메뉴 건너뛰기




Volumn 110, Issue 3, 2013, Pages 538-544

β-Hydroxy-β-methylbutyrate free acid reduces markers of exercise-induced muscle damage and improves recovery in resistance-trained men

Author keywords

Hydroxy methylbutyrate free acid; Hormones; Muscle damage; Recovery

Indexed keywords

3 METHYLHISTIDINE; BETA HYDROXY BETA METHYLBUTRATE; BUTYRIC ACID DERIVATIVE; C REACTIVE PROTEIN; CREATINE KINASE; HYDROCORTISONE; PLACEBO; TESTOSTERONE; UNCLASSIFIED DRUG;

EID: 84873526592     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114512005387     Document Type: Article
Times cited : (57)

References (40)
  • 1
    • 0033793052 scopus 로고    scopus 로고
    • Skeletal muscle regeneration and the mitotic clock
    • Renault V, Piron-Hamelin G, Forestier C, et al. (2000) Skeletal muscle regeneration and the mitotic clock. Exp Gerontol 35, 711-719.
    • (2000) Exp Gerontol , vol.35 , pp. 711-719
    • Renault, V.1    Piron-Hamelin, G.2    Forestier, C.3
  • 2
    • 0023202327 scopus 로고
    • Regenerating skeletal muscle cells express insulin-like growth factor i
    • Jennische E & Hansson HA (1987) Regenerating skeletal muscle cells express insulin-like growth factor I. Acta Physiol Scand 130, 327-332.
    • (1987) Acta Physiol Scand , vol.130 , pp. 327-332
    • Jennische, E.1    Hansson, H.A.2
  • 3
    • 73449107531 scopus 로고    scopus 로고
    • MTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms
    • Ge Y, Wu AL, Warnes C, et al. (2009) mTOR regulates skeletal muscle regeneration in vivo through kinase-dependent and kinase-independent mechanisms. Am J Physiol Cell Physiol 297, C1434-C1444.
    • (2009) Am J Physiol Cell Physiol , vol.297
    • Ge, Y.1    Wu, A.L.2    Warnes, C.3
  • 4
    • 0031711596 scopus 로고    scopus 로고
    • Strength training. Single versus multiple sets
    • Carpinelli RN & Otto RM (1998) Strength training. Single versus multiple sets. Sports Med [Review] 26, 73-84.
    • (1998) Sports Med [Review] , vol.26 , pp. 73-84
    • Carpinelli, R.N.1    Otto, R.M.2
  • 5
    • 0033674307 scopus 로고    scopus 로고
    • Betahydroxy-beta-methylbutyrate ingestion, part I: Effects on strength and fat free mass
    • Gallagher PM, Carrithers JA, Godard MP, et al. (2000) Betahydroxy-beta-methylbutyrate ingestion, part I: effects on strength and fat free mass. Med Sci Sports Exerc 32, 2109-2115.
    • (2000) Med Sci Sports Exerc , vol.32 , pp. 2109-2115
    • Gallagher, P.M.1    Carrithers, J.A.2    Godard, M.P.3
  • 6
    • 0034930037 scopus 로고    scopus 로고
    • Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program
    • Jowko E, Ostaszewski P, Jank M, et al. (2001) Creatine and beta-hydroxy-beta-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program. Nutrition 17, 558-566.
    • (2001) Nutrition , vol.17 , pp. 558-566
    • Jowko, E.1    Ostaszewski, P.2    Jank, M.3
  • 7
    • 0029807071 scopus 로고    scopus 로고
    • Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training
    • Nissen S, Sharp R, Ray M, et al. (1996) Effect of leucine metabolite beta-hydroxy-beta-methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol 81, 2095-2104.
    • (1996) J Appl Physiol , vol.81 , pp. 2095-2104
    • Nissen, S.1    Sharp, R.2    Ray, M.3
  • 8
    • 67650046943 scopus 로고    scopus 로고
    • Effects of amino acids supplement on physiological adaptations to resistance training
    • Kraemer WJ, Hatfield DL, Volek JS, et al. (2009) Effects of amino acids supplement on physiological adaptations to resistance training. Med Sci Sports Exerc 41, 1111-1121.
