Combination of N-acetylcysteine, α-lipoic acid and α-tocopherol substantially prevents the brain synaptosomal alterations and memory and learning deficits of aged rats

Experimental Gerontology

Volumn 50, Issue 1, 2014, Pages 19-25

  Thakurta, Ishita Guha ^a   Banerjee, Priyanjalee ^a   Bagh, Maria Bindu ^a,b   Ghosh, Arindam ^a   Sahoo, Arghyadip ^a   Chattopadhyay, Sita ^a   Chakrabarti, Sasanka ^a  

^a INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

Antioxidant; Brain aging; Cognitive deficit; Ion channel; Membrane potential; Oxidative stress; Synaptosome

Indexed keywords

4 HYDROXYNONENAL; ACETYLCYSTEINE; ALPHA TOCOPHEROL; CALCIUM ION; POTASSIUM ION; SODIUM ION; THIOCTIC ACID;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN PROTECTION; BRAIN SYNAPTOSOME; CONTROLLED STUDY; DENSITY GRADIENT CENTRIFUGATION; DRUG EFFECT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LEARNING DISORDER; MEMORY DISORDER; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPATIAL LEARNING; SPATIAL MEMORY; SYNAPTIC POTENTIAL;

ANTIOXIDANT; BRAIN AGING; COGNITIVE DEFICIT; ION CHANNEL; MEMBRANE POTENTIAL; OXIDATIVE STRESS; SYNAPTOSOME;

ACETYLCYSTEINE; AGING; ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; BRAIN; CALCIUM; DIETARY SUPPLEMENTS; DRUG EVALUATION, PRECLINICAL; DRUG THERAPY, COMBINATION; LEARNING DISORDERS; MAZE LEARNING; MEMBRANE POTENTIALS; MEMORY DISORDERS; OXIDATIVE STRESS; POTASSIUM; RATS; SODIUM; SYNAPTOSOMES; THIOCTIC ACID;

EID: 84890328542     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2013.11.008     Document Type: Article

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