메뉴 건너뛰기




Volumn 98, Issue 12, 2013, Pages 4872-4881

Disuse impairs the muscle protein synthetic response to protein ingestion in healthy men

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIAN TARGET OF RAPAMYCIN; MUSCLE PROTEIN; PHENYLALANINE DERIVATIVE; S6 KINASE;

EID: 84889860146     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-2098     Document Type: Article
Times cited : (132)

References (66)
  • 1
    • 84875667802 scopus 로고
    • The effect of immobilization on metabolic and physiological functions of normal men
    • Deitrick JE. The effect of immobilization on metabolic and physiological functions of normal men. Bull N Y Acad Med. 1948;24: 364-375.
    • (1948) Bull N Y Acad Med , vol.24 , pp. 364-375
    • Deitrick, J.E.1
  • 2
    • 0023141415 scopus 로고
    • Decrease in human quadriceps muscle protein turnover consequent upon leg immobilization
    • Gibson J, Halliday D, Morrison W, et al. Decrease in human quadriceps muscle protein turnover consequent upon leg immobilization. Clin Sci (Lond). 1987;72:503-509.
    • (1987) Clin Sci (Lond) , vol.72 , pp. 503-509
    • Gibson, J.1    Halliday, D.2    Morrison, W.3
  • 5
    • 0029964564 scopus 로고    scopus 로고
    • Prolonged bed rest decreases skeletal muscle and whole body protein synthesis
    • Ferrando A, Lane H, Stuart C, Davis-Street J, Wolfe R. Prolonged bed rest decreases skeletal muscle and whole body protein synthesis. Am J Physiol. 1996;270(4 Pt 1):E627-E633.
    • (1996) Am J Physiol , vol.270 , Issue.4 PART 1
    • Ferrando, A.1    Lane, H.2    Stuart, C.3    Davis-Street, J.4    Wolfe, R.5
  • 6
    • 84883290555 scopus 로고    scopus 로고
    • Skeletal muscle atrophy during short-term disuse: Implications for age-related sarcopenia
    • Wall BT, Dirks ML, van Loon LJ. Skeletal muscle atrophy during short-term disuse: implications for age-related sarcopenia. Ageing Res Rev. 2013;12:898-906.
    • (2013) Ageing Res Rev , vol.12 , pp. 898-906
    • Wall, B.T.1    Dirks, M.L.2    Van Loon, L.J.3
  • 7
    • 73849139203 scopus 로고    scopus 로고
    • Protecting muscle mass and function in older adults during bed rest
    • English KL, Paddon-Jones D. Protecting muscle mass and function in older adults during bed rest. Curr Opin Clin Nutr Metab Care. 2010;13:34-39.
    • (2010) Curr Opin Clin Nutr Metab Care , vol.13 , pp. 34-39
    • English, K.L.1    Paddon-Jones, D.2
  • 8
    • 0031002537 scopus 로고    scopus 로고
    • Resistance exercise maintains skeletal muscle protein synthesis during bed rest
    • Ferrando AA, Tipton KD, Bamman MM, Wolfe R. Resistance exercise maintains skeletal muscle protein synthesis during bed rest. J Appl Physiol. 1997;82:807-810.
    • (1997) J Appl Physiol , vol.82 , pp. 807-810
    • Ferrando, A.A.1    Tipton, K.D.2    Bamman, M.M.3    Wolfe, R.4
  • 9
    • 34247534568 scopus 로고    scopus 로고
    • Effect of 10 days of bed rest on skeletal muscle in healthy older adults
    • Kortebein P, Ferrando A, Lombeida J, Wolfe R, Evans W. Effect of 10 days of bed rest on skeletal muscle in healthy older adults.JAMA. 2007;297:1772-1774.