    • (2009) Med Sci Sports Exerc , vol.41 , pp. 1111-1121
    • Kraemer, W.J.1    Hatfield, D.L.2    Volek, J.S.3
  • 9
    • 32444435321 scopus 로고    scopus 로고
    • Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise
    • Norton LE & Layman DK (2006) Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise. J Nutr 136, 533S-537S.
    • (2006) J Nutr , vol.136
    • Norton, L.E.1    Layman, D.K.2
  • 10
    • 25144519685 scopus 로고    scopus 로고
    • Dietary toxicity of calcium beta-hydroxy-beta-methyl butyrate (CaHMB)
    • Baxter JH, Carlos JL, Thurmond J, et al. (2005) Dietary toxicity of calcium beta-hydroxy-beta-methyl butyrate (CaHMB). Food Chem Toxicol 43, 1731-1741.
    • (2005) Food Chem Toxicol , vol.43 , pp. 1731-1741
    • Baxter, J.H.1    Carlos, J.L.2    Thurmond, J.3
  • 11
    • 11244259394 scopus 로고    scopus 로고
    • Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}-methylbutyrate in cancer-induced muscle loss
    • Smith HJ, Mukerji P & Tisdale MJ (2005) Attenuation of proteasome-induced proteolysis in skeletal muscle by {beta}-hydroxy-{beta}- methylbutyrate in cancer-induced muscle loss. Cancer Res 65, 277-283.
    • (2005) Cancer Res , vol.65 , pp. 277-283
    • Smith, H.J.1    Mukerji, P.2    Tisdale, M.J.3
  • 12
    • 9244227105 scopus 로고    scopus 로고
    • Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by beta-hydroxy-beta-methylbutyrate
    • Smith HJ, Wyke SM & Tisdale MJ (2004) Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by beta-hydroxy-beta-methylbutyrate. Cancer Res 64, 8731-8735.
    • (2004) Cancer Res , vol.64 , pp. 8731-8735
    • Smith, H.J.1    Wyke, S.M.2    Tisdale, M.J.3
  • 13
    • 0030593939 scopus 로고    scopus 로고
    • Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway
    • Mitch WE & Goldberg AL (1996) Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N Eng J Med 335, 1897-1905.
    • (1996) N Eng J Med , vol.335 , pp. 1897-1905
    • Mitch, W.E.1    Goldberg, A.L.2
  • 14
    • 0033832198 scopus 로고    scopus 로고
    • Nutritional supplementation of the leucine metabolite beta-hydroxybeta-methylbutyrate (HMB) during resistance training
    • Panton LB, Rathmacher JA, Baier S, et al. (2000) Nutritional supplementation of the leucine metabolite beta-hydroxybeta-methylbutyrate (HMB) during resistance training. Nutrition 16, 734-739.
    • (2000) Nutrition , vol.16 , pp. 734-739
    • Panton, L.B.1    Rathmacher, J.A.2    Baier, S.3
  • 15
    • 39449095102 scopus 로고    scopus 로고
    • Effects of dietary b-hydroxy-b-methylbutyrate on body composition in collegiate football players
    • [Abstract]
    • Neighbors KL, Ransone JW, Jacobson BH, et al. (2000) Effects of dietary b-hydroxy-b-methylbutyrate on body composition in collegiate football players. Med Sci Sports Exerc [Abstract] 32, S60.
    • (2000) Med Sci Sports Exerc , vol.32
    • Neighbors, K.L.1    Ransone, J.W.2    Jacobson, B.H.3
  • 16
    • 60849090756 scopus 로고    scopus 로고
    • Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage
    • Wilson JM, Kim JS, Lee SR, et al. (2009) Acute and timing effects of beta-hydroxy-beta-methylbutyrate (HMB) on indirect markers of skeletal muscle damage. Nutr Metab 6, 6.
