Possible role of Akt to improve vascular endothelial dysfunction in diabetic and hyperhomocysteinemic rats

Molecular and Cellular Biochemistry

Volumn 295, Issue 1-2, 2007, Pages 65-74

  Shah, Dhvanit I ^a   Singh, Manjeet ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

Akt; Demethylasterroquinone B1; Diabetes mellitus; Hyperhomocysteinemia; Vascular endothelial dysfunction

Indexed keywords

ACETYLCHOLINE; ANTIOXIDANT; ATORVASTATIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HOMOCYSTEINE; MESSENGER RNA; METHIONINE; N(G) NITROARGININE METHYL ESTER; NITRATE; NITRITE; NORASTERRIQUINONE B1; PROTEIN KINASE B; PROTEIN P22; STREPTOZOCIN; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERY DILATATION; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DIABETIC ANGIOPATHY; ELECTRON MICROSCOPY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HYPERHOMOCYSTEINEMIA; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STREPTOZOCIN DIABETES; THORACIC AORTA; VASCULAR ENDOTHELIUM;

ACETYLCHOLINE; ANIMALS; AORTA; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMOCYSTEINE; HYPERHOMOCYSTEINEMIA; MALE; NADPH OXIDASE; NITRATES; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; PROTO-ONCOGENE PROTEINS C-AKT; QUINONES; RATS; RATS, WISTAR; RNA, MESSENGER; SUPEROXIDES; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VASODILATION;

RATTUS;

EID: 33846519417     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9273-9     Document Type: Article

References (42)