    • (2007) JAMA , vol.297 , pp. 1772-1774
    • Kortebein, P.1    Ferrando, A.2    Lombeida, J.3    Wolfe, R.4    Evans, W.5
  • 10
    • 75949099307 scopus 로고    scopus 로고
    • EAAsupplementation to increase nitrogen intake improves muscle function during bed rest in the elderly
    • Ferrando AA, Paddon-Jones D, Hays N, et al.EAAsupplementation to increase nitrogen intake improves muscle function during bed rest in the elderly. Clin Nutr. 2010;29:18-23.
    • (2010) Clin Nutr , vol.29 , pp. 18-23
    • Ferrando, A.A.1    Paddon-Jones, D.2    Hays, N.3
  • 11
    • 67650079061 scopus 로고    scopus 로고
    • Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity
    • Symons TB, Sheffield-Moore M, Chinkes DL, Ferrando AA, Paddon- Jones D. Artificial gravity maintains skeletal muscle protein synthesis during 21 days of simulated microgravity. J Appl Physiol. 2009;107:34-38.
    • (2009) J Appl Physiol , vol.107 , pp. 34-38
    • Symons, T.B.1    Sheffield-Moore, M.2    Chinkes, D.L.3    Ferrando, A.A.4    Paddon-Jones, D.5
  • 12
    • 0023805436 scopus 로고
    • Prevention of disuse muscle atrophy by means of electrical stimulation: Maintenance of protein synthesis
    • Gibson JN, Smith K, Rennie MJ. Prevention of disuse muscle atrophy by means of electrical stimulation: maintenance of protein synthesis. Lancet. 1988;2:767-770.
    • (1988) Lancet , vol.2 , pp. 767-770
    • Gibson, J.N.1    Smith, K.2    Rennie, M.J.3
  • 13
    • 57649232182 scopus 로고    scopus 로고
    • Immobilization induces anabolic resistance inhumanmyofibrillar protein synthesis with low and high dose amino acid infusion
    • Glover EI, Phillips SM, Oates BR, et al. Immobilization induces anabolic resistance inhumanmyofibrillar protein synthesis with low and high dose amino acid infusion. J Physiol. 2008;586:6049- 6061.
    • (2008) J Physiol , vol.586 , pp. 6049-6061
    • Glover, E.I.1    Phillips, S.M.2    Oates, B.R.3
  • 14
    • 36248952729 scopus 로고    scopus 로고
    • The temporal responses of protein synthesis, gene expression and cell signalling inhumanquadriceps muscle and patellar tendon to disuse
    • de Boer MD, Selby A, Atherton P, et al. The temporal responses of protein synthesis, gene expression and cell signalling inhumanquadriceps muscle and patellar tendon to disuse. J Physiol. 2007;585: 241-251.
    • (2007) J Physiol , vol.585 , pp. 241-251
    • De Boer, M.D.1    Selby, A.2    Atherton, P.3
  • 15
    • 69749089808 scopus 로고    scopus 로고
    • Alterations of protein turnover underlying disuse atrophy in human skeletal muscle
    • Phillips SM, Glover EI, Rennie MJ. Alterations of protein turnover underlying disuse atrophy in human skeletal muscle. J Appl Physiol. 2009;107:645-654.
    • (2009) J Appl Physiol , vol.107 , pp. 645-654
    • Phillips, S.M.1    Glover, E.I.2    Rennie, M.J.3
  • 16
    • 84875661699 scopus 로고    scopus 로고
    • Nutritional strategies to attenuate muscle disuse atrophy
    • Wall BT, van Loon LJ. Nutritional strategies to attenuate muscle disuse atrophy. Nutrition Reviews. 2013;71:195-208.
    • (2013) Nutrition Reviews , vol.71 , pp. 195-208
    • Wall, B.T.1    Van Loon, L.J.2
  • 17
    • 0020464729 scopus 로고
    • Muscle protein synthesis measured by stable isotope techniques in man: The effects of feeding and fasting
    • Rennie M, Edwards R, Halliday D, Matthews D, Wolman S, Millward D. Muscle protein synthesis measured by stable isotope techniques in man: the effects of feeding and fasting. Clin Sci (Lond). 1982;63:519-523.
