Intracellular distribution-based anticancer drug targeting: Exploiting a lysosomal acidification defect associated with cancer cells

Molecular and Cellular Pharmacology

Volumn 2, Issue 4, 2010, Pages 131-136

  Ndolo, Rosemary A ^a   Jacobs, Damon T ^a   Forrest, M Laird ^a   Krise, Jeffrey P ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Anticancer; Drug delivery; Drug targeting; Heat shock proteins; Intracellular; Lysosomes

Indexed keywords

17 DEMETHOXY 17 (2 DIMETHYLAMINOETHYLAMINO)GELDANAMYCIN; ANTINEOPLASTIC AGENT; CHLOROQUINE; GELDANAMYCIN; HEAT SHOCK PROTEIN 60; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ACIDIFICATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG STRUCTURE; IC 50; IN VITRO STUDY; IN VIVO STUDY; IONIZATION; LYSOSOME; MOUSE; NONHUMAN; PH; PHYSICAL CHEMISTRY; QUANTITATIVE ANALYSIS;

MUS;

EID: 78049444148     PISSN: None     EISSN: 19381247     Source Type: Journal    
DOI: 10.4255/mcpharmacol.10.18     Document Type: Article

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