메뉴 건너뛰기




Volumn 118, Issue 2, 2011, Pages 368-379

Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA SECRETASE INHIBITOR; NOTCH1 RECEPTOR;

EID: 79960493275     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-12-326058     Document Type: Article
Times cited : (82)

References (49)
  • 2
    • 0025010979 scopus 로고
    • The GTPase superfamily: A conserved switch for diverse cell functions
    • Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: a conserved switch for diverse cell functions. Nature. 1990;348(6297):125-132.
    • (1990) Nature , vol.348 , Issue.6297 , pp. 125-132
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 3
    • 0026026818 scopus 로고
    • The GTPase superfamily: Conserved structure and molecular mechanism
    • Bourne HR, Sanders DA, McCormick F. The GTPase superfamily: conserved structure and molecular mechanism. Nature. 1991;349(6305):117-127. (Pubitemid 21912023)
    • (1991) Nature , vol.349 , Issue.6305 , pp. 117-127
    • Bourne, H.R.1    Sanders, D.A.2    McCormick, F.3
  • 4
    • 0024376173 scopus 로고
    • ras Oncogenes in human cancer: A review
    • Bos JL. Ras oncogenes in human cancer: a review. Cancer Res. 1989;49(17):4682-4689. (Pubitemid 19213607)
    • (1989) Cancer Research , vol.49 , Issue.17 , pp. 4682-4689
    • Bos, J.L.1
  • 6
    • 33745042174 scopus 로고    scopus 로고
    • Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia
    • DOI 10.1111/j.1600-0609.2006.00663.x
    • Auewarakul CU, Lauhakirti D, Tocharoentanaphol C. Frequency of RAS gene mutation and its cooperative genetic events in Southeast Asian adult acute myeloid leukemia. Eur J Haematol. 2006;77(1):51-56. (Pubitemid 43876205)
    • (2006) European Journal of Haematology , vol.77 , Issue.1 , pp. 51-56
    • Auewarakul, C.U.1    Lauhakirti, D.2    Tocharoentanaphol, C.3
  • 7
    • 3042848958 scopus 로고    scopus 로고
    • Myelodysplastic/myeloproliferative diseases
    • Vardiman JW. Myelodysplastic/myeloproliferative diseases. Cancer Treatment Research. 2004;121:13-43.
    • (2004) Cancer Treatment Research , vol.121 , pp. 13-43
    • Vardiman, J.W.1
  • 8
    • 33745006857 scopus 로고    scopus 로고
    • Chronic neutrophilic leukemia and chronic myelomonocytic leukemia: WHO defined
    • DOI 10.1016/j.beha.2005.07.012, PII S1521692605000988
    • Elliott MA. Chronic neutrophilic leukemia and chronic myelomonocytic leukemia: WHO defined. Best Pract Res Clin Haematol. 2006;19(3):571-593. (Pubitemid 43863143)
    • (2006) Best Practice and Research: Clinical Haematology , vol.19 , Issue.3 , pp. 571-593
    • Elliott, M.A.1
  • 9
    • 0034284027 scopus 로고    scopus 로고
    • Targeting the Ras signaling pathway: A rational, mechanism-based treatment for hematologic malignancies?
    • Reuter CW, Morgan MA, Bergmann L. Targeting the Ras signaling pathway: a rational, mechanism-based treatment for hematologic malignancies? Blood. 2000;96(5):1655-1669.
    • (2000) Blood , vol.96 , Issue.5 , pp. 1655-1669
    • Reuter, C.W.1    Morgan, M.A.2    Bergmann, L.3
  • 10
    • 47649104857 scopus 로고    scopus 로고
    • Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia
    • Emanuel PD. Juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. Leukemia. 2008;22(7):1335-1342.
    • (2008) Leukemia , vol.22 , Issue.7 , pp. 1335-1342
    • Emanuel, P.D.1
  • 11
    • 0022458965 scopus 로고
    • Absence of oncogene amplifications and occasional activation of N-ras in lymphoblastic leukemia of childhood
    • Rodenhuis S, Bos JL, Slater RM, Behrendt H, van 't Veer M, Smets LA. Absence of oncogene amplifications and occasional activation of N-ras in lymphoblastic leukemia of childhood. Blood. 1986;67(6):1698-1704.