    • (1982) Clin Sci (Lond) , vol.63 , pp. 519-523
    • Rennie, M.1    Edwards, R.2    Halliday, D.3    Matthews, D.4    Wolman, S.5    Millward, D.6
  • 18
  • 19
    • 0032080924 scopus 로고    scopus 로고
    • Exogenous amino acids stimulate net muscle protein synthesis in the elderly
    • Volpi E, Ferrando AA, Yeckel CW, Tipton KD, Wolfe RR. Exogenous amino acids stimulate net muscle protein synthesis in the elderly. J Clin Invest. 1998;101:2000-2007.
    • (1998) J Clin Invest , vol.101 , pp. 2000-2007
    • Volpi, E.1    Ferrando, A.A.2    Yeckel, C.W.3    Tipton, K.D.4    Wolfe, R.R.5
  • 20
    • 0032835655 scopus 로고    scopus 로고
    • Oral amino acids stimulate muscle protein anabolism in the elderly despite higher firstpass splanchnic extraction
    • Volpi E, Mittendorfer B, Wolf S, Wolfe RR. Oral amino acids stimulate muscle protein anabolism in the elderly despite higher firstpass splanchnic extraction. Am J Physiol. 1999;277:513-520.
    • (1999) Am J Physiol , vol.277 , pp. 513-520
    • Volpi, E.1    Mittendorfer, B.2    Wolf, S.3    Wolfe, R.R.4
  • 21
    • 84860506912 scopus 로고    scopus 로고
    • Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults
    • Drummond MJ, Dickinson JM, Fry CS, et al. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab. 2012;302:E1113 - e1122.
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Drummond, M.J.1    Dickinson, J.M.2    Fry, C.S.3
  • 22
    • 84875667419 scopus 로고    scopus 로고
    • The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type 2 muscle fiber size
    • Nilwik R, Snijders T, Leenders M, Groen BB, et al. The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type 2 muscle fiber size. Exp Gerontol. 2013;48:492-498.
    • (2013) Exp Gerontol , vol.48 , pp. 492-498
    • Nilwik, R.1    Snijders, T.2    Leenders, M.3    Groen, B.B.4
  • 24
    • 0002014525 scopus 로고
    • Strength Testing: Development and evaluation of methodology
    • Maud P, Foster C, eds, Leeds, UK: Human Kinetics
    • Kraemer W, Fry A. Strength testing: development and evaluation of methodology. In: Maud P, Foster C, eds. Physiological Assessment of Physical Fitness. Leeds, UK: Human Kinetics; 1995:115-133.
    • (1995) Physiological Assessment of Physical Fitness , pp. 115-133
    • Kraemer, W.1    Fry, A.2
  • 25
    • 0019458610 scopus 로고
    • Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man
    • Abumrad NN, Rabin D, Diamond MP, Lacy WW. Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metabolism. 1981;30:936-940.
    • (1981) Metabolism , vol.30 , pp. 936-940
    • Abumrad, N.N.1    Rabin, D.2    Diamond, M.P.3    Lacy, W.W.4
  • 26
    • 0016723939 scopus 로고
    • Percutaneous needle biopsy of skeletal muscle in physiological and clinical research
    • Bergstrom J. Percutaneous needle biopsy of skeletal muscle in physiological and clinical research. Scand J Clin Lab Invest. 1975;35: 609-616.
    • (1975) Scand J Clin Lab Invest , vol.35 , pp. 609-616
    • Bergstrom, J.1
  • 27
    • 79955412532 scopus 로고    scopus 로고
    • Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men
    • Pennings B, Boirie Y, Senden JM, Gijsen AP, Kuipers H, van Loon LJ. Whey protein stimulates postprandial muscle protein accretion more effectively than do casein and casein hydrolysate in older men. Am J Clin Nutr. 2011;93:997-1005.
    • (2011) Am J Clin Nutr , vol.93 , pp. 997-1005
    • Pennings, B.1    Boirie, Y.2    Senden, J.M.3    Gijsen, A.P.4    Kuipers, H.5    Van Loon, L.J.6
  • 28
    • 15444361842 scopus 로고    scopus 로고
    • Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects
    • Koopman R, Wagenmakers AJ, Manders RJ, et al. Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects. Am J Physiol Endocrinol Metab. 2005;288:E645-E653.
