NF-κB, JNK and p53 pathways are involved in tubeimoside-1-induced apoptosis in HepG2 cells with oxidative stress and G 2/M cell cycle arrest

Food and Chemical Toxicology

Volumn 49, Issue 12, 2011, Pages 3046-3054

  Yin, Yan ^a   Chen, Wei ^a   Tang, Changyan ^a   Ding, Hanjing ^a   Jang, Jongchol ^a   Weng, Meizhi ^a   Cai, Yongjun ^a   Zou, Guolin ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Apoptosis; G 2 M arrest; HepG2; ROS; Tubeimoside 1

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; FAS LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TUBEIMOSIDE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL STRAIN HEPG2; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG STRUCTURE; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; MALE; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASE 8; CASPASE 9; CUCURBITACEAE; DRUGS, CHINESE HERBAL; FAS LIGAND PROTEIN; G2 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION; HEP G2 CELLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SAPONINS; SIGNAL TRANSDUCTION; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEIN P53;

BOLBOSTEMMA PANICULATUM; CUCURBITACEAE;

EID: 80054862185     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.10.001     Document Type: Article

References (41)

1. Ashkenazi A. Targeting death and decoy receptors of the tumour-necrosis factor superfamily. Nat. Rev. Cancer 2002, 2:420-430.
2. Bosch F.X., Ribes J., Diaz M., Cleries R. Primary liver cancer: worldwide incidence and trends. Gastroenterology 2004, 127:S5-S16.
3. Chandra J., Samali A., Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic. Biol. Med. 2000, 29:323-333.
4. Chen F., Castranova V., Shi X.L., Demers L.M. New insights into the role of nuclear factor-kappa B, a ubiquitous transcription factor in the initiation of diseases. Clin. Chem. 1999, 45:7-17.
5. Chen W., Hou J., Yin Y., Jang J.C., Zheng Z.L., Fan H.D., Zou G.L. Alpha-Bisabolol induces dose- and time-dependent apoptosis in HepG2 cells via a Fas- and mitochondrial-related pathway, involves p53 and NF kappa B. Biochem. Pharmacol. 2010, 80:247-254.
6. Chipuk J.E., Kuwana T., Bouchier-Hayes L., Droin N.M., Newmeyer D., Schuler M., Green D.R. Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 2004, 303:1010-1014.
7. Choi J.A., Kim J.Y., Lee J.Y., Kang C.M., Kwon H.J., Yoo Y.D., Kim T.W., Lee Y.S., Lee S.J. Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin. Int. J. Oncol. 2001, 19:837-844.
8. Evan G.I., Vousden K.H. Proliferation, cell cycle and apoptosis in cancer. Nature 2001, 411:342-348.
9. Fimognari C., Nusse M., Cesari R., Iori R., Cantelli-Forti G., Hrelia P. Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane. Carcinogenesis 2002, 23:581-586.
10. Gaiotti D., Chung J., Iglesias M., Nees M., Baker P.D., Evans C.H., Woodworth C.D. Tumor necrosis factor-alpha promotes human papillomavirus (HPV) E6/E7 RNA expression and cyclin-dependent kinase activity in HPV-immortalized keratinocytes by a ras-dependent pathway. Mol. Carcinog. 2000, 27:97-109.
11. Gloire G., Legrand-Poels S., Piette J. NF-kappa B activation by reactive oxygen species: fifteenyears later. Biochem. Pharmacol. 2006, 72:1493-1505.
12. Hengartner M.O. The biochemistry of apoptosis. Nature 2000, 407:770-776.
13. Herrmann M., Lorenz H.M., Voll R., Grunke M., Woith W., Kalden J.R. A rapid and simple method for the isolation of apoptotic DNA fragments. Nucleic Acids Res. 1994, 22:5506-5507.
14. Hoffmann A., Baltimore D. Circuitry of nuclear factor kappa B signaling. Immunol. Rev. 2006, 210:171-186.
15. Karin M. Nuclear factor-kappa B in cancer development and progression. Nature 2006, 441:431-436.
16. Kaufmann S.H., Earnshaw W.C. Induction of apoptosis by cancer chemotherapy. Exp. Cell Res. 2000, 256:42-49.
17. Lee D.H., Rhee J.G., Lee Y.J. Reactive oxygen species up-regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin. Br. J. Pharmacol. 2009, 157:1189-1202.