    • (2009) Nutr Metab , vol.6 , pp. 6
    • Wilson, J.M.1    Kim, J.S.2    Lee, S.R.3
  • 17
    • 39449139944 scopus 로고    scopus 로고
    • Effects of betahydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: A review
    • Wilson GJ, Wilson JM & Manninen AH (2008) Effects of betahydroxy-beta-methylbutyrate (HMB) on exercise performance and body composition across varying levels of age, sex, and training experience: a review. Nutr Metab (Lond) 5, 1.
    • (2008) Nutr Metab (Lond) , vol.5 , pp. 1
    • Wilson, G.J.1    Wilson, J.M.2    Manninen, A.H.3
  • 18
    • 79951680457 scopus 로고    scopus 로고
    • Free acid gel form of beta-hydroxy-beta-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt
    • Fuller JC Jr, Sharp RL, Angus HF, et al. (2011) Free acid gel form of beta-hydroxy-beta-methylbutyrate (HMB) improves HMB clearance from plasma in human subjects compared with the calcium HMB salt. Br J Nutr 105, 367-372.
    • (2011) Br J Nutr , vol.105 , pp. 367-372
    • Fuller Jr., J.C.1    Sharp, R.L.2    Angus, H.F.3
  • 19
    • 33644794580 scopus 로고    scopus 로고
    • Changes in the force development characteristics of muscle following repeated maximum force and power exercise
    • Gilbert G & Lees A (2005) Changes in the force development characteristics of muscle following repeated maximum force and power exercise. Ergonomics 48, 1576-1584.
    • (2005) Ergonomics , vol.48 , pp. 1576-1584
    • Gilbert, G.1    Lees, A.2
  • 20
    • 0026954068 scopus 로고
    • Gas chromatographic/mass spectrometric analysis of stable isotopes of 3-methylhistidine in biological fluids: Application to plasma kinetics in vivo
    • Rathmacher JA, Link GA, Flakoll PJ, et al. (1992) Gas chromatographic/mass spectrometric analysis of stable isotopes of 3-methylhistidine in biological fluids: application to plasma kinetics in vivo. Biol Mass Spectrom 21, 560-566.
    • (1992) Biol Mass Spectrom , vol.21 , pp. 560-566
    • Rathmacher, J.A.1    Link, G.A.2    Flakoll, P.J.3
  • 22
    • 24644448212 scopus 로고    scopus 로고
    • Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man
    • van Someren KA, Edwards AJ & Howatson G (2005) Supplementation with beta-hydroxy-beta-methylbutyrate (HMB) and alpha-ketoisocaproic acid (KIC) reduces signs and symptoms of exercise-induced muscle damage in man. Int J Sport Nutr Exerc Metab 15, 413-424.
    • (2005) Int J Sport Nutr Exerc Metab , vol.15 , pp. 413-424
    • Van Someren, K.A.1    Edwards, A.J.2    Howatson, G.3
  • 23
    • 0031688209 scopus 로고    scopus 로고
    • Overtraining and recovery. A conceptual model
    • Kentta G & Hassmen P (1998) Overtraining and recovery. A conceptual model. Sports Med [Review] 26, 1-16.
    • (1998) Sports Med [Review] , vol.26 , pp. 1-16
    • Kentta, G.1    Hassmen, P.2
  • 24
    • 0036155430 scopus 로고    scopus 로고
    • The scientific basis for high-intensity interval training: Optimising training programmes and maximising performance in highly trained endurance athletes
    • Laursen PB & Jenkins DG (2002) The scientific basis for high-intensity interval training: optimising training programmes and maximising performance in highly trained endurance athletes. Sports Med [Review] 32, 53-73.
    • (2002) Sports Med [Review] , vol.32 , pp. 53-73
    • Laursen, P.B.1    Jenkins, D.G.2
  • 25
    • 79953905660 scopus 로고    scopus 로고
    • A practical approach to monitoring recovery: Development of a perceived recovery status scale
    • Laurent CM, Green JM, Bishop PA, et al. (2011) A practical approach to monitoring recovery: development of a perceived recovery status scale. J Strength Cond Res 25, 620-628.