1. De Vriese AS, Verbeuren TJ, van de Voorde J, Lameire NH, Vanhoutte PM (2000) Endothelial dysfunction in diabetes. Br J Pharmacol 130:963-974
2. Lentz SR, Rodionov RN, Dayal S (2003) Hyperhomocysteinemia, endothelial dysfunction and cardiovascular risk: The potential role of ADMA. Atheroscler Suppl 4:61-65
3. Luscher TF, Vanhoutte PM (1987) Endothelium dependent vascular response in normotensive and hypertensive dahl rats. Hypertension 9:157-163
4. Bonetti PO, Lerman L, Lerman A (2003) Endothelial dysfunction: A marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 23: 168-175
5. Pieper GM, Langenstroer P, Siebeneich W (1997) Diabetic induced endothelial dysfunction in rat aorta: Role of hydroxyl radicals. Cardiovasc Res 37:145-156
6. Ungwari Z, Paeher P, Rischak K, Szollar L, Koller A (1999) Dysfunction of nitric oxide mediation in isolated rat arterioles with methionine diet-induced hyperhomocystenemia. Arterioscler Thromb Vasc Biol 19:1899-1904
7. 2 activity in isolated arterioles and platelets of rats with hyperhomocysteinemia. Arterioscler Thromb Vasc Biol 20:1203-1208
8. Li H, Forstermann U (2000) Nitric oxide in the pathogenesis of vascular disease. J Pathol 190:244-262
9. Endemann DH, Schiffrin EL (2004) Endothelial dysfunction. J Am Soc Nephrol 15:1983-1992
10. Dimmeler S, Fleming B, Fisslthaler B, Herman C, Busse B, Zeiher AM (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399:601-605
11. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropolous A, Sessa WC (1999) Regulation of endothelium derived nitric oxide production by the protein kinase Akt. Nature 400:792
12. Suzuki J, Iwai M, Li Z, Li JM, Min LJ, Ide A, Yoshii T, Oshita A, Mogi M, Horiuchi M (2005) Effect of combination of calcium antagonist, azelnidipine, and AT1 receptor blocker, olmesartan, on atherosclerosis in apolipoprotein E-deficient mice. J Hypertens 23:1383-1389
13. Hanada M, Feng J, Hemmings BA (2004) Structure, regulation and function of PKB/Akt - a major therapeutic target. Biochem Biophys Acta 1697:3-16
14. Iaccarino G, Ciccarelli M, Sorriento D, Cipoletta E, Cerullo V, Iovino GL, Paudice A, Elia A, Santulli G, Campanile A, Arcuccie O, Pastore L, Salvatore F, Condorelli G, Trimareo B. (2004) Akt participates in endothelial dysfunction in hypertension. Circulation 109:2587-2593
15. Zhang B, Salituro G, Szalkowski D, Li Z, Zhang Y, Royo I, Vilella D, Diez MT, Peelaez F, Rubey C, Kendall RL, Mao X, Griffin P, Calaycay J, Zierath JR, Heck JV, Smith RG, Moller DE (1999) Discovery of a small molecule insulin mimetic with antidiabetic activity in mice. Science 284:974-977
16. Westerlund J, Wolf BA, Bergsten P (2002) Glucose dependent promotion of insulin release from mouse pancreatic islet by the insulin-mimetic compound L-783,281. Diabetes 51:S50-S52
17. Webster NG, Park K, Pirrung MC (2003) Signaling effect of demethylasterroquinone b1, a selective insulin receptor modulator. ChemBioChem 4:379-385
18. Dimitrova KR, DeGroot KW, Pacquing AM, Suyderhoud JP, Pirovic EA, Munro TJ, Wieneke JA, Myers AK, Kim YD (2002) Estradiol prevents homocysteine-induced endothelial injury in male rats. Cardiovasc Res 53:589-596
19. Mitra S, Singh M (1998) Possible mechanism of captopril induced endothelium-dependent relaxation in isolated rabbit aorta. Mol Cell Biochem 183:63-67
20. Ignarro LJ, Bryns RE, Buga GM, Wood KS, Chaudhari G (1988) Pharmacological evidence that endothelium-derived relaxing factor is NO: use of pyrogallol and superoxide dismutase to study endothelium dependent and NO-elicited vascular smooth muscle relaxation. J Pharmacol Exp Ther 244:181-188
21. Schiller NK, Timothy AM, Chen IL, Rice RC, Akers DL, Kadowitz PJ, McNamaran DB (1999) Endothelial cell regrowth and morphology after balloon catheter injury of alloxan-induced diabetic rabbits. Am J Physiol 277:240-248
22. Chomezynskl P, Sacchi N (1987) Single step method of RNA isolation by acid guanidium thiocynate-phenol-chloroform extraction. Anal Biochem 162:156-159
23. Sastry KVH, Moudgal RP, Mohan J, Tyagi JS, Rao GS (2002) Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. Anal Biochem 306:79-82
24. Wang HD, Pagano PJ, Du Y, Cayatte AJ, Quihin MT, Brecher P (1998) Cohen RASuperoxide anion from the adventitia of the rat thoracic aorta inactivates nitric oxide. Circ Res 82:810-818
25. Ma FA, Liu LY, Xiong XM (2003) Protective effects of lovastatin on vascular endothelium injured by low density lipoprotein. Acta Pharmacol Sin 24:1027-1032
26. Kohn AD, Summer SA, Birnbaum MJ, Roth RA (1996) Expression of constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271:31372-31378
27. Calera MR, Martinez C, Liu H, Jack AKE, Birnbaum MJ, Pilch PF (1998) Insulin increases the association of Akt-2 with Glut4-containing vesicles. J Biol Chem 273:7201-7204
28. Burgering BMT, Coffer PJ (1995) Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602
29. Begum N, Sandu OA, Ito M, Lohman SM, Smolenski A (2001) Active Rho kinase associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells. J Biol Chem 22:6214-6222
30. Waly M, Olteanu H, Banerjee R, Choi S-W, Mason JB, Parker BS, Sukumar S, Shim S, Sharma A, Benzecry JM, Power-Charnitsky V-A, Deth RC (2004) Activation of methionine synthase by insulin-like growth factor-1 and dopamine: A target for neurodevelopemental toxins and thimerosal. Mol Psychiatry 9:358-370
31. Fonesca V, Keebler M, Dicker-Brown A, DeSouza C, Poirier LA, Murthy SN, McNamara DB (2002) The effect of troglitazone on plasma homocysteine, hepatic and red blood cell S-adenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in zucker rats. Metabolism 61:783-786
32. Zdychova J, Komers R (2005) Emerging role of Akt kinase/protein kinase B signaling in pathophysiology of diabetes and its complications. Physiol Res 54:1-16
33. Zhang HS, Cao EH, Qin JF (2005) Homocysteine induces cell cycle G1 arrest in endothelial cells through the PI3K/Akt/FOXO signaling pathway. Pharmacology 74:57-64
34. Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD, Glass DJ (2004) The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell 14:395-403
35. Potente M, Urbich C, Sasaki KI, Hofmann WK, Heeschen C, Aicher A, Kollipara R, DePinho RA, Zeiher AM, Dimmeler S (2005) Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest 115:2382-2392
36. Toba H, Gomyo E, Miki S, Shimizu T, Yoshimura A, Inoue R, Sawai N, Tsukamoto R, Asayama J, Kobara M, Nakata T (2006) Hyperinsulinaemia increases the gene expression of endothelial nitric oxide synthase and the phosphatidylinositol 3-kinase/akt pathway in rat aorta. Clin Exp Pharmacol Physiol 33:440-447
37. Kung CF, Moreau P, Takase H, Luscher TF (1994) L-NAME hypertension alters endothelial and smooth muscle function in rat aorta. Hypertension 26:744-750
38. Hayden MR, Tyagi SC (2004) Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: The pleotropic effects of folate supplementation. Nutr J 3:4-27
39. Zalba G, Beaumont FJ, San Jose G, Fortuño A, Fortuño MA, Etayo JC, Díez J (2000) Vascular NADH/NADPH oxidase is involved in enhanced superoxide production in spontaneously hypertensive rats. Hypertension 35:1055-1061
40. van Heerebeek L, Meischl C, Stooker W, Meijer CJLM, Niessen HWM, Ross D (2002) NADPH oxidase(s): New source(s) of reactive oxygen species in the vascular system? J Clin Pathol 55:561-568
41. Kobayashi N, Mita S, Yoshida K (2003) Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 via NF-κB induced by oxidative stress. Hypertension 42:1004-1013
42. Wagner AH, Schroeter MR, Hecker M (2001) 17β-Estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J 15:2121-2130