메뉴 건너뛰기




Volumn 12, Issue 12, 2013, Pages 3898-3907

Proximity ligation assay for high-content profiling of cell signaling pathways on a microfluidic chip

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; PROTEIN S6; TRANSCRIPTION FACTOR FKHRL1;

EID: 84890206912     PISSN: 15359476     EISSN: 15359484     Source Type: Journal    
DOI: 10.1074/mcp.M113.032821     Document Type: Article
Times cited : (28)

References (36)
  • 1
    • 70350230233 scopus 로고    scopus 로고
    • Quantitative time-lapse fluorescence microscopy in single cells
    • Muzzey, D., and van Oudenaarden, A. (2009) Quantitative time-lapse fluorescence microscopy in single cells. Annu. Rev. Cell Dev. Biol. 25, 301-327
    • (2009) Annu. Rev. Cell Dev. Biol , vol.25 , pp. 301-327
    • Muzzey, D.1    Van Oudenaarden, A.2
  • 3
    • 84856738084 scopus 로고    scopus 로고
    • High-throughput examination of fluorescence resonance energy transfer- detected metal-ion response in mammalian cells
    • Ma, H., Gibson, E. A., Dittmer, P. J., Jimenez, R., and Palmer, A. E. (2012) High-throughput examination of fluorescence resonance energy transfer- detected metal-ion response in mammalian cells. J. Am. Chem. Soc. 134, 2488-2491
    • (2012) J. Am. Chem. Soc , vol.134 , pp. 2488-2491
    • Ma, H.1    Gibson, E.A.2    Dittmer, P.J.3    Jimenez, R.4    Palmer, A.E.5
  • 4
    • 14044266297 scopus 로고    scopus 로고
    • Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter
    • Kunkel, M. T., Ni, Q., Tsien, R. Y., Zhang, J., and Newton, A. C. (2004) Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. J. Biol. Chem. 280, 5581-5587
    • (2004) J. Biol. Chem , vol.280 , pp. 5581-5587
    • Kunkel, M.T.1    Ni, Q.2    Tsien, R.Y.3    Zhang, J.4    Newton, A.C.5
  • 5
    • 0004172941 scopus 로고    scopus 로고
    • Fluorescence Microscopy
    • 2nd ed.,Oxford, UK
    • Herman, B. Fluorescence Microscopy, 2nd ed., Bios Scientific Publishers, Oxford, UK, 1998
    • (1998) Bios Scientific Publishers
    • Herman, B.1
  • 8
    • 60049093598 scopus 로고    scopus 로고
    • BlobFinder, a tool for fluorescence microscopy image cytometry
    • Allalou, A., and Wählby, C. (2009) BlobFinder, a tool for fluorescence microscopy image cytometry. Comput. Methods Programs Biom. 94, 58-65
    • (2009) Comput. Methods Programs Biom , vol.94 , pp. 58-65
    • Allalou, A.1    Wählby, C.2
  • 9
    • 0035984039 scopus 로고    scopus 로고
    • Poly(dimethylsiloxane) as a material for fabricating microfluidic devices
    • McDonald, J., and Whitesides, G. (2002) Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. Accounts Chem. Res. 35, 491-499
    • (2002) Accounts Chem. Res , vol.35 , pp. 491-499
    • McDonald, J.1    Whitesides, G.2
  • 10
    • 77954541844 scopus 로고    scopus 로고
    • Single-cell NF-B dynamics reveal digital activation and analogue information processing
    • Tay, S., Hughey, J. J., Lee, T. K., Lipniacki, T., Quake, S. R., and Covert, M. W. (2010) Single-cell NF-B dynamics reveal digital activation and analogue information processing. Nature 466, 267-271
    • (2010) Nature , vol.466 , pp. 267-271
    • Tay, S.1    Hughey, J.J.2    Lee, T.K.3    Lipniacki, T.4    Quake, S.R.5    Covert, M.W.6
  • 11
    • 63049111520 scopus 로고    scopus 로고
    • High content cell screening in a microfluidic device
    • Cheong, R., Wang, C. J., and Levchenko, A. (2009) High content cell screening in a microfluidic device. Mol. Cell. Proteomics 8, 433-442
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 433-442
    • Cheong, R.1    Wang, C.J.2    Levchenko, A.3
  • 13
    • 84868575194 scopus 로고    scopus 로고
    • High-performance binary protein interaction screening in a microfluidic format
    • Meier, M., Sit, R., Pan, W., and Quake, S. R. (2012) High-performance binary protein interaction screening in a microfluidic format. Anal. Chem. 21, 9572-9578
    • (2012) Anal. Chem , vol.21 , pp. 9572-9578
    • Meier, M.1    Sit, R.2    Pan, W.3    Quake, S.R.4
  • 14
    • 0024315697 scopus 로고
    • Structure and function of plateletderived growth factor (PDGF) and related proteins
    • Hannink, M., and Donoghue, D. J. (1989) Structure and function of plateletderived growth factor (PDGF) and related proteins. Biochim. Biophys. Acta 989, 1-10
    • (1989) Biochim. Biophys. Acta , vol.989 , pp. 1-10
    • Hannink, M.1    Donoghue, D.J.2
  • 15
    • 0028871766 scopus 로고
    • Platelet-derived growth factor induces apoptosis in growth-arrested murine fibroblasts
    • Kim, H. R., Upadhyay, S., Li, G., Palmer, K. C., and Deuel, T. F. (1995) Platelet-derived growth factor induces apoptosis in growth-arrested murine fibroblasts. Proc. Natl. Acad. Sci. U.S.A. 92, 9500-9504
    • (1995) Proc. Natl. Acad. Sci. U.S.A , vol.92 , pp. 9500-9504
    • Kim, H.R.1    Upadhyay, S.2    Li, G.3    Palmer, K.C.4    Deuel, T.F.5
  • 16
    • 63749119765 scopus 로고    scopus 로고
    • PIKKing on PKB: Regulation of PKB activity by phosphorylation
