-hydroxy beta-methylbutyrate on power performance and indices of muscle damage and stress during high-intensity training. J Stren Cond Res 18:747-752
    • (2004) J Stren Cond Res , vol.18 , pp. 747-752
    • Hoffman, J.R.1    Cooper, J.2    Wendell, M.3
  • 22
    • 58149199535 scopus 로고    scopus 로고
    • Effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues
    • 19056452 10.1016/j.fct.2008.11.021 1:CAS:528:DC%2BD1MXksVehsA%3D%3D
    • Holecek M, Muthny T, Kovarik M et al (2009) Effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues. Food Chem Toxicol 47:255-259
    • (2009) Food Chem Toxicol , vol.47 , pp. 255-259
    • Holecek, M.1    Muthny, T.2    Kovarik, M.3
  • 23
    • 33845387898 scopus 로고    scopus 로고
    • Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit
    • 17077073 1:CAS:528:DC%2BD2sXls1Gntw%3D%3D
    • Hsieh LC, Chien SL, Huang MS et al (2006) Anti-inflammatory and anticatabolic effects of short-term beta-hydroxy-beta-methylbutyrate supplementation on chronic obstructive pulmonary disease patients in intensive care unit. Asia Pac J Clin Nutr 15:544-550
    • (2006) Asia Pac J Clin Nutr , vol.15 , pp. 544-550
    • Hsieh, L.C.1    Chien, S.L.2    Huang, M.S.3
  • 24
    • 77955065134 scopus 로고    scopus 로고
    • Effect of beta-hydroxy-beta-methylbutyrate on protein metabolism in bed-ridden elderly receiving tube feeding
    • 20460233 1:CAS:528:DC%2BC3cXovVKhtb0%3D
    • Hsieh LC, Chow CJ, Chang WC et al (2010) Effect of beta-hydroxy-beta- methylbutyrate on protein metabolism in bed-ridden elderly receiving tube feeding. Asia Pac J Clin Nutr 19:200-208
    • (2010) Asia Pac J Clin Nutr , vol.19 , pp. 200-208
    • Hsieh, L.C.1    Chow, C.J.2    Chang, W.C.3
  • 25
    • 0034930037 scopus 로고    scopus 로고
    • Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program
    • 11448573 10.1016/S0899-9007(01)00540-8
    • Jówko E, Ostaszewski P, Jank M et al (2001) Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program. Nutrition 17:558-566
    • (2001) Nutrition , vol.17 , pp. 558-566
    • Jówko, E.1    Ostaszewski, P.2    Jank, M.3
  • 26
    • 0033781846 scopus 로고    scopus 로고
    • Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run
    • 11007567 1:CAS:528:DC%2BD3cXotlyltbg%3D
    • Knitter AE, Panton L, Rathmacher JA et al (2000) Effects of beta-hydroxy-beta-methylbutyrate on muscle damage after a prolonged run. J Appl Physiol 89:1340-1344
    • (2000) J Appl Physiol , vol.89 , pp. 1340-1344
    • Knitter, A.E.1    Panton, L.2    Rathmacher, J.A.3
  • 27
    • 67349278470 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3 K/Akt pathways
    • 19211028 10.1016/j.bbamcr.2008.12.017 1:CAS:528:DC%2BD1MXmtVCjsrc%3D
    • Kornasio R, Riederer I, Butler-Browne G et al (2009) Beta-hydroxy-beta- methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3 K/Akt pathways. Biochim Biophys Acta 1793:755-763
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 755-763
    • Kornasio, R.1    Riederer, I.2    Butler-Browne, G.3
  • 28
    • 78650172783 scopus 로고    scopus 로고
    • Effects of β-hydroxy-β-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats
    • 20725872 10.1007/s13105-010-0037-3 1:CAS:528:DC%2BC3cXhtlKhtbvP
    • Kovarik M, Muthny T, Sispera L et al (2010) Effects of β-hydroxy-β-methylbutyrate treatment in different types of skeletal muscle of intact and septic rats. J Physiol Biochem 66:311-319
    • (2010) J Physiol Biochem , vol.66 , pp. 311-319