    • (1986) Blood , vol.67 , Issue.6 , pp. 1698-1704
    • Rodenhuis, S.1    Bos, J.L.2    Slater, R.M.3    Behrendt, H.4    Van 'T Veer, M.5    Smets, L.A.6
  • 14
    • 57749114621 scopus 로고    scopus 로고
    • 250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies
    • Dunbar AJ, Gondek LP, O'Keefe CL, et al. 250K single nucleotide polymorphism array karyotyping identifies acquired uniparental disomy and homozygous mutations, including novel missense substitutions of c-Cbl, in myeloid malignancies. Cancer Res. 2008;68(24):10349-10357.
    • (2008) Cancer Res , vol.68 , Issue.24 , pp. 10349-10357
    • Dunbar, A.J.1    Gondek, L.P.2    O'Keefe, C.L.3
  • 15
    • 33751165545 scopus 로고    scopus 로고
    • Recurrent KRAS codon 146 mutations in human colorectal cancer
    • Edkins S, O'Meara S, Parker A, et al. Recurrent KRAS codon 146 mutations in human colorectal cancer. Cancer Biol Ther. 2006;5(8):928-932.
    • (2006) Cancer Biol Ther , vol.5 , Issue.8 , pp. 928-932
    • Edkins, S.1    O'Meara, S.2    Parker, A.3
  • 16
    • 0033559734 scopus 로고    scopus 로고
    • Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice
    • MacKenzie KL, Dolnikov A, Millington M, Shounan Y, Symonds G. Mutant N-ras induces myeloproliferative disorders and apoptosis in bone marrow repopulated mice. Blood. 1999;93(6):2043-2056. (Pubitemid 29128508)
    • (1999) Blood , vol.93 , Issue.6 , pp. 2043-2056
    • MacKenzie, K.L.1    Dolnikov, A.2    Millington, M.3    Shounan, Y.4    Symonds, G.5
  • 17
    • 33749320394 scopus 로고    scopus 로고
    • Oncogenic NRAS rapidly and efficiently induces CMML- And AML-like diseases in mice
    • DOI 10.1182/blood-2004-08-009498
    • Parikh C, Subrahmanyam R, Ren R. Oncogenic NRAS rapidly and efficiently induces CMML- and AML-like diseases in mice. Blood. 2006;108(7):2349-2357. (Pubitemid 44497519)
    • (2006) Blood , vol.108 , Issue.7 , pp. 2349-2357
    • Parikh, C.1    Subrahmanyam, R.2    Ren, R.3
  • 19
    • 78650651360 scopus 로고    scopus 로고
    • Endogenous oncogenic Nras mutation leads to aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia
    • Wang JY, Liu YG, Li ZY, et al. Endogenous oncogenic Nras mutation leads to aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood. 2010;116(26):5991-6002.
    • (2010) Blood , vol.116 , Issue.26 , pp. 5991-6002
    • Wang, J.Y.1    Liu, Y.G.2    Li, Z.Y.3
  • 20
    • 52949129499 scopus 로고    scopus 로고
    • Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates
    • Kotecha N, Flores NJ, Irish JM, et al. Single-cell profiling identifies aberrant STAT5 activation in myeloid malignancies with specific clinical and biologic correlates. Cancer Cell. 2008;14(4):335-343.
    • (2008) Cancer Cell , vol.14 , Issue.4 , pp. 335-343
    • Kotecha, N.1    Flores, N.J.2    Irish, J.M.3
  • 21
    • 0033667449 scopus 로고    scopus 로고
    • Importance of quantitative genetic variations in the etiology of hypertension
    • Smithies O, Kim HS, Takahashi N, Edgell MH. Importance of quantitative genetic variations in the etiology of hypertension. Kidney Int. 2000;58(6):2265-2280.
    • (2000) Kidney Int , vol.58 , Issue.6 , pp. 2265-2280
    • Smithies, O.1    Kim, H.S.2    Takahashi, N.3    Edgell, M.H.4
  • 22
    • 0344826470 scopus 로고    scopus 로고
    • Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: Functional analysis by a flow cytometry-based novel culture system
    • DOI 10.1182/blood-2003-05-1479
    • Zhang J, Socolovsky M, Gross AW, Lodish HF. Role of Ras signaling in erythroid differentiation of mouse fetal liver cells: functional analysis by a flow cytometry-based novel culture system. Blood. 2003;102(12):3938-3946. (Pubitemid 37486974)
    • (2003) Blood , vol.102 , Issue.12 , pp. 3938-3946
    • Zhang, J.1    Socolovsky, M.2    Gross, A.W.3    Lodish, H.F.4
  • 23
    • 26844473307 scopus 로고    scopus 로고
    • Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo
    • DOI 10.1073/pnas.0507446102
    • Zhang J, Lodish HF. Identification of K-ras as the major regulator for cytokine-dependent Akt activation in erythroid progenitors in vivo. Proc Natl Acad Sci U S A. 2005;102(41):14605-14610. (Pubitemid 41457104)
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.41 , pp. 14605-14610
    • Zhang, J.1    Lodish, H.F.2
  • 24
    • 60849083841 scopus 로고    scopus 로고
    • Oncogenic Kras-induced leukemogeneis: Hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation
    • Zhang J, Wang J, Liu Y, et al. Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. Blood. 2009;113(6):1304-1314.