    • (2011) J Strength Cond Res , vol.25 , pp. 620-628
    • Laurent, C.M.1    Green, J.M.2    Bishop, P.A.3
  • 26
    • 0018200306 scopus 로고
    • Ntau-methylhistidine (3-methylhistidine) and muscle protein turnover: An overview
    • Young VR & Munro HN (1978) Ntau-methylhistidine (3-methylhistidine) and muscle protein turnover: an overview. Fed Proc 37, 2291-2300.
    • (1978) Fed Proc , vol.37 , pp. 2291-2300
    • Young, V.R.1    Munro, H.N.2
  • 27
    • 0018123239 scopus 로고
    • Urinary excretion of N-gamma-methylihistidine (3-methylihistidine): A tool to study metabolic responses in relation to nutrient and hormonal status in health and disease of man
    • Munro HN & Young VR (1978) Urinary excretion of N-gamma- methylihistidine (3-methylihistidine): a tool to study metabolic responses in relation to nutrient and hormonal status in health and disease of man. Am J Clin Nutr 31, 1608-1614.
    • (1978) Am J Clin Nutr , vol.31 , pp. 1608-1614
    • Munro, H.N.1    Young, V.R.2
  • 28
    • 0019378737 scopus 로고
    • Clinical usefulness of urinary 3-methylhistidine excretion in indicating muscle protein breakdown
    • Elia M, Carter A, Bacon S, et al. (1981) Clinical usefulness of urinary 3-methylhistidine excretion in indicating muscle protein breakdown. Br Med J 282, 351-354.
    • (1981) Br Med J , vol.282 , pp. 351-354
    • Elia, M.1    Carter, A.2    Bacon, S.3
  • 29
    • 73949131768 scopus 로고    scopus 로고
    • Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors
    • West DW, Burd NA, Tang JE, et al. (2010) Elevations in ostensibly anabolic hormones with resistance exercise enhance neither training-induced muscle hypertrophy nor strength of the elbow flexors. J Appl Physiol 108, 60-67.
    • (2010) J Appl Physiol , vol.108 , pp. 60-67
    • West, D.W.1    Burd, N.A.2    Tang, J.E.3
  • 30
    • 80053923985 scopus 로고    scopus 로고
    • Physiological elevation of endogenous hormones results in superior strength training adaptation
    • Ronnestad BR, Nygaard H & Raastad T (2011) Physiological elevation of endogenous hormones results in superior strength training adaptation. Eur J Appl Physiol 111, 2249-2259.
    • (2011) Eur J Appl Physiol , vol.111 , pp. 2249-2259
    • Ronnestad, B.R.1    Nygaard, H.2    Raastad, T.3
  • 31
    • 0024238952 scopus 로고
    • Neuromuscular and hormonal adaptations in athletes to strength training in two years
    • Hakkinen K, Pakarinen A, Alen M, et al. (1988) Neuromuscular and hormonal adaptations in athletes to strength training in two years. J Appl Physiol 65, 2406-2412.
    • (1988) J Appl Physiol , vol.65 , pp. 2406-2412
    • Hakkinen, K.1    Pakarinen, A.2    Alen, M.3
  • 32
    • 0021916370 scopus 로고
    • Serum hormones during prolonged training of neuromuscular performance
    • Hakkinen K, Pakarinen A, Alen M, et al. (1985) Serum hormones during prolonged training of neuromuscular performance. Eur J Appl Physiol Occup Physiol 53, 287-293.
    • (1985) Eur J Appl Physiol Occup Physiol , vol.53 , pp. 287-293
    • Hakkinen, K.1    Pakarinen, A.2    Alen, M.3
  • 33
    • 50949129836 scopus 로고    scopus 로고
    • Significant strength gains observed in rugby players after specific resistance exercise protocols based on individual salivary testosterone responses
    • Beaven CM, Cook CJ & Gill ND (2008) Significant strength gains observed in rugby players after specific resistance exercise protocols based on individual salivary testosterone responses. J Strength Cond Res 22, 419-425.