    • Kovarik, M.1    Muthny, T.2    Sispera, L.3
  • 29
    • 67650046943 scopus 로고    scopus 로고
    • Effects of amino acids supplement on physiological adaptations to resistance training
    • 19346975 10.1249/MSS.0b013e318194cc75 1:CAS:528:DC%2BD1MXntFyqt7Y%3D
    • Kraemer WJ, Hatfield DL, Volek JS et al (2009) Effects of amino acids supplement on physiological adaptations to resistance training. Med Sci Sports Exerc 41:1111-1121
    • (2009) Med Sci Sports Exerc , vol.41 , pp. 1111-1121
    • Kraemer, W.J.1    Hatfield, D.L.2    Volek, J.S.3
  • 30
    • 0032736421 scopus 로고    scopus 로고
    • Effects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strength
    • 10606212 10.1055/s-1999-8835 1:CAS:528:DyaK1MXnvVyhtbs%3D
    • Kreider RB, Ferreira M, Wilson M et al (1999) Effects of calcium beta-hydroxy-beta-methylbutyrate (HMB) supplementation during resistance-training on markers of catabolism, body composition and strength. Int J Sports Med 20:503-509
    • (1999) Int J Sports Med , vol.20 , pp. 503-509
    • Kreider, R.B.1    Ferreira, M.2    Wilson, M.3
  • 31
    • 84862248713 scopus 로고    scopus 로고
    • Bax/Bcl-2 protein expression ratio and leukocyte function are related to reduction of walker-256 tumor growth after β-hydroxy-β-methylbutyrate (HMB) administration in wistar rats
    • 10.1080/01635581.2012.647229 1:CAS:528:DC%2BC38XisFWrsr4%3D
    • Kuczera D, Paro de Oliveira HH, Fonseca Guimarães Fde S et al (2012) Bax/Bcl-2 protein expression ratio and leukocyte function are related to reduction of walker-256 tumor growth after β-hydroxy-β-methylbutyrate (HMB) administration in wistar rats. Nutr Can 64:286-293
    • (2012) Nutr Can , vol.64 , pp. 286-293
    • Kuczera, D.1    Paro De Oliveira, H.H.2    Fonseca Guimarães Fde, S.3
  • 32
    • 33846214753 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methylbutyrate supplementation in critically ill trauma patients
    • 17215743 10.1097/TA.0b013e31802dca93 1:CAS:528:DC%2BD2sXhvVWqtLY%3D
    • Kuhls DA, Rathmacher JA, Musngi MD et al (2007) Beta-hydroxy-beta- methylbutyrate supplementation in critically ill trauma patients. J Trauma 62:125-132
    • (2007) J Trauma , vol.62 , pp. 125-132
    • Kuhls, D.A.1    Rathmacher, J.A.2    Musngi, M.D.3
  • 33
    • 34249697009 scopus 로고    scopus 로고
    • Effects of beta-hydroxy-beta-methylbutyrate on aerobic-performance components and body composition in college students
    • 1:CAS:528:DC%2BD2sXjsFeks7Y%3D
    • Lamboley CR, Royer D, Dionne IJ (2007) Effects of beta-hydroxy-beta- methylbutyrate on aerobic-performance components and body composition in college students. Int J Sport Nut Exer Metab 17:56-69
    • (2007) Int J Sport Nut Exer Metab , vol.17 , pp. 56-69
    • Lamboley, C.R.1    Royer, D.2    Dionne, I.J.3
  • 34
    • 18744371554 scopus 로고    scopus 로고
    • Dietary treatment of rheumatoid cachexia with beta-hydroxy-beta- methylbutyrate, glutamine and arginine: A randomised controlled trial
    • 15896432 10.1016/j.clnu.2005.01.006 1:CAS:528:DC%2BD2MXkt1CkurY%3D
    • Marcora S, Lemmey A, Maddison P (2005) Dietary treatment of rheumatoid cachexia with beta-hydroxy-beta-methylbutyrate, glutamine and arginine: a randomised controlled trial. Clin Nutr 24:442-454
    • (2005) Clin Nutr , vol.24 , pp. 442-454
    • Marcora, S.1    Lemmey, A.2    Maddison, P.3
  • 35
    • 0036227772 scopus 로고    scopus 로고
    • Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine
