Dietary supplementation with N-acetylcysteine, α-tocopherol and α-lipoic acid prevents age related decline in Na+, K+-ATPase activity and associated peroxidative damage in rat brain synaptosomes

Biogerontology

Volumn 9, Issue 6, 2008, Pages 421-428

  Bagh, Maria Bindu ^a   Maiti, Arpan Kumar ^a   Roy, Arun ^b   Chakrabarti, Sasanka ^a  

^a INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^b UNIVERSITY OF CALCUTTA   (India)

Author keywords

Lipoic acid; Tocopherol; Brain aging; N acetylcysteine; Na+,K+ ATPase; Protein carbonyl

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALPHA TOCOPHEROL; ANTIOXIDANT; THIOCTIC ACID;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; BRAIN SYNAPTOSOME; CONFERENCE PAPER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG ACTIVITY; ENZYME ACTIVITY; FEMALE; IMMUNOBLOTTING; IMMUNODETECTION; KINETICS; LIPID PEROXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; WESTERN BLOTTING;

ACETYLCYSTEINE; AGING; ALPHA-TOCOPHEROL; ANIMALS; ANTIOXIDANTS; BRAIN; DIETARY SUPPLEMENTS; FEMALE; FREE RADICAL SCAVENGERS; LIPID PEROXIDATION; MALE; RATS; RATS, INBRED STRAINS; SODIUM-POTASSIUM-EXCHANGING ATPASE; SYNAPTOSOMES; THIOCTIC ACID;

EID: 56049107269     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-008-9175-1     Document Type: Conference Paper

References (40)

