Spatial delayed alternation of rats in a T-maze: Effects of neurotoxic lesions of the medial prefrontal cortex and of T-maze rotations

Behavioural Brain Research

Volumn 84, Issue 1-2, 1997, Pages 73-79

  Sánchez Santed, Fernando ^a,b   De Bruin, Jan P C ^a   Heinsbroek, Rob P W ^a   Verwer, Ronald W H ^a  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b UNIVERSITY OF ALMERÍA   (Spain)

Author keywords

medial prefrontal cortex; neurotoxic lesion; rat; spatial delayed alternation; spatial memory; T maze; working memory

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; MALE; MAZE TEST; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; SPATIAL MEMORY;

EID: 0343144793     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-4328(97)83327-X     Document Type: Article

References (37)

1. Barnes, C.A., Nadel, L. and Honig, W.K., Spatial memory deficit in senescent rats, Can. J. Psychol., 34 (1980) 29-39.
2. Brito, G.N.O. and Brito, L.S.O., Septohippocampal system and the prelimbic sector of frontal cortex: a neuropsychological battery analysis in the rat, Behav. Brain Res., 36 (1990) 127-146.
3. Brito, G.N.O., Thomas, G.J., Davis, B.J. and Gingold, S.I., Prelimbic cortex, mediodorsal thalamus, septum and delayed alternation in rats, Exp. Brain Res., 46 (1982) 52-58.
4. Broersen, L.M., Heinsbroek, R.P.W., de Bruin, J.P.C., Uylings, H.B.M. and Olivier, B., The role of the medial prefrontal cortex of rats in short-term memory functioning: further support for involvement of cholinergic, rather than dopaminergic mechanisms, Brain Res., 674 (1995) 221-229.
5. De Brabander, J.M., de Bruin, J.P.C. and van Eden, C.G., Comparison of the effects of neonatal and adult medial prefrontal cortex on food hoarding and spatial delayed alternation, Behav. Brain Res., 42 (1991) 67-75.
6. De Brabander, J.M., van Eden, C.G. and de Bruin, J.P.C., Neuroanatomical correlates of sparing of function after neonatal medial prefrontal cortex lesions, Brain Res., 568 (1991) 24-34.
7. De Bruin, J.P.C., Sánchez-Santed, F., Heinsbroek, R.P.W., Donker, A. and Postmes, P., A behavioural analysis of rats with damage to the medial prefrontal cortex using the Morris water maze: evidence for behavioural flexibility, but not for impaired spatial navigation, Brain Res., 652 (1994) 323-333.
8. Dunnett, S., The role and repair of forebrain cholinergic systems in short-term memory. In F.J. Seil (Ed.), Advances in Neurology, Vol. 59, Raven Press, New York, 1993, pp. 53-65.
9. Eichenbaum, H., Clegg, R.A. and Feeley, A., Reexamination of functional subdivisions of the rodent prefrontal cortex, Exp. Neurol., 79 (1983) 434-451.
10. Goldman-Rakic, P.S., Cellular and circuit basis of working memory in prefrontal cortex of nonhuman primates. In H.B.M. Uylings, C.G. van Eden, J.P.C. de Bruin, M.A. Corner and M.G.P. Feenstra (Eds.), The Prefrontal Cortex: Its Structure, Function and Pathology, Progress in Brain Research, Vol. 85, Elsevier, Amsterdam, 1990, pp. 325-336.
11. Jarrard, L.E., On the role of the hippocampus in learning and memory in the rat, Behav. Neural Biol., 60 (1993) 9-26.
12. Kesner, R.P., Farnsworth, G. and DiMattia, B.V., Double dissociation of egocentric and allocentric space following medial prefrontal and parietal cortex lesions in the rat, Behav. Neurosci., 103 (1989) 956-961.
13. Kolb, B., Functions of the frontal cortex of the rat: a comparative review, Brain Res. Rev., 8 (1984) 65-98.
14. Kolb, B., Pittman, K., Sutherland, R.J. and Whishaw, I.Q., Dissociation of the contributions of the prefrontal cortex and dorsomedial thalamic nucleus to spatially guided behavior in the rat, Behav. Brain Res., 6 (1982) 365-378.
15. Kolb, B., Animal models for human PFC-related disordes. In H.B.M. Uylings, C.G. van Eden, J.P.C. de Bruin, M.A. Corner and M.G.P. Feenstra (Eds.), The Prefrontal Cortex: Its Structure, Function and Pathology, Progress in Brain Research, Vol. 85, Elsevier, Amsterdam, 1990, pp. 501-520.