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Koopman, R.1    Wagenmakers, A.J.2    Manders, R.J.3
  • 29
    • 4344621095 scopus 로고    scopus 로고
    • Short-term bed rest impairs amino acid-induced protein anabolism in humans
    • Biolo G, Ciocchi B, Lebenstedt M, et al. Short-term bed rest impairs amino acid-induced protein anabolism in humans. J Physiol. 2004; 558:381-388.
    • (2004) J Physiol , vol.558 , pp. 381-388
    • Biolo, G.1    Ciocchi, B.2    Lebenstedt, M.3
  • 30
    • 0043065470 scopus 로고    scopus 로고
    • Sensitivity of whole body protein synthesis to amino acid administration during short-term bed rest
    • Biolo G, Ciocchi B, Lebenstedt M, Heer M, Guarnieri G. Sensitivity of whole body protein synthesis to amino acid administration during short-term bed rest. J Gravit Physiol. 2002;9:P197-P198.
    • (2002) J Gravit Physiol , vol.9
    • Biolo, G.1    Ciocchi, B.2    Lebenstedt, M.3    Heer, M.4    Guarnieri, G.5
  • 31
    • 9444290436 scopus 로고    scopus 로고
    • Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans
    • Guillet C, Prod'homme M, Balage M, et al. Impaired anabolic response of muscle protein synthesis is associated with S6K1 dysregulation in elderly humans. FASEB J. 2004;18:1586-1587.
    • (2004) FASEB J , vol.18 , pp. 1586-1587
    • Guillet, C.1    Prod'homme, M.2    Balage, M.3
  • 32
    • 14644444464 scopus 로고    scopus 로고
    • Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
    • Cuthbertson D, Smith K, Babraj J, et al. Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle. FASEB J. 2005;19:422-424.
    • (2005) FASEB J , vol.19 , pp. 422-424
    • Cuthbertson, D.1    Smith, K.2    Babraj, J.3
  • 33
    • 33646267446 scopus 로고    scopus 로고
    • Insulin resistance of muscle protein metabolism in aging
    • Rasmussen BB, Fujita S, Wolfe RR, et al. Insulin resistance of muscle protein metabolism in aging. FASEB J. 2006;20:768-769.
    • (2006) FASEB J , vol.20 , pp. 768-769
    • Rasmussen, B.B.1    Fujita, S.2    Wolfe, R.R.3
  • 34
    • 0034485454 scopus 로고    scopus 로고
    • The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly
    • Volpi E, Mittendorfer B, Rasmussen BB, Wolfe RR. The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly. J Clin Endocrinol Metab. 2000;85:4481-4490.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4481-4490
    • Volpi, E.1    Mittendorfer, B.2    Rasmussen, B.B.3    Wolfe, R.R.4
  • 36
    • 0016274311 scopus 로고
    • Catabolic" loss of body nitrogen in response to surgery
    • O'Keefe SJ, Sender PM, James WP. "Catabolic" loss of body nitrogen in response to surgery. Lancet. 1974;2:1035-1038.
    • (1974) Lancet , vol.2 , pp. 1035-1038
    • O'Keefe, S.J.1    Sender, P.M.2    James, W.P.3
  • 37
    • 0017353342 scopus 로고
    • Protein turnover in patients before and after elective orthopaedic operations
    • Crane CW, Picou D, Smith R, Waterlow JC. Protein turnover in patients before and after elective orthopaedic operations. Br J Surg. 1977;64:129-133.
    • (1977) Br J Surg , vol.64 , pp. 129-133
    • Crane, C.W.1    Picou, D.2    Smith, R.3    Waterlow, J.C.4
  • 38
    • 37749046701 scopus 로고    scopus 로고
    • Maintenance of the musculoskeletal mass by control of protein turnover: The concept of anabolic resistance and its relevance to the transplant recipient
    • Rennie MJ, Wilkes EA. Maintenance of the musculoskeletal mass by control of protein turnover: the concept of anabolic resistance and its relevance to the transplant recipient. Ann Transplant. 2005;10: 31-34.
