β-hydroxy-β-methylbutyrate supplementation in critically ill trauma patients

Journal of Trauma - Injury, Infection and Critical Care

Volumn 62, Issue 1, 2007, Pages 125-131

  Kuhls, Deborah A ^a   Rathmacher, John A ^b   Musngi, M Diana ^a   Frisch, Donald A ^c   Nielson, Jeremiah ^a   Barber, Annabel ^a   MacIntyre, Allan D ^a   Coates, Jay E ^a   Fildes, John J ^a  

^a UNIVERSITY OF NEVADA   (United States)

^b IOWA STATE UNIVERSITY   (United States)

^c University Medical Center of Southern Nevada   (United States)

Author keywords

Hydroxy Methylbutyrate; Arginine; Critical illness; Glutamine; Leucine; Muscle loss; Nutrition; Trauma surgery

Indexed keywords

3 HYDROXY 3 METHYLGLUTARIC ACID; 3 METHYLHISTIDINE; ARGININE; GLUTAMINE; NITROGEN; PLACEBO;

ADULT; ARTICLE; BLOOD ANALYSIS; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DISEASE SEVERITY; FEMALE; HUMAN; INJURY; INJURY SCALE; MAJOR CLINICAL STUDY; MALE; MUSCLE ATROPHY; NITROGEN BALANCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; RANDOMIZED CONTROLLED TRIAL; SUPPLEMENTATION; TUBE FEEDING; URINALYSIS;

3-HYDROXYBUTYRIC ACID; ADULT; ARGININE; BIOLOGICAL MARKERS; ENTERAL NUTRITION; FEMALE; GLUTAMINE; HUMANS; MALE; METHYLHISTIDINES; MUSCLE, SKELETAL; MUSCULAR ATROPHY; NITROGEN; SURVIVAL ANALYSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; WOUNDS AND INJURIES;

EID: 33846214753     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31802dca93     Document Type: Article

References (29)

1. Kudsk KA, Croce MA, Fabian TC, et al. Enteral vs. parenteral feeding: effects on septic morbidity following blunt and penetrating abdominal trauma. Ann Surg. 1992;215:503-513.
2. Moore FA, Moore E, et al. Benefits of immediate jejunostomy feeding after major abdominal trauma: a prospective, randomized study. J Trauma. 1986;26:874-881.
3. Kudsk KA, Minard G, Croce MA, et al. A randomized trial of isonitrogenous enteral diets after severe trauma: an immune-enhancing diet reduces septic complications. Ann Surg. 1996;224:531-543.
4. Galban C, Montejo JC, Messejo A, et al. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients. Crit Care Med. 2000;28:643-648.
5. Bengmark S. Gut microenvironment and immune function. Curr Opinion Clin Nutr Metab Care. 1999;2:1-3.
6. Moore EE, More FA. The role of the gut in provoking the systemic inflammatory response. J Crit Care Nut. 1994;2:9-15.
7. Cera FB. Hypermetabolism, organ failure and metabolic support. Surgery. 1987;101:1-11.
8. Jacobs DG, Jacobs DO, Kudsk KA, et al. Practice management guidelines for nutritional support of the trauma patient. J Trauma. 2004;57:600-679.
9. Alexander JW. Immunoenhancement via enteral nutrition. Arch Surg. 1993;128:1242-1245.
10. Barbul A. Arginine: biochemistry, physiology, and therapeutic implications. J Parenter Enteral Nutr. 1986;10:227-238.
11. Kirk SJ, Barbul A. Role of arginine in trauma, sepsis and immunity. J Parenter Enteral Nutr. 1990;14:226S-229S.
12. Kinsella JE, Lokesh B, Broughton S, Whelan J. Dietary polyunsaturated fatty acids and eicosanoids: potential effects on the modulation of inflammatory and immune cells: an overview. Nutrition. 1990;6:24-44.
13. Kulkarni AD, Rudolph FB, Van Buren CT. The role of dietary sources of nucleotides in immune function: a review. J Nutr. 1994;124:1442S-1446S.
14. Nissen SL, Abumrad NN. Nutritional role of the leucine metabolite B-hydroxy-B-methylbutyrate (HMB). J Nutr Biochem. 1997;8:300-311.
15. Ostaszewski S, Kostiuk B, Balaskinska I, et al. The effect of the leucine metabolite 3-hydroxy-3methylbutyrate (HMB) on muscle protein synthesis and protein breakdown in chick and rat muscle. J Anim Sci. 1996;74:138.
16. Rathmacher JA, Zachwieja JJ, Smith SR, et al. The effect of the leucine metabolite B-hydroxy-B-methylbutyrate on lean body mass and muscle strength during prolonged bed rest. FASEB J. 1999;13:A909.
17. May PE, Barber A, D'Olimpio JT, et al. Reversal of cancer-related wasting using oral supplementation with a combination of b-hydroxy-B-methylbutyrate, arginine, and glutamine. Am J Surg. 2002;183:471-479.
18. Smith HJ, Mukerji PR, Tisdale M. Attenuation of proteasome-induced proteolysis in skeletal muscle by B-Hydroxy-B-Methylbutyrate in cancer-induced muscle loss. Cancer Res. 2005;65:277-283.
19. Young VR, Munro HN. Nt-Methylhistidine (3-methylhistidine) and muscle protein turnover: an overview. Fed Proc. 1978;37:2291-2300.
20. Long CL, Dillard DR, Bodzin HJ, et al. Validity of 3-methylhistidine excretion as an indicator of skeletal muscle protein breakdown in humans. Metabolism. 1988;37:844-849.
21. SAS Institute Inc. SAS User's Guide: Statistics. Cary, NC: SAS Institute Inc., 1985.
22. Marcora S, Lemmey A, Maddison P. Dietary treatment of rheumatoid cachexia with B-hydroxy-B-methylbutyrate, glutamine and arginine: a randomized controlled trial. Clin Nutr. 2005;442-454.
23. Nissen S, Sharp M, Ray JA, et al. Effect of leucine metabolite B-hydroxy-B-methylbutyrate on muscle metabolism during resistance-exercise training. J Appl Physiol. 1996;81:2095-2104.
24. Flakoll P, Sharp R, Baier S, et al. Effect of B-hydroxy-B-methylbutyrate, arginine and lysine supplementation on strength, functionality, body composition and protein metabolism in elderly women. Nutrition. 2004;20:445-451.
25. Cerra FB, Lehmann S, Konstantinides N, et al. Improvement in immune function in ICU patients by enteral nutrition supplemented with arginine, RNA, and menhaden oil is independent of nitrogen balance. Nutrition 1991;7:193-199.
26. Heyland DK, Novak F, Drover JW, et al. Should immunonutrition become routine in critically ill patients? A systematic review of the evidence. JAMA. 2001;286:944-953.
27. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med. 1992;20:864-874.
28. Malone DL, Kuhls D, Napolitano LM, et al. Back to basics: validation of the admission systemic inflammatory response syndrome score in predicting outcome in trauma. J Trauma. 2001;51:458-463.
29. Bochicchio GV, Napolitano LM, Joshi M, et al. Persistent systemic inflammatory response syndrome is predictive of nosocomial infection in trauma. J Trauma. 2002;53:245-250.