Mechanism of hyperhomocysteinemia-induced vascular endothelium dysfunction - Possible dysregulation of phosphatidylinositol-3-kinase and its downstream phosphoinositide dependent kinase and protein kinase B

European Journal of Pharmacology

Volumn 721, Issue 1-3, 2013, Pages 365-372

  Sharma, Saurabh ^a   Singh, Manjeet ^a   Sharma, Pyare Lal ^a  

^a ISF COLLEGE OF PHARMACY   (India)

Author keywords

eNOS (Endothelial nitric oxide synthatase); Hyperhomocysteinemia; Protein tyrosine phosphatase; Vascular endothelium dysfunction

Indexed keywords

3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; 7 HYDROXYSTAUROSPORINE; ATORVASTATIN; INSULIN; MESSENGER RNA; METHIONINE; N(G) NITROARGININE METHYL ESTER; NITRITE; NORASTERRIQUINONE B1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TETRAHYDROISOQUINOLINE; TRICIRIBINE; UNCLASSIFIED DRUG; WORTMANNIN; YS 49;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG EFFECT; ELECTRON MICROSCOPY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; HYPERHOMOCYSTEINEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RISK FACTOR; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM DYSFUNCTION;

ENOS (ENDOTHELIAL NITRIC OXIDE SYNTHATASE); HYPERHOMOCYSTEINEMIA; PROTEIN TYROSINE PHOSPHATASE; VASCULAR ENDOTHELIUM DYSFUNCTION;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; ACETYLCHOLINE; ANIMALS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; MALE; NITRATES; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; NITROPRUSSIDE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; RNA, MESSENGER; VASODILATION;

EID: 84890129206     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.08.028     Document Type: Article

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