Design, synthesis and anti-inflammatory evaluation of novel 5-benzylidene-3,4-dihalo-furan-2-one derivatives

European Journal of Medicinal Chemistry

Volumn 72, Issue , 2014, Pages 35-45

  Wang, Fang ^a   Sun, Jun Rong ^a   Huang, Mei Yan ^a   Wang, Hui Ying ^a   Sun, Ping Hua ^a   Lin, Jing ^a   Chen, Wei Min ^a  

^a JINAN UNIVERSITY   (China)

Author keywords

3,4 Dihalo furan 2 one; Action mechanism; Anti inflammation; PPAR ; Synthesis

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 3,4 DIBROMO 5 [3 ETHOXY 4 (2 (5 ETHYLPYRIDIN 2 YL) ETHOXY)BENZYLIDENE] FURAN 2(5H) ONE; 3,4 DIBROMO 5 [3 ETHOXY 4 (2 (PYRIDIN 2 YL)ETHOXY) BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DIBROMO 5 [3 ETHOXY 4 (PYRIDIN 2 YLMETHOXY)BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DIBROMO 5 [3 METHOXY 4 ((3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY)BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DIBROMO 5 [3 METHOXY 4 (2 (PYRIDIN 2 YL)ETHOXY) BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DIBROMO 5 [3 METHOXY 4 (PYRIDIN 2 YLMETHOXY) BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DIBROMO 5 [4 ((3,5,6 TRIMETHYLPYRAZIN 2 YL) METHOXY)BENZYLIDENE] FURAN 2(5H) ONE; 3,4 DIBROMO 5 [4 (2 (5 ETHYLPYRIDIN 2 YL)ETHOXY) 3 METHOXYBENZYLIDENE] FURAN 2(5H) ONE; 3,4 DIBROMO 5 [4 (2 (5 ETHYLPYRIDIN 2 YL)ETHOXY)BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DIBROMO 5 [4 (2 (PYRIDIN 2 YL)ETHOXY)BENZYLIDENE] FURAN 2(5H) ONE; 3,4 DIBROMO 5 [4 (PYRIDIN 2 YLMETHOXY)BENZYLIDENE] FURAN 2(5H) ONE; 3,4 DICHLORO 5 [3 ETHOXY 4 (2 (PYRIDIN 2 YL)ETHOXY) BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DICHLORO 5 [3 ETHOXY 4 (PYRIDIN 2 YLMETHOXY)BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DICHLORO 5 [3 METHOXY 4 (2 (PYRIDIN 2 YL)ETHOXY) BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DICHLORO 5 [3 METHOXY 4 (PYRIDIN 2 YLMETHOXY) BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DICHLORO 5 [4 (2 (5 ETHYLPYRIDIN 2 YL)ETHOXY)BENZYLIDENE]FURAN 2(5H) ONE; 3,4 DICHLORO 5 [4 (2 (PYRIDIN 2 YL)ETHOXY)BENZYLIDENE] FURAN 2(5H) ONE; 3,4 DICHLORO 5 [4 (PYRIDIN 2 YLMETHOXY)BENZYLIDENE] FURAN 2(5H) ONE; 5 [3 ((3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY)BENZYLIDENE]THIAZOLIDINE 2,4 DIONE; 5 [3 ETHOXY 4 ((3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY) BENZYLIDENE] THIAZOLIDINE 2,4 DIONE; 5 [3 METHOXY 4 ((3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY) BENZYLIDENE] THIAZOLIDINE 2,4 DIONE; 5 [4 ((3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY)BENZYLIDENE] THIAZOLIDINE 2,4 DIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 2-CHLORO-5-NITROBENZANILIDE; ANILIDE; BENZYLIDENE DERIVATIVE; FURAN DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; MASS SPECTROMETRY; MEDIATOR; MOLECULAR DOCKING; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; SYNTHESIS;

ANILIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZYLIDENE COMPOUNDS; CELL LINE; CELL SURVIVAL; DRUG DESIGN; FURANS; INTERLEUKIN-6; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NF-KAPPA B; NITRIC OXIDE; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84889965426     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.10.074     Document Type: Article

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