    • 11975938 10.1016/S0002-9610(02)00823-1 1:CAS:528:DC%2BD38XivF2rtL8%3D
    • May PE, Barber A, D'Olimpio JT et al (2002) Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta- methylbutyrate, arginine, and glutamine. Am J Surg 183:471-479
    • (2002) Am J Surg , vol.183 , pp. 471-479
    • May, P.E.1    Barber, A.2    D'Olimpio, J.T.3
  • 36
    • 0030740694 scopus 로고    scopus 로고
    • Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB)
    • 10.1016/S0955-2863(97)00048-X 1:CAS:528:DyaK2sXkslCjtrw%3D
    • Nissen SL, Abumrad NN (1997) Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB). J Nutr Biochem 8:300-311
    • (1997) J Nutr Biochem , vol.8 , pp. 300-311
    • Nissen, S.L.1    Abumrad, N.N.2
  • 37
    • 0029807071 scopus 로고    scopus 로고
    • Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training
    • 8941534 1:CAS:528:DyaK2sXjs1KqsA%3D%3D
    • Nissen S, Sharp R, Ray M et al (1996) Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol 81:2095-2104
    • (1996) J Appl Physiol , vol.81 , pp. 2095-2104
    • Nissen, S.1    Sharp, R.2    Ray, M.3
  • 38
    • 0033934852 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors
    • 10917905 1:CAS:528:DC%2BD3cXltl2hu7c%3D
    • Nissen S, Sharp RL, Panton L et al (2000) Beta-hydroxy-beta- methylbutyrate (HMB) supplementation in humans is safe and may decrease cardiovascular risk factors. J Nutr 130:1937-1945
    • (2000) J Nutr , vol.130 , pp. 1937-1945
    • Nissen, S.1    Sharp, R.L.2    Panton, L.3
  • 39
    • 77950614121 scopus 로고    scopus 로고
    • Exercise-induced muscle damage is not attenuated by beta-hydroxy-beta- methylbutyrate and alpha-ketoisocaproic acid supplementation
    • 10.1519/JSC.0b013e3181c4d370
    • Nunan D, Howatson G, van Someren KA (2010) Exercise-induced muscle damage is not attenuated by beta-hydroxy-beta-methylbutyrate and alpha-ketoisocaproic acid supplementation. J Stren Cond Res 24:531-537
    • (2010) J Stren Cond Res , vol.24 , pp. 531-537
    • Nunan, D.1    Howatson, G.2    Van Someren, K.A.3
  • 40
    • 44949245770 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in walker 256 tumor-bearing rats by modifying nuclear factor-kappaB expression
    • 19083450 10.1016/j.nutres.2008.04.006 1:CAS:528:DC%2BD1cXnt1Kqtrc%3D
    • Nunes EA, Kuczera D, Brito GA et al (2008) Beta-hydroxy-beta- methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in walker 256 tumor-bearing rats by modifying nuclear factor-kappaB expression. Nutr Res 28:487-493
    • (2008) Nutr Res , vol.28 , pp. 487-493
    • Nunes, E.A.1    Kuczera, D.2    Brito, G.A.3
  • 41
    • 78649976047 scopus 로고    scopus 로고
    • β-hydroxy-β-methylbutyrate modifies human peripheral blood mononuclear cell proliferation and cytokine production in vitro
    • 20541366 10.1016/j.nut.2009.12.008 1:CAS:528:DC%2BC3cXhsFCqtrjN
    • Nunes EA, Lomax AR, Noakes PS et al (2011) β-hydroxy-β- methylbutyrate modifies human peripheral blood mononuclear cell proliferation and cytokine production in vitro. Nutrition 27:92-99
    • (2011) Nutrition , vol.27 , pp. 92-99
    • Nunes, E.A.1    Lomax, A.R.2    Noakes, P.S.3
  • 42
    • 0037367543 scopus 로고    scopus 로고
    • Effects of beta-hydroxy-beta-methylbutyrate and creatine monohydrate supplementation on the aerobic and anaerobic capacity of highly trained athletes
    • O'Connor DM, Crowe MJ (2003) Effects of beta-hydroxy-beta-methylbutyrate and creatine monohydrate supplementation on the aerobic and anaerobic capacity of highly trained athletes. J Sports Med Phys Fit 43:64-68