16. Krettek, J.E. and Price, J.L., The cortical projections of the mediodorsal nucleus and adjacent thalamic nuclei in the rat, J. Comp. Neurol., 171 (1977) 157-192.
17. Larsen, J.K. and Divac, I., Selective ablations within the prefrontal cortex of the rat and performance of delayed alternation, Physiol. Psychol., 6 (1978) 15-17.
18. Leonard, C.M., The prefrontal cortex of the rat. I. Cortical projection of the mediodorsal nucleus. II. Efferent projections, Brain Res., 12 (1969) 321-343.
19. Markowska, A.L., Olton, D.S., Murray, E.A. and Gaffan, D., A comparative analysis of the role of fornix and cingulate cortex in memory: rats, Exp. Brain Res., 74 (1989) 187-201.
20. Muir, J.L., Everitt, B.J. and Robbins, T.W., AMPA-induced excitotoxic lesions of the basal forebrain: a significant role for the cortical cholinergic system in attentional function, J. Neurosci., 14 (1994) 2313-2326.
21. Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, Sydney, 1982.
22. Pohl, W., Dissociation of spatial discrimination deficits following frontal and parietal lesions in monkeys, J. Comp. Physiol. Psychol., 82 (1973) 227-239.
23. Poucet, B., Spatial cognitive maps in animals: new hypotheses on their structure and neural mechanisms, Psychol. Rev., 100 (1993) 163-182.
24. Ridley, R.M., Clark, B.A., Durnford, L.J. and Baker, H.F., Stimulus-bound perseveration after frontal ablations in marmosets, Neuroscience, 52 (1993) 595-604.
25. Rose, J.E. and Woolsey, C.N., The orbitofrontal cortex and its connections with the mediodorsal nucleus in rabbit, sheep and cat, Res. Publ. Ass. Nerv. Ment. Dis., 27 (1948) 210-232.
26. Semmes, J., Winstein, S., Ghent, L. and Teuber, H.L., Correlates of impaired orientation in personal and extrapersonal space, Brain, 86 (1963) 747-772.
27. Skeen, L.C. and Masterton, R.B., Origins of anthropoid intelligence. IV. Role of prefrontal system in delayed alternation and spatial reversal learning in a conservative Eutherian (Paraechinus hypomelas), Brain Behav. Evol., 21 (1982) 185-198.
28. Sokolowski, J.D. and Salamone, J.D., Effects of dopamine depletions in the medial prefrontal cortex on DRL performance and motor activity in the rat, Brain Res., 642 (1994) 20-28.
29. Squire, L.R., Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans, Psychol. Rev., 99 (1992) 195-231.
30. Stam, C.J., de Bruin, J.P.C., van Haelst, A.M., van der Gugten, J. and Kalsbeek, A., Influence of the mesocortical dopaminergic system on activity, food hoarding, social-agonistic behavior, and spatial delayed alternation in male rats, Behav. Neurosci., 103 (1989) 24-35.
31. Swinkels, W.A.M., de Brabander, J.M. and de Bruin, J.P.C., Egocentric spatial learning of rats in the Morris water maze: involvement of medial prefrontal cortex, Abstracts of The Meeting of European Neuroscience (1995) 181.
32. Thomas, G.J. and Brito, G.N.O., Recovery of delayed alternation in rats after lesions in medial frontal cortex and septum, J. Comp. Physiol. Psychol., 94 (1980) 808-818.
33. Uylings, H.B.M. and van Eden, C.G., Qualitative and quantitative comparison of the prefrontal cortex in rat and in primates, including humans. In H.B.M. Uylings, C.G. van Eden, J.P.C. de Bruin, M.A. Corner and M.G.P. Feenstra (Eds.), The Prefrontal Cortex: Its Structure, Function and Pathology, Progress in Brain Research, Vol. 85, Elsevier, Amsterdam, 1990, pp. 31-62.
34. Van Eden, C.G. and Uylings, H.B.M., Postnatal cytoarchitectonic development of the prefrontal cortex in the rat, J. Comp. Neurol., 241 (1985) 253-267.
35. Van Haaren, F., de Bruin, J.P.C., Heinsbroek, R.P.W. and van de Poll, N.E., Delayed spatial response alternation: effects of delay-interval duration and lesions of the medial prefrontal cortex on response accuracy of male and female Wistar rats, Behav. Brain Res., 18 (1985) 41-49.
36. Wilcott, R.C., Prefrontal cortex and bulbar reticular formation and behavioral inhibition in the rat, Brain Res. Bull., 12 (1984) 63-69.
37. Wolf, C., Waksman, D., Finger, S. and Almli, C.R., Large and small medial frontal cortex lesions and spatial performance of the rat, Brain Res. Bull., 18 (1987) 1-5.