    • (2009) Blood , vol.113 , Issue.6 , pp. 1304-1314
    • Zhang, J.1    Wang, J.2    Liu, Y.3
  • 25
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • DOI 10.1038/35004599
    • Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000; 404(6774):193-197. (Pubitemid 30154488)
    • (2000) Nature , vol.404 , Issue.6774 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 26
    • 0036070180 scopus 로고    scopus 로고
    • Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment
    • DOI 10.1016/S1534-5807(02)00201-0
    • Miyamoto T, Iwasaki H, Reizis B, et al. Myeloid or lymphoid promiscuity as a critical step in hematopoietic lineage commitment. Dev Cell. 2002;3(1):137-147. (Pubitemid 34778402)
    • (2002) Developmental Cell , vol.3 , Issue.1 , pp. 137-147
    • Miyamoto, T.1    Iwasaki, H.2    Reizis, B.3    Ye, M.4    Graf, T.5    Weissman, I.L.6    Akashi, K.7
  • 27
    • 70350497395 scopus 로고    scopus 로고
    • Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML
    • Bereshchenko O, Mancini E, Moore S, et al. Hematopoietic stem cell expansion precedes the generation of committed myeloid leukemia-initiating cells in C/EBPalpha mutant AML. Cancer Cell. 2009;16(5):390-400.
    • (2009) Cancer Cell , vol.16 , Issue.5 , pp. 390-400
    • Bereshchenko, O.1    Mancini, E.2    Moore, S.3
  • 28
    • 0042452295 scopus 로고    scopus 로고
    • Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5
    • DOI 10.1016/S1535-6108(02)00185-X
    • Roberts CW, Leroux MM, Fleming MD, Orkin SH. Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5. Cancer Cell. 2002;2(5):415-425. (Pubitemid 41039107)
    • (2002) Cancer Cell , vol.2 , Issue.5 , pp. 415-425
    • Roberts, C.W.M.1    Leroux, M.M.2    Fleming, M.D.3    Orkin, S.H.4
  • 30
    • 10944256767 scopus 로고    scopus 로고
    • Systematic identification and analysis of exonic splicing silencers
    • DOI 10.1016/j.cell.2004.11.010, PII S0092867404010566
    • Wang Z, Rolish ME, Yeo G, Tung V, Mawson M, Burge CB. Systematic identification and analysis of exonic splicing silencers. Cell. 2004;119(6):831-845. (Pubitemid 40017689)
    • (2004) Cell , vol.119 , Issue.6 , pp. 831-845
    • Wang, Z.1    Rolish, M.E.2    Yeo, G.3    Tung, V.4    Mawson, M.5    Burge, C.B.6
  • 31
    • 0034114458 scopus 로고    scopus 로고
    • Epiblast-restricted Cre expression in MORE mice: A tool to distinguish embryonic vs. extra-embryonic gene function
    • DOI 10.1002/(SICI)1526-968X(200002)26:2<113::AID-GENE3>3.0.CO;2-2
    • Tallquist MD, Soriano P. Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function. Genesis. 2000;26(2):113-115. (Pubitemid 30158091)
    • (2000) Genesis , vol.26 , Issue.2 , pp. 113-115
    • Tallquist, M.D.1    Soriano, P.2
  • 32
    • 73349131391 scopus 로고    scopus 로고
    • A restricted spectrum of NRAS mutations causes Noonan syndrome
    • Cirstea IC, Kutsche K, Dvorsky R, et al. A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat Genet. 2010;42(1):27-29.
    • (2010) Nat Genet , vol.42 , Issue.1 , pp. 27-29
    • Cirstea, I.C.1    Kutsche, K.2    Dvorsky, R.3
  • 33
    • 0029155706 scopus 로고
    • Inducible gene targeting in mice
    • Kuhn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science. 1995;269(5229):1427-1429.