    • (2003) J Sports Med Phys Fit , vol.43 , pp. 64-68
    • O'Connor, D.M.1    Crowe, M.J.2
  • 43
    • 34250823538 scopus 로고    scopus 로고
    • Effects of 6 weeks of beta-hydroxy-beta-methylbutyrate (HMB) and HMB/creatine supplementation on strength, power, and anthropometry of highly trained athletes
    • O'Connor DM, Crowe MJ (2007) Effects of 6 weeks of beta-hydroxy-beta- methylbutyrate (HMB) and HMB/creatine supplementation on strength, power, and anthropometry of highly trained athletes. J Stren Cond Res 21:419-423
    • (2007) J Stren Cond Res , vol.21 , pp. 419-423
    • O'Connor, D.M.1    Crowe, M.J.2
  • 44
    • 0035670865 scopus 로고    scopus 로고
    • Short-term beta-hydroxy-beta-methylbutyrate supplementation does not reduce symptoms of eccentric muscle damage
    • 1:CAS:528:DC%2BD38Xns1OrsA%3D%3D
    • Paddon-Jones D, Keech A, Jenkins D (2001) Short-term beta-hydroxy-beta- methylbutyrate supplementation does not reduce symptoms of eccentric muscle damage. Int J Sport Nut Exer Metab 11:442-450
    • (2001) Int J Sport Nut Exer Metab , vol.11 , pp. 442-450
    • Paddon-Jones, D.1    Keech, A.2    Jenkins, D.3
  • 45
    • 0033832198 scopus 로고    scopus 로고
    • Nutritional supplementation of the leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) during resistance training
    • 10978853 10.1016/S0899-9007(00)00376-2 1:CAS:528:DC%2BD3cXmt1aju78%3D
    • Panton LB, Rathmacher JA, Baier S et al (2000) Nutritional supplementation of the leucine metabolite beta-hydroxy-beta-methylbutyrate (HMB) during resistance training. Nutrition 16:734-739
    • (2000) Nutrition , vol.16 , pp. 734-739
    • Panton, L.B.1    Rathmacher, J.A.2    Baier, S.3
  • 46
    • 79951851521 scopus 로고    scopus 로고
    • β-hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway
    • 10.1186/1743-7075-8-11 1:CAS:528:DC%2BC3MXjslKnu7Y%3D
    • Pimentel GD, Rosa JC, Lira FS et al (2011) β-hydroxy-β- methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway. Nutr Metab 8:11
    • (2011) Nutr Metab , vol.8 , pp. 11
    • Pimentel, G.D.1    Rosa, J.C.2    Lira, F.S.3
  • 47
    • 84864678197 scopus 로고    scopus 로고
    • Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscle
    • 22075640 10.1007/s00421-011-2224-5 1:CAS:528:DC%2BC38XosFCku7w%3D
    • Pinheiro CH, Gerlinger-Romero F, Guimarães-Ferreira L et al (2012) Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscle. Eur J Appl Physiol 112:2531-2537
    • (2012) Eur J Appl Physiol , vol.112 , pp. 2531-2537
    • Pinheiro, C.H.1    Gerlinger-Romero, F.2    Guimarães-Ferreira, L.3
  • 48
    • 77956538059 scopus 로고    scopus 로고
    • Effect of HMB supplementation on body composition, fitness, hormonal profile and muscle damage indices
    • 20857835 1:CAS:528:DC%2BC3cXhtFahsbjF
    • Portal S, Eliakim A, Nemet D et al (2010) Effect of HMB supplementation on body composition, fitness, hormonal profile and muscle damage indices. J Pediatr Endocrinol Metab 23:641-650
    • (2010) J Pediatr Endocrinol Metab , vol.23 , pp. 641-650
    • Portal, S.1    Eliakim, A.2    Nemet, D.3
  • 49
    • 80053900683 scopus 로고    scopus 로고
    • The effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: A prospective randomized, double-blind, placebo-controlled study
    • 21327797 10.1007/s00421-011-1855-x 1:CAS:528:DC%2BC3MXht1Krs7fE
