Synthesis and biological evaluation of novel thiazolidinedione analogues as 15-hydroxyprostaglandin dehydrogenase inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 14, 2011, Pages 5260-5264

  Wu, Ying ^a   Karna, Sandeep ^a   Choi, Cheol Hee ^a,b   Tong, Min ^c   Tai, Hsin Hsiung ^c   Na, Dong Hee ^d   Jang, Chul Ho ^a,e   Cho, Hoon ^a  

^a Chosun University   (South Korea)

^b Chosun University College of Medicine   (South Korea)

^c University of Kentucky   (United States)

^d Kyungsung University   (South Korea)

^e Chonnam National University Medical School   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 [3 BROMO 4 (2 CYCLOHEXYLETHOXY)BENZYLIDENE]THIAZOLIDINE 2,4 DIONE; 5 [3 CHLORO 4 (2 CYCLOHEXYLETHOXY)BENZYLIDENE]THIAZOLIDINE 2,4 DIONE; 5 [3 CHLORO 4 (CYCLOHEXYLBUTOXY)BENZYLIDENE]THIAZOLIDINE 2,4 DIONE; 5 [3 CHLORO 4 (CYCLOHEXYLMETHOXY)BENZYLIDENE]THIAZOLIDINE 2,4 DIONE; 5 [3 CHLORO 4 (CYCLOHEXYLOXY)BENZYLIDENE]THIAZOLIDINE 2,4 DIONE; 5 [3 CHLORO 4 (CYCLOHEXYLPROPOXY)BENZYLIDENE]THIAZOLIDINE 2,4 DIONE; 5 [4 (2 CYCLOHEXYLETHOXY) 3 METHOXYBENZYLIDENE]THIAZOLIDINE 2,4 DIONE; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL ACTIVITY; COCHLEA BLOOD FLOW; CONTROLLED STUDY; DRUG SYNTHESIS; GUINEA PIG; HUMAN; HUMAN CELL; IC 50; MALE; MONOLAYER CULTURE; NONHUMAN; WOUND; WOUND HEALING;

ANIMALS; CELL LINE, TUMOR; COCHLEA; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DINOPROSTONE; GUINEA PIGS; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; MALE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANIC ANION TRANSPORTERS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES; WOUND HEALING;

EID: 79960620668     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200390u     Document Type: Article

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