    • (1995) Science , vol.269 , Issue.5229 , pp. 1427-1429
    • Kuhn, R.1    Schwenk, F.2    Aguet, M.3    Rajewsky, K.4
  • 37
    • 54049141335 scopus 로고    scopus 로고
    • K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors
    • Kindler T, Cornejo MG, Scholl C, et al. K-RasG12D-induced T-cell lymphoblastic lymphoma/leukemias harbor Notch1 mutations and are sensitive to gamma-secretase inhibitors. Blood. 2008;112(8):3373-3382.
    • (2008) Blood , vol.112 , Issue.8 , pp. 3373-3382
    • Kindler, T.1    Cornejo, M.G.2    Scholl, C.3
  • 38
    • 65949123563 scopus 로고    scopus 로고
    • Oncogenic Kras initiates leukemia in hematopoietic stem cells
    • Sabnis AJ, Cheung LS, Dail M, et al. Oncogenic Kras initiates leukemia in hematopoietic stem cells. PLoS Biol. 2009;7(3):e59.
    • (2009) PLoS Biol , vol.7 , Issue.3
    • Sabnis, A.J.1    Cheung, L.S.2    Dail, M.3
  • 39
    • 78650335900 scopus 로고    scopus 로고
    • Deletion-based mechanisms of Notch1 activation in T-ALL: Key roles for RAG recombinase and a conserved internal translational start site in Notch1
    • Ashworth TD, Pear WS, Chiang MY, et al. Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood. 2010;116(25):5455-5464.
    • (2010) Blood , vol.116 , Issue.25 , pp. 5455-5464
    • Ashworth, T.D.1    Pear, W.S.2    Chiang, M.Y.3
  • 41
    • 35748972639 scopus 로고    scopus 로고
    • NOTCH and PI3K-AKT pathways intertwined
    • Gutierrez A, Look AT. NOTCH and PI3K-AKT pathways intertwined. Cancer Cell. 2007;12(5):411-413.
    • (2007) Cancer Cell , vol.12 , Issue.5 , pp. 411-413
    • Gutierrez, A.1    Look, A.T.2
  • 42
    • 0030944150 scopus 로고    scopus 로고
    • Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: A useful method for the diagnosis of lymphoblastic lymphoma
    • DOI 10.1002/(SICI)1096-9896(199705)182:1<86::AID-PATH821>3.0.CO;2-I
    • Suzumiya J, Ohshima K, Kikuchi M, Takeshita M, Akamatsu M, Tashiro K. Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma. J Pathol. 1997;182(1):86-91. (Pubitemid 27240453)
    • (1997) Journal of Pathology , vol.182 , Issue.1 , pp. 86-91
    • Suzumiya, J.1    Ohshima, K.2    Kikuchi, M.3    Takhshita, M.4    Akamatsu, M.5    Tashiro, K.6
  • 44
    • 34247897276 scopus 로고    scopus 로고
    • Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
    • Sarkisian CJ, Keister BA, Stairs DB, Boxer RB, Moody SE, Chodosh LA. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol. 2007;9(5):493-505.
    • (2007) Nat Cell Biol , vol.9 , Issue.5 , pp. 493-505
    • Sarkisian, C.J.1    Keister, B.A.2    Stairs, D.B.3    Boxer, R.B.4    Moody, S.E.5    Chodosh, L.A.6
  • 47
    • 0033519238 scopus 로고    scopus 로고
    • The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity
    • DOI 10.1084/jem.189.9.1399
    • Li S, Ilaria RL Jr, Million RP, Daley GQ, Van Etten RA. The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med. 1999;189(9):1399-1412. (Pubitemid 29227526)
    • (1999) Journal of Experimental Medicine , vol.189 , Issue.9 , pp. 1399-1412
    • Li, S.1    Ilaria Jr., R.L.2    Million, R.P.3    Daley, G.Q.4    Van Etten, R.A.5
  • 49
    • 34547113747 scopus 로고    scopus 로고
    • Tumor growth need not be driven by rare cancer stem cells
    • DOI 10.1126/science.1142596
    • Kelly PN, Dakic A, Adams JM, Nutt SL, Strasser A. Tumor growth need not be driven by rare cancer stem cells. Science. 2007;317(5836):337. (Pubitemid 47106366)
    • (2007) Science , vol.317 , Issue.5836 , pp. 337
    • Kelly, P.N.1    Dakic, A.2    Adams, J.M.3    Nutt, S.L.4    Strasser, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.