    • (2005) Ann Transplant , vol.10 , pp. 31-34
    • Rennie, M.J.1    Wilkes, E.A.2
  • 39
    • 70350520654 scopus 로고    scopus 로고
    • Anabolic resistance in critically ill patients
    • Rennie MJ. Anabolic resistance in critically ill patients. Crit Care Med. 2009;37(10 Suppl):S398-S399.
    • (2009) Crit Care Med , vol.37 , Issue.SUPPL. 10
    • Rennie, M.J.1
  • 40
    • 77955347040 scopus 로고    scopus 로고
    • Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling
    • Timmerman KL, Lee JL, Dreyer HC, et al. Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. J Clin Endocrinol Metab. 2010;95: 3848-3857.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 3848-3857
    • Timmerman, K.L.1    Lee, J.L.2    Dreyer, H.C.3
  • 41
    • 77950839133 scopus 로고    scopus 로고
    • Anincrease in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle
    • Drummond M, Glynn E, Fry C, Timmerman K, Volpi E, Rasmussen B.Anincrease in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. Am J Physiol Endocrinol Metab. 2010;298:E1011-E1018.
    • (2010) Am J Physiol Endocrinol Metab , vol.298
    • Drummond, M.1    Glynn, E.2    Fry, C.3    Timmerman, K.4    Volpi, E.5    Rasmussen, B.6
  • 42
    • 79960285539 scopus 로고    scopus 로고
    • Aging impairs contractioninduced human skeletal muscle m TORC1 signaling and protein synthesis
    • Fry C, Drummond M, Glynn E, et al. Aging impairs contractioninduced human skeletal muscle m TORC1 signaling and protein synthesis. Skelet Muscle. 2011;1:11.
    • (2011) Skelet Muscle , vol.1 , pp. 11
    • Fry, C.1    Drummond, M.2    Glynn, E.3
  • 43
    • 84860577206 scopus 로고    scopus 로고
    • GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance
    • Biensø RS, Ringholm S, Kiilerich K, et al. GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance. Diabetes. 2012;61:1090-1099.
    • (2012) Diabetes , vol.61 , pp. 1090-1099
    • Biensø, R.S.1    Ringholm, S.2    Kiilerich, K.3
  • 44
    • 0025966905 scopus 로고
    • Seven days of bed rest decrease insulin action on glucose uptake in leg and whole body
    • Mikines KJ, Richter EA, Dela F, Galbo H. Seven days of bed rest decrease insulin action on glucose uptake in leg and whole body. J Appl Physiol. 1991;70:1245-1254.
    • (1991) J Appl Physiol , vol.70 , pp. 1245-1254
    • Mikines, K.J.1    Richter, E.A.2    Dela, F.3    Galbo, H.4
  • 45
    • 68449094247 scopus 로고    scopus 로고
    • Upraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: Evidence of a true age-related insulin resistance of muscle protein metabolism
    • Fujita S, Glynn EL, Timmerman KL, Rasmussen BB, Volpi E. upraphysiological hyperinsulinaemia is necessary to stimulate skeletal muscle protein anabolism in older adults: evidence of a true age-related insulin resistance of muscle protein metabolism. Diabetologia. 2009;52:1889-1898.
    • (2009) Diabetologia , vol.52 , pp. 1889-1898
    • Fujita, S.1    Glynn, E.L.2    Timmerman, K.L.3    Rasmussen, B.B.4    Volpi, E.5
  • 47
    • 0036720367 scopus 로고    scopus 로고
    • Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise
    • Kimball SR, Farrell PA, Jefferson LS. Invited Review: Role of insulin in translational control of protein synthesis in skeletal muscle by amino acids or exercise. J Appl Physiol. 2002;93:1168-1180.
