Tetramethylpyrazine suppresses interleukin-8 expression in LPS-stimulated human umbilical vein endothelial cell by blocking ERK, p38 and nulear factor-κB signaling pathways

Journal of Ethnopharmacology

Volumn 125, Issue 1, 2009, Pages 83-89

  Li, Xiu Ying ^a   He, Jun Lin ^a   Liu, Hong Tao ^a,b   Li, Wen Ming ^a   Yu, Chao ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

Author keywords

Human umbilical vein endothelial cells; Interleukin 8; MAP kinase; Nulear factor B; Tetramethylpyrazine

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; SYNAPTOTAGMIN I; TETRAMETHYLPYRAZINE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CELL ADHESION; CELL ASSAY; CELL NUCLEUS; CELL STRAIN U937; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; WESTERN BLOTTING;

BASE SEQUENCE; CELL ADHESION; CELLS, CULTURED; CULTURE MEDIA; DNA PRIMERS; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PYRAZINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; U937 CELLS; UMBILICAL VEINS;

EID: 67651108746     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.06.008     Document Type: Article

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