    • (2008) J Strength Cond Res , vol.22 , pp. 419-425
    • Beaven, C.M.1    Cook, C.J.2    Gill, N.D.3
  • 34
    • 80052719303 scopus 로고    scopus 로고
    • Salivary hormone and immune responses to three resistance exercise schemes in elite female athletes
    • Nunes JA, Crewther BT, Ugrinowitsch C, et al. (2011) Salivary hormone and immune responses to three resistance exercise schemes in elite female athletes. J Strength Cond Res 25, 2322-2327.
    • (2011) J Strength Cond Res , vol.25 , pp. 2322-2327
    • Nunes, J.A.1    Crewther, B.T.2    Ugrinowitsch, C.3
  • 35
    • 81355163681 scopus 로고    scopus 로고
    • Acute response of plasma markers of bone turnover to a single bout of resistance training or plyometrics
    • Rogers RS, Dawson AW, Wang Z, et al. (2011) Acute response of plasma markers of bone turnover to a single bout of resistance training or plyometrics. J Appl Physiol 111, 1353-1360.
    • (2011) J Appl Physiol , vol.111 , pp. 1353-1360
    • Rogers, R.S.1    Dawson, A.W.2    Wang, Z.3
  • 36
    • 84880780417 scopus 로고    scopus 로고
    • Adrenal cortical responses to high intensity, short rest, resistance exercise in men and women
    • (Epublication ahead of print version 3 May 2012)
    • Szivak TK, Hooper DR, Kupchak BK, et al. (2012) Adrenal cortical responses to high intensity, short rest, resistance exercise in men and women. J Strength Cond Res (Epublication ahead of print version 3 May 2012).
    • (2012) J Strength Cond Res
    • Szivak, T.K.1    Hooper, D.R.2    Kupchak, B.K.3
  • 37
    • 28844485607 scopus 로고    scopus 로고
    • Effects of eccentric exercise-induced muscle injury on blood levels of platelet activating factor (PAF) and other inflammatory markers
    • Milias GA, Nomikos T, Fragopoulou E, et al. (2005) Effects of eccentric exercise-induced muscle injury on blood levels of platelet activating factor (PAF) and other inflammatory markers. Eur J Appl Physiol 95, 504-513.
    • (2005) Eur J Appl Physiol , vol.95 , pp. 504-513
    • Milias, G.A.1    Nomikos, T.2    Fragopoulou, E.3
  • 38
    • 2442661489 scopus 로고    scopus 로고
    • Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running
    • Malm C, Sjodin TL, Sjoberg B, et al. (2004) Leukocytes, cytokines, growth factors and hormones in human skeletal muscle and blood after uphill or downhill running. J Physiol 556, 983-1000.
    • (2004) J Physiol , vol.556 , pp. 983-1000
    • Malm, C.1    Sjodin, T.L.2    Sjoberg, B.3
  • 39
    • 40149100803 scopus 로고    scopus 로고
    • Hormone and recovery responses to resistance exercise with slow movement
    • Goto K, Takahashi K, Yamamoto M, et al. (2008) Hormone and recovery responses to resistance exercise with slow movement. J Physiol Sci 58, 7-14.
    • (2008) J Physiol Sci , vol.58 , pp. 7-14
    • Goto, K.1    Takahashi, K.2    Yamamoto, M.3
  • 40
    • 84865125794 scopus 로고    scopus 로고
    • Exercise-induced muscle damage and inflammation: Re-evaluation by proteomics
    • Malm C & Yu JG (2012) Exercise-induced muscle damage and inflammation: re-evaluation by proteomics. Histochem Cell Biol 138, 89-99.
    • (2012) Histochem Cell Biol , vol.138 , pp. 89-99
    • Malm, C.1    Yu, J.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.