    • (2002) J Appl Physiol , vol.93 , pp. 1168-1180
    • Kimball, S.R.1    Farrell, P.A.2    Jefferson, L.S.3
  • 48
    • 63849130621 scopus 로고    scopus 로고
    • Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis
    • Drummond MJ, Fry CS, Glynn EL, et al. Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. J Physiol. 2009;587:1535-1546.
    • (2009) J Physiol , vol.587 , pp. 1535-1546
    • Drummond, M.J.1    Fry, C.S.2    Glynn, E.L.3
  • 49
    • 77954752950 scopus 로고    scopus 로고
    • Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy
    • Glover EI, Yasuda N, TarnopolskyMA,Abadi A, Phillips SM. Little change in markers of protein breakdown and oxidative stress in humans in immobilization-induced skeletal muscle atrophy. Appl Physiol Nutr Metab. 2010;35:125-133.
    • (2010) Appl Physiol Nutr Metab , vol.35 , pp. 125-133
    • Glover, E.I.1    Yasuda, N.2    Tarnopolsky, M.A.3    Abadi, A.4    Phillips, S.M.5
  • 50
    • 80051993134 scopus 로고    scopus 로고
    • Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise
    • West DW, Burd NA, Coffey VG, et al. Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. Am J Clin Nutr. 2011; 94:795-803.
    • (2011) Am J Clin Nutr , vol.94 , pp. 795-803
    • West, D.W.1    Burd, N.A.2    Coffey, V.G.3
  • 51
    • 84861707373 scopus 로고    scopus 로고
    • Supplementation of a suboptimal protein dose with leucine or essential amino acids: Effects on myofibrillar protein synthesis at rest and following resistance exercise in men
    • Churchward-Venne TA, Burd NA, Mitchell CJ, et al. Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. J Physiol. 2012;590:2751-2765.
    • (2012) J Physiol , vol.590 , pp. 2751-2765
    • Churchward-Venne, T.A.1    Burd, N.A.2    Mitchell, C.J.3
  • 52
    • 77951959117 scopus 로고    scopus 로고
    • A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity
    • Krogh-Madsen R, Thyfault JP, Broholm C, et al. A 2-wk reduction of ambulatory activity attenuates peripheral insulin sensitivity. J Appl Physiol. 2010;108:1034-1040.
    • (2010) J Appl Physiol , vol.108 , pp. 1034-1040
    • Krogh-Madsen, R.1    Thyfault, J.P.2    Broholm, C.3
  • 53
    • 84878507725 scopus 로고    scopus 로고
    • Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly
    • Breen L, Stokes KA, Churchward-Venne TA, et al. Two weeks of reduced activity decreases leg lean mass and induces "anabolic resistance" of myofibrillar protein synthesis in healthy elderly. J Clin Endocrinol Metab. 2013;98:2604-2612.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 2604-2612
    • Breen, L.1    Stokes, K.A.2    Churchward-Venne, T.A.3
  • 54
    • 4544351389 scopus 로고    scopus 로고
    • Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest
    • Paddon-Jones D, Sheffield-Moore M, Urban R, et al. Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest. J Clin Endocrinol Metab. 2004;89:4351-4358.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4351-4358
    • Paddon-Jones, D.1    Sheffield-Moore, M.2    Urban, R.3
  • 55
    • 0032819476 scopus 로고    scopus 로고
    • Attenuation of the protein wasting associated with bed rest by branched-chain amino acids
    • Stein TP, Schluter MD, Leskiw MJ, Boden G. Attenuation of the protein wasting associated with bed rest by branched-chain amino acids. Nutrition. 1999;15:656-660.
    • (1999) Nutrition , vol.15 , pp. 656-660
    • Stein, T.P.1    Schluter, M.D.2    Leskiw, M.J.3    Boden, G.4
  • 56
    • 34547101459 scopus 로고    scopus 로고
    • The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation
    • Fitts RH, Romatowski JG, Peters JR, Paddon-Jones D, Wolfe RR, Ferrando AA. The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation. Am J Physiol Cell Physiol. 2007;293: C313-320.