1. Afaq F, Abidi P, Rahman Q (2000) N-acetyl L-cysteine attenuates oxidant-mediated toxicity induced by chrysotile fibers. Toxicol Lett 117:53-60. doi: 10.1016/S0378-4274(00)00236-8
2. Arivazhagan P, Thilakavathy T, Panneerselvam C (2000) Antioxidant lipoate and tissue antioxidants in aged rats. J Nutr Biochem 11:122-127. doi: 10.1016/S0955-2863(99)00079-0
3. Babusikova E, Hatok J, Dobrota D, Kaplan P (2007) Age-related oxidative modifications of proteins and lipids in rat brain. Neurochem Res 32:1351-1356. doi: 10.1007/s11064-007-9314-0
4. Beal MF (1995) Aging, energy and oxidative stress in neurodegenerative diseases. Ann Neurol 38:357-366. doi: 10.1002/ana.410380304
5. Benevenga NJ, Calvert C, Eckhert CD, Fahey GC, Greger JL, Keen CL et al (1995) Subcommittee on laboratory animal nutrition, Committee on animal nutrition, Board on agriculture, National research Council Nutrient requirements of Laboratory Animals. National Academic Press, Washington
6. Cakatay U, Telci A, Kayali R, Tekeli F, Akcay T, Sivas A (2001) Relation of oxidative protein damage and nitrotyrosine levels in the aging rat brain. Exp Gerontol 36:221-229. doi: 10.1016/S0531-5565(00)00197-2
7. + -ATPase in rat brain crude synaptosomes. Exp Gerontol 38:705-710. doi: 10.1016/S0531-5565(03)00066-4
8. Dillard CJ, Tappel AL (1973) Fluorescent products from reaction of peroxidizing polyunsaturated fatty acids with phosphatidyl ethanolamine and phenylalanine. Lipids 8:183-189. doi: 10.1007/BF02544632
9. +-ATPase: Molar and specific activity, protein determination. Methods Enzymol 156:105-115. doi: 10.1016/ 0076-6879(88)56013-5
10. +-ATPase isoenzymes in whole brain membranes. J Neurochem 60:246-252. doi: 10.1111/j.1471-4159.1993.tb05844.x
11. Gray EG, Whittaker VP (1962) The isolation of nerve endings from brain: an electron microscopic study of cell fragments derived by homogenization and centrifugation. J Anat 96:78-88
12. Halliwell B, Gutteridge JMC (1999) Free radicals in biology and medicine. Oxford University Press, New York
13. Harvey BH, Joubert C, Preez JL, Berk M (2008) Effect of chronic N-acetylcysteine administration on oxidative status in the presence and absence of induced oxidative stress in rat striatum. Neurochem Res 33:508-517. doi: 10.1007/s11064-007-9466-y
14. + -ATPase activity induced by 4-hydroxy-2-nonenal. Biol Pharm Bull 26:787-795. doi: 10.1248/bpb.26.787
15. Kagan VE, Shvedova A, Serbinova E, Khan S, Swanson C, Powell R et al (1992) Dihydrolipoic acid - a universal antioxidant both in the membrane and in the aqueous phase. Reduction of peroxyl, ascorbyl and chromanoxyl radicals. Biochem Pharmacol 44:1637-1649. doi: 10.1016/ 0006-2952(92)90482-X
16. +-ATPase activity in crude synaptosomal-mitochondrial fraction from rat brain. Free Radic Res 37:597-601. doi: 10.1080/1071576031000115651
17. Kikugawa K, Kato T, Beppu M, Hayasaka A (1989) Fluorescent and cross-linked proteins formed by free radical and aldehyde species generated during lipid oxidation. Adv Exp Med Biol 266:345-356
18. +-ATPase in cortical brain slices incubated in normal Krebs-ringer phosphate medium at 1 and at 10 atm oxygen pressures. J Neurochem 36:333-341. doi: 10.1111/j.1471-4159.1981.tb02418.x
19. Kurella EG, Tyulina OV, Boldyrev AA (1999) Oxidative resistance of Na/ K-ATPase. Cell Mol Neurobiol 19:133-140. doi: 10.1023/A:1006976810642
20. 4. Nature 227:680-685. doi: 10.1038/227680a0
21. Lehotsky J, Kaplan P, Racay P, Matejovicova M, Drgova A, Mezesova V (1999) Membrane ion transport systems during oxidative stress in rodent brain: Protective effect of stobadine and other antioxidants. Life Sci 65:1951-1958. doi: 10.1016/S0024-3205(99)00454-3
22. Levine RL, Williams JA, Stadman ER, Shacter E (1994) Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol 233:346-380. doi: 10.1016/S0076-6879(94)33040-9
23. +-ATPase inhibitors, and brain function. Neurochem Res 26:971-978. doi: 10.1023/A:1012340702763
24. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with Folin-Phenol reagent. J Biol Chem 193:265-275
25. Matsugo S, Yan LJ, Han D, Trischler HJ, Packer L (1995) Elucidation of antioxidant activity of alpha-lipoic acid toward hydroxyl radical. Biochem Biophys Res Commun 208:161-167. doi: 10.1006/bbrc.1995.1318
26. Mattson MP, Chan SL, Duan W (2002) Modification of brain aging and neurodegenerative disorders by genes, diet and behavior. Physiol Rev 82:637-672
27. Melhem MF, Craven PA, Derubertis FR (2001) Effects of dietary supplementation of α-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol 12:124-133
28. +, and strophanthidin in vitro. Neurochem Res 14:845-851. doi: 10.1007/BF00964813
29. +-ATPase by modification with 4-hydroxy-2-nonenal. Biol Pharm Bull 26:1652-1656. doi: 10.1248/bpb.26.1652
30. + ATPase alpha subunit mutants. J Neurosci 23:1276-1286
31. Santos MS, Moreno AJ, Carvalho AP (1996) Relationships between ATP depletion, membrane potential and the release of neurotransmitters in rat nerve terminals. An in vitro study under conditions that mimic anoxia, hypoglycemia and ischemia. Stroke 27:941-950
32. Sen T, Sen N, Jana S, Khan FH, Chatterjee U, Chakrabarti S (2007) Depolarization and cardiolipin depletion in aged rat brain mitochondria: relationship with oxidative stress and electron transport chain activity. Neurochem Int 50:719-725. doi: 10.1016/j.neuint.2007.01.007
33. Shacter E, Williams JA, Stadtman ER, Levine RL (1996) Determination of carbonyl groups in oxidized protein. In: Punchard NA, Kelly KJ (eds) Free radicals - a practical approach. Oxford University Press, Oxford, pp 159-170
34. Shepherd GM (1994) Neurobiology. Oxford University Press, New York
35. Shimasaki H (1994) Assay of fluorescent lipid peroxidation products. Methods Enzymol 233:338-346. doi: 10.1016/S0076-6879(94)33039-5
36. Sohal RS, Agarwal S, Candas M, Forster MJ, Lal H (1994) Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev 76:215-224. doi: 10.1016/ 0047-6374(94)91595-4
37. Tanaka Y, Ando S (1992) Age-related changes in [3H] ouabain binding to synaptic plasma membranes isolated from mouse brains. J Biochem 112:117-121
38. Viani P, Cervato G, Fiorilli A, Cestaro B (1991) Age-related differences in synaptosomal peroxidative damage and membrane properties. J Neurochem 56:253-258. doi: 10.1111/j.1471-4159.1991.tb02589.x
39. Vizi ES, Torok T, Seregi A, Serfozo P, Adam-Vizi V (1982) Na-K activated ATPase and the release of acetylcholine and noradrenaline. J Physiol (Paris) 78:399-406
40. Xiao AY, Wei L, Xia S, Rothman S, Yu SP (2002) Ionic mechanism of ouabain-induced concurrent apoptosis and necrosis in individual cultured cortical neurons. J Neurosci 22:1350-1362