    • Bozulic, L., and Hemmings, B. A. (2009) PIKKing on PKB: regulation of PKB activity by phosphorylation. Curr. Opin. Cell Biol. 21, 256-261
    • (2009) Curr. Opin. Cell Biol , vol.21 , pp. 256-261
    • Bozulic, L.1    Hemmings, B.A.2
  • 17
    • 34047095297 scopus 로고    scopus 로고
    • The two torcs and akt
    • Bhaskar, P. T., and Hay, N. (2007) The Two TORCs and Akt. Dev. Cell 12, 487-502
    • (2007) Dev. Cell , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 18
    • 0032055131 scopus 로고    scopus 로고
    • Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: Comparison with protein kinase B alpha
    • Walker, K. S., Deak, M., Paterson, A., Hudson, K., Cohen, P., and Alessi, K. S. (1998) Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. Biochem. J. 331, 299-308
    • (1998) Biochem. J , vol.331 , pp. 299-308
    • Walker, K.S.1    Deak, M.2    Paterson, A.3    Hudson, K.4    Cohen, P.5    Alessi, K.S.6
  • 19
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.4
  • 20
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross, D. A., Alessi, D. R., Cohen, P., Andjelkovich, M., and Hemmings, B. A. (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378, 785-789
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 22
    • 0023726116 scopus 로고
    • Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide
    • Krieg, J., Hofsteenge, J., and Thomas, G. (1988) Identification of the 40 S ribosomal protein S6 phosphorylation sites induced by cycloheximide. J. Biol. Chem. 263, 11473-11477
    • (1988) J. Biol. Chem. , vol.263 , pp. 11473-11477
    • Krieg, J.1    Hofsteenge, J.2    Thomas, G.3
  • 23
    • 0033595011 scopus 로고    scopus 로고
    • Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
    • Biggs, W. H., III, Meisenhelder, J., Hunter, T., Cavenee, W. K., and Arden, K. C. (1999) Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. U.S.A. 96, 7421-7426
    • (1999) Proc. Natl. Acad. Sci. U.S.A , vol.96 , pp. 7421-7426
    • Biggs III, W.H.1    Meisenhelder, J.2    Hunter, T.3    Cavenee, W.K.4    Arden, K.C.5
  • 25
    • 36448935709 scopus 로고    scopus 로고
    • Versatile, fully automated, microfluidic cell culture system
    • Gó mez-Sjöberg, R., Leyrat, A., Pirone, D., Chen, C., and Quake, R. S. (2007) Versatile, fully automated, microfluidic cell culture system. Anal. Chem. 79, 8557-8563
    • (2007) Anal. Chem , vol.79 , pp. 8557-8563
    • Gómez-Sjöberg, R.1    Leyrat, A.2    Pirone, D.3    Chen, C.4    Quake, R.S.5
  • 26
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning, B. D., and Cantley, L. C. (2007) AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 30
    • 0141733263 scopus 로고    scopus 로고
    • Kinetic analysis of platelet-derived growth factor receptor/ phosphoinositide 3-kinase/Akt signaling in fibroblasts
    • Park, C. S., Schneider, I. C., and Haugh, J. M. (2003) Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts. J. Biol. Chem. 278, 37064-37072
    • (2003) J. Biol. Chem. , vol.278 , pp. 37064-37072
    • Park, C.S.1    Schneider, I.C.2    Haugh, J.M.3
  • 31
    • 21844468767 scopus 로고    scopus 로고
    • Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
    • Chiang, G. G., and Abraham, R. T. (2005) Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J. Biol. Chem. 280, 25485-25490
    • (2005) J. Biol. Chem , vol.280 , pp. 25485-25490
    • Chiang, G.G.1    Abraham, R.T.2
  • 32
    • 22544455676 scopus 로고    scopus 로고
    • Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
    • Holz, M. K. (2005) Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J. Biol. Chem. 280, 26089-26093
    • (2005) J. Biol. Chem , vol.280 , pp. 26089-26093
    • Holz, M.K.1
  • 34
    • 84555187735 scopus 로고    scopus 로고
    • Inducible raptor and rictor knockout mpuse embryonic fibroblasts
    • Cybulski, N., Zinzalla, V., and Hall, M. N. (2012) Inducible raptor and rictor knockout mpuse embryonic fibroblasts. Methods Mol. Biol. 821, 267-278
    • (2012) Methods Mol. Biol , vol.821 , pp. 267-278
    • Cybulski, N.1    Zinzalla, V.2    Hall, M.N.3
  • 35
    • 84890303026 scopus 로고    scopus 로고
    • Platelet-derived growth factorinduced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D
    • Razmara, M., and Heldin, C. H. (2013) Platelet-derived growth factorinduced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D. Cell Commun. Signal. 11, 1-12
    • (2013) Cell Commun. Signal , vol.11 , pp. 1-12
    • Razmara, M.1    Heldin, C.H.2
  • 36
    • 0034615958 scopus 로고    scopus 로고
    • Monolithic microfabricated valves and pumps by multilayer soft lithography
    • Unger, M. A., Chou, H. P., Thorsen, T., Scherer, A., and Quake, S. R. (2000) Monolithic microfabricated valves and pumps by multilayer soft lithography. Science 288, 113-116
    • (2000) Science , vol.288 , pp. 113-116
    • Unger, M.A.1    Chou, H.P.2    Thorsen, T.3    Scherer, A.4    Quake, S.R.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.