Insulin signaling in hypertension

International Congress Series

Volumn 1303, Issue , 2007, Pages 41-47

  Trimarco, Bruno ^a   Crispo, Salvatore ^a   Morisco, Carmine ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Adrenergic receptors; Angiotensin II; Glucose uptake; Oxidative stress; Protein kinase B

Indexed keywords

EID: 34447619695     PISSN: 05315131     EISSN: None     Source Type: Book Series    
DOI: 10.1016/j.ics.2007.04.005     Document Type: Article

References (35)

1. Olefsky J., Farquhar J.W., and Reaven G. Relationship between fasting plasma insulin level and resistance to insulin-mediated glucose uptake in normal and diabetic subjects. Diabetes 22 7 (1973) 507-513
2. Kolterman O.G., et al. Mechanisms of insulin resistance in human obesity: evidence for receptor and postreceptor defects. J. Clin. Invest. 65 6 (1980) 1272-1284
3. Ferrannini E., et al. Insulin resistance in essential hypertension. N. Engl. J. Med. 317 6 (1987) 350-357
4. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). Jama 285 19 (2001) 2486-2497
5. Paolisso G., et al. Insulin resistance and hyperinsulinemia in patients with chronic congestive heart failure. Metabolism 40 9 (1991) 972-977
6. Shah A., and Shannon R.P. Insulin resistance in dilated cardiomyopathy. Rev. Cardiovasc. Med. 4 Suppl 6 (2003) S50-S57
7. Scherrer U., et al. Nitric oxide release accounts for insulin's vascular effects in humans. J. Clin. Invest. 94 6 (1994) 2511-2515
8. Lee J., and Pilch P.F. The insulin receptor: structure, function, and signaling. Am. J. Physiol. 266 2 Pt 1 (1994) C319-C334
9. Cong L.N., et al. Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol. Endocrinol. 11 13 (1997) 1881-1890
10. Kim Y.B., et al. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J. Clin. Invest. 104 6 (1999) 733-741
11. Egawa K., et al. Persistent activation of phosphatidylinositol 3-kinase causes insulin resistance due to accelerated insulin-induced insulin receptor substrate-1 degradation in 3T3-L1 adipocytes. Endocrinology 141 6 (2000) 1930-1935
12. Goldstein B.J., et al. Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol. Cell. Biochem. 182 1-2 (1998) 91-99
13. Hotamisligil G.S. Mechanisms of TNF-alpha-induced insulin resistance. Exp. Clin. Endocrinol. Diabetes 107 2 (1999) 119-125
14. Lembo G., et al. Abnormal sympathetic overactivity evoked by insulin in the skeletal muscle of patients with essential hypertension. J. Clin. Invest. 90 1 (1992) 24-29
15. Lembo G., et al. Insulin modulation of vascular reactivity is already impaired in prehypertensive spontaneously hypertensive rats. Hypertension 26 2 (1995) 290-293
16. Abe H., et al. Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. J. Clin. Invest. 101 8 (1998) 1784-1788
17. Wheatcroft S.B., et al. Preserved glucoregulation but attenuation of the vascular actions of insulin in mice heterozygous for knockout of the insulin receptor. Diabetes 53 10 (2004) 2645-2652
18. Cheng Z.J., et al. Endothelial dysfunction and salt-sensitive hypertension in spontaneously diabetic Goto-Kakizaki rats. Hypertension 37 2 Part 2 (2001) 433-439
19. Ouchi Y., et al. Augmented contractile function and abnormal Ca2+ handling in the aorta of Zucker obese rats with insulin resistance. Diabetes 45 Suppl 3 (1996) S55-S58
20. Morisco C., et al. Insulin-stimulated cardiac glucose uptake is impaired in spontaneously hypertensive rats: role of early steps of insulin signalling. J. Hypertens. 18 4 (2000) 465-473
21. Mancia G., et al. Sympathetic activation in the pathogenesis of hypertension and progression of organ damage. Hypertension 34 4 Pt 2 (1999) 724-728
22. Yusuf S., et al. Ramipril and the development of diabetes. Jama 286 15 (2001) 1882-1885
23. Julius S., et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 363 9426 (2004) 2022-2031
24. Scheen A.J. DREAM study: prevention of type 2 diabetes with ramipril and/or rosiglitazone in persons with dysglycaemia but no cardiovascular disease. Rev. Med. Liege, Suppl. 61 10 (2006) 728-732
25. Sowers J.R. Insulin resistance and hypertension. Am. J. Physiol, Heart Circ. Physiol. 286 5 (2004) H1597-H1602
26. Taniyama Y., et al. Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II. Arterioscler. Thromb. Vasc. Biol. 25 6 (2005) 1142-1147
27. Ogihara T., et al. Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling. Hypertension 40 6 (2002) 872-879
28. Andreozzi F., et al. Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser312 and Ser616 in human umbilical vein endothelial cells. Circ. Res. 94 9 (2004) 1211-1218
29. Klein J., et al. Beta(3)-adrenergic stimulation differentially inhibits insulin signaling and decreases insulin-induced glucose uptake in brown adipocytes. J. Biol. Chem. 274 49 (1999) 34795-34802
30. Morisco C., et al. Akt mediates the cross-talk between beta-adrenergic and insulin receptors in neonatal cardiomyocytes. Circ. Res. 96 2 (2005) 180-188
31. Nagoshi T., et al. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J. Clin. Invest. 115 8 (2005) 2128-2138
32. Dandona P., et al. Insulin suppresses plasma concentration of vascular endothelial growth factor and matrix metalloproteinase-9. Diabetes Care 26 12 (2003) 3310-3314
33. Aljada A., et al. Insulin inhibits the pro-inflammatory transcription factor early growth response gene-1 (Egr)-1 expression in mononuclear cells (MNC) and reduces plasma tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) concentrations. J. Clin. Endocrinol. Metab. 87 3 (2002) 1419-1422
34. Condorelli G., et al. Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptations to chronic pressure overload in the rat. Circulation 99 23 (1999) 3071-3078
35. Jonassen A.K., et al. Insulin administered at reoxygenation exerts a cardioprotective effect in myocytes by a possible anti-apoptotic mechanism. J. Mol. Cell. Cardiol. 32 5 (2000) 757-764