    • Portal S, Zadik Z, Rabinowitz J et al (2011) The effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: a prospective randomized, double-blind, placebo-controlled study. Eur J Appl Physiol 111:2261-2269
    • (2011) Eur J Appl Physiol , vol.111 , pp. 2261-2269
    • Portal, S.1    Zadik, Z.2    Rabinowitz, J.3
  • 50
    • 0037295258 scopus 로고    scopus 로고
    • The effect of beta-hydroxy beta-methylbutyrate on muscular strength and body composition in collegiate football players
    • Ransone J, Neighbors K, Lefavi R et al (2003) The effect of beta-hydroxy beta-methylbutyrate on muscular strength and body composition in collegiate football players. J Stren Cond Res 17:34-39
    • (2003) J Stren Cond Res , vol.17 , pp. 34-39
    • Ransone, J.1    Neighbors, K.2    Lefavi, R.3
  • 51
    • 1642375575 scopus 로고    scopus 로고
    • Supplementation with a combination of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parameters
    • 10.1177/014860710402800265 1:CAS:528:DC%2BD2cXnvVOktbw%3D
    • Rathmacher JA, Nissen S, Panton L et al (2004) Supplementation with a combination of beta-hydroxy-beta-methylbutyrate (HMB), arginine, and glutamine is safe and could improve hematological parameters. JPEN J Parenter Enter Nutr 28:65-75
    • (2004) JPEN J Parenter Enter Nutr , vol.28 , pp. 65-75
    • Rathmacher, J.A.1    Nissen, S.2    Panton, L.3
  • 52
    • 73349134003 scopus 로고    scopus 로고
    • Mechanism of attenuation by beta-hydroxy-beta-methylbutyrate of muscle protein degradation induced by lipopolysaccharide
    • 19404720 10.1007/s11010-009-0130-5 1:CAS:528:DC%2BD1MXhtlCqurjP
    • Russell ST, Tisdale MJ (2009) Mechanism of attenuation by beta-hydroxy-beta-methylbutyrate of muscle protein degradation induced by lipopolysaccharide. Mol Cell Biochem 330:171-179
    • (2009) Mol Cell Biochem , vol.330 , pp. 171-179
    • Russell, S.T.1    Tisdale, M.J.2
  • 53
    • 33747068292 scopus 로고    scopus 로고
    • Nutrition modulation of cachexia/proteolysis
    • 10.1177/0115426506021002155
    • Siddiqui R, Pandya D, Harvey K et al (2006) Nutrition modulation of cachexia/proteolysis. Nut Clin Prac 21:155-167
    • (2006) Nut Clin Prac , vol.21 , pp. 155-167
    • Siddiqui, R.1    Pandya, D.2    Harvey, K.3
  • 54
    • 0034035611 scopus 로고    scopus 로고
    • Beta-hydroxy beta-methylbutyrate (HMB) supplementation does not influence the urinary testosterone: Epitestosterone ratio in healthy males
    • 10839231 10.1016/S1440-2440(00)80050-X 1:STN:280:DC%2BD3cvhvFSitg%3D%3D
    • Slater GJ, Logan PA, Boston T et al (2000) Beta-hydroxy beta-methylbutyrate (HMB) supplementation does not influence the urinary testosterone: epitestosterone ratio in healthy males. J Sci Med Sport 3:79-83
    • (2000) J Sci Med Sport , vol.3 , pp. 79-83
    • Slater, G.J.1    Logan, P.A.2    Boston, T.3
  • 55
    • 0034821985 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men
    • 1:CAS:528:DC%2BD3MXnt1Gjtrc%3D
    • Slater G, Jenkins D, Logan P et al (2001) Beta-hydroxy-beta- methylbutyrate (HMB) supplementation does not affect changes in strength or body composition during resistance training in trained men. Int J Sport Nut Exer Metab 11:384-396
    • (2001) Int J Sport Nut Exer Metab , vol.11 , pp. 384-396
    • Slater, G.1    Jenkins, D.2    Logan, P.3
  • 56
    • 9244227105 scopus 로고    scopus 로고
    • Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by beta-hydroxy-beta-methylbutyrate
    • 10.1158/0008-5472.CAN-04-1760 1:CAS:528:DC%2BD2cXhtVCjs7vM
