Age-related oxidative inactivation of Na+, K+-ATPase in rat brain crude synaptosomes

Experimental Gerontology

Volumn 38, Issue 6, 2003, Pages 705-710

  Chakraborty, Hemontika ^a   Sen, Papparani ^a   Sur, Arghya ^a   Chatterjee, Uttara ^a   Chakrabarti, Sasanka ^a  

^a MEDICAL COLLEGE AND HOSPITAL   (India)

Author keywords

Brain aging; Fluorescent peroxidation products; Na+, K+ ATPase; Oxidative damage; Protein carbonyls; Synaptosomes

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; ASCORBIC ACID; BUTYLCRESOL; IRON; MEMBRANE PROTEIN;

AGE DISTRIBUTION; AGING; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME MODIFICATION; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SYNAPTIC MEMBRANE;

ANIMALIA;

EID: 0038241846     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(03)00066-4     Document Type: Article

References (23)

1. Beal M.F. Aging, energy and oxidative stress in neurodegenerative diseases. Ann. Neurol. 38:1995;357-366.
2. +-ATPase inhibits the activity of the enzyme. Proc. Natl. Acad. Sci. 88:1991;11359-11362.
3. Chakraborty H., Ray S.N., Chakrabarti S. Lipid peroxidation associated protein damage in rat brain crude synaptosomal fraction mediated by iron and ascorbate. Neurochem. Int. 39:2001;311-317.
4. +-ATPase activity in brain slices and synaptosomes by arachidonic acid. J. Neurochem. 40:1983;309-316.
5. Driver A.S., Kodavanti P.R., Mundy W.R. Age-related changes in reactive oxygen species production in rat brain homogenates. Neurotoxicol. Teratol. 22:2000;175-181.
6. + adenosine triphosphatase in rat striatal synaptosomes. Neurosci. Lett. 277:1999;91-94.
7. Gabbita S.P., Butterfield D.A., Hensley K., Shaw W., Carney J.M. Aging and caloric restriction affect mitochondrial respiration and lipid membrane status: an electron paramagnetic resonance investigation. Free Radic. Biol. Med. 23:1997;191-201.
8. Gorini A., Canosi U., Devecchi E., Geroldi D., Villa R.F. ATPases enzyme activities during ageing in different types of somatic and synaptic plasma membranes from rat frontal cerebral cortex. Prog. Neuropsychopharmacol. Biol. Psychiatry. 26:2002;81-90.
9. Gray E.G., Whittaker V.P. The isolation of nerve endings from brain: an electron microscopic study of cell fragments derived by homogenization and centrifugation. J. Anat. 96:1962;78-88.
10. Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine. 2nd ed. 1989;Clarendon Press, Oxford.
11. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
12. Lehtosky J., Kaplan P., Racay P., Matejovicova M., Drgova A., Mezesova V. Membrane ion transport systems during oxidative stress in rodent brain: protective effect of stobadine and other antioxidants. Life Sci. 65:1999;1951-1958.
13. Levine R.L. Oxidative modification of glutamine synthetase. Inactivation is due to loss of one histidine residue. J. Biol. Chem. 258:1983;11823-11827.
14. Levine R.L., Williams J.A., Stadtman E.R., Shacter E. Carbonyl assays for determination of oxidatively modified proteins. Meth. Enzymol. 233:1994;346-357.
15. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin-phenol reagent. J. Biol. Chem. 193:1951;265-275.
16. 1A adrenoceptor possibly by dephosphorylation of the enzyme. J. Neurochem. 74:2000;1574-1578.
17. Mark R.J., Lovell M.A., Markesbery W.R., Uchida K., Mattson M.P. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide. J. Neurochem. 68:1997;255-264.
18. Shacter E., Williams J.A., Stadtman E.R., Levine R.L. Determination of carbonyl groups in oxidized proteins. Punchard N.A., Kelly K.J. Free Radicals - A Practical Approach. 1996;159-170 Oxford University Press, Oxford.
19. Shepherd G.M. Neurobiology. 3rd ed. 1994;Oxford University Press, New York.
20. Shimasaki H. Assay of fluorescent lipid peroxidation products. Meth. Enzymol. 233:1994;338-346.
21. +-ATPase. Brain Res. 506:1990;46-52.
22. 3H] ouabain binding to synaptic plasma membranes isolated from mouse brains. J. Biochem. (Tokyo). 112:1992;117-121.
23. Viani P., Cervato G., Fiorilli A., Cestaro B. Age-related differences in synaptosomal peroxidative damage and membrane properties. J. Neurochem. 56:1991;253-258.