The effects of excipients on protein aggregation during agitation: An interfacial shear rheology study

Journal of Pharmaceutical Sciences

Volumn 102, Issue 8, 2013, Pages 2460-2470

  Liu, Lu ^a   Qi, Wei ^a   Schwartz, Daniel K ^b   Randolph, Theodore W ^b   Carpenter, John F ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b University of Colorado at Boulder   (United States)

Author keywords

Particle size; Physical stability; Protein aggregation; Protein formulation; Rheology; Surfactants; UV Vis spectroscopy

Indexed keywords

BUFFER; EXCIPIENT; FIBROBLAST GROWTH FACTOR 10; HEPARIN; POLYSORBATE 80; PROTEIN; SUCROSE; WATER;

AGITATION; AIR; ARTICLE; FLOW KINETICS; GEL; GELATION; IMAGING; MEASUREMENT; MICROFLOW IMAGING; PARTICLE SIZE; PROTEIN AGGREGATION; ULTRAVIOLET SPECTROSCOPY;

EID: 84881025601     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23622     Document Type: Article

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