    • Smith HJ, Wyke SM, Tisdale MJ (2004) Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by beta-hydroxy-beta-methylbutyrate. Can Res 64:8731-8735
    • (2004) Can Res , vol.64 , pp. 8731-8735
    • Smith, H.J.1    Wyke, S.M.2    Tisdale, M.J.3
  • 57
    • 11244259394 scopus 로고    scopus 로고
    • Attenuation of proteasome-induced proteolysis in skeletal muscle by (beta)-hydroxy-(beta)-methylbutyrate in cancer-induced muscle loss
    • 10.1158/0008-5472.CAN-05-0169 1:CAS:528:DC%2BD2MXhvFamtg%3D%3D
    • Smith HJ, Mukerji P, Tisdale MJ (2005) Attenuation of proteasome-induced proteolysis in skeletal muscle by (beta)-hydroxy-(beta)-methylbutyrate in cancer-induced muscle loss. Can Res 65:277-283
    • (2005) Can Res , vol.65 , pp. 277-283
    • Smith, H.J.1    Mukerji, P.2    Tisdale, M.J.3
  • 58
    • 0030049206 scopus 로고    scopus 로고
    • Calcium beta-hydroxy-beta-methylbutyrate 1. Potential role as a phosphate binder in uremia: In vitro study
    • 8852485 10.1159/000188901 1:CAS:528:DyaK28Xit1ChurY%3D
    • Sousa MF, Abumrad NN, Martins C et al (1996) Calcium beta-hydroxy-beta- methylbutyrate 1. Potential role as a phosphate binder in uremia: in vitro study. Nephron 72:391-394
    • (1996) Nephron , vol.72 , pp. 391-394
    • Sousa, M.F.1    Abumrad, N.N.2    Martins, C.3
  • 59
    • 68049137820 scopus 로고    scopus 로고
    • Effects of 9 weeks of beta-hydroxy-beta-methylbutyrate supplementation on strength and body composition in resistance trained men
    • 10.1519/JSC.0b013e3181a00d47
    • Thomson JS, Watson PE, Rowlands DS (2009) Effects of 9 weeks of beta-hydroxy-beta-methylbutyrate supplementation on strength and body composition in resistance trained men. J Stren Cond Res 23:827-835
    • (2009) J Stren Cond Res , vol.23 , pp. 827-835
    • Thomson, J.S.1    Watson, P.E.2    Rowlands, D.S.3
  • 60
    • 0026605461 scopus 로고
    • Oxidation of leucine and alpha-ketoisocaproate to beta-hydroxy-beta methylbutyrate in vivo
    • 1733247
    • Van Koevering M, Nissen S (1992) Oxidation of leucine and alpha-ketoisocaproate to beta-hydroxy-beta methylbutyrate in vivo. Am J Physiol 262:E27-E31
    • (1992) Am J Physiol , vol.262
    • Van Koevering, M.1    Nissen, S.2
  • 61
    • 24644448212 scopus 로고    scopus 로고
    • Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man
    • van Someren KA, Edwards AJ, Howatson G (2005) Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man. Int J Sport Nut Exer Metab 15:413-424
    • (2005) Int J Sport Nut Exer Metab , vol.15 , pp. 413-424
    • Van Someren, K.A.1    Edwards, A.J.2    Howatson, G.3
  • 62
    • 33750215167 scopus 로고    scopus 로고
    • Mechanisms of skeletal muscle atrophy
    • 17053511 10.1097/01.bor.0000245731.25383.de 1:CAS:528:DC%2BD28XhtV2rs77M
    • Ventadour S, Attaix D (2006) Mechanisms of skeletal muscle atrophy. Curr Opin Rheumatol 18:631-635
    • (2006) Curr Opin Rheumatol , vol.18 , pp. 631-635
    • Ventadour, S.1    Attaix, D.2
  • 63
    • 0035515574 scopus 로고    scopus 로고
    • Effect of beta-hydroxy beta-methylbutyrate on the onset of blood lactate accumulation and V(O)(2) peak in endurance-trained cyclists
    • 1:STN:280:DC%2BD38%2FivVOitg%3D%3D
    • Vukovich MD, Dreifort GD (2001) Effect of beta-hydroxy beta-methylbutyrate on the onset of blood lactate accumulation and V(O)(2) peak in endurance-trained cyclists. J Stren Cond Res 15:491-497
    • (2001) J Stren Cond Res , vol.15 , pp. 491-497
    • Vukovich, M.D.1    Dreifort, G.D.2
  • 64
    • 0034767552 scopus 로고    scopus 로고
