Methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate (HIMOXOL), a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MDA-MB-231 breast cancer cells

Chemico-Biological Interactions

Volumn 208, Issue 1, 2014, Pages 47-57

  Lisiak, Natalia ^a   Paszel Jaworska, Anna ^a   Bednarczyk Cwynar, Barbara ^a   Zaprutko, Lucjusz ^a   Kaczmarek, Mariusz ^a   Rybczyńska, Maria ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

Apoptosis; Autophagy; Breast cancer; HIMOXOL

Indexed keywords

BECLIN 1; CASPASE 3; CASPASE 8; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; METHYL 3 HYDROXYIMINO 11 OXOOLEAN 12 EN 28 OATE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; OLEANOLIC ACID DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER INHIBITION; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME INDUCTION; HUMAN; HUMAN CELL; IC 50; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

2-CYANO-3,12-DIOXOOLEAN-1,9-DIEN-28-OIC ACID; APOPTOSIS; AUTOPHAGY; BECLIN 1; BECN 1; BREAST CANCER; CDDO; HALF MAXIMAL INHIBITORY CONCENTRATION; HIMOXOL; IC(50); MAP LC3Β; MAPK; MDC; METHYL 3-HYDROXYIMINO-11-OXOOLEAN-12-EN-28-OATE; MICROTUBULE-ASSOCIATED PROTEIN LIGHT CHAIN BETA; MITOGEN-ACTIVATED PROTEIN KINASE; MONODANSYLCADAVERINE; OA; OLEANOLIC ACID; UA; URSOLIC ACID;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CASPASE 3; CASPASE 8; CELL CYCLE; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HUMANS; MEMBRANE PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OLEANOLIC ACID; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84890445949     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2013.11.009     Document Type: Article

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