Renewal of the air-water interface as a critical system parameter of protein stability: Aggregation of the human growth hormone and its prevention by surface-active compounds

Langmuir

Volumn 29, Issue 49, 2013, Pages 15240-15250

  Wiesbauer, Johanna ^a,b   Prassl, Ruth ^c   Nidetzky, Bernd ^a,b  

^a RESEARCH CENTER PHARMACEUTICAL ENGINEERING GMBH   (Austria)

^b GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AIR WATER INTERFACES; HUMAN GROWTH HORMONE; PROTEIN AGGREGATES; PROTEIN-SURFACTANT INTERACTION; RECOMBINANT HUMAN GROWTH HORMONE (RHGH); SECONDARY STRUCTURAL ELEMENTS; SMALL ANGLE X-RAY SCATTERING; SURFACE-ACTIVE COMPOUNDS;

AIR; CIRCULAR DICHROISM SPECTROSCOPY; LIQUIDS; NONIONIC SURFACTANTS; PROTEINS;

AGGLOMERATION;

HUMAN GROWTH HORMONE; POLOXAMER; SURFACTANT; WATER;

AIR; ARTICLE; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECT; HUMAN; PROTEIN STABILITY;

AIR; HUMAN GROWTH HORMONE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; POLOXAMER; PROTEIN STABILITY; SURFACE-ACTIVE AGENTS; WATER;

EID: 84890413359     PISSN: 07437463     EISSN: 15205827     Source Type: Journal    
DOI: 10.1021/la4028223     Document Type: Article

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