    • Beta-hydroxy-beta-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans
    • 12031256 10.1016/S0955-2863(01)00182-6 1:CAS:528:DC%2BD3MXnslWqsLw%3D
    • Vukovich MD, Slater G, Macchi MB et al (2001a) Beta-hydroxy-beta- methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans. J Nutr Biochem 12:631-639
    • (2001) J Nutr Biochem , vol.12 , pp. 631-639
    • Vukovich, M.D.1    Slater, G.2    Macchi, M.B.3
  • 65
    • 0034942611 scopus 로고    scopus 로고
    • Body composition in 70-year-old adults responds to dietary beta-hydroxy-beta-methylbutyrate similarly to that of young adults
    • 11435528 1:CAS:528:DC%2BD3MXlt1amsrY%3D
    • Vukovich MD, Stubbs NB, Bohlken RM (2001b) Body composition in 70-year-old adults responds to dietary beta-hydroxy-beta-methylbutyrate similarly to that of young adults. J Nutr 131:2049-2052
    • (2001) J Nutr , vol.131 , pp. 2049-2052
    • Vukovich, M.D.1    Stubbs, N.B.2    Bohlken, R.M.3
  • 66
    • 0036724734 scopus 로고    scopus 로고
    • Effect of a specialized amino acid mixture on human collagen deposition
    • 12192323 10.1097/00000658-200209000-00013
    • Williams JZ, Abumrad N, Barbul A (2002) Effect of a specialized amino acid mixture on human collagen deposition. Ann Surg 236:369-375
    • (2002) Ann Surg , vol.236 , pp. 369-375
    • Williams, J.Z.1    Abumrad, N.2    Barbul, A.3
  • 67
    • 39449139944 scopus 로고    scopus 로고
    • Effects of beta-hydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review
    • 10.1186/1743-7075-5-1
    • Wilson GJ, Wilson JM, Manninen AH (2008) Effects of beta-hydroxy-beta- methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: a review. Nut Metab 5:1-17
    • (2008) Nut Metab , vol.5 , pp. 1-17
    • Wilson, G.J.1    Wilson, J.M.2    Manninen, A.H.3
  • 68
    • 60849090756 scopus 로고    scopus 로고
    • Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage
    • 10.1186/1743-7075-6-1
    • Wilson JM, Kim JS, Lee SR et al (2009) Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage. Nut Metab 6:1-8
    • (2009) Nut Metab , vol.6 , pp. 1-8
    • Wilson, J.M.1    Kim, J.S.2    Lee, S.R.3
  • 69
    • 84873526592 scopus 로고    scopus 로고
    • β-hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men
    • Wilson JM, Lowery RP, Joy JM et al (2013) β-hydroxy-β- methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men. Br J Nutr 3:1-7
    • (2013) Br J Nutr , vol.3 , pp. 1-7
    • Wilson, J.M.1    Lowery, R.P.2    Joy, J.M.3
  • 70
    • 48349086611 scopus 로고    scopus 로고
    • Potential antiproteolytic effects of l-leucine: Observations of in vitro and in vivo studies
    • 10.1186/1743-7075-5-20
    • Zanchi NE, Nicastro H, Lancha AH Jr (2008) Potential antiproteolytic effects of l-leucine: observations of in vitro and in vivo studies. Nut Metab 5:20
    • (2008) Nut Metab , vol.5 , pp. 20
    • Zanchi, N.E.1    Nicastro, H.2    Lancha Jr., A.H.3
  • 71
    • 79954445776 scopus 로고    scopus 로고
    • HMB supplementation: Clinical and athletic performance-related effects and mechanisms of action
    • 20607321 10.1007/s00726-010-0678-0
    • Zanchi NE, Gerlinger-Romero F, Guimarães-Ferreira L et al (2010) HMB supplementation: clinical and athletic performance-related effects and mechanisms of action. Amino Acids 40:1015-1025
    • (2010) Amino Acids , vol.40 , pp. 1015-1025
    • Zanchi, N.E.1    Gerlinger-Romero, F.2    Guimarães-Ferreira, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.