Mechanism of attenuation of muscle protein degradation induced by tumor necrosis factor-α and angiotensin II by β-hydroxy-β- methylbutyrate

American Journal of Physiology - Endocrinology and Metabolism

Volumn 295, Issue 6, 2008, Pages

  Eley, Helen L ^a   Russell, Steven T ^a   Tisdale, Michael J ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Caspase; Double stranded RNA dependent protein kinase; Reactive oxygen species

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANGIOTENSIN II; BETA HYDROXY BETA METHYLBUTYRATE; BUTYRIC ACID DERIVATIVE; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 8; CASPASE 8 INHIBITOR; ENZYME VARIANT; GAMMA INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MUSCLE PROTEIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PROTEASOME; PROTEIN KINASE R; REACTIVE OXYGEN METABOLITE; ROTENONE; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; MOUSE; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; WILD TYPE;

ANGIOTENSIN II; ANIMALS; CASPASE 3; CASPASE 8; CELLS, CULTURED; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; IMIDAZOLES; INTERFERON-GAMMA; METABOLIC NETWORKS AND PATHWAYS; MICE; MODELS, BIOLOGICAL; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCULAR ATROPHY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENYLALANINE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PYRIDINES; REACTIVE OXYGEN SPECIES; TUMOR NECROSIS FACTOR-ALPHA; VALERATES;

EID: 57349098717     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.90567.2008     Document Type: Article

References (37)

