β-Hydroxy-β-methylbutyrate supplementation reduces tumor growth and tumor cell proliferation ex vivo and prevents cachexia in Walker 256 tumor-bearing rats by modifying nuclear factor-κB expression

Nutrition Research

Volumn 28, Issue 7, 2008, Pages 487-493

  Nunes, Everson Araújo ^a   Kuczera, Diogo ^a   Brito, Gleisson Alisson Pereira ^a   Bonatto, Sandro J R ^a   Yamazaki, Ricardo Key ^a   Tanhoffer, Ricardo Antonio ^a   Mund, Rogéria Campus ^a   Kryczyk, Marcelo ^a   Fernandes, Luiz Claudio ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Hydroxy methylbutyrate (HMB) supplementation; Cancer cachexia; Cell proliferation; Tumor growth; Walker 256 rat

Indexed keywords

BETA HYDROXY BETA METHYLBUTYRATE; BUTYRIC ACID DERIVATIVE; GLUCOSE; GLYCOGEN; I KAPPA B KINASE ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTIC ACID; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CACHEXIA; CELL PROLIFERATION; CONTROLLED STUDY; EX VIVO STUDY; GLUCOSE BLOOD LEVEL; LACTATE BLOOD LEVEL; MALE; MUSCLE MASS; NONHUMAN; NUTRITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SHAM FEEDING; SUPPLEMENTATION; TUMOR CELL; TUMOR GROWTH; WALKER CARCINOMA; WISTAR RAT;

ANIMALS; CACHEXIA; CARCINOMA 256, WALKER; CELL DIVISION; GLYCOGEN; LIVER; MALE; MUSCLE, SKELETAL; NF-KAPPA B; RATS; RATS, WISTAR; VALERATES;

RATTUS; RATTUS NORVEGICUS;

EID: 44949245770     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2008.04.006     Document Type: Article

References (47)