    • (2007) Am J Physiol Cell Physiol , vol.293
    • Fitts, R.H.1    Romatowski, J.G.2    Peters, J.R.3    Paddon-Jones, D.4    Wolfe, R.R.5    Ferrando, A.A.6
  • 57
    • 50649116617 scopus 로고    scopus 로고
    • Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit
    • Brooks N, Cloutier GJ, Cadena SM, et al. Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit. J Appl Physiol. 2008;105:241-248.
    • (2008) J Appl Physiol , vol.105 , pp. 241-248
    • Brooks, N.1    Cloutier, G.J.2    Cadena, S.M.3
  • 58
    • 34548594086 scopus 로고    scopus 로고
    • Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women
    • Trappe T, Burd N, Louis E, Lee G, Trappe S. Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60 days of bed rest in women. Acta Physiol (Oxf). 2007;191:147-159.
    • (2007) Acta Physiol (Oxf) , vol.191 , pp. 147-159
    • Trappe, T.1    Burd, N.2    Louis, E.3    Lee, G.4    Trappe, S.5
  • 59
    • 84859463673 scopus 로고    scopus 로고
    • Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men
    • Pennings B, Groen B, de Lange A, et al. Amino acid absorption and subsequent muscle protein accretion following graded intakes of whey protein in elderly men.AmJ Physiol Endocrinol Metab. 2012; 302:E992-999.
    • (2012) AmJ Physiol Endocrinol Metab , vol.302
    • Pennings, B.1    Groen, B.2    De Lange, A.3
  • 60
    • 84870043638 scopus 로고    scopus 로고
    • Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men
    • Yang Y, Breen L, Burd NA, et al. Resistance exercise enhances myofibrillar protein synthesis with graded intakes of whey protein in older men. Br J Nutr. 2012;108:1780-1788.
    • (2012) Br J Nutr , vol.108 , pp. 1780-1788
    • Yang, Y.1    Breen, L.2    Burd, N.A.3
  • 62
    • 67649848083 scopus 로고    scopus 로고
    • Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein
    • Koopman R, Crombach N, Gijsen A, et al. Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. Am J Clin Nutr. 2009;90:106-115.
    • (2009) Am J Clin Nutr , vol.90 , pp. 106-115
    • Koopman, R.1    Crombach, N.2    Gijsen, A.3
  • 63
    • 84877133779 scopus 로고    scopus 로고
    • Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men
    • Wall BT, Hamer HM, de Lange A, et al. Leucine co-ingestion improves post-prandial muscle protein accretion in elderly men. Clin Nutr. 2013;32:412-419.
    • (2013) Clin Nutr , vol.32 , pp. 412-419
    • Wall, B.T.1    Hamer, H.M.2    De Lange, A.3
  • 64
    • 33746876019 scopus 로고    scopus 로고
    • Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia
    • Rieu I, Balage M, Sornet C, et al. Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia. J Physiol. 2006;575:305-315.
    • (2006) J Physiol , vol.575 , pp. 305-315
    • Rieu, I.1    Balage, M.2    Sornet, C.3
  • 65
    • 33745853476 scopus 로고    scopus 로고
    • Ahigh proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly
    • Katsanos C, Kobayashi H, Sheffield-Moore M, Aarsland A, Wolfe RR.Ahigh proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab. 2006;291:E381-E387.
    • (2006) Am J Physiol Endocrinol Metab , vol.291
    • Katsanos, C.1    Kobayashi, H.2    Sheffield-Moore, M.3    Aarsland, A.4    Wolfe, R.R.5
  • 66
    • 83455176892 scopus 로고    scopus 로고
    • Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men
    • Groen B, Res P, Pennings B, et al. Intragastric protein administration stimulates overnight muscle protein synthesis in elderly men. Am J Physiol Endocrinol Metab. 2012;302:E52-E60.
    • (2012) Am J Physiol Endocrinol Metab , vol.302
    • Groen, B.1    Res, P.2    Pennings, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.