1. Adigun AQ, Ajayi AA. The effects of enalapril-digoxin-diuretic combination therapy on nutritional and anthropometric indices in congestive heart failure: preliminary findings in cardiac cachexia. Eur J Heart Fail 3: 359-363, 2001.
2. Bar-Shai M, Reznick AZ. Reactive nitrogen species induce nuclear factor-κB-mediated protein degradation in skeletal muscle cells. Free Radic Biol Med 40: 2112-2125, 2006.
3. Buck M, Chojkier M. Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants. EMBO J 15: 1753-1765, 1996.
4. Clark RH, Feleke G, Din M, Yasmin T, Singh G, Khan FA, Rathmacher JA. Nutritional treatment for acquired immunodeficiency virus-associated wasting using β-hydroxy-β-methylbutyrate, glutamine and arginine: a randomised, double-blind, placebo-controlled study. JPEN J Parenter Enteral Nutr 24: 133-139, 2000.
5. Cuenda A, Rouse J, Doza YN, Meirer R, Cohen P, Gallagher TF, Young PR, Lee JC. SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364: 229-233, 1995.
6. Di Marco S, Mazroui R, Dallaire P, Chittur S, Tenebaum SA, Radzioch D, Marette A, Gallouzi IE. NF-κB-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Mol Cell Biol 25: 6533-6545, 2005.
7. Du J, Wang X, Miereles C, Bailey JL, Debigare R, Zheng B, Price SR, Mitch WE. Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions. J Clin Invest 113: 115-123, 2004.
8. Eley HL, Russell ST, Baxter JH, Mukerji P, Tisdale MJ. Signaling pathways initiated by β-hydroxy-β-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am J Physiol Endocrinol Metab 293: E923-E931, 2007.
9. Eley HL, Russell ST, Tisdale MJ. Effect of branched-chain amino acids on muscle atrophy on cancer cachexia. Biochem J 407: 113-120, 2007.
10. Eley HL, Tisdale MJ. Skeletal muscle atrophy. A link between depression of protein synthesis and increase in degradation. J Biol Chem 282: 7087-7097, 2007.
11. Evans W. Functional and metabolic consequences of sarcopenia. J Nutr 127: 998S-1003S, 1997.
12. 2-M checkpoint in response to oxidative stress. J Biol Chem 277: 26729-26732, 2002.
13. Gomes-Marcondes MCC, Tisdale MJ. Induction of protein catabolism and the ubiquitin-proteasome pathway by mild oxidative stress. Cancer Lett 180: 69-74, 2002.
14. 2 and PDGF in mesangial cells. Am J Physiol Renal Physiol 282: F485-F491, 2002.
15. Khal J, Hine AV, Fearon KCH, Dejong CHC, Tisdale MJ. Increased expression of proteasome subunits in skeletal muscle of cancer patients with weight loss. Int J Biochem Cell Biol 37: 2196-2206, 2005.
16. Lawler JM, Song W, Demaree SR. Hindlimb unloading increases oxidative stress and disrupts antioxidant capacity in skeletal muscle. Free Radic Biol Med 35: 9-16, 2003.
17. Li YP, Chen Y, John J, Moylan J, Jin B, Mann DL, Reid MB. TNF-α acts via p38MAPK to stimulate expression of the ubiquitin ligase atrogin 1/MAFbx in skeletal muscle. FASEB J 19: 362-370, 2005.
18. Li YP, Reid MB. NF-κB mediates the protein loss induces by TNF-α in differentiated skeletal muscle myotubes. Am J Physiol Regul Integr Comp Physiol 279: R1165-R1170, 2000.
19. Li YP, Schwartz RJ, Waddell ID, Holloway BR, Reid MB. Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-κB activation in response to tumor necrosis factor α. FASEB J 12: 871-880, 1998.
20. May PE, Barber A, D'Olimpio JT, Hourichane A, Abumrad NN. Reversal of cancer-related wasting using oral supplementation with a combination of β-hydroxy-β-methylbutyrate, arginine and glutamine. Am J Surg 183: 471-479, 2002.
21. Merforth S, Omers A, Dahlmann B. Alterations of proteasome activities in skeletal muscle tissue of diabetic rats. Mol Biol Rep 26: 83- 87, 1999.
22. Mitch WE, Medina R, Grieber S, May RC, England BK, Price SR, Bailey JL, Goldberg AL. Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes. J Clin Invest 93: 2127-2133, 1994.
23. Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, Huang TT, Epstein CJ, Roberts LJ 2nd, Csete M, Faulkner JA, Van Remmen H. Absence of CuZn superoxide dismutase leads to elevated stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic Biol Med 40: 1993-2004, 2006.
24. Powers SK, Kavazis AN, DeRuisseau KC. Mechanism of disuse atrophy: role of oxidative stress. Am J Physiol Regul Integr Comp Physiol 288: R337-R344, 2005.
25. Pueyo ME, Arnal JF, Rami J, Michel JB. Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells. Am J Physiol Cell Physiol 274: C214-C220, 1998.
26. Russell ST, Eley HL, Tisdale MJ. Role of reactive oxygen species in protein degradation in murine myotubes induced by proteolysis-inducing factor and angiotensin II. Cell Signal 19: 1797-1806, 2007.
27. Russell ST, Wyke SM, Tisdale MJ. Mechanism of induction of muscle protein degradation by angiotensin II. Cell Signal 18: 1087-1096, 2006.
28. Saelens X, Kalai M, Vandenabeele P. Translation inhibition in apoptosis. Caspase-dependent PKR activation and eIF2α phosphorylation. J Biol Chem 276: 41620-41628, 2001.
29. Silva AM, Whitmore M, Xu Z, Jiang Z, Li X, Williams BRG. Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation. J Biol Chem 279: 37670-37676, 2004.
30. Smith HJ, Mukherji P, Tisdale MJ. Attenuation of proteasome-induced proteolysis in skeletal muscle by β-hydroxy-β- methylbutyrate in cancer-induced muscle loss. Cancer Res 65: 277-283, 2005.
31. Smith HJ, Wyke SM, Tisdale MJ. Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by β-hydroxy-β-methylbutyrate. Cancer Res 64: 8731-8735, 2004.
32. Suen KC, Yu MS, So KF, Chang RCC, Hugon J. Upstream signaling pathways leading to the activation of double-strand RNA-dependent serine-threonine protein kinase in β-amyloid peptide neurotoxicity. J Biol Chem 278: 49819-49827, 2003.
33. 2+-activated and ATP-ubiquitin-dependent proteinases in the unweighted rat soleus muscle. Biochem J 316: 65-72, 1996.
34. Tiao G, Fagan JM, Samuels N, James JH, Hudson J, Lieberman M, Fischer JE, Hasselgren PO. Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle. J Clin Invest 94: 2255-2264, 1994.
35. Vukovich MD, Stubbs NB, Bohicken RM. Body composition in 70 year old adults responds to dietary β-hydroxy-β-methylbutyrate similarly to that of young adults. J Nutr 131: 2049-2052, 2001.
36. 2 linked cascade. J Biol Chem 275: 32357-32362, 2000.
37. Wyke SM, Tisdale MJ. NF-κB mediates proteolysis-inducing factor induced protein degradation and expression of the ubiquitin-proteasome system in skeletal muscle. Br J Cancer 92: 711-721, 2005.