18. Lei K., Davis R.J. JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis. Proc. Natl Acad. Sci. USA 2003, 100:2432-2437.
19. Llovet J.M., Burroughs A., Bruix J. Hepatocellular carcinoma. Lancet 2003, 362:1907-1917.
20. Luo J.L., Kamata H., Karin M. IKK/NF-kappa B signaling: balancing life and death - a new approach to cancer therapy. J. Clin. Invest. 2005, 115:2625-2632.
21. Ma R.D., Song G., You W.B., Yu L.J., Su W.M., Liao M.N., Zhang Y.P., Huang L.Z., Zhang X.Y., Yu T.X. Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin. Cancer Chemother. Pharmacol. 2008, 62:559-568.
22. Mansouri A., Ridgway L.D., Korapati A.L., Zhang Q.X., Tian L., Wang Y.B., Siddik Z.H., Mills G.B., Claret F.X. Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. J. Biol. Chem. 2003, 278:19245-19256.
23. Martindale J.L., Holbrook N.J. Cellular response to oxidative stress: signaling for suicide and survival. J. Cell. Physiol. 2002, 192:1-15.
24. Okazaki T., Sakamuro D. Induction of Fas (CD95/APO-1) ligand is essential for p53-dependent apoptosis in an in vitro renal carcinoma model system. J. Cancer Res. Clin. Oncol. 2007, 133:581-588.
25. Oren M. Decision making by p53: life, death and cancer. Cell Death Differ. 2003, 10:431-442.
26. Papa S., Zazzeroni F., Pham C.G., Bubici C., Franzoso G. Linking JNK signaling to NF-kappa B: a key to survival. J. Cell Sci. 2004, 117:5197-5208.
27. Peter M.E., Krammer P.H. The CD95(APO-1/Fas) DISC and beyond. Cell Death Differ. 2003, 10:26-35.
28. Sauer H., Wartenberg M., Hescheler J. Reactive oxygen species as intracellular messengers during cell growth and differentiation. Cell. Physiol. Biochem. 2001, 11:173-186.
29. Shen H.M., Liu Z.G. JNK signaling pathway is a key modulator in cell death mediated by reactive oxygen and nitrogen species. Free Radic. Biol. Med. 2006, 40:928-939.
30. Szlosarek P.W., Balkwill F.R. Tumour necrosis factor alpha: a potential target for the therapy of solid tumours. Lancet Oncol. 2003, 4:565-573.
31. Taylor W.R., Stark G.R. Regulation of the G2/M transition by p53. Oncogene 2001, 20:1803-1815.
32. Tselepis C., Perry I., Dawson C., Hardy R., Darnton S.J., McConkey C., Stuart R.C., Wright N., Harrison R., Jankowski J.A.Z. Tumour necrosis factor-alpha in Barrett's oesophagus: a potential novel mechanism of action. Oncogene 2002, 21:6071-6081.
33. Varfolomeev E.E., Ashkenazi A. Tumor necrosis factor: an apoptosis JuNKie?. Cell 2004, 116:491-497.
34. Vermeulen K., Berneman Z.N., Van Bockstaele D.R. Cell cycle and apoptosis. Cell Prolif. 2003, 36:165-175.
35. Wang F., Ma R.D., Yu L.J. Role of mitochondria and mitochondrial cytochrome c in tubeimoside I-mediated apoptosis of human cervical carcinoma HeLa cell line. Cancer Chemother. Pharmacol. 2006, 57:389-399.
36. Wisdom R., Johnson R.S., Moore C. C-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 1999, 18:188-197.
37. Xu Y., Chiu L.F., He Q.Y., Chen F. Tubeimoside-1 exerts cytotoxicity in HeLa cells through mitochondrial dysfunction and endoplasmic reticulum stress pathways. J. Proteome Res. 2009, 8:1585-1593.
38. Yu J.Q., Bin Liu H., Tian D.Z., Liu Y.W., Lei J.C., Zou G.L. Changes in mitochondrial membrane potential and reactive oxygen species during wogonin-induced cell death in human hepatoma cells. Hepatol. Res. 2007, 37:68-76.
39. Yu L., Ma R., Wang Y., Nishino H. Potent anti-tumor activity and low toxicity of tubeimoside 1 isolated from Bolbostemma paniculatum. Planta Med. 1994, 60:204-208.
40. Yu L., Yu T., Ma R. Inhibition of the tumor promoting action of 12-O-tetradecanoylphorbol-13-acetate by tubeimoside III isolated from Bolbostemma paniculatum. Carcinogenesis 1995, 16:3045-3048.
41. Zhao, Y.Y., Chao, X., Zhang, Y., Sun, L.J., Zhang, H., Lin, R.C., Shen, X., Sun, W.J., 2010. Cytotoxic activities of tubeimoside-2 on human hepatoma HepG2 cells by induction of G2/M phase arrest and apoptosis in a p53-dependent manner. Apoptosis.