1. Tisdale M.J. Cancer anorexia and cachexia. Nutrition 17 (2001) 438-442
2. May P.E., Barber A., D'olimpo J.T., et al. Reversal of cancer-related wasting using oral supplementation with a combination of β-hydroxy-β-methyl-butyrate, arginine and glutamine. Am J Surg 183 (2002) 471-479
3. Rubin H. Systemic effects of cancer: role of multiple proteases and their toxic peptide products. Med Sci Moni 117 (2005) 221-228
4. Dulger H., Alici S., Sekeroglu M.R., et al. Serum levels of leptin and proinflammatory cytokines in patients with gastrointestinal cancer. Int J Clin Pract 58 (2004) 545-549
5. Siddiqui R.A., and Williams J.F. Tentative identification of the toxohormones of cancer cachexia: roles of vasopressin, prostaglandin E2 and cachectin-TNF. Biochem Int 20 (1990) 787-797
6. Wang W., Andersson M., Lonnroth C., et al. Prostaglandin E and prostacyclin receptor expression in tumor and host tissues from MCG 101-bearing mice: a model with prostanoid-related cachexia. Int J Cancer 115 (2005) 582-590
7. Huang Q., Zhang X., Jiang Z.W., et al. Hypoleptinemia in gastric cancer patients: relation to body fat mass, insulin, and growth hormone. J Parenter Enteral Nut 29 (2005) 229-235
8. Fernandes L.C., Machado U.F., Nogueira C.R., et al. Insulin secretion in Walker 256 tumor cachexia. Am J Physiol 258 (1990) 1033-1036
9. Tisdale M.J. Protein loss in cancer cachexia. Science 289 (2000) 2293-2295
10. MacDonald N., Easson A.M., Mazurak V.Z., et al. Understanding and managing cancer cachexia. J Am Coll Surg 197 (2003) 143-161
11. Argilés J.M., Costelli P., Carbo N., et al. Tumor growth and nitrogen metabolism in host. International Journal of Oncology 14 (1999) 479-486
12. Argilés J.M., and Lopez-Soriano F.J. The role of cytokines in cancer cachexia. Med Res Rev 19 (1999) 223-248
13. Gallagher P.M., Carrithens J.A., Godard M.P., et al. β-Hydroxy-β-methyl-butyrate ingestion, part I: effects on strength and fat free mass. Med Sci Sport Exerc 32 (2000) 2109-2115
14. Nissen S.L., and Abumrad N.N. Nutritional role of the leucine metabolite β-hydroxy-β-methylbutyrate HMB. Nut Biochem 8 (1997) 300-311
15. Ostaszewski P., Kostiuk S., Balasinska M., et al. The leucine metabolite 3-hydroxy-3methylbutyrate (HMB) modifies protein turnover in muscles of laboratory rats and domestic chickens in vitro. J Anim Physiol Anim Nutr 84 (2000) 1-8
16. Smith H.J., Mukerji P., and Tisdale M.J. Attenuation of proteosome-induced proteolysis in skeletal muscle by β-hydroxy-β-methylbutyrate in cancer-induced muscle loss. Cancer Res 65 (2005) 277-283
17. Greten F.R., and Karin M. The IKK/NF-kappaB activation pathway-a target for prevention and treatment of cancer. Cancer Lett 8 (2004) 193-199
18. Caperuto E.A., Tomatieli R.V., Colquhoun A., et al. β-Hydroxy-β-methylbutyrate supplementation affects Walker 256 tumor-bearing rats in a time-dependent manner. Clin Nut 26 1 (2007) 117-122
19. Stewart H.L., Snell K.C., Dunham L.J., et al. Atlas of Tumor Pathology, Section XII (1959), Air Force Inst Pathol, Washington, DC 216-271
20. Pizato N., Bonatto S., Piconcelli M., et al. Fish oil alters T-lymphocyte proliferation and macrophage responses in Walker 256 tumor-bearing rats. Nutrition 22 (2006) 425-432
21. Trinder R. Determination of glucose in blood using glucose oxidase with alternative oxygen acceptor. Ann Clin Biochem 6 (1969) 27-34
22. Engle P.C., and Jones J.B. Causes and elimination of erratic blanks in enzymatic metabolite assays involving the use of NAD in alkaline hydrazine buffers: improved conditions for the assay of l-glutamine, l-lactate, and other metabolites. Ann Biochem 88 (1978) 475-484
23. Fernandes L.C., Carpinelli A.R., Hell N.S., et al. Improvement of cancer cachexia and inhibition of tumor growth by insulin administration in rats. Canc Ther Cont 1 (1991) 259-268
24. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities utilizing the principle of protein dye binding. Anal Biochem 142 (1976) 79-83
25. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage. Nature 227 (1970) 680-685
26. Towbin H., Staehelin T., and Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A 76 (1979) 4350-4354
27. Strang P. The effect of megestrol acetate on anorexia, weight loss and cachexia in cancer and AIDS patients review. Anticanc Res 17 (1997) 657-662
28. Ventrucci G., Ramos-Silva L.G., Roston-Mello M.A., et al. Effects of a leucine-rich diet on body composition during nutritional recovery in rats. Nutrition 20 (2004) 213-217
29. Clark R.H., Feleke G., Din M., et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. J Parenter Enteral Nut 24 (2000) 133-139
30. Eley H.L., Russell S.T., Baxter J.H., et al. Signaling pathways initiated by beta-hydroxy-beta-methylbutyrate to attenuate the depression of protein synthesis in skeletal muscle in response to cachectic stimuli. Am J Physiol EndocrinolMetab 293 (2007) E923-E931
31. Smith H.J., Wyke S.M., and Tisdale M.J. Mechanism of the attenuation of proteolysis-inducing factor stimulated protein degradation in muscle by β-hydroxy-β-methylbutyrate. Cancer Res 64 (2004) 8731-8735
32. Togni V., Ota C.C., Folador A., et al. Cancer cachexia and tumor growth reduction in Walker 256 tumor-bearing rats supplemented with N-3 polyunsaturated fatty acids for one generation. Nut Cancer 46 (2003) 52-58
33. Piffar P.M., Fernandez R., Tchaikovski O., et al. Naproxen, clenbuterol and insulin administration ameliorates cancer cachexia and reduce tumor growth in Walker 256 tumor-bearing rats. Cancer Lett 25 (2003) 139-148
34. Pinto-Jr J.Á., Folador A., Bonato S.J., et al. Fish oil supplementation in F1 generation associated with naproxen, clenbuterol, and insulin administration reduce tumor growth and cachexia in Walker 256 tumor-bearing rats. J Nut Biochem 15 (2004) 358-365
35. Pizato N., Bonatto S., Yamazaki R.K., et al. Ratio of n6 to n-3 fatty acids in the diet affects tumor growth and cachexia in Walker 256 tumor-bearing rats. Nut Cancer 53 (2005) 194-201
36. Smith H.J., Wyke S.M., and Tisdale M.J. Role of protein kinase C and NF-κB in proteolysis inducing factor induced proteossome expression in C2C12 myotubes. Br J Cancer 90 (2004) 1850-1857
37. Vertegaal A.C.O., Kuiperij H.B., Yamaoka S., et al. Protein kinase C-alpha is an upstream activator of the IkappaB kinase complex in the TPA signal transduction pathway to NF-kappaB in U2OS cells. Cell Signal 12 (2000) 759-768
38. Mackay H.J., and Twelves C.J. Protein kinase C: a target for anticancer drugs-endocrine-related. Cancer 10 (2003) 389-396
39. Gokmen-Polar Y., Murria N.R., Velasco M.A., et al. Elevated protein kinase C betaII is an early promotive event in colon carcinogenesis. Cancer Res 15 (2001) 1375-1381
40. Chandler N.M., Canete J.J., and Callery M.P. Increased expression of NF-kappa B subunits in human pancreatic cancer cells. J Surg Res 1 (2004) 9-14
41. Suh J., Payvandi F., Edelstein L.C., et al. Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells. Prostate 1 (2002) 183-200
42. Kojima M., Morisaki T., Sasaki N., et al. Increased nuclear factor-kB activation in human colorectal carcinoma and its correlation with tumor progression. Anticancer Res 24 (2004) 675-681
43. Viatour P., Merville M.P., Bours B., et al. Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation. Tren Biochem Sci 30 (2005) 43-53
44. Yu Y.Y., Li Q., and Zhu Z.G. NF-kappaB as a molecular target in adjuvant therapy of gastrointestinal carcinomas. Eur J Surg Oncnol 31 (2005) 386-392
45. Wang W., McLead H.L., and Cassidy J. Disulfiram-mediated inhibition of NF-kappaB activity enhances cytotoxicity of 5-fluorouracil in human colorectal cancer cell lines. Int J Cancer 104 (2003) 504-511
46. Biswas D.K., Shi Q., Baily S., et al. NF-kappa B activation in human breast cancer specimens and its role in cell proliferation and apoptosis. Proc Natl Acad Sci U S A 62 (2004) 10137-10142
47. Robe P.A., Bentires-Alj M., Bonif M., et al. In vitro and in vivo activity of the nuclear factor-kappaB inhibitor sulfasalazine in human glioblastomas. Clin Cancer Res 15 (2004) 5595-5603