Synthesis of novel ligustrazine derivatives as Na+/H+ exchange inhibitors

Chemistry and Biodiversity

Volumn 7, Issue 11, 2010, Pages 2727-2736

  Ren, Mei ^a   Dong, Jin ^a   Xu, Yungen ^a   Wen, Nan ^a   Gong, Guoqing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Guanidine derivatives, benzoyl ; Inhibitors; Ligustrazine derivatives; Na + H+ Exchange (NHE) inhibitors

Indexed keywords

3 BROMO N (DIAMINOMETHYLIDENE) 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZAMIDE HYDROCHLORIDE; 3 BROMO N (DIAMINOMETHYLIDENE) 4 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZAMIDE HYDROCHLORIDE; 3 CHLORO N (DIAMINOMETHYLIDENE) 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZAMIDE HYDROCHLORIDE; 3 CHLORO N (DIAMINOMETHYLIDENE) 4 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZAMIDE HYDROCHLORIDE; ETHYL 2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZOATE; ETHYL 2 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZOATE; ETHYL 3 BROMO 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZOATE; ETHYL 3 BROMO 4 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZOATE; ETHYL 3 CHLORO 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZOATE; ETHYL 3 CHLORO 4 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZOATE; ETHYL 3 METHOXY 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZOATE; ETHYL 3 NITRO 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZOATE; ETHYL 3 NITRO 4 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZOATE; ETHYL 4 (TRIFLUOROMETHYL) 2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZOATE; ETHYL 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZOATE; ETHYL 4 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZOATE; ETHYL 4 METHYL 3 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZOATE; METHYL 3 METHYL 4 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZOATE; N (DIAMINOMETHYLIDENE) 2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZAMIDE HYDROCHLORIDE; N (DIAMINOMETHYLIDENE) 2 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZAMIDE HYDROCHLORIDE; N (DIAMINOMETHYLIDENE) 3 METHOXY 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZAMIDE HYDROCHLORIDE; N (DIAMINOMETHYLIDENE) 3 METHYL 4 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZAMIDE HYDROCHLORIDE; N (DIAMINOMETHYLIDENE) 3 NITRO 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZAMIDE HYDROCHLORIDE; N (DIAMINOMETHYLIDENE) 3 NITRO 4 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZAMIDE HYDROCHLORIDE; N (DIAMINOMETHYLIDENE) 4 (TRIFLUOROMETHYL) 2 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZAMIDE HYDROCHLORIDE; N (DIAMINOMETHYLIDENE) 4 [(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHOXY]BENZAMIDE HYDROCHLORIDE; N (DIAMINOMETHYLIDENE) 4 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZAMIDE HYDROCHLORIDE; N (DIAMINOMETHYLIDENE) 4 METHYL 3 [[(3,5,6 TRIMETHYLPYRAZIN 2 YL)METHYL]AMINO]BENZAMIDE HYDROCHLORIDE; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; HEART INFARCTION; HEART INFARCTION SIZE; MALE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON SODIUM EXCHANGE; RAT;

ANIMALS; BENZAMIDES; CARDIOTONIC AGENTS; CREATINE KINASE; DISEASE MODELS, ANIMAL; MYOCARDIAL INFARCTION; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-HYDROGEN ANTIPORTER; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 78649238148     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.